BE645649A - - Google Patents

Info

Publication number
BE645649A
BE645649A BE645649A BE645649A BE645649A BE 645649 A BE645649 A BE 645649A BE 645649 A BE645649 A BE 645649A BE 645649 A BE645649 A BE 645649A BE 645649 A BE645649 A BE 645649A
Authority
BE
Belgium
Application number
BE645649A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of BE645649A publication Critical patent/BE645649A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BE645649A 1958-06-20 1964-03-24 BE645649A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB19793/58A GB860303A (en) 1958-06-20 1958-06-20 Pharmaceutical compositions comprising ª‡-aryloxy-aliphatic carboxylic acids and/or ª

Publications (1)

Publication Number Publication Date
BE645649A true BE645649A (fr) 1964-07-16

Family

ID=10135310

Family Applications (1)

Application Number Title Priority Date Filing Date
BE645649A BE645649A (fr) 1958-06-20 1964-03-24

Country Status (5)

Country Link
US (1) US3262850A (fr)
BE (1) BE645649A (fr)
CY (1) CY282A (fr)
GB (1) GB860303A (fr)
MY (1) MY6400061A (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2043488A1 (fr) * 1969-05-29 1971-02-19 Roussel Uclaf
FR2108980A1 (en) * 1970-10-27 1972-05-26 Biosedra Lab Pure ethyl alpha-p-iodophenoxyisobutyrate - with hypolipaemic activity
DE1593907B1 (de) * 1966-03-31 1972-05-31 Ici Ltd alpha[4-(p-subst.Phenyl)-phenoxy]-carbonsaeuren,deren Derivate sowie diese Verbindungen enthaltende Arzneimittel
FR2126077A1 (en) * 1971-02-23 1972-10-06 Lafon Victor Ethyl (3, 5-diethoxy-phenoxy)isobutyrate - as hypocholesteremic

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3097139A (en) * 1960-03-10 1963-07-09 Ici Ltd Hypocholesterolaemia compositions
BE630211A (fr) * 1962-03-28
GB992152A (en) * 1962-07-11 1965-05-19 Prodotti Schering Soc It Aminoesters
US3332842A (en) * 1963-08-30 1967-07-25 Ciba Geigy Corp Ether acids and derivatives thereof
US3332957A (en) * 1964-09-02 1967-07-25 Ciba Geigy Corp Amino esters of substituted phenoxy acetic acids
SE337383B (fr) * 1965-01-05 1971-08-09 Yoshitomi Pharmaceutical
US3452081A (en) * 1965-05-27 1969-06-24 Merck & Co Inc Phenoxy substituted 2-alkenoic acids
US3538227A (en) * 1967-01-30 1970-11-03 Ciba Geigy Corp Tricyclic phenoxy-acid and ester hypocholesterolemic compositions
SE344742B (fr) * 1968-09-25 1972-05-02 Ciba Geigy Ag
US4031134A (en) * 1969-04-16 1977-06-21 Sumitomo Chemical Company, Limited Phenoxy carboxylic acid derivative
FI52570C (fi) * 1969-04-16 1977-10-10 Sumitomo Chemical Co Menetelmä veren kolesteroli- tai lipoidipitoisuutta alentavien fenoxia lifaattisten karboksyylihappoyhdisteiden ja -esteriyhdisteiden valmist amiseksi.
US3692895A (en) * 1970-09-08 1972-09-19 Norman A Nelson Method of reducing hypercholesteremia in humans employing a copolymer of polyethylenepolyamine and a bifunctional substance, such as epichlorohydria
GB1348642A (en) * 1970-10-15 1974-03-20 Howard A N Hypocholesterolaemic compositions
JPS575214B2 (fr) * 1972-06-01 1982-01-29
US3952096A (en) * 1973-06-15 1976-04-20 Bristol-Myers Company Mixture of calcium carbonate and calcium-α-p-chlorophenoxyisobutyrate as an antihyperlipemic agent
DE2342118C2 (de) * 1973-08-21 1982-09-23 Merck Patent Gmbh, 6100 Darmstadt Phenoxypropionsäurederivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen
US4039683A (en) * 1973-08-21 1977-08-02 Merck Patent Gesellschaft Mit Beschrankter Haftung Phenoxypropionic acid derivatives and pharmaceutical preparations containing same
NL7416412A (nl) * 1973-12-27 1975-07-01 Siegfried Ag Werkwijze ter bereiding van nieuwe cholesterol- gende verbindingen.
US4182902A (en) * 1973-12-27 1980-01-08 Siegfried Aktiengesellschaft Novel cholesterol-lowering compounds
AT353776B (de) * 1973-12-27 1979-12-10 Siegfried Ag Verfahren zur herstellung von neuen alkan- saeuren, deren estern und salzen
CH617417A5 (fr) * 1973-12-27 1980-05-30 Siegfried Ag
US4012523A (en) * 1974-01-24 1977-03-15 The Dow Chemical Company Hypolipidemic 2-(3,5-di-tert-butyl-4-hydroxyphenyl)-(thio or sulfonyl) alkanoic acids and derivatives
US4067998A (en) * 1974-02-11 1978-01-10 The Dow Chemical Company 2-((3,5-Di-tert-butylphenyl)thio) alkanoic acids and derivatives
DK115374A (fr) 1974-03-04 1975-11-03 Byk Gulden Lomberg Chem Fab
US4243819A (en) * 1978-02-16 1981-01-06 Zoecon Corporation Substituted amino acids
US4250191A (en) * 1978-11-30 1981-02-10 Edwards K David Preventing renal failure
JPS58150563A (ja) * 1982-03-04 1983-09-07 Taisho Pharmaceut Co Ltd ３−ベンゾイル−２−メルカプトプロピオン酸誘導体
US4704402A (en) * 1982-06-12 1987-11-03 University Of Pittsburgh Method of treating sickle cell anemia
US4482571A (en) * 1982-06-21 1984-11-13 University Of Pittsburgh Sickle cell anemia treatment and compound
IN160141B (fr) * 1983-05-09 1987-06-27 Council Scient Ind Res
ES8600261A1 (es) * 1983-06-24 1985-10-01 Yamanouchi Pharma Co Ltd Un compuesto fenoxi
EP0320501A3 (fr) * 1983-06-24 1989-12-06 Yamanouchi Pharmaceutical Co., Ltd. Dérivés phénoxy, leur préparation et compositions pharmaceutiques les contenant
DE3621861A1 (de) * 1986-06-30 1988-01-14 Laszlo Dr Med Ilg Verwendung von aryloxycarbonsaeure-derivaten gegen dermatologische erkrankungen
US4859703A (en) * 1987-06-15 1989-08-22 Warner-Lambert Company Lipid regulating compositions
EP0515684A4 (en) * 1990-02-14 1993-04-21 Chugai Seiyaku Kabushiki Kaisha Inhibitor of denatured ldl formation
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
US6268392B1 (en) 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
US6262277B1 (en) 1994-09-13 2001-07-17 G.D. Searle And Company Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6083497A (en) 1997-11-05 2000-07-04 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers
AU4154799A (en) * 1998-06-02 1999-12-20 Arthromics Plc Compounds which interact with the thyroid hormone receptor for the treatment of fibrotic disease
WO2000038725A1 (fr) * 1998-12-23 2000-07-06 G.D. Searle Llc Combinaisons utilisees dans le cadre de troubles cardio-vasculaires
NZ512534A (en) 1998-12-23 2003-11-28 G Combinations of cholesteryl ester transfer protein inhibitors and fibric acid derivatives for cardiovascular indications
ATE242008T1 (de) 1998-12-23 2003-06-15 Searle Llc Kombnationen von cholesteryl ester transfer protein inhibitoren und gallensäure sequestriermitteln für kardiovaskuläre indikationen
WO2000038722A1 (fr) 1998-12-23 2000-07-06 G.D. Searle & Co. COMBINAISONS D'INHIBITEURS DE LA PROTEINE DE TRANSFERT DE L'ESTER DE CHOLESTERYLE ET D'INHIBITEURS DE LA HMG CoA-REDUCTASE UTILISEES DANS LE CADRE DE TROUBLES CARDIO-VASCULAIRES
MXPA01006472A (es) 1998-12-23 2004-03-10 Searle Llc Combinaciones de inhibidores de transporte de acido biliar ileal y derivados de acido fibrico para indicaciones cardiovasculares.
WO2000038721A1 (fr) 1998-12-23 2000-07-06 G.D. Searle Llc Combinaisons d'inhibiteurs de la proteine de transfert du cholesteryle-ester et de derives de l'acide nicotinique utilisees dans le cadre de troubles cardio-vasculaires
JP2002533414A (ja) * 1998-12-23 2002-10-08 ジー．ディー．サール エルエルシー 心臓血管に適用するための回腸胆汁酸輸送阻害剤および胆汁酸隔離剤の組み合わせ
ATE241386T1 (de) * 1998-12-23 2003-06-15 Searle Llc Kombinationen von ileumgallensäuretransports inhibitoren und cholesteryl ester transfer protein inhibitoren
AU2001247331A1 (en) * 2000-03-10 2001-09-24 Pharmacia Corporation Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders
US6794544B2 (en) 2000-03-10 2004-09-21 Pharmacia Corporation Method for the preparation of tetrahydrobenzothiepines
US20040077625A1 (en) * 2001-07-25 2004-04-22 Tremont Samuel J. Novel 1,4-benzothiazepine and 1,5-benzothiazepine compounds as inhibitors of apical sodium codependent bile acid transport abd taurocholate uptake
WO2003040127A1 (fr) * 2001-11-02 2003-05-15 G.D. Searle Llc Composes benzothiepine mono- et di-fluores en tant qu'inhibiteurs du transport d'acides biliaires a co-dependance sodique apicale (asbt) et de reprise de taurocholate
BR0306643A (pt) 2002-01-17 2004-10-19 Pharmacia Corp Novos compostos de hidroxi alquil/aril ou ceto tiepina como inibidores do transporte co-dependente de ácido biliar-sódio apical
ITRM20020629A1 (it) * 2002-12-19 2004-06-20 Sigma Tau Ind Farmaceuti Uso di acidi alfa-feniltiocarbossilici e alfa-fenilossicarbossilici ad attivita' ipoglicemizzante e/o ipolipidemizzante.
US7601756B2 (en) * 2003-06-06 2009-10-13 Snowden Pharmaceuticals, Llc Method of treatment for irritable bowel syndrome
DE602004020649D1 (de) * 2003-11-07 2009-05-28 Jj Pharma Inc Hdl-verstärkende kombinationstherapie-komplexe
US20070190079A1 (en) * 2004-10-29 2007-08-16 Kalypsys, Inc. Methods for the selective modulation of ppar
FR2880887B1 (fr) * 2005-01-14 2009-01-30 Merck Sante Soc Par Actions Si Derives d'hydroxyphenols, procedes pour leur preparation, compositions pharmaceutiques les contenant et applications en therapeutique
CL2007002958A1 (es) * 2006-10-12 2008-05-09 Epix Delaware Inc Compuestos derivados de heteroaril-carboxamida, antagonistas del receptor de quimioquina; composicion farmaceutica; y uso para el tratamiento o prevencion de enfermedades tales como rechazo de transplante de organos, artritis reumatoidea, lupus, entr
EP2134169A2 (fr) 2007-03-09 2009-12-23 Indigene Pharmaceuticals Inc. Combinaison de metformine r-(+) lipoate et d'agents antihyperlipidémiques pour le traitement de l'hyperglycémie diabétique et de complications diabétiques
US20090054450A1 (en) * 2007-06-19 2009-02-26 Ironwood Pharmaceuticals, Inc. Compositions and methods of use for treating or preventing lipid related disorders
US20100331298A1 (en) * 2007-12-10 2010-12-30 Cytopathfinder, Inc. Carboxamide Compounds and Their Use
EP2280766A1 (fr) 2007-12-11 2011-02-09 CytoPathfinder, Inc. Composés à base de carboxamide et leur utilisation en tant qu'agonistes du récepteur des chimiokines
PT2462118E (pt) 2009-08-03 2014-07-25 Acraf Processo para a preparação de 1-benzil-3-hidroximetil-1 hindazole e derivados do mesmo e intermédios de magnésio requeridos
ES2905872T3 (es) 2015-02-06 2022-04-12 Intercept Pharmaceuticals Inc Composiciones farmacéuticas para terapia combinada
KR101956805B1 (ko) * 2019-02-21 2019-03-11 한국식품연구원 부테인 또는 이소유제놀을 포함하는 pcsk9 유전자의 발현 감소 또는 저밀도 지단백 수용체 증가용 조성물

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2580653A (en) * 1946-08-23 1952-01-01 Johnson & Son Inc S C Composition for killing weeds
US2937117A (en) * 1953-06-19 1960-05-17 Chimie Atomistique Process for lowering high blood cholesterol levels
US2957760A (en) * 1957-11-19 1960-10-25 Amchem Prod Process for thinning stone fruits with alpha-(3-chlorophenoxy)-propionic acid and its salts and esters

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1593907B1 (de) * 1966-03-31 1972-05-31 Ici Ltd alpha[4-(p-subst.Phenyl)-phenoxy]-carbonsaeuren,deren Derivate sowie diese Verbindungen enthaltende Arzneimittel
DE1593907C2 (de) * 1966-03-31 1973-01-04 Imperial Chemical Industries Ltd., London alpha eckige Klammer auf 4-(p-subst.Phenyl>phenoxy eckige Klammer zu -carbonsäuren, deren Derivate sowie diese Verbindungen enthaltende Arzneimittel
FR2043488A1 (fr) * 1969-05-29 1971-02-19 Roussel Uclaf
FR2108980A1 (en) * 1970-10-27 1972-05-26 Biosedra Lab Pure ethyl alpha-p-iodophenoxyisobutyrate - with hypolipaemic activity
FR2126077A1 (en) * 1971-02-23 1972-10-06 Lafon Victor Ethyl (3, 5-diethoxy-phenoxy)isobutyrate - as hypocholesteremic

Also Published As

Publication number Publication date
CY282A (en) 1964-03-27
MY6400061A (en) 1964-12-31
US3262850A (en) 1966-07-26
GB860303A (en) 1961-02-01

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