BE515311A - - Google Patents

Info

Publication number

BE515311A

BE515311A BE515311DA BE515311A BE 515311 A BE515311 A BE 515311A BE 515311D A BE515311D A BE 515311DA BE 515311 A BE515311 A BE 515311A

Authority

BE

Belgium

Prior art keywords

extraction

alkaline

water

liters

isopropyl

Prior art date

Links

• Espacenet
• Global Dossier
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• KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 15
• 238000000605 extraction Methods 0.000 claims description 12
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
• 239000000284 extract Substances 0.000 claims description 7
• 238000000855 fermentation Methods 0.000 claims description 6
• 230000004151 fermentation Effects 0.000 claims description 6
• 238000002425 crystallisation Methods 0.000 claims description 5
• 230000008025 crystallization Effects 0.000 claims description 5
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 5
• 238000001556 precipitation Methods 0.000 claims description 5
• ZNQVEEAIQZEUHB-UHFFFAOYSA-N 2-ethoxyethanol Chemical compound CCOCCO ZNQVEEAIQZEUHB-UHFFFAOYSA-N 0.000 claims description 4
• 239000002253 acid Substances 0.000 claims description 4
• 239000000706 filtrate Substances 0.000 claims description 4
• 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 4
• 239000012535 impurity Substances 0.000 claims description 4
• CYDMQBQPVICBEU-UHFFFAOYSA-N chlorotetracycline Natural products C1=CC(Cl)=C2C(O)(C)C3CC4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-UHFFFAOYSA-N 0.000 claims description 3
• 229960004475 chlortetracycline Drugs 0.000 claims description 3
• 235000019365 chlortetracycline Nutrition 0.000 claims description 3
• 238000001914 filtration Methods 0.000 claims description 3
• 238000000034 method Methods 0.000 claims description 3
• CYDMQBQPVICBEU-XRNKAMNCSA-N chlortetracycline Chemical compound C1=CC(Cl)=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-XRNKAMNCSA-N 0.000 claims description 2
• 238000009938 salting Methods 0.000 claims 2
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
• QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
• 239000002904 solvent Substances 0.000 description 4
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
• 150000003839 salts Chemical class 0.000 description 3
• QYAPHLRPFNSDNH-MRFRVZCGSA-N (4s,4as,5as,6s,12ar)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide;hydrochloride Chemical compound Cl.C1=CC(Cl)=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]4(O)C(=O)C3=C(O)C2=C1O QYAPHLRPFNSDNH-MRFRVZCGSA-N 0.000 description 2
• 239000007788 liquid Substances 0.000 description 2
• 239000000047 product Substances 0.000 description 2
• 239000002002 slurry Substances 0.000 description 2
• 239000011780 sodium chloride Substances 0.000 description 2
• 241000187747 Streptomyces Species 0.000 description 1
• 239000012043 crude product Substances 0.000 description 1
• 239000012467 final product Substances 0.000 description 1
• 230000020477 pH reduction Effects 0.000 description 1
• 238000011084 recovery Methods 0.000 description 1
• 238000005406 washing Methods 0.000 description 1