AU9260598A - Zymogenic protease precursors that can be autocatalytically activated and their use - Google Patents

Zymogenic protease precursors that can be autocatalytically activated and their use

Info

Publication number
AU9260598A
AU9260598A AU92605/98A AU9260598A AU9260598A AU 9260598 A AU9260598 A AU 9260598A AU 92605/98 A AU92605/98 A AU 92605/98A AU 9260598 A AU9260598 A AU 9260598A AU 9260598 A AU9260598 A AU 9260598A
Authority
AU
Australia
Prior art keywords
protease
zymogenic
precursor
host cell
active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU92605/98A
Other languages
English (en)
Inventor
Wolfram Bode
Karl-Peter Hopfner
Robert Huber
Erhard Kopetzki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Publication of AU9260598A publication Critical patent/AU9260598A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6427—Chymotrypsins (3.4.21.1; 3.4.21.2); Trypsin (3.4.21.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6432—Coagulation factor Xa (3.4.21.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21006—Coagulation factor Xa (3.4.21.6)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU92605/98A 1997-08-22 1998-08-12 Zymogenic protease precursors that can be autocatalytically activated and their use Abandoned AU9260598A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP97114513 1997-08-22
EP97114513 1997-08-22
EP97117816 1997-10-15
EP97117816 1997-10-15
PCT/EP1998/005094 WO1999010503A1 (de) 1997-08-22 1998-08-12 Autokatalytisch aktivierbare zymogene vorstufen von proteasen und deren verwendung

Publications (1)

Publication Number Publication Date
AU9260598A true AU9260598A (en) 1999-03-16

Family

ID=26145739

Family Applications (1)

Application Number Title Priority Date Filing Date
AU92605/98A Abandoned AU9260598A (en) 1997-08-22 1998-08-12 Zymogenic protease precursors that can be autocatalytically activated and their use

Country Status (9)

Country Link
EP (1) EP1012307B1 (enExample)
JP (1) JP3947653B2 (enExample)
AT (1) ATE294869T1 (enExample)
AU (1) AU9260598A (enExample)
CA (1) CA2301698A1 (enExample)
DE (1) DE59812768D1 (enExample)
DK (1) DK1012307T3 (enExample)
IL (1) IL134653A0 (enExample)
WO (1) WO1999010503A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6159722A (en) 1997-12-03 2000-12-12 Boehringer Mannheim Gmbh Chimeric serine proteases
GB9911689D0 (en) * 1999-05-19 1999-07-21 Medical Res Council Refolding method
IL147411A0 (en) 1999-08-09 2002-08-14 Biochemie Gmbh Production of proteins by autoproteolytic cleavage
SK287488B6 (sk) * 1999-08-09 2010-11-08 Sandoz Ag Spôsob rekombinantnej produkcie heterológneho polypeptidu pomocou peptidu s autoproteolytickou aktivitou
WO2001019970A2 (en) * 1999-09-15 2001-03-22 Eli Lilly And Company Chymotrypsin-free trypsin
WO2001066771A2 (en) * 2000-03-03 2001-09-13 Zymogenetics, Inc. Human serine protease
DK1399568T3 (da) 2001-02-01 2006-03-27 Hoffmann La Roche Fremgangsmåde til fremstilling af rekombinant trypsin
DK1546302T3 (da) 2002-08-30 2009-12-14 Novozymes Inc Fremgangsmåder til fremstilling af pattedyrs-trypsiner
JP2006507813A (ja) * 2002-10-04 2006-03-09 シエーリング アクチエンゲゼルシャフト 置換体活性化配列を有する修飾されたヘプシン分子及びその使用
CN101109011A (zh) * 2003-06-11 2008-01-23 舍林股份公司 新的具有取代活化序列的经修饰的corin分子及其用途
JP2015092852A (ja) * 2013-11-12 2015-05-18 倉敷紡績株式会社 生体組織分散用組成物
WO2018174231A1 (ja) * 2017-03-24 2018-09-27 株式会社カネカ 酵母におけるプロテアーゼの製造方法
JP2025538565A (ja) 2022-11-23 2025-11-28 エフ． ホフマン－ラ ロシュ アーゲー 組換えタンパク質発現を増加させるための方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1340740C (en) * 1987-12-08 1999-09-14 Eileen R. Mulvihill Co-expression in eukaryotic cells
DE4140699A1 (de) * 1991-01-11 1992-07-16 Boehringer Mannheim Gmbh Rekombinante iga-protease
CA2102673A1 (en) * 1992-11-13 1994-05-14 Michael G. Greaney Expression vectors for bovine trypsin and trypsinogen and host cells transformed therewith
JP3920331B2 (ja) * 1994-12-09 2007-05-30 ノボ ノルディスク アクティーゼルスカブ 細菌において細胞外タンパク質を製造するための方法
EP0833898A1 (en) * 1995-06-16 1998-04-08 Novo Nordisk A/S A process for producing trypsin (trypsinogen)

Also Published As

Publication number Publication date
DE59812768D1 (de) 2005-06-09
EP1012307A1 (de) 2000-06-28
IL134653A0 (en) 2001-04-30
WO1999010503A1 (de) 1999-03-04
ATE294869T1 (de) 2005-05-15
EP1012307B1 (de) 2005-05-04
JP3947653B2 (ja) 2007-07-25
DK1012307T3 (da) 2005-09-05
JP2001514003A (ja) 2001-09-11
CA2301698A1 (en) 1999-03-04

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase