ZA879523B - Indolecarboxamide derivatives - Google Patents

Indolecarboxamide derivatives

Info

Publication number
ZA879523B
ZA879523B ZA879523A ZA879523A ZA879523B ZA 879523 B ZA879523 B ZA 879523B ZA 879523 A ZA879523 A ZA 879523A ZA 879523 A ZA879523 A ZA 879523A ZA 879523 B ZA879523 B ZA 879523B
Authority
ZA
South Africa
Prior art keywords
image
double bond
nhco
dimethylpropyl
dimethylethyl
Prior art date
Application number
ZA879523A
Inventor
Francois Clemence
Clemence Francois
Jacques Guillaume
Guillaume Jacques
Gilles Hamon
Hamon Gilles
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR868617810A external-priority patent/FR2608601B2/en
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of ZA879523B publication Critical patent/ZA879523B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
    • C07D209/64—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles with an oxygen atom in position 1

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Products (I): <IMAGE> in which either R2, R3 = H, B = COHN, b = H, a and c = double bond, or <IMAGE> or R1 and R with N = morpholine, or A = -(CH2)3, R1 = H, R = 1,1-dimethylpropyl, cyclohexyl, cyclohexylmethyl, propyl, isopropyl, <IMAGE> or R1, R2, R3 = H, B = NHCO, b = H, a and c = double bond, or A = -(CH2)3, R = cyclopentyl, cyclohexyl, 1,1-dimethylpropyl, <IMAGE> or A = -(CH2)4, R = 1,1-(dimethylethyl), or R2 = CH3, R3 = H, B = NHCO, b = H, a and c = double bond, <IMAGE> R = 1,1-(dimethylethyl), or R1 and R with <IMAGE> A = -(CH2)n, <IMAGE> R3 = H, C1-C5 alk, C1-C5 Oalk, Cl, Br, I, NO2, HN2, optionally substituted, a and b = oxo or a and c = double bond, R2 = H, alk, alkenyl, alkynyl, optionally substituted aralkyl, cycloallylalkyl, their preparation, their application as antiarrhythmic medications.
ZA879523A 1986-12-19 1987-12-18 Indolecarboxamide derivatives ZA879523B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR868617810A FR2608601B2 (en) 1985-07-11 1986-12-19 NOVEL CARBOXAMIDE INDOLE DERIVATIVES, SALTS THEREOF, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION, APPLICATION AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM

Publications (1)

Publication Number Publication Date
ZA879523B true ZA879523B (en) 1989-02-22

Family

ID=9342092

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA879523A ZA879523B (en) 1986-12-19 1987-12-18 Indolecarboxamide derivatives

Country Status (12)

Country Link
EP (1) EP0275762B1 (en)
JP (1) JPS63233972A (en)
KR (1) KR880007459A (en)
AT (1) ATE97403T1 (en)
AU (1) AU617094B2 (en)
DE (1) DE3788207T2 (en)
DK (1) DK169328B1 (en)
ES (1) ES2059402T3 (en)
FI (1) FI85139C (en)
HU (1) HU199792B (en)
IE (1) IE61987B1 (en)
ZA (1) ZA879523B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2584713B1 (en) * 1985-07-11 1988-09-09 Roussel Uclaf NOVEL CARBOXAMIDE INDOLE DERIVATIVES, SALTS THEREOF, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION, APPLICATION AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM
FR2609464B1 (en) * 1987-01-09 1990-12-07 Roussel Uclaf NOVEL N- (1H-INDOL 4-YL) BENZAMIDE DERIVATIVES AND THEIR SALTS, THEIR USE AS MEDICAMENTS, AND THE COMPOSITIONS CONTAINING THEM
US4908367A (en) * 1985-07-11 1990-03-13 Roussel Uclaf N-(1H-indole-4-yl)-benzamides
JP2004529110A (en) 2001-03-06 2004-09-24 アストラゼネカ アクチボラグ Indole derivatives with vascular damage activity

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2528043A1 (en) * 1982-06-03 1983-12-09 Roussel Uclaf NOVEL 1,3-DIHYDRO 4- / 1-HYDROXY-2-AMINO-ETHYL / 2H-INDOL-2-ONE DERIVATIVES, THEIR SALTS, PREPARATION METHOD, MEDICAMENT APPLICATION AND COMPOSITIONS COMPRISING THE SAME
FR2558158B1 (en) * 1984-01-13 1986-05-16 Roussel Uclaf ETHENYL PHENOL INDOLE DERIVATIVES, SALTS THEREOF, PROCESS FOR THEIR PREPARATION, APPLICATION AS MEDICAMENTS, COMPOSITIONS CONTAINING THEM AND INTERMEDIATES
US4853408A (en) * 1985-04-23 1989-08-01 Roussel Uclaf 4-phenylpropyl-indoles having antiarythmic activity
FR2583047B1 (en) * 1985-06-05 1988-01-08 Roussel Uclaf PROCESS FOR THE PREPARATION OF INDOLE 4-PHENYLPROPYL DERIVATIVES AND INTERMEDIATES
JP2950710B2 (en) * 1992-07-15 1999-09-20 小島プレス工業株式会社 Shift lever device

Also Published As

Publication number Publication date
FI85139B (en) 1991-11-29
KR880007459A (en) 1988-08-27
IE873441L (en) 1988-06-19
EP0275762B1 (en) 1993-11-18
JPS63233972A (en) 1988-09-29
DK169328B1 (en) 1994-10-10
AU8280587A (en) 1988-06-23
ES2059402T3 (en) 1994-11-16
DE3788207D1 (en) 1993-12-23
HUT47245A (en) 1989-02-28
ATE97403T1 (en) 1993-12-15
FI875586A0 (en) 1987-12-18
AU617094B2 (en) 1991-11-21
EP0275762A1 (en) 1988-07-27
FI875586A (en) 1988-06-20
HU199792B (en) 1990-03-28
DE3788207T2 (en) 1994-03-31
FI85139C (en) 1992-03-10
DK668687A (en) 1988-06-20
DK668687D0 (en) 1987-12-18
IE61987B1 (en) 1994-12-14

Similar Documents

Publication Publication Date Title
DK183386D0 (en) SUCRALFATSUSPENSION
ATE114316T1 (en) NEW PHOSPHOLIPID DERIVATIVES OF NUCLEOSIDS, THEIR PRODUCTION AND USE AS ANTIVIRAL PHARMACEUTICALS.
IL89921A0 (en) 1,3-dioxolane derivatives and pharmaceutical compositions containing the same
IT1228288B (en) COMPOUNDS WITH ANTI-SEROTONIN ACTIVITY
ZA879523B (en) Indolecarboxamide derivatives
DE68917660D1 (en) 2,4,6-Triaminopyrimidine-3-oxide derivatives containing urea, their preparation and their use for cosmetics and skin pharmacy.
JPS6419066A (en) Dihydropyridineamides
ATE198890T1 (en) ANTIDEPRESSANTS
IL73757A0 (en) Thiolane-2,4-dione-3-carboxamides,their preparation and their use as pesticides
ES2125849T3 (en) 1-DIMETILCARBAMOIL-3-SUBSTITUTE-5-SUBSTITUTE-1H-1,2,4-TRIAZOLES.
DE59208349D1 (en) 2-arylpropene acids and their use in the manufacture of S-ketoprofen
ATE160806T1 (en) N1-TRIFLUORALKYL SUBSTITUTED 2-NITRO-P-PHENYLENEDIAMINE DYES
ES2091571T3 (en) NEW ACTIVE PEPTIDIC DERIVATIVES IN THE CELL ADHESION PROCESSES, THEIR PREPARATION PROCEDURE AND THE PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
ATE89555T1 (en) 3-SUBSTITUTED 1-(2-HALOGENALKOXYBENZENESULFONYL)-3-HETEROARYL UREAS.
PL298827A1 (en) Novel enantiomers derivatives of (s)-2-amino(3,4-dichlorobenzyl) propanol-1