AU783310B2 - Genetic markers of toxicity, preparation and uses thereof - Google Patents

Genetic markers of toxicity, preparation and uses thereof Download PDF

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Publication number
AU783310B2
AU783310B2 AU74269/00A AU7426900A AU783310B2 AU 783310 B2 AU783310 B2 AU 783310B2 AU 74269/00 A AU74269/00 A AU 74269/00A AU 7426900 A AU7426900 A AU 7426900A AU 783310 B2 AU783310 B2 AU 783310B2
Authority
AU
Australia
Prior art keywords
nucleic acid
situation
cells
apoptosis
bank
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU74269/00A
Other languages
English (en)
Other versions
AU7426900A (en
Inventor
Laurent Bracco
Fabien Schweighoffer
Bruno Tocque
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ExonHit Therapeutics SA
Original Assignee
ExonHit Therapeutics SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ExonHit Therapeutics SA filed Critical ExonHit Therapeutics SA
Publication of AU7426900A publication Critical patent/AU7426900A/en
Application granted granted Critical
Publication of AU783310B2 publication Critical patent/AU783310B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AU74269/00A 1999-09-13 2000-09-12 Genetic markers of toxicity, preparation and uses thereof Ceased AU783310B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9911405 1999-09-13
FR9911405A FR2798392B1 (fr) 1999-09-13 1999-09-13 Marqueurs genetiques de la toxicite, preparation et utilisations
PCT/FR2000/002503 WO2001020029A2 (fr) 1999-09-13 2000-09-12 Marquers genetiques de la toxicite, preparation et utilisations

Publications (2)

Publication Number Publication Date
AU7426900A AU7426900A (en) 2001-04-17
AU783310B2 true AU783310B2 (en) 2005-10-13

Family

ID=9549766

Family Applications (1)

Application Number Title Priority Date Filing Date
AU74269/00A Ceased AU783310B2 (en) 1999-09-13 2000-09-12 Genetic markers of toxicity, preparation and uses thereof

Country Status (13)

Country Link
US (2) US6509153B1 (enExample)
EP (1) EP1220950B9 (enExample)
JP (1) JP2003509066A (enExample)
AT (1) ATE263255T1 (enExample)
AU (1) AU783310B2 (enExample)
CA (1) CA2380383A1 (enExample)
DE (1) DE60009530T2 (enExample)
DK (1) DK1220950T3 (enExample)
ES (1) ES2216958T3 (enExample)
FR (1) FR2798392B1 (enExample)
IL (1) IL148615A0 (enExample)
PT (1) PT1220950E (enExample)
WO (1) WO2001020029A2 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6881571B1 (en) * 1998-03-11 2005-04-19 Exonhit Therapeutics S.A. Qualitative differential screening
FR2798673B1 (fr) * 1999-09-16 2004-05-28 Exonhit Therapeutics Sa Methodes et compositions pour la detection d'evenements pathologiques
US7361488B2 (en) * 2000-02-07 2008-04-22 Illumina, Inc. Nucleic acid detection methods using universal priming
DE60236559D1 (de) * 2001-08-24 2010-07-08 Daikin Ind Ltd Verfahren zum Nachweis toxischer Substanzen
GB0410105D0 (en) * 2004-05-06 2004-06-09 Amersham Biosciences Uk Ltd Method for characterising compounds
US20080194417A1 (en) * 2005-03-09 2008-08-14 Luca Barella Method for Measuring and Comparing the Activity of Biologically Active Compounds
CN101611315A (zh) * 2006-10-23 2009-12-23 Uab研究基金会 用于对抗癌试剂敏感的癌症的生物标记物及其用途
DE102010024898B4 (de) * 2010-06-24 2012-10-25 Merck Patent Gmbh Genexpressionsanalysen zur Charakterisierung und Identifizierung genotoxischer Verbindungen

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2755984A1 (fr) * 1996-11-15 1998-05-22 Bourachot Philippe Borne escamotable
WO1999042606A1 (en) * 1998-02-23 1999-08-26 Phylonix Pharmaceuticals, Inc. Methods of screening agents for activity using teleosts
WO2000012760A2 (en) * 1998-08-28 2000-03-09 Incyte Pharmaceuticals, Inc. Toxicological response markers

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4965188A (en) * 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US5985549A (en) * 1985-10-22 1999-11-16 University Of Massachusetts Non-isotopic in-situ hybridization method for detection of nucleic acids
US4888278A (en) * 1985-10-22 1989-12-19 University Of Massachusetts Medical Center In-situ hybridization to detect nucleic acid sequences in morphologically intact cells
US5057410A (en) * 1988-08-05 1991-10-15 Cetus Corporation Chimeric messenger RNA detection methods
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US6309822B1 (en) * 1989-06-07 2001-10-30 Affymetrix, Inc. Method for comparing copy number of nucleic acid sequences
US5474796A (en) * 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US5674682A (en) * 1992-10-29 1997-10-07 Thomas Jefferson University Nucleic acid primers for detecting micrometastasis of prostate cancer
US5521297A (en) * 1993-06-04 1996-05-28 Salk Institute Biotechnology/Industrial Associates Nucleic acids encoding human metabotropic glutamate receptors
US5837832A (en) * 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
US5529925A (en) * 1993-12-03 1996-06-25 St. Jude Children's Research Hospital Nucleic acid sequences and fusion proteins present in human t(2;5) lymphoma
US5484702A (en) * 1994-01-27 1996-01-16 Research Foundation Of The State University Of New York At Buffalo Method for preselecting recombinant clones containing a specific nucleic acid sequence and subsequent transformation with preselected clones
US5679541A (en) * 1994-02-14 1997-10-21 California Institute Of Technology Programmed cell death antagonist protein
PH31414A (en) * 1994-02-24 1998-10-29 Boehringer Ingelheim Int Method of diagnosing cancer precancerous state, orsusceptibility to other forms of diseases by anal ysis of irf-1 specific rna in biopsy samples.
US5767258A (en) * 1995-05-12 1998-06-16 The Johns Hopkins University School Of Medicine Cell cycle regulatory gene
WO1997013877A1 (en) * 1995-10-12 1997-04-17 Lynx Therapeutics, Inc. Measurement of gene expression profiles in toxicity determination
US5922535A (en) * 1995-11-07 1999-07-13 Huo; Li Identifying sequence differences in nucleic acid populations
FR2775984B1 (fr) * 1998-03-11 2006-09-15 Bioscreen Therapeutics Sa Criblage differentiel qualitatif
US6881571B1 (en) * 1998-03-11 2005-04-19 Exonhit Therapeutics S.A. Qualitative differential screening
US6060240A (en) * 1996-12-13 2000-05-09 Arcaris, Inc. Methods for measuring relative amounts of nucleic acids in a complex mixture and retrieval of specific sequences therefrom
CA2225187A1 (en) * 1997-07-14 1999-01-14 Universite D'ottawa/ University Of Ottawa Xaf genes and polypeptides: methods and reagents for modulating apoptosis
US6849400B1 (en) * 1997-07-23 2005-02-01 Gen-Probe Incorporated Methods for detecting and measuring spliced nucleic acids
GB9717766D0 (en) * 1997-08-22 1997-10-29 Zeneca Ltd Methods
US6432640B1 (en) * 1997-09-17 2002-08-13 The Johns Hopkins University P53-induced apoptosis
JPH11262621A (ja) * 1998-03-17 1999-09-28 Ebara Corp 除湿空調装置
US6168920B1 (en) * 1998-08-10 2001-01-02 Incyte Genomics, Inc. Extracellular adhesive proteins
US6160105A (en) * 1998-10-13 2000-12-12 Incyte Pharmaceuticals, Inc. Monitoring toxicological responses
FR2798673B1 (fr) * 1999-09-16 2004-05-28 Exonhit Therapeutics Sa Methodes et compositions pour la detection d'evenements pathologiques
EP1654371A4 (en) * 2001-06-21 2010-02-10 Verenium Corp METHOD FOR PRODUCING PURE ENANTIOMERIC PURELY COMPOUNDS AND SELECTION OF ENANTIOSELECTIVE ENZYMES

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2755984A1 (fr) * 1996-11-15 1998-05-22 Bourachot Philippe Borne escamotable
WO1999042606A1 (en) * 1998-02-23 1999-08-26 Phylonix Pharmaceuticals, Inc. Methods of screening agents for activity using teleosts
WO2000012760A2 (en) * 1998-08-28 2000-03-09 Incyte Pharmaceuticals, Inc. Toxicological response markers

Also Published As

Publication number Publication date
EP1220950B9 (fr) 2004-11-03
ATE263255T1 (de) 2004-04-15
ES2216958T3 (es) 2004-11-01
US20030059788A1 (en) 2003-03-27
US6509153B1 (en) 2003-01-21
EP1220950B1 (fr) 2004-03-31
WO2001020029A3 (fr) 2001-11-29
JP2003509066A (ja) 2003-03-11
IL148615A0 (en) 2002-09-12
AU7426900A (en) 2001-04-17
PT1220950E (pt) 2004-07-30
FR2798392A1 (fr) 2001-03-16
DE60009530T2 (de) 2005-02-03
WO2001020029A2 (fr) 2001-03-22
DE60009530D1 (de) 2004-05-06
FR2798392B1 (fr) 2005-07-15
CA2380383A1 (fr) 2001-03-22
DK1220950T3 (da) 2004-08-02
EP1220950A2 (fr) 2002-07-10

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase
TH Corrigenda

Free format text: IN VOL 15, NO 27, PAGE(S) 5693-5698 UNDER THE HEADING APPLICATIONS LAPSED, REFUSED OR WITHDRAWN PLEASE DELETE ALL REFERENCE TO APPLICATION NO. 67234/00, 68732/00, 70182/00, 70382/00, 70412/00, 73091/00, 73095/00, 74173/00, 74269/00, 77706/00 AND 13798/01