BE557083A - - Google Patents

Info

Publication number

BE557083A

BE557083A BE557083DA BE557083A BE 557083 A BE557083 A BE 557083A BE 557083D A BE557083D A BE 557083DA BE 557083 A BE557083 A BE 557083A

Authority

BE

Belgium

Prior art keywords

alkali metal

metal salt

parts

potassium

phenoxymethylpenicillin

Prior art date

Links

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• 239000011780 sodium chloride Substances 0.000 claims description 32
• 229910052783 alkali metal Inorganic materials 0.000 claims description 27
• -1 alkali metal salt Chemical class 0.000 claims description 24
• BPLBGHOLXOTWMN-MBNYWOFBSA-N Phenoxymethylpenicillin Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)COC1=CC=CC=C1 BPLBGHOLXOTWMN-MBNYWOFBSA-N 0.000 claims description 16
• SCVFZCLFOSHCOH-UHFFFAOYSA-M Potassium acetate Chemical group [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 claims description 13
• 239000007864 aqueous solution Substances 0.000 claims description 13
• 230000000875 corresponding Effects 0.000 claims description 13
• 238000000034 method Methods 0.000 claims description 12
• 229960004331 phenoxymethylpenicillin Drugs 0.000 claims description 11
• 239000007787 solid Substances 0.000 claims description 9
• 235000011056 potassium acetate Nutrition 0.000 claims description 7
• 150000003839 salts Chemical class 0.000 claims description 7
• HCTVWSOKIJULET-LQDWTQKMSA-M phenoxymethylpenicillin potassium Chemical compound [K+].N([C@H]1[C@H]2SC([C@@H](N2C1=O)C([O-])=O)(C)C)C(=O)COC1=CC=CC=C1 HCTVWSOKIJULET-LQDWTQKMSA-M 0.000 claims description 6
• WCUXLLCKKVVCTQ-UHFFFAOYSA-M potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 5
• 150000001340 alkali metals Chemical class 0.000 claims description 3
• 239000001103 potassium chloride Substances 0.000 claims description 3
• 235000011164 potassium chloride Nutrition 0.000 claims description 3
• 239000002994 raw material Substances 0.000 claims description 3
• 239000011541 reaction mixture Substances 0.000 claims description 2
• 239000000126 substance Substances 0.000 claims 1
• 239000000243 solution Substances 0.000 description 14
• 230000036515 potency Effects 0.000 description 13
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
• DKPFZGUDAPQIHT-UHFFFAOYSA-N Butyl acetate Natural products CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 description 6
• ZLMJMSJWJFRBEC-UHFFFAOYSA-N potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 6
• 229910052700 potassium Inorganic materials 0.000 description 6
• 239000011591 potassium Substances 0.000 description 6
• 229940056367 Penicillin V Drugs 0.000 description 5
• 239000000203 mixture Substances 0.000 description 5
• 229910052751 metal Inorganic materials 0.000 description 4
• 239000002184 metal Substances 0.000 description 4
• 239000002253 acid Substances 0.000 description 3
• 239000000463 material Substances 0.000 description 3
• 238000000926 separation method Methods 0.000 description 3
• HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
• UIIMBOGNXHQVGW-UHFFFAOYSA-M NaHCO3 Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
• TYJJADVDDVDEDZ-UHFFFAOYSA-M Potassium bicarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 2
• ASCUXPQGEXGEMJ-GPLGTHOPSA-N [(2R,3S,4S,5R,6S)-3,4,5-triacetyloxy-6-[[(2R,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-(4-methylanilino)oxan-2-yl]methoxy]oxan-2-yl]methyl acetate Chemical compound CC(=O)O[C@@H]1[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H](COC(=O)C)O[C@@H]1OC[C@@H]1[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H](NC=2C=CC(C)=CC=2)O1 ASCUXPQGEXGEMJ-GPLGTHOPSA-N 0.000 description 2
• QTBSBXVTEAMEQO-UHFFFAOYSA-M acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
• 239000006286 aqueous extract Substances 0.000 description 2
• 239000000284 extract Substances 0.000 description 2
• 239000011736 potassium bicarbonate Substances 0.000 description 2
• 235000015497 potassium bicarbonate Nutrition 0.000 description 2
• 229910000028 potassium bicarbonate Inorganic materials 0.000 description 2
• 229940094025 potassium bicarbonate Drugs 0.000 description 2
• KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 2
• 229910052708 sodium Inorganic materials 0.000 description 2
• 239000011734 sodium Substances 0.000 description 2
• FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
• 229940040526 Anhydrous Sodium Acetate Drugs 0.000 description 1
• 229940049954 Penicillin Drugs 0.000 description 1
• JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
• 229960000626 benzylpenicillin Drugs 0.000 description 1
• 238000000605 extraction Methods 0.000 description 1
• 239000012535 impurity Substances 0.000 description 1
• 239000007788 liquid Substances 0.000 description 1
• 230000001264 neutralization Effects 0.000 description 1
• 239000003960 organic solvent Substances 0.000 description 1
• 238000000746 purification Methods 0.000 description 1
• VMHLLURERBWHNL-UHFFFAOYSA-M sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
• 235000017557 sodium bicarbonate Nutrition 0.000 description 1
• 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
• 238000003756 stirring Methods 0.000 description 1
• 238000005406 washing Methods 0.000 description 1