BE531071A - - Google Patents

Info

Publication number

BE531071A

BE531071A BE531071DA BE531071A BE 531071 A BE531071 A BE 531071A BE 531071D A BE531071D A BE 531071DA BE 531071 A BE531071 A BE 531071A

Authority

BE

Belgium

Prior art keywords

precipitate

chlorotetracycline

extraction

water

solvent

Prior art date

Links

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• Global Dossier
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• 238000000034 method Methods 0.000 claims description 9
• DHPRQBPJLMKORJ-XRNKAMNCSA-N (4S,4aS,5aS,6S,12aR)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide Chemical compound C1=CC(Cl)=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]4(O)C(=O)C3=C(O)C2=C1O DHPRQBPJLMKORJ-XRNKAMNCSA-N 0.000 claims description 8
• 238000007792 addition Methods 0.000 claims description 7
• BDERNNFJNOPAEC-UHFFFAOYSA-N propanol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 6
• DKGAVHZHDRPRBM-UHFFFAOYSA-N t-BuOH Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 claims description 5
• KFZMGEQAYNKOFK-UHFFFAOYSA-N iso-propanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 2
• 238000000746 purification Methods 0.000 claims description 2
• 239000002244 precipitate Substances 0.000 description 12
• 239000001963 growth media Substances 0.000 description 9
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
• 239000000284 extract Substances 0.000 description 8
• 238000000605 extraction Methods 0.000 description 8
• 239000002904 solvent Substances 0.000 description 8
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
• 230000001476 alcoholic Effects 0.000 description 6
• FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
• 239000002253 acid Substances 0.000 description 5
• VEXZGXHMUGYJMC-UHFFFAOYSA-M chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 5
• 239000002609 media Substances 0.000 description 5
• VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
• 239000003513 alkali Substances 0.000 description 4
• 238000000855 fermentation Methods 0.000 description 4
• 230000004151 fermentation Effects 0.000 description 4
• AHEVKYYGXVEWNO-UEPZRUIBSA-N lymecycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(=O)NCNCCCC[C@H](N)C(O)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O AHEVKYYGXVEWNO-UEPZRUIBSA-N 0.000 description 4
• 239000012535 impurity Substances 0.000 description 3
• 230000020477 pH reduction Effects 0.000 description 3
• 239000012071 phase Substances 0.000 description 3
• 239000011780 sodium chloride Substances 0.000 description 3
• CAFAOQIVXSSFSY-UHFFFAOYSA-N 1-ethoxyethanol Chemical compound CCOC(C)O CAFAOQIVXSSFSY-UHFFFAOYSA-N 0.000 description 2
• 241000186984 Kitasatospora aureofaciens Species 0.000 description 2
• QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
• 239000003242 anti bacterial agent Substances 0.000 description 2
• 239000008346 aqueous phase Substances 0.000 description 2
• 230000003115 biocidal Effects 0.000 description 2
• 235000012970 cakes Nutrition 0.000 description 2
• 239000003518 caustics Substances 0.000 description 2
• 238000005352 clarification Methods 0.000 description 2
• 238000002425 crystallisation Methods 0.000 description 2
• 230000005712 crystallization Effects 0.000 description 2
• 238000010908 decantation Methods 0.000 description 2
• 229910052500 inorganic mineral Inorganic materials 0.000 description 2
• 239000011707 mineral Substances 0.000 description 2
• CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
• 239000007787 solid Substances 0.000 description 2
• 238000003756 stirring Methods 0.000 description 2
• 239000000126 substance Substances 0.000 description 2
• 239000006228 supernatant Substances 0.000 description 2
• 239000000725 suspension Substances 0.000 description 2
• 229940064005 Antibiotic throat preparations Drugs 0.000 description 1
• 229940083879 Antibiotics FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Drugs 0.000 description 1
• 229940042052 Antibiotics for systemic use Drugs 0.000 description 1
• 229940042786 Antitubercular Antibiotics Drugs 0.000 description 1
• 229960004475 Chlortetracycline Drugs 0.000 description 1
• 241000233866 Fungi Species 0.000 description 1
• 229940093922 Gynecological Antibiotics Drugs 0.000 description 1
• 229940024982 Topical Antifungal Antibiotics Drugs 0.000 description 1
• 241001459538 Ute Species 0.000 description 1
• 150000007513 acids Chemical class 0.000 description 1
• 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
• 150000001342 alkaline earth metals Chemical class 0.000 description 1
• SATZVFKUEAMFPB-UHFFFAOYSA-N azanium;sodium;chloride Chemical compound [NH4+].[Na].[Cl-] SATZVFKUEAMFPB-UHFFFAOYSA-N 0.000 description 1
• 229910052788 barium Inorganic materials 0.000 description 1
• DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium(0) Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 1
• OYPRJOBELJOOCE-UHFFFAOYSA-N calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
• 229910052791 calcium Inorganic materials 0.000 description 1
• 239000011575 calcium Substances 0.000 description 1
• XZMCDFZZKTWFGF-UHFFFAOYSA-N carbodiimide Chemical compound NC#N XZMCDFZZKTWFGF-UHFFFAOYSA-N 0.000 description 1
• 235000019365 chlortetracycline Nutrition 0.000 description 1
• 239000000470 constituent Substances 0.000 description 1
• 239000012043 crude product Substances 0.000 description 1
• 239000000706 filtrate Substances 0.000 description 1
• 238000001914 filtration Methods 0.000 description 1
• 229910001504 inorganic chloride Inorganic materials 0.000 description 1
• 229940079866 intestinal antibiotics Drugs 0.000 description 1
• 150000002500 ions Chemical class 0.000 description 1
• 238000002955 isolation Methods 0.000 description 1
• 238000009630 liquid culture Methods 0.000 description 1
• FYYHWMGAXLPEAU-UHFFFAOYSA-N magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
• 229910052749 magnesium Inorganic materials 0.000 description 1
• 239000011777 magnesium Substances 0.000 description 1
• 238000004519 manufacturing process Methods 0.000 description 1
• 235000015097 nutrients Nutrition 0.000 description 1
• 229940005935 ophthalmologic Antibiotics Drugs 0.000 description 1
• 239000000047 product Substances 0.000 description 1
• 238000000926 separation method Methods 0.000 description 1
• 239000002002 slurry Substances 0.000 description 1
• 239000001187 sodium carbonate Substances 0.000 description 1
• 229910000029 sodium carbonate Inorganic materials 0.000 description 1
• 229910000679 solder Inorganic materials 0.000 description 1
• 238000000638 solvent extraction Methods 0.000 description 1
• CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 description 1
• 229910052712 strontium Inorganic materials 0.000 description 1
• 125000001935 tetracenyl group Chemical class C1(=CC=CC2=CC3=CC4=CC=CC=C4C=C3C=C12)* 0.000 description 1