BE544584A - - Google Patents
Info
- Publication number
- BE544584A BE544584A BE544584DA BE544584A BE 544584 A BE544584 A BE 544584A BE 544584D A BE544584D A BE 544584DA BE 544584 A BE544584 A BE 544584A
- Authority
- BE
- Belgium
- Prior art keywords
- sep
- betaine
- glycocyamine
- compound
- hydrochloride
- Prior art date
Links
- KWIUHFFTVRNATP-UHFFFAOYSA-N Trimethylglycine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 131
- 150000001875 compounds Chemical class 0.000 claims description 79
- 229960003237 betaine Drugs 0.000 claims description 65
- BPMFZUMJYQTVII-UHFFFAOYSA-N guanidinoacetic acid zwitterion Chemical compound NC(=N)NCC(O)=O BPMFZUMJYQTVII-UHFFFAOYSA-N 0.000 claims description 62
- 229960003403 Betaine Hydrochloride Drugs 0.000 claims description 23
- HOPSCVCBEOCPJZ-UHFFFAOYSA-N carboxymethyl(trimethyl)azanium;chloride Chemical compound [Cl-].C[N+](C)(C)CC(O)=O HOPSCVCBEOCPJZ-UHFFFAOYSA-N 0.000 claims description 23
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 20
- NJZRLXNBGZBREL-UHFFFAOYSA-O hydron;2-(trimethylazaniumyl)acetate;hydrate Chemical compound O.C[N+](C)(C)CC(O)=O NJZRLXNBGZBREL-UHFFFAOYSA-O 0.000 claims description 18
- UIIMBOGNXHQVGW-UHFFFAOYSA-M NaHCO3 Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 14
- 239000003995 emulsifying agent Substances 0.000 claims description 14
- 239000002253 acid Substances 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 12
- 229960002989 Glutamic Acid Drugs 0.000 claims description 11
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 11
- 229960003707 glutamic acid hydrochloride Drugs 0.000 claims description 9
- 150000004682 monohydrates Chemical class 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 8
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 7
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 7
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 7
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 7
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 7
- 235000005979 Citrus limon Nutrition 0.000 claims description 6
- 240000002268 Citrus limon Species 0.000 claims description 6
- 229960004106 citric acid Drugs 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 claims description 6
- 235000013923 monosodium glutamate Nutrition 0.000 claims description 6
- 239000004223 monosodium glutamate Substances 0.000 claims description 6
- 229940072033 potash Drugs 0.000 claims description 6
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Substances [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 6
- 235000015320 potassium carbonate Nutrition 0.000 claims description 6
- KWYUFKZDYYNOTN-UHFFFAOYSA-M potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 6
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 6
- 230000001225 therapeutic Effects 0.000 claims description 6
- 239000000796 flavoring agent Substances 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- CVHZOJJKTDOEJC-UHFFFAOYSA-N Saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims description 3
- 229940081974 Saccharin Drugs 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 235000019204 saccharin Nutrition 0.000 claims description 3
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 claims description 3
- TYJJADVDDVDEDZ-UHFFFAOYSA-M Potassium bicarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 claims description 2
- -1 alkali metal bicarbonate Chemical class 0.000 claims description 2
- 229940094025 potassium bicarbonate Drugs 0.000 claims description 2
- 239000011736 potassium bicarbonate Substances 0.000 claims description 2
- 229910000028 potassium bicarbonate Inorganic materials 0.000 claims description 2
- 235000015497 potassium bicarbonate Nutrition 0.000 claims description 2
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- 235000015165 citric acid Nutrition 0.000 claims 1
- 239000000470 constituent Substances 0.000 claims 1
- 229910052737 gold Inorganic materials 0.000 claims 1
- 229920001098 polystyrene-block-poly(ethylene/propylene) Polymers 0.000 description 193
- XXOMCDWWEZZWBJ-UHFFFAOYSA-N 2-(diaminomethylideneamino)acetic acid;hydrochloride Chemical compound Cl.NC(=N)NCC(O)=O XXOMCDWWEZZWBJ-UHFFFAOYSA-N 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 11
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 9
- 230000002378 acidificating Effects 0.000 description 8
- 239000004480 active ingredient Substances 0.000 description 7
- 229940023579 ANHYDROUS BETAINE Drugs 0.000 description 6
- 239000004615 ingredient Substances 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate dianion Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 4
- FEWJPZIEWOKRBE-XIXRPRMCSA-N Mesotartaric acid Chemical compound OC(=O)[C@@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-XIXRPRMCSA-N 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000011975 tartaric acid Substances 0.000 description 3
- 229960001367 tartaric acid Drugs 0.000 description 3
- 235000002906 tartaric acid Nutrition 0.000 description 3
- 241000416162 Astragalus gummifer Species 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-N Carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 2
- 229960003624 Creatine Drugs 0.000 description 2
- 241000282414 Homo sapiens Species 0.000 description 2
- 229920001615 Tragacanth Polymers 0.000 description 2
- 230000000875 corresponding Effects 0.000 description 2
- 239000006046 creatine Substances 0.000 description 2
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine zwitterion Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000004945 emulsification Methods 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 230000002496 gastric Effects 0.000 description 2
- 235000013922 glutamic acid Nutrition 0.000 description 2
- 239000004220 glutamic acid Substances 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 201000010830 physical disease Diseases 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000036642 wellbeing Effects 0.000 description 2
- IVLXQGJVBGMLRR-UHFFFAOYSA-N 2-aminoacetic acid;hydron;chloride Chemical compound Cl.NCC(O)=O IVLXQGJVBGMLRR-UHFFFAOYSA-N 0.000 description 1
- 206010013911 Dysgeusia Diseases 0.000 description 1
- 235000007297 Gaultheria procumbens Nutrition 0.000 description 1
- 229960001269 Glycine Hydrochloride Drugs 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 235000016247 Mentha requienii Nutrition 0.000 description 1
- 235000002899 Mentha suaveolens Nutrition 0.000 description 1
- 208000006883 Neuromuscular Disease Diseases 0.000 description 1
- 229940023488 Pill Drugs 0.000 description 1
- 208000000474 Poliomyelitis Diseases 0.000 description 1
- 241000333569 Pyrola minor Species 0.000 description 1
- 229940116362 Tragacanth Drugs 0.000 description 1
- 229910000288 alkali metal carbonate Inorganic materials 0.000 description 1
- 150000008041 alkali metal carbonates Chemical class 0.000 description 1
- 229950010582 betaine anhydrous Drugs 0.000 description 1
- 235000006682 bigleaf mint Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000001055 chewing Effects 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000001804 emulsifying Effects 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 238000005755 formation reaction Methods 0.000 description 1
- 201000010238 heart disease Diseases 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 150000003840 hydrochlorides Chemical class 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000018984 mastication Effects 0.000 description 1
- 239000012022 methylating agents Substances 0.000 description 1
- 230000011987 methylation Effects 0.000 description 1
- 238000007069 methylation reaction Methods 0.000 description 1
- 235000006679 mint Nutrition 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- HEKURBKACCBNEJ-UHFFFAOYSA-M potassium;1,1-dioxo-1,2-benzothiazol-2-id-3-one Chemical compound [K+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 HEKURBKACCBNEJ-UHFFFAOYSA-M 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 235000019600 saltiness Nutrition 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 230000002588 toxic Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE544584A true BE544584A (no) |
Family
ID=172507
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE544584D BE544584A (no) |
Country Status (1)
| Country | Link |
|---|---|
| BE (1) | BE544584A (no) |
-
0
- BE BE544584D patent/BE544584A/fr unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2184570C2 (ru) | Препараты для орального введения | |
| EP0287488B1 (fr) | Médicament, produit diététique et produit d'hygiène sous la forme d'une composition pulvérulente obtenue par adsorption de principes actifs sur un sucre à dissolution rapide et procédé d'obtention de ladite composition | |
| EP0785769B1 (fr) | Association therapeutique vitamino-calcique sous forme galenique unitaire de comprimes, son procede d'obtention et son utilisation | |
| FR2488508A1 (fr) | Capsule analgesique alcaline | |
| BE1015217A5 (no) | ||
| JPH0517345A (ja) | 経口摂取可能な活性成分のための非アルコール性供給系 | |
| LU86932A1 (fr) | Nouvelles compositions pharmaceutiques a base de sels de calcium | |
| SK74396A3 (en) | Organoleptically acceptable oral pharmaceutical compositions | |
| JPH07112973B2 (ja) | イブプロフェン又はその塩を活物質とする可溶性の消炎性組成物及びその製造方法 | |
| FR2813761A1 (fr) | Produit alimentaire d'activation intestinale utilisant de la poudre de natto | |
| EP1032372B1 (fr) | Masquant pour gouts pharmaceutiques en poudre | |
| JP2001010977A (ja) | 経口用組成物 | |
| BE544584A (no) | ||
| CA2909750C (fr) | Composition pharmaceutique, dietetique ou alimentaire liquide ou semi-liquide depourvue d'amertume contenant un sel d'arginine | |
| US4539315A (en) | Sublingually absorbable nontoxic aspirin composition | |
| JP3995202B2 (ja) | 経口用ウコン類組成物 | |
| EP3484453B1 (en) | Effervescent composition containing metamizole sodium monohydrate and method of preparing same | |
| JPH01275522A (ja) | 体臭の経口消臭剤 | |
| EP0910341B1 (fr) | Composition pharmaceutique destinee a une administration par voie buccale | |
| CN115804759B (zh) | 一种含有辅酶q10和钙的颗粒剂 | |
| FR2504802A1 (fr) | Preparations pharmaceutiques a liberation reglee | |
| BE1007926A3 (fr) | Composition pharmaceutique contenant de la n-acetyl-cysteine. | |
| EP3233060B1 (fr) | Libération maîtrisée de substances actives | |
| EP3922237A1 (fr) | Composition orodispersible sous forme d'un comprimé fondant / sous forme d'un comprimé orodispersible comprenant au moins une vitamine comme substance active | |
| FR2838351A1 (fr) | Nouvelles solutions medicamenteuses associant l'oeuf de caille japonaise aux plantes medicinales administrees par voie orale et sublinguale dans les allergies, la pathologie generale et leur procede de fabrication |