BE492921A - - Google Patents
Info
- Publication number
- BE492921A BE492921A BE492921DA BE492921A BE 492921 A BE492921 A BE 492921A BE 492921D A BE492921D A BE 492921DA BE 492921 A BE492921 A BE 492921A
- Authority
- BE
- Belgium
- Prior art keywords
- thymol
- ester
- isoamyl
- reaction
- formula
- Prior art date
Links
- 239000005844 Thymol Substances 0.000 claims description 18
- 229960000790 thymol Drugs 0.000 claims description 18
- 229930007823 thymol Natural products 0.000 claims description 18
- MGSRCZKZVOBKFT-UHFFFAOYSA-N Thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 claims description 14
- 150000002148 esters Chemical class 0.000 claims description 11
- -1 isoamyl halide Chemical class 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- BMFVGAAISNGQNM-UHFFFAOYSA-N isopentylamine Chemical compound CC(C)CCN BMFVGAAISNGQNM-UHFFFAOYSA-N 0.000 claims description 5
- 238000002844 melting Methods 0.000 claims description 4
- ACMPWZQOUILVFB-UHFFFAOYSA-N 4-methylpentanamide Chemical compound CC(C)CCC(N)=O ACMPWZQOUILVFB-UHFFFAOYSA-N 0.000 claims description 2
- 229910052736 halogen Inorganic materials 0.000 claims description 2
- 150000002367 halogens Chemical class 0.000 claims description 2
- 238000007127 saponification reaction Methods 0.000 claims description 2
- KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- 239000011734 sodium Substances 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-N Carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 description 14
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 8
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Inorganic materials [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 7
- 125000003639 thymyl group Chemical class C1(=CC(C)=CC=C1C(C)C)* 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 206010014881 Enterobiasis Diseases 0.000 description 3
- 238000009835 boiling Methods 0.000 description 3
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 3
- 235000011121 sodium hydroxide Nutrition 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- UQNAQAROTUILLB-UHFFFAOYSA-N 1-isocyanato-3-methylbutane Chemical compound CC(C)CCN=C=O UQNAQAROTUILLB-UHFFFAOYSA-N 0.000 description 2
- 241000498255 Enterobius vermicularis Species 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- HOMVDRDAAUYWKL-UHFFFAOYSA-M [Cl-].C(CC(C)C)N Chemical compound [Cl-].C(CC(C)C)N HOMVDRDAAUYWKL-UHFFFAOYSA-M 0.000 description 2
- 150000001408 amides Chemical group 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 241000700199 Cavia porcellus Species 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 230000001058 adult Effects 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- HEDRZPFGACZZDS-UHFFFAOYSA-N chloroform Substances ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 230000029578 entry into host Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 231100000086 high toxicity Toxicity 0.000 description 1
- 239000005457 ice water Substances 0.000 description 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N methyl alcohol Substances OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 244000045947 parasites Species 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 230000001225 therapeutic Effects 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE492921A true BE492921A (ja) |
Family
ID=137046
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE492921D BE492921A (ja) |
Country Status (1)
| Country | Link |
|---|---|
| BE (1) | BE492921A (ja) |
-
0
- BE BE492921D patent/BE492921A/fr unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0233106B1 (fr) | (-)-Benzhydrylsulfinylacétamide, procédé de préparation et utilisation en thérapeutique | |
| CA1116635A (fr) | Procede de preparation de nouveaux derives de la benzene propanamine et de leurs sels | |
| EP0078785A1 (fr) | Sels d'acide valproîque, leur préparation et leur utilisation | |
| CH624952A5 (ja) | ||
| CA1312333C (fr) | Sel de strontium, son procede de preparation et les compositions pharmaceutiques le renfermant | |
| EP0173597B1 (fr) | Nouveaux éther-oxydes dérivés de cyclopropylphénols | |
| CA1128946A (fr) | Procede de preparation de derives du piperidyl-indole | |
| BE492921A (ja) | ||
| CA1140155A (fr) | PROCEDE DE PREPARATION D'UN NOUVEAU DERIVE DU 1.alpha.,25-DIHYDROXY CHOLECALCIFEROL | |
| CH649919A5 (fr) | Derives substitues de l'acide 4-phenyl 4-oxo 2-hydroxy butanoique a titre de medicaments. | |
| FR2478094A1 (fr) | Derives de cinnamylmoranoline a substitution ammonio, a activite d'inhibition de l'augmentation de niveau de sucre dans le sang | |
| CA1068270A (fr) | Diamino-2,4-bromo-5 chloro-6 pyrimidines utilisables comme medicaments et procede pour leur preparation | |
| FR2491471A1 (fr) | Benzoxazolinones substituees, leur preparation et leur application en therapeutique | |
| FR2547726A1 (fr) | Acide 2-(4-biphenylyl)-4-hexenoique et ses derives ayant une activite anti-inflammatoire | |
| EP0005422A2 (fr) | Dérivés d'acides oméga-dialkylalkanoiques, leurs procédés de préparation ainsi que leur utilisation en thérapeutique | |
| BE528076A (ja) | ||
| BE538582A (ja) | ||
| CH402842A (fr) | Procédé de préparation de nouveaux dérivés de l'héparine | |
| FR2560191A1 (fr) | Derives de nitrodiaryl sulfoxyde, procede pour leur preparation et compositions pharmaceutiques et pesticides les contenant comme ingredient actif | |
| BE580111A (ja) | ||
| FR2508038A1 (fr) | Derives d'acide aminosulfonylbenzoique utiles comme medicaments | |
| BE484261A (ja) | ||
| EP0066934A1 (fr) | Sels de nitrofurantoine, leur préparation et leur utilisation | |
| BE480069A (ja) | ||
| CH275969A (fr) | Procédé de préparation d'une sulfanilamido-quinoxaline substituée. |