AU8280587A - New indolecarboxamide derivatives as well as salts thereof, process and intermediates for preparation, application of these derivatives by way of medicinal products and compositions containing them - Google Patents
New indolecarboxamide derivatives as well as salts thereof, process and intermediates for preparation, application of these derivatives by way of medicinal products and compositions containing themInfo
- Publication number
- AU8280587A AU8280587A AU82805/87A AU8280587A AU8280587A AU 8280587 A AU8280587 A AU 8280587A AU 82805/87 A AU82805/87 A AU 82805/87A AU 8280587 A AU8280587 A AU 8280587A AU 8280587 A AU8280587 A AU 8280587A
- Authority
- AU
- Australia
- Prior art keywords
- derivatives
- image
- preparation
- application
- intermediates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
- C07D209/64—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles with an oxygen atom in position 1
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Products (I): <IMAGE> in which either R2, R3 = H, B = COHN, b = H, a and c = double bond, or <IMAGE> or R1 and R with N = morpholine, or A = -(CH2)3, R1 = H, R = 1,1-dimethylpropyl, cyclohexyl, cyclohexylmethyl, propyl, isopropyl, <IMAGE> or R1, R2, R3 = H, B = NHCO, b = H, a and c = double bond, or A = -(CH2)3, R = cyclopentyl, cyclohexyl, 1,1-dimethylpropyl, <IMAGE> or A = -(CH2)4, R = 1,1-(dimethylethyl), or R2 = CH3, R3 = H, B = NHCO, b = H, a and c = double bond, <IMAGE> R = 1,1-(dimethylethyl), or R1 and R with <IMAGE> A = -(CH2)n, <IMAGE> R3 = H, C1-C5 alk, C1-C5 Oalk, Cl, Br, I, NO2, HN2, optionally substituted, a and b = oxo or a and c = double bond, R2 = H, alk, alkenyl, alkynyl, optionally substituted aralkyl, cycloallylalkyl, their preparation, their application as antiarrhythmic medications.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8617810 | 1986-12-19 | ||
FR868617810A FR2608601B2 (en) | 1985-07-11 | 1986-12-19 | NOVEL CARBOXAMIDE INDOLE DERIVATIVES, SALTS THEREOF, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION, APPLICATION AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM |
Publications (2)
Publication Number | Publication Date |
---|---|
AU8280587A true AU8280587A (en) | 1988-06-23 |
AU617094B2 AU617094B2 (en) | 1991-11-21 |
Family
ID=9342092
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU82805/87A Ceased AU617094B2 (en) | 1986-12-19 | 1987-12-18 | New indolecarboxamide derivatives as well as salts thereof, process and intermediates for preparation, application of these derivatives by way of medicinal products and compositions containing them |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0275762B1 (en) |
JP (1) | JPS63233972A (en) |
KR (1) | KR880007459A (en) |
AT (1) | ATE97403T1 (en) |
AU (1) | AU617094B2 (en) |
DE (1) | DE3788207T2 (en) |
DK (1) | DK169328B1 (en) |
ES (1) | ES2059402T3 (en) |
FI (1) | FI85139C (en) |
HU (1) | HU199792B (en) |
IE (1) | IE61987B1 (en) |
ZA (1) | ZA879523B (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU601687B2 (en) * | 1985-07-11 | 1990-09-20 | Roussel-Uclaf | New derivatives of carboxamide indole, their salts, process and intermediates for preparation, use as medicaments and compositions containing them |
AU619728B2 (en) * | 1987-01-09 | 1992-02-06 | Roussel-Uclaf | New N-(1H-indol-4-yl)benzamide derivatives and also their salts, their application by way of medicinal products and the compositions containing them |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4908367A (en) * | 1985-07-11 | 1990-03-13 | Roussel Uclaf | N-(1H-indole-4-yl)-benzamides |
WO2002070478A1 (en) | 2001-03-06 | 2002-09-12 | Astrazeneca Ab | Indolone derivatives having vascular-damaging activity |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2528043A1 (en) * | 1982-06-03 | 1983-12-09 | Roussel Uclaf | NOVEL 1,3-DIHYDRO 4- / 1-HYDROXY-2-AMINO-ETHYL / 2H-INDOL-2-ONE DERIVATIVES, THEIR SALTS, PREPARATION METHOD, MEDICAMENT APPLICATION AND COMPOSITIONS COMPRISING THE SAME |
FR2558158B1 (en) * | 1984-01-13 | 1986-05-16 | Roussel Uclaf | ETHENYL PHENOL INDOLE DERIVATIVES, SALTS THEREOF, PROCESS FOR THEIR PREPARATION, APPLICATION AS MEDICAMENTS, COMPOSITIONS CONTAINING THEM AND INTERMEDIATES |
US4853408A (en) * | 1985-04-23 | 1989-08-01 | Roussel Uclaf | 4-phenylpropyl-indoles having antiarythmic activity |
FR2583047B1 (en) * | 1985-06-05 | 1988-01-08 | Roussel Uclaf | PROCESS FOR THE PREPARATION OF INDOLE 4-PHENYLPROPYL DERIVATIVES AND INTERMEDIATES |
JP2950710B2 (en) * | 1992-07-15 | 1999-09-20 | 小島プレス工業株式会社 | Shift lever device |
-
1987
- 1987-12-17 ES ES87402892T patent/ES2059402T3/en not_active Expired - Lifetime
- 1987-12-17 AT AT87402892T patent/ATE97403T1/en not_active IP Right Cessation
- 1987-12-17 EP EP87402892A patent/EP0275762B1/en not_active Expired - Lifetime
- 1987-12-17 DE DE87402892T patent/DE3788207T2/en not_active Expired - Fee Related
- 1987-12-18 AU AU82805/87A patent/AU617094B2/en not_active Ceased
- 1987-12-18 ZA ZA879523A patent/ZA879523B/en unknown
- 1987-12-18 DK DK668687A patent/DK169328B1/en not_active IP Right Cessation
- 1987-12-18 HU HU875870A patent/HU199792B/en not_active IP Right Cessation
- 1987-12-18 JP JP62319123A patent/JPS63233972A/en active Pending
- 1987-12-18 FI FI875586A patent/FI85139C/en not_active IP Right Cessation
- 1987-12-18 IE IE344187A patent/IE61987B1/en not_active IP Right Cessation
- 1987-12-19 KR KR870014617A patent/KR880007459A/en not_active Application Discontinuation
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU601687B2 (en) * | 1985-07-11 | 1990-09-20 | Roussel-Uclaf | New derivatives of carboxamide indole, their salts, process and intermediates for preparation, use as medicaments and compositions containing them |
AU619728B2 (en) * | 1987-01-09 | 1992-02-06 | Roussel-Uclaf | New N-(1H-indol-4-yl)benzamide derivatives and also their salts, their application by way of medicinal products and the compositions containing them |
Also Published As
Publication number | Publication date |
---|---|
FI85139C (en) | 1992-03-10 |
DK668687A (en) | 1988-06-20 |
DK668687D0 (en) | 1987-12-18 |
ES2059402T3 (en) | 1994-11-16 |
DE3788207T2 (en) | 1994-03-31 |
HU199792B (en) | 1990-03-28 |
IE61987B1 (en) | 1994-12-14 |
KR880007459A (en) | 1988-08-27 |
IE873441L (en) | 1988-06-19 |
EP0275762B1 (en) | 1993-11-18 |
EP0275762A1 (en) | 1988-07-27 |
AU617094B2 (en) | 1991-11-21 |
ATE97403T1 (en) | 1993-12-15 |
FI875586A (en) | 1988-06-20 |
FI85139B (en) | 1991-11-29 |
ZA879523B (en) | 1989-02-22 |
HUT47245A (en) | 1989-02-28 |
DK169328B1 (en) | 1994-10-10 |
JPS63233972A (en) | 1988-09-29 |
FI875586A0 (en) | 1987-12-18 |
DE3788207D1 (en) | 1993-12-23 |
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