AU774229B2 - Method of screening candidate compounds for susceptibility to oxidative metabolism - Google Patents

Method of screening candidate compounds for susceptibility to oxidative metabolism Download PDF

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Publication number
AU774229B2
AU774229B2 AU15250/00A AU1525000A AU774229B2 AU 774229 B2 AU774229 B2 AU 774229B2 AU 15250/00 A AU15250/00 A AU 15250/00A AU 1525000 A AU1525000 A AU 1525000A AU 774229 B2 AU774229 B2 AU 774229B2
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AU
Australia
Prior art keywords
enzyme
metabolism
cytochrome
compound
testosterone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU15250/00A
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English (en)
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AU1525000A (en
Inventor
Cuiping Chen
Dhiren R. Thakker
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University of North Carolina at Chapel Hill
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University of North Carolina at Chapel Hill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by University of North Carolina at Chapel Hill filed Critical University of North Carolina at Chapel Hill
Publication of AU1525000A publication Critical patent/AU1525000A/en
Application granted granted Critical
Publication of AU774229B2 publication Critical patent/AU774229B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AU15250/00A 1998-12-04 1999-11-15 Method of screening candidate compounds for susceptibility to oxidative metabolism Ceased AU774229B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/205762 1998-12-04
US09/205,762 US6312917B1 (en) 1998-12-04 1998-12-04 Method of screening candidate compounds for susceptibility to oxidative metabolism
PCT/US1999/027130 WO2000034506A2 (en) 1998-12-04 1999-11-15 Method of screening candidate compounds for susceptibility to oxidative metabolism

Publications (2)

Publication Number Publication Date
AU1525000A AU1525000A (en) 2000-06-26
AU774229B2 true AU774229B2 (en) 2004-06-17

Family

ID=22763550

Family Applications (1)

Application Number Title Priority Date Filing Date
AU15250/00A Ceased AU774229B2 (en) 1998-12-04 1999-11-15 Method of screening candidate compounds for susceptibility to oxidative metabolism

Country Status (12)

Country Link
US (2) US6312917B1 (enExample)
EP (1) EP1135521B1 (enExample)
JP (1) JP2002531138A (enExample)
KR (1) KR20010093140A (enExample)
AT (1) ATE317914T1 (enExample)
AU (1) AU774229B2 (enExample)
BR (1) BR9916458A (enExample)
CA (1) CA2352523A1 (enExample)
DE (1) DE69929900T2 (enExample)
MX (1) MXPA01005528A (enExample)
NZ (1) NZ512217A (enExample)
WO (1) WO2000034506A2 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6632630B2 (en) * 2000-03-29 2003-10-14 Aclara Biosciences, Inc. Monooxygenase assays
WO2003102192A1 (en) * 2002-05-30 2003-12-11 Astex Technology Limited Methods of purification of cytochrome p450 proteins and of their crystallizing
US20070179716A1 (en) * 2001-04-02 2007-08-02 Astex Therapeutics Limited Crystal structure of cytochrome P450 3A4 and uses thereof
US20050032119A1 (en) * 2001-04-02 2005-02-10 Astex Technology Ltd. Crystal structure of cytochrome P450
US7148046B2 (en) * 2001-04-02 2006-12-12 Astex Therapeutics Limited Crystal structure of cytochrome P450
US20050159901A1 (en) * 2001-04-02 2005-07-21 Astex Technology Limited Crystal structure of cytochrome P450
JP2005512532A (ja) * 2001-08-03 2005-05-12 ディヴァーサ コーポレイション Ｐ４５０酵素、それらをコードした核酸及びそれらの作製と使用
US20040053383A1 (en) * 2001-10-25 2004-03-18 Astex Technology Ltd. Crystals of cytochrome P450 2C9, structures thereof and their use
DE60214869T2 (de) * 2001-10-25 2007-04-12 Astex Technology Ltd., Cambridge Cytochrome p450 2c9 kristalle, strukturen und dessen verwendung
US20040096874A1 (en) * 2002-04-11 2004-05-20 Third Wave Technologies, Inc. Characterization of CYP 2D6 genotypes
GB0216203D0 (en) * 2002-07-12 2002-08-21 Imp Cancer Res Tech Mondulation of cytochrome P450 reductase activity
EP1546162B1 (en) * 2002-09-20 2011-06-22 Promega Corporation Luminescence-based methods and probes for measuring cytochrome p450 activity
DE03758362T1 (de) * 2002-10-25 2005-08-25 Astex Technology Ltd., Cambridge Kristallstruktur des Cythochroms P450 3A4 und dessen Verwendung
WO2004078131A2 (en) * 2003-03-01 2004-09-16 Symyx Technologies, Inc. Evaluating effects of exposure conditions on drug samples over time
WO2005098025A2 (en) * 2004-04-05 2005-10-20 The University Of North Carolina At Chapel Hill High throughput reactive oxygen species-based cytochrome p450 inhibition assay
US20060046278A1 (en) * 2004-08-26 2006-03-02 Qualyst, Inc. Methods and kits for determining metabolic stability of compounds
US20060223135A1 (en) * 2005-04-05 2006-10-05 The University Of North Carolina At Chapel Hill High throughput reactive oxygen species-based cytochrome P450 inhibition assay
EP2778234B1 (en) 2005-05-31 2017-09-27 Promega Corporation Luminogenic and fluorogenic compounds and methods to detect molecules or conditions
US20090318561A1 (en) * 2008-06-23 2009-12-24 Mutual Pharmaceutical Company, Inc. Colchicine products, method of manufacture, and methods of use
WO2010021686A1 (en) 2008-08-18 2010-02-25 Promega Corporation Luminogenic compounds and methods to detect cytochrome p450 3a enzymes
US9790537B2 (en) 2014-01-29 2017-10-17 Promega Corporation Quinone-masked probes as labeling reagents for cell uptake measurements
WO2018118897A1 (en) * 2016-12-19 2018-06-28 Dice Molecules Sv, Llc Methods of estimating metabolic stability of tagged combinatorial library compounds
WO2024223797A1 (en) 2023-04-28 2024-10-31 Institut National de la Santé et de la Recherche Médicale Use of cyp3a4 inhibitors for the treatment of hepatitis d virus (hdv) infections

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997039352A1 (en) * 1996-04-15 1997-10-23 Fox Chase Cancer Center Assays for detection of purine metabolites

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4341868A (en) * 1978-08-18 1982-07-27 Kyowa Hakko Kogyo Co., Ltd. Method and test composition for the determination of the substrate for xanthine oxidase
DE2965849D1 (en) 1978-08-18 1983-08-18 Kyowa Hakko Kogyo Kk Method and test composition for the determination of a substrate for xanthine-oxidase, including a novel xanthine-oxidase and method for the preparation thereof
JP2515551B2 (ja) * 1987-06-08 1996-07-10 和光純薬工業株式会社 新規な過酸化水素の定量方法
US5413915A (en) 1988-07-12 1995-05-09 Resource Technologies Group, Inc. Method and sensor for detecting toxic chemical exposure effects and metabolic activation of carcinogenic chemical agents
GB9821932D0 (en) 1998-10-09 1998-12-02 Univ Leicester Cytochrome P450 electrochemical system

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997039352A1 (en) * 1996-04-15 1997-10-23 Fox Chase Cancer Center Assays for detection of purine metabolites

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ARCHIVES BIOCHEM. BIOPHY. 318, PP. 314-321 (1955) *
CHEM. RES. TOXICOL. 7 PP. 609-613 (1994) *

Also Published As

Publication number Publication date
NZ512217A (en) 2002-03-28
CA2352523A1 (en) 2000-06-15
DE69929900T2 (de) 2006-08-17
AU1525000A (en) 2000-06-26
EP1135521A2 (en) 2001-09-26
EP1135521B1 (en) 2006-02-15
WO2000034506A3 (en) 2000-11-23
MXPA01005528A (es) 2002-04-24
WO2000034506A2 (en) 2000-06-15
KR20010093140A (ko) 2001-10-27
US6312917B1 (en) 2001-11-06
US20020058295A1 (en) 2002-05-16
DE69929900D1 (de) 2006-04-20
JP2002531138A (ja) 2002-09-24
ATE317914T1 (de) 2006-03-15
BR9916458A (pt) 2001-09-04

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