AU9791198A - Yeast cells expressing modified g proteins and methods of use therefor - Google Patents

Yeast cells expressing modified g proteins and methods of use therefor Download PDF

Info

Publication number
AU9791198A
AU9791198A AU97911/98A AU9791198A AU9791198A AU 9791198 A AU9791198 A AU 9791198A AU 97911/98 A AU97911/98 A AU 97911/98A AU 9791198 A AU9791198 A AU 9791198A AU 9791198 A AU9791198 A AU 9791198A
Authority
AU
Australia
Prior art keywords
heterologous
protein
yeast
receptor
subunit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU97911/98A
Other languages
English (en)
Inventor
Anupama N. Benegal
James R Broach
Christine A. Klein
John P Manfredi
Andrew J. M. Murphy
Jeremy I. Paul
Joshua Trueheart
Jun Xu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cadus Pharmaceutical Corp
Original Assignee
Cadus Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/946,298 external-priority patent/US6864060B1/en
Application filed by Cadus Pharmaceutical Corp filed Critical Cadus Pharmaceutical Corp
Publication of AU9791198A publication Critical patent/AU9791198A/en
Priority to AU2003200966A priority Critical patent/AU2003200966B2/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4722—G-proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C07K14/395—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
AU97911/98A 1997-10-07 1998-10-07 Yeast cells expressing modified g proteins and methods of use therefor Abandoned AU9791198A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003200966A AU2003200966B2 (en) 1997-10-07 2003-03-06 Yeast cells expressing modified G proteins and methods of use therefor

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/946,298 US6864060B1 (en) 1993-03-31 1997-10-07 Yeast cells expressing modified G proteins and methods of use therefor
US08946298 1997-10-07
PCT/US1998/021168 WO1999018211A1 (fr) 1997-10-07 1998-10-07 Cellules de levure exprimant des proteines modifiees g et procedes d'utilisation associes

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2003200966A Division AU2003200966B2 (en) 1997-10-07 2003-03-06 Yeast cells expressing modified G proteins and methods of use therefor

Publications (1)

Publication Number Publication Date
AU9791198A true AU9791198A (en) 1999-04-27

Family

ID=25484279

Family Applications (1)

Application Number Title Priority Date Filing Date
AU97911/98A Abandoned AU9791198A (en) 1997-10-07 1998-10-07 Yeast cells expressing modified g proteins and methods of use therefor

Country Status (5)

Country Link
EP (1) EP1021538A1 (fr)
JP (2) JP2001519157A (fr)
AU (1) AU9791198A (fr)
CA (1) CA2305204A1 (fr)
WO (1) WO1999018211A1 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6746852B1 (en) 1998-05-08 2004-06-08 Osi Pharmaceuticals, Inc. AGS proteins and nucleic acid molecules and uses thereof
WO1999058670A1 (fr) * 1998-05-08 1999-11-18 Cadus Pharmaceutical Corporation Molecules d'acides nucleiques et proteines ags, et utilisations correspondantes
US6733991B1 (en) 1998-05-08 2004-05-11 Osi Pharmaceuticals, Inc. AGS proteins and nucleic acid molecules and uses therefor
GB9824682D0 (en) * 1998-11-10 1999-01-06 Isis Innovation Bacillus strain and assay method
EP1179006A4 (fr) * 1999-05-07 2003-03-19 Musc Found For Res Dev Nouvelles proteines de modulateur de proteine g (gpm), molecules d'acide nucleique, et leurs utilisations
US6555325B1 (en) 1999-06-14 2003-04-29 Cadus Technologies, Inc. System for detection of a functional interaction between a compound and a cellular signal transduction component
US6362324B1 (en) 1999-06-30 2002-03-26 Millennium Pharmaceuticals, Inc. 17867 a novel human aminopeptidase
US6369210B1 (en) * 1999-06-30 2002-04-09 Millennium Pharmaceuticals, Inc. 22012, human carboxypeptidase
US7223533B2 (en) 1999-09-10 2007-05-29 Cadus Technologies, Inc. Cell surface proteins and use thereof as indicators of activation of cellular signal transduction pathways
US7067277B1 (en) 1999-12-23 2006-06-27 H. Lundbeck A/S Chimeric G proteins and uses thereof
US6559128B1 (en) * 2000-01-21 2003-05-06 Northwestern University Inhibitors of G protein-mediated signaling, methods of making them, and uses thereof
AU5561301A (en) 2000-04-24 2001-11-20 American Home Prod Transgenic animal
NZ513755A (en) 2001-08-24 2001-09-28 Ann Rachel Holmes Protein expression system in yeast comprising a vector encoding a heterologous membrane protein and its application in screening for drugs
JP5224491B2 (ja) * 2003-12-16 2013-07-03 Ｂｉｏ−ｅｎｅｒｇｙ株式会社 レセプター結合性物質のスクリーニング方法
JP4977012B2 (ja) * 2005-03-29 2012-07-18 Ｂｉｏ−ｅｎｅｒｇｙ株式会社 レセプター結合性物質のスクリーニング方法
ITMI20112038A1 (it) * 2011-11-10 2013-05-11 Arterra Bioscience S R L "nuovi recettori gpcr chimerici, loro usi per lo screening di fitofarmaci, e metodi di screening relativi"
EP2809680B1 (fr) * 2012-01-31 2016-06-15 Canvax Biotech, S.L. Gpcr avec expression amelioree sur la surface cellulaire
CN105463009B (zh) * 2015-12-28 2019-03-22 中国科学院天津工业生物技术研究所 利用重组载体在丝状真菌中筛选外源基因的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE20020110A1 (en) * 1990-09-13 2003-05-28 Univ Duke Expression of G Protein Coupled Receptors in Yeast
DK0692025T3 (da) * 1993-03-31 2002-02-11 Cadus Pharmaceutical Corp Gærceller, der er konstrueret således, at de producerer surrogater for proteiner i feromonsystemet, og anvendelser deraf
CA2188950C (fr) * 1994-04-26 2001-07-03 James R. Broach Expression fonctionnelle d'adenylyle-cyclase de mammifere dans la levure
EP0862614A1 (fr) * 1995-09-20 1998-09-09 Molecular Geriatrics Corporation Recepteur de levure et proteine de fusion de proteine g
CA2266543C (fr) * 1996-09-24 2003-12-09 Cadus Pharmaceutical Corporation Procedes et compositions pour identifier des modulateurs de recepteur

Also Published As

Publication number Publication date
JP2001519157A (ja) 2001-10-23
CA2305204A1 (fr) 1999-04-15
WO1999018211A1 (fr) 1999-04-15
JP2009143932A (ja) 2009-07-02
EP1021538A1 (fr) 2000-07-26

Similar Documents

Publication Publication Date Title
EP0929691B1 (fr) Procedes et compositions pour identifier des modulateurs de recepteur
US20080268475A1 (en) Yeast cells expressing modified g proteins and methods of use therefor
CA2188950C (fr) Expression fonctionnelle d'adenylyle-cyclase de mammifere dans la levure
US6255059B1 (en) Methods for identifying G protein coupled receptor effectors
US7081360B2 (en) Expression of G protein-coupled receptors with altered ligand binding and/or coupling properties
EP0692025B1 (fr) Cellules de levure traitees pour produire des substituts de proteines du systeme de pheromones, et leurs emplois
JP2009143932A (ja) 改変ｇ蛋白質を発現する酵母細胞及びそれらの利用方法
US5789184A (en) Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor
US20030008380A1 (en) Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor
US7319009B2 (en) Methods and compositions for identifying receptor effectors
US5876951A (en) Yeast cells engineered to produce pheromone system protein surrogates and uses therefor
US6355473B1 (en) Yeast cells having mutations in stp22 and uses therefor
US7273747B2 (en) Cell having amplified signal transduction pathway responses and uses therefor
US6251605B1 (en) Yeast cells having mutations in Cav1 and uses therefor
US7250263B2 (en) Methods and compositions for identifying receptor effectors
US20030009022A1 (en) Methods and compositions for identifying receptor effectors
US7611854B2 (en) Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor
US20020015967A1 (en) Functional expression of adenosine receptors in yeast
US7235648B1 (en) Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor

Legal Events

Date Code Title Description
MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted