DK668687A - INDOLCARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND MEDICINAL PRODUCTS WITH CONTENTS - Google Patents

INDOLCARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND MEDICINAL PRODUCTS WITH CONTENTS

Info

Publication number
DK668687A
DK668687A DK668687A DK668687A DK668687A DK 668687 A DK668687 A DK 668687A DK 668687 A DK668687 A DK 668687A DK 668687 A DK668687 A DK 668687A DK 668687 A DK668687 A DK 668687A
Authority
DK
Denmark
Prior art keywords
image
preparation
double bond
indolcarboxamide
derivatives
Prior art date
Application number
DK668687A
Other languages
Danish (da)
Other versions
DK169328B1 (en
DK668687D0 (en
Inventor
Francois Clemence
Jacques Guillaume
Gilles Hamon
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR868617810A external-priority patent/FR2608601B2/en
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of DK668687D0 publication Critical patent/DK668687D0/en
Publication of DK668687A publication Critical patent/DK668687A/en
Application granted granted Critical
Publication of DK169328B1 publication Critical patent/DK169328B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
    • C07D209/64—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles with an oxygen atom in position 1

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Products (I): <IMAGE> in which either R2, R3 = H, B = COHN, b = H, a and c = double bond, or <IMAGE> or R1 and R with N = morpholine, or A = -(CH2)3, R1 = H, R = 1,1-dimethylpropyl, cyclohexyl, cyclohexylmethyl, propyl, isopropyl, <IMAGE> or R1, R2, R3 = H, B = NHCO, b = H, a and c = double bond, or A = -(CH2)3, R = cyclopentyl, cyclohexyl, 1,1-dimethylpropyl, <IMAGE> or A = -(CH2)4, R = 1,1-(dimethylethyl), or R2 = CH3, R3 = H, B = NHCO, b = H, a and c = double bond, <IMAGE> R = 1,1-(dimethylethyl), or R1 and R with <IMAGE> A = -(CH2)n, <IMAGE> R3 = H, C1-C5 alk, C1-C5 Oalk, Cl, Br, I, NO2, HN2, optionally substituted, a and b = oxo or a and c = double bond, R2 = H, alk, alkenyl, alkynyl, optionally substituted aralkyl, cycloallylalkyl, their preparation, their application as antiarrhythmic medications.
DK668687A 1986-12-19 1987-12-18 Indole carboxamide derivatives, their preparation and pharmaceutical preparations containing them DK169328B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR868617810A FR2608601B2 (en) 1985-07-11 1986-12-19 NOVEL CARBOXAMIDE INDOLE DERIVATIVES, SALTS THEREOF, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION, APPLICATION AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM
FR8617810 1986-12-19

Publications (3)

Publication Number Publication Date
DK668687D0 DK668687D0 (en) 1987-12-18
DK668687A true DK668687A (en) 1988-06-20
DK169328B1 DK169328B1 (en) 1994-10-10

Family

ID=9342092

Family Applications (1)

Application Number Title Priority Date Filing Date
DK668687A DK169328B1 (en) 1986-12-19 1987-12-18 Indole carboxamide derivatives, their preparation and pharmaceutical preparations containing them

Country Status (12)

Country Link
EP (1) EP0275762B1 (en)
JP (1) JPS63233972A (en)
KR (1) KR880007459A (en)
AT (1) ATE97403T1 (en)
AU (1) AU617094B2 (en)
DE (1) DE3788207T2 (en)
DK (1) DK169328B1 (en)
ES (1) ES2059402T3 (en)
FI (1) FI85139C (en)
HU (1) HU199792B (en)
IE (1) IE61987B1 (en)
ZA (1) ZA879523B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2609464B1 (en) * 1987-01-09 1990-12-07 Roussel Uclaf NOVEL N- (1H-INDOL 4-YL) BENZAMIDE DERIVATIVES AND THEIR SALTS, THEIR USE AS MEDICAMENTS, AND THE COMPOSITIONS CONTAINING THEM
US4908367A (en) * 1985-07-11 1990-03-13 Roussel Uclaf N-(1H-indole-4-yl)-benzamides
FR2584713B1 (en) * 1985-07-11 1988-09-09 Roussel Uclaf NOVEL CARBOXAMIDE INDOLE DERIVATIVES, SALTS THEREOF, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION, APPLICATION AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM
EP1370527A1 (en) 2001-03-06 2003-12-17 AstraZeneca AB Indolone derivatives having vascular-damaging activity

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2528043A1 (en) * 1982-06-03 1983-12-09 Roussel Uclaf NOVEL 1,3-DIHYDRO 4- / 1-HYDROXY-2-AMINO-ETHYL / 2H-INDOL-2-ONE DERIVATIVES, THEIR SALTS, PREPARATION METHOD, MEDICAMENT APPLICATION AND COMPOSITIONS COMPRISING THE SAME
FR2558158B1 (en) * 1984-01-13 1986-05-16 Roussel Uclaf ETHENYL PHENOL INDOLE DERIVATIVES, SALTS THEREOF, PROCESS FOR THEIR PREPARATION, APPLICATION AS MEDICAMENTS, COMPOSITIONS CONTAINING THEM AND INTERMEDIATES
US4853408A (en) * 1985-04-23 1989-08-01 Roussel Uclaf 4-phenylpropyl-indoles having antiarythmic activity
FR2583047B1 (en) * 1985-06-05 1988-01-08 Roussel Uclaf PROCESS FOR THE PREPARATION OF INDOLE 4-PHENYLPROPYL DERIVATIVES AND INTERMEDIATES
JP2950710B2 (en) * 1992-07-15 1999-09-20 小島プレス工業株式会社 Shift lever device

Also Published As

Publication number Publication date
IE61987B1 (en) 1994-12-14
ATE97403T1 (en) 1993-12-15
HU199792B (en) 1990-03-28
EP0275762B1 (en) 1993-11-18
FI85139C (en) 1992-03-10
DE3788207T2 (en) 1994-03-31
AU8280587A (en) 1988-06-23
JPS63233972A (en) 1988-09-29
KR880007459A (en) 1988-08-27
EP0275762A1 (en) 1988-07-27
ES2059402T3 (en) 1994-11-16
DE3788207D1 (en) 1993-12-23
ZA879523B (en) 1989-02-22
DK169328B1 (en) 1994-10-10
FI875586A0 (en) 1987-12-18
IE873441L (en) 1988-06-19
DK668687D0 (en) 1987-12-18
FI875586A (en) 1988-06-20
HUT47245A (en) 1989-02-28
AU617094B2 (en) 1991-11-21
FI85139B (en) 1991-11-29

Similar Documents

Publication Publication Date Title
IL89921A (en) 1,3-dioxolane derivatives and pharmaceutical compositions containing the same
ATE114316T1 (en) NEW PHOSPHOLIPID DERIVATIVES OF NUCLEOSIDS, THEIR PRODUCTION AND USE AS ANTIVIRAL PHARMACEUTICALS.
FI861674A (en) SUKRALFATSUSPENSION.
NO934300L (en) Pyrrolidine and thiazolidine derivatives, their preparation and medicaments containing the compounds
ES2167463T3 (en) COMPONENTS OF A MEDICINAL COMPOUND THAT INCLUDE N-SUBSTITUTED DERIVATIVES OF O-TOLUIDINE AND PERCUTANEOUSLY ABSORBABLE PREPARATION.
FI870457A0 (en) PHARMACEUTICAL FORM FOR STABILIZATION OF THE INTERFERENCE.
IT1228288B (en) COMPOUNDS WITH ANTI-SEROTONIN ACTIVITY
ATE108437T1 (en) SUBSTITUTED DIAMINOPHTHALIMIDES AND ANALOGUES.
DK668687A (en) INDOLCARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND MEDICINAL PRODUCTS WITH CONTENTS
ES2058572T3 (en) NEW DERIVATIVES OF UREYLENE-2,4,6-TRIAMINE-PIRIMIDINE-3-OXIDE, ITS PREPARATION AND ITS USE IN COSMETICS AND DERMOPHARMACY.
NO943898D0 (en) 3,4-dihydro-2H-1,2,4-benzothiadiazine-1,1-dioxide-3-carboxylic acid derivatives, their preparation and the medicaments containing the derivatives
ATE78693T1 (en) A MEDICINAL PRODUCT CONTAINING DIDEOXYNUCLEOSIDE.
ATE198890T1 (en) ANTIDEPRESSANTS
DE59404557D1 (en) Hetero-tricyclic-substituted phenyl-cyclohexane-carboxylic acid derivatives
MX9207395A (en) NOVEL TIAZOLES.
DE69432000D1 (en) Use of tetrahydropyridine derivatives for the preparation of cardioprotective drugs
ES2091571T3 (en) NEW ACTIVE PEPTIDIC DERIVATIVES IN THE CELL ADHESION PROCESSES, THEIR PREPARATION PROCEDURE AND THE PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
DK324987D0 (en) 3-SUBSTITUTED 1- (2-HALOGENAL COXY-BENZEN-SULPHONYL) -3-HETEROARYL- (THIO) URINENTS, PROCEDURES FOR THEIR PREPARATION AND THEIR USE AS HERBICIDES
DE3767940D1 (en) PYRANDE DERIVATIVES.
IL105599A0 (en) Enantiomers derived from(s)-2-amino-2(3,4-dichlorobenzyl)-1-propanol and pharmaceutical compositions containing same
IT8622051A1 (en) PHARMACEUTICAL COMPOSITIONS WITH HEALING ACTIVITY
IT8919283A0 (en) PHARMACEUTICAL COMPOSITION INCLUDING AS ACTIVE INGREDIENT 3 N PIPERIDINOMETHYL AZINO METHYLRIFAMICIN S.
IT1230053B (en) COMPOSITION FOR THE INCREASE OF THE WEIGHT GAIN.

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed