BE425345A - - Google Patents

Info

Publication number

BE425345A

BE425345A BE425345DA BE425345A BE 425345 A BE425345 A BE 425345A BE 425345D A BE425345D A BE 425345DA BE 425345 A BE425345 A BE 425345A

Authority

BE

Belgium

Prior art keywords

calcium

double

parts

water

ascorbic acid

Prior art date

Links

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• CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 18
• 235000010323 ascorbic acid Nutrition 0.000 claims description 10
• 239000011668 ascorbic acid Substances 0.000 claims description 9
• 229960005070 ascorbic acid Drugs 0.000 claims description 9
• 159000000007 calcium salts Chemical class 0.000 claims description 9
• 239000002253 acid Substances 0.000 claims description 6
• 150000007513 acids Chemical class 0.000 claims description 6
• 238000000034 method Methods 0.000 claims description 6
• 230000003472 neutralizing effect Effects 0.000 claims 1
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 10
• 229960005069 calcium Drugs 0.000 description 10
• 229910052791 calcium Inorganic materials 0.000 description 10
• 239000011575 calcium Substances 0.000 description 10
• 239000004227 calcium gluconate Substances 0.000 description 9
• 229960004494 calcium gluconate Drugs 0.000 description 9
• 235000013927 calcium gluconate Nutrition 0.000 description 9
• NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 description 9
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
• 235000010376 calcium ascorbate Nutrition 0.000 description 6
• 229940047036 calcium ascorbate Drugs 0.000 description 6
• 239000011692 calcium ascorbate Substances 0.000 description 6
• BLORRZQTHNGFTI-ZZMNMWMASA-L calcium-L-ascorbate Chemical compound [Ca+2].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] BLORRZQTHNGFTI-ZZMNMWMASA-L 0.000 description 6
• VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
• 239000000243 solution Substances 0.000 description 4
• 239000007924 injection Substances 0.000 description 3
• 238000002347 injection Methods 0.000 description 3
• 230000001225 therapeutic effect Effects 0.000 description 3
• RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
• 229910000019 calcium carbonate Inorganic materials 0.000 description 2
• 235000012208 gluconic acid Nutrition 0.000 description 2
• 238000010438 heat treatment Methods 0.000 description 2
• 239000000843 powder Substances 0.000 description 2
• 238000002360 preparation method Methods 0.000 description 2
• 150000003839 salts Chemical class 0.000 description 2
• AAWZDTNXLSGCEK-LNVDRNJUSA-N (3r,5r)-1,3,4,5-tetrahydroxycyclohexane-1-carboxylic acid Chemical compound O[C@@H]1CC(O)(C(O)=O)C[C@@H](O)C1O AAWZDTNXLSGCEK-LNVDRNJUSA-N 0.000 description 1
• 239000002970 Calcium lactobionate Substances 0.000 description 1
• AAWZDTNXLSGCEK-UHFFFAOYSA-N Cordycepinsaeure Natural products OC1CC(O)(C(O)=O)CC(O)C1O AAWZDTNXLSGCEK-UHFFFAOYSA-N 0.000 description 1
• RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
• 150000000996 L-ascorbic acids Chemical class 0.000 description 1
• AAWZDTNXLSGCEK-ZHQZDSKASA-N Quinic acid Natural products O[C@H]1CC(O)(C(O)=O)C[C@H](O)C1O AAWZDTNXLSGCEK-ZHQZDSKASA-N 0.000 description 1
• 239000007864 aqueous solution Substances 0.000 description 1
• 229940076638 ascorbic acid and calcium Drugs 0.000 description 1
• LUULGDQBMOTIRA-QANWPUCUSA-L calcium (3R,5R)-1,3,4,5-tetrahydroxycyclohexane-1-carboxylate Chemical compound [Ca++].O[C@@H]1CC(O)(C[C@@H](O)C1O)C([O-])=O.O[C@@H]1CC(O)(C[C@@H](O)C1O)C([O-])=O LUULGDQBMOTIRA-QANWPUCUSA-L 0.000 description 1
• AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
• -1 calcium gluconate Chemical class 0.000 description 1
• 239000000920 calcium hydroxide Substances 0.000 description 1
• 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
• 235000011116 calcium hydroxide Nutrition 0.000 description 1
• 229940050954 calcium lactobionate Drugs 0.000 description 1
• 235000019307 calcium lactobionate Nutrition 0.000 description 1
• RHEMCSSAABKPLI-SQCCMBKESA-L calcium;(2r,3r,4r,5r)-2,3,5,6-tetrahydroxy-4-[(2s,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexanoate Chemical compound [Ca+2].[O-]C(=O)[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O.[O-]C(=O)[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O RHEMCSSAABKPLI-SQCCMBKESA-L 0.000 description 1
• 150000001875 compounds Chemical class 0.000 description 1
• 238000001816 cooling Methods 0.000 description 1
• 238000002425 crystallisation Methods 0.000 description 1
• 230000008025 crystallization Effects 0.000 description 1
• 238000001704 evaporation Methods 0.000 description 1
• 230000008020 evaporation Effects 0.000 description 1
• 238000011049 filling Methods 0.000 description 1
• 239000000174 gluconic acid Substances 0.000 description 1
• 239000012535 impurity Substances 0.000 description 1
• 239000011664 nicotinic acid Substances 0.000 description 1
• 239000003960 organic solvent Substances 0.000 description 1
• 238000001556 precipitation Methods 0.000 description 1
• 230000002035 prolonged effect Effects 0.000 description 1
• 239000007787 solid Substances 0.000 description 1
• 238000002560 therapeutic procedure Methods 0.000 description 1
• 238000001665 trituration Methods 0.000 description 1