AU772682B2 - Highly-mineralized osteogenic sponge compositions, and uses thereof - Google Patents
Highly-mineralized osteogenic sponge compositions, and uses thereof Download PDFInfo
- Publication number
- AU772682B2 AU772682B2 AU27568/00A AU2756800A AU772682B2 AU 772682 B2 AU772682 B2 AU 772682B2 AU 27568/00 A AU27568/00 A AU 27568/00A AU 2756800 A AU2756800 A AU 2756800A AU 772682 B2 AU772682 B2 AU 772682B2
- Authority
- AU
- Australia
- Prior art keywords
- osteogenic
- sponge
- bone
- composition
- matrix material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 230000002188 osteogenic effect Effects 0.000 title claims abstract description 108
- 239000000203 mixture Substances 0.000 title claims abstract description 98
- 229910052500 inorganic mineral Inorganic materials 0.000 claims abstract description 68
- 238000000034 method Methods 0.000 claims abstract description 68
- 239000011707 mineral Substances 0.000 claims abstract description 68
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 52
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 claims abstract description 23
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 claims abstract description 23
- 229940112869 bone morphogenetic protein Drugs 0.000 claims abstract description 23
- 239000007943 implant Substances 0.000 claims abstract description 21
- 230000002138 osteoinductive effect Effects 0.000 claims abstract description 6
- 239000011159 matrix material Substances 0.000 claims description 68
- 102000008186 Collagen Human genes 0.000 claims description 46
- 108010035532 Collagen Proteins 0.000 claims description 46
- 229920001436 collagen Polymers 0.000 claims description 46
- 230000004927 fusion Effects 0.000 claims description 36
- 241000288906 Primates Species 0.000 claims description 30
- 230000008468 bone growth Effects 0.000 claims description 26
- 239000002245 particle Substances 0.000 claims description 26
- 241000124008 Mammalia Species 0.000 claims description 21
- 239000001506 calcium phosphate Substances 0.000 claims description 14
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 14
- 230000006698 induction Effects 0.000 claims description 12
- 102100033337 PDZ and LIM domain protein 7 Human genes 0.000 claims description 11
- 101710121660 PDZ and LIM domain protein 7 Proteins 0.000 claims description 11
- 230000002051 biphasic effect Effects 0.000 claims description 11
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 11
- 235000011010 calcium phosphates Nutrition 0.000 claims description 11
- 210000002997 osteoclast Anatomy 0.000 claims description 10
- 210000000963 osteoblast Anatomy 0.000 claims description 9
- 230000008569 process Effects 0.000 claims description 9
- 239000000919 ceramic Substances 0.000 claims description 7
- 230000001939 inductive effect Effects 0.000 claims description 7
- 230000001054 cortical effect Effects 0.000 claims description 6
- 210000001185 bone marrow Anatomy 0.000 claims description 5
- 239000004068 calcium phosphate ceramic Substances 0.000 claims description 5
- 239000002773 nucleotide Substances 0.000 claims description 5
- 125000003729 nucleotide group Chemical group 0.000 claims description 5
- 108010049931 Bone Morphogenetic Protein 2 Proteins 0.000 claims description 4
- 102100024506 Bone morphogenetic protein 2 Human genes 0.000 claims description 4
- 238000003780 insertion Methods 0.000 claims description 4
- 230000037431 insertion Effects 0.000 claims description 4
- 230000000717 retained effect Effects 0.000 claims description 4
- 108050007372 Fibroblast Growth Factor Proteins 0.000 claims description 2
- 102000018233 Fibroblast Growth Factor Human genes 0.000 claims description 2
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims description 2
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 claims description 2
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 claims description 2
- 102000013275 Somatomedins Human genes 0.000 claims description 2
- 230000002708 enhancing effect Effects 0.000 claims description 2
- 229940126864 fibroblast growth factor Drugs 0.000 claims description 2
- 230000012010 growth Effects 0.000 claims description 2
- 150000003431 steroids Chemical class 0.000 claims description 2
- 230000001131 transforming effect Effects 0.000 claims description 2
- 108010049870 Bone Morphogenetic Protein 7 Proteins 0.000 claims 2
- 102100022544 Bone morphogenetic protein 7 Human genes 0.000 claims 2
- 102000003839 Human Proteins Human genes 0.000 claims 2
- 108090000144 Human Proteins Proteins 0.000 claims 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 229910010293 ceramic material Inorganic materials 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 abstract description 5
- 230000008439 repair process Effects 0.000 abstract description 3
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 239000002131 composite material Substances 0.000 description 14
- 239000002002 slurry Substances 0.000 description 12
- 241001465754 Metazoa Species 0.000 description 9
- 239000000463 material Substances 0.000 description 8
- 230000011164 ossification Effects 0.000 description 7
- 241000282412 Homo Species 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 4
- 239000000515 collagen sponge Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 4
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 230000001954 sterilising effect Effects 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- 239000013598 vector Substances 0.000 description 4
- 239000011800 void material Substances 0.000 description 4
- 241000282560 Macaca mulatta Species 0.000 description 3
- 102100026632 Mimecan Human genes 0.000 description 3
- 101800002327 Osteoinductive factor Proteins 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 239000003462 bioceramic Substances 0.000 description 3
- 230000010256 bone deposition Effects 0.000 description 3
- 238000002591 computed tomography Methods 0.000 description 3
- 230000007547 defect Effects 0.000 description 3
- 238000002513 implantation Methods 0.000 description 3
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 3
- 235000019731 tricalcium phosphate Nutrition 0.000 description 3
- 229940078499 tricalcium phosphate Drugs 0.000 description 3
- 206010002091 Anaesthesia Diseases 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- 101000762366 Homo sapiens Bone morphogenetic protein 2 Proteins 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 230000037005 anaesthesia Effects 0.000 description 2
- 208000037873 arthrodesis Diseases 0.000 description 2
- 239000000316 bone substitute Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 102000045896 human BMP2 Human genes 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000001599 osteoclastic effect Effects 0.000 description 2
- 230000002980 postoperative effect Effects 0.000 description 2
- 210000003491 skin Anatomy 0.000 description 2
- 210000002435 tendon Anatomy 0.000 description 2
- 230000008733 trauma Effects 0.000 description 2
- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 description 1
- 241000112853 Arthrodes Species 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- 102000012422 Collagen Type I Human genes 0.000 description 1
- 108010022452 Collagen Type I Proteins 0.000 description 1
- 102000001187 Collagen Type III Human genes 0.000 description 1
- 108010069502 Collagen Type III Proteins 0.000 description 1
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 101000762379 Homo sapiens Bone morphogenetic protein 4 Proteins 0.000 description 1
- 101000899361 Homo sapiens Bone morphogenetic protein 7 Proteins 0.000 description 1
- PIWKPBJCKXDKJR-UHFFFAOYSA-N Isoflurane Chemical compound FC(F)OC(Cl)C(F)(F)F PIWKPBJCKXDKJR-UHFFFAOYSA-N 0.000 description 1
- 208000023178 Musculoskeletal disease Diseases 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 241001447056 Uristes Species 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 229940064804 betadine Drugs 0.000 description 1
- 230000010072 bone remodeling Effects 0.000 description 1
- 239000008366 buffered solution Substances 0.000 description 1
- SIEYLFHKZGLBNX-UHFFFAOYSA-N bupivacaine hydrochloride (anhydrous) Chemical compound [Cl-].CCCC[NH+]1CCCCC1C(=O)NC1=C(C)C=CC=C1C SIEYLFHKZGLBNX-UHFFFAOYSA-N 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 102000013373 fibrillar collagen Human genes 0.000 description 1
- 108060002894 fibrillar collagen Proteins 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 102000046148 human BMP4 Human genes 0.000 description 1
- 230000008105 immune reaction Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 229960002725 isoflurane Drugs 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 210000004705 lumbosacral region Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229940106885 marcaine Drugs 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000005541 medical transmission Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000000921 morphogenic effect Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 238000007500 overflow downdraw method Methods 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000036647 reaction Effects 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 229940052907 telazol Drugs 0.000 description 1
- 238000003325 tomography Methods 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dispersion Chemistry (AREA)
- Immunology (AREA)
- Materials Engineering (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Zoology (AREA)
- Composite Materials (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11861599P | 1999-02-04 | 1999-02-04 | |
| US60/118615 | 1999-02-04 | ||
| PCT/US2000/003043 WO2000045871A1 (en) | 1999-02-04 | 2000-02-04 | Highly-mineralized osteogenic sponge compositions, and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2756800A AU2756800A (en) | 2000-08-25 |
| AU772682B2 true AU772682B2 (en) | 2004-05-06 |
Family
ID=22379695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU27568/00A Ceased AU772682B2 (en) | 1999-02-04 | 2000-02-04 | Highly-mineralized osteogenic sponge compositions, and uses thereof |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US7563455B2 (enExample) |
| EP (1) | EP1150726B1 (enExample) |
| JP (1) | JP2002536077A (enExample) |
| AT (1) | ATE253385T1 (enExample) |
| AU (1) | AU772682B2 (enExample) |
| CA (1) | CA2362049A1 (enExample) |
| DE (1) | DE60006356T2 (enExample) |
| ES (1) | ES2209820T3 (enExample) |
| WO (1) | WO2000045871A1 (enExample) |
Families Citing this family (115)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040081704A1 (en) | 1998-02-13 | 2004-04-29 | Centerpulse Biologics Inc. | Implantable putty material |
| EP1150725B1 (en) * | 1999-02-04 | 2005-06-01 | SDGI Holdings, Inc. | Osteogenic paste compositions and uses thereof |
| DE60006356T2 (de) * | 1999-02-04 | 2004-09-09 | SDGI Holding, Inc., Wilmington | Hochmineralisierte osteogene schwammzusammensetzungen und ihre verwendung |
| US7435260B2 (en) * | 1999-08-13 | 2008-10-14 | Ferree Bret A | Use of morphogenetic proteins to treat human disc disease |
| ES2319506T3 (es) * | 2000-10-24 | 2009-05-08 | Warsaw Orthopedic, Inc. | Metodos y dispositivos de fusion vertebral. |
| US20020114795A1 (en) | 2000-12-22 | 2002-08-22 | Thorne Kevin J. | Composition and process for bone growth and repair |
| US6949251B2 (en) | 2001-03-02 | 2005-09-27 | Stryker Corporation | Porous β-tricalcium phosphate granules for regeneration of bone tissue |
| DK1448246T4 (en) | 2001-11-19 | 2015-12-21 | Scil Technology Gmbh | Homogeneously coated device with osteoinductive and osteoconductive properties |
| JP2003169845A (ja) * | 2001-12-07 | 2003-06-17 | Japan Science & Technology Corp | スポンジ状多孔質アパタイト・コラーゲン複合体、スポンジ状超多孔質アパタイト・コラーゲン複合体及びそれらの製造方法 |
| TW200400062A (en) | 2002-04-03 | 2004-01-01 | Mathys Medizinaltechnik Ag | Kneadable, pliable bone replacement material |
| US7166133B2 (en) * | 2002-06-13 | 2007-01-23 | Kensey Nash Corporation | Devices and methods for treating defects in the tissue of a living being |
| PL207552B1 (pl) | 2002-09-10 | 2010-12-31 | Scil Technology Gmbh | Sposób wytwarzania urządzenia, urządzenie, kompozycja farmaceutyczna, zastosowanie urządzenia i zestaw |
| WO2004041319A1 (ja) * | 2002-11-07 | 2004-05-21 | Pentax Corporation | 骨形成治療デバイス |
| US7067123B2 (en) | 2003-04-29 | 2006-06-27 | Musculoskeletal Transplant Foundation | Glue for cartilage repair |
| US7901457B2 (en) | 2003-05-16 | 2011-03-08 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
| US8734421B2 (en) | 2003-06-30 | 2014-05-27 | Johnson & Johnson Consumer Companies, Inc. | Methods of treating pores on the skin with electricity |
| AU2003261747A1 (en) * | 2003-08-27 | 2005-03-29 | Makoto Ogiso | Structural body constituted of biocompatible material impregnated with fine bone dust and process for producing the same |
| US7666230B2 (en) | 2003-12-08 | 2010-02-23 | Depuy Products, Inc. | Implant device for cartilage regeneration in load bearing articulation regions |
| US7189263B2 (en) * | 2004-02-03 | 2007-03-13 | Vita Special Purpose Corporation | Biocompatible bone graft material |
| US20050192675A1 (en) * | 2004-03-01 | 2005-09-01 | Robinson Dane Q. | Device for use in stimulating bone growth |
| US9220595B2 (en) | 2004-06-23 | 2015-12-29 | Orthovita, Inc. | Shapeable bone graft substitute and instruments for delivery thereof |
| US20090012625A1 (en) * | 2004-09-14 | 2009-01-08 | Ying Jackie Y | Porous biomaterial-filler composite and method for making the same |
| US7722895B1 (en) | 2004-09-20 | 2010-05-25 | Warsaw Orthopedic, Inc. | Osteogenic implants with combined implant materials, and materials and methods for same |
| US7837740B2 (en) | 2007-01-24 | 2010-11-23 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
| US20060083769A1 (en) * | 2004-10-14 | 2006-04-20 | Mukesh Kumar | Method and apparatus for preparing bone |
| US7670384B2 (en) * | 2004-10-14 | 2010-03-02 | Biomet Manufacturing Corp. | Bone graft composition comprising a bone material and a carrier comprising denatured demineralized bone |
| US7473678B2 (en) * | 2004-10-14 | 2009-01-06 | Biomimetic Therapeutics, Inc. | Platelet-derived growth factor compositions and methods of use thereof |
| DE102005016443A1 (de) * | 2004-11-23 | 2006-05-24 | Ossacur Ag | Bioresorbierbares und mineralisiertes Material zur Füllung von Knochendefekten |
| WO2006089359A1 (en) * | 2005-02-25 | 2006-08-31 | Eugene Sherry | Replacement bone tissue |
| CA2604622A1 (en) | 2005-04-15 | 2006-10-26 | Musculoskeletal Transplant Foundation | Vertebral disc repair |
| US7857853B2 (en) * | 2005-04-29 | 2010-12-28 | Sdgi Holdings, Inc | Synthetic loadbearing collagen-mineral composites useful for spinal implants, and methods of manufacture |
| US8506646B2 (en) * | 2005-04-29 | 2013-08-13 | Warsaw Orthopedic, Inc. | Multi-purpose medical implant devices |
| US8092548B2 (en) * | 2005-06-22 | 2012-01-10 | Warsaw Orthopedic, Inc. | Osteograft treatment to promote osteoinduction and osteograft incorporation |
| US7815926B2 (en) | 2005-07-11 | 2010-10-19 | Musculoskeletal Transplant Foundation | Implant for articular cartilage repair |
| WO2007035778A2 (en) | 2005-09-19 | 2007-03-29 | Histogenics Corporation | Cell-support matrix and a method for preparation thereof |
| US20070077267A1 (en) * | 2005-10-03 | 2007-04-05 | Sdgi Holdings, Inc. | Bioactive composite implants |
| US9132208B2 (en) * | 2008-08-07 | 2015-09-15 | Lifenet Health | Composition for a tissue repair implant and methods of making the same |
| US9005646B2 (en) | 2005-10-12 | 2015-04-14 | Lifenet Health | Compositions for repair of defects in tissues, and methods of making the same |
| BRPI0618794A2 (pt) | 2005-11-17 | 2011-09-13 | Biomimetic Therapeutics Inc | uso de uma matriz biocompatìvel, kit e composição para aumento ósseo, especialmente para aumento do osso maxilofacial |
| US7939092B2 (en) * | 2006-02-01 | 2011-05-10 | Warsaw Orthopedic, Inc. | Cohesive osteogenic putty and materials therefor |
| US7824703B2 (en) | 2006-02-01 | 2010-11-02 | Warsaw Orthopedics, Inc. | Medical implants with reservoir(s), and materials preparable from same |
| EP2311505B1 (en) * | 2006-02-09 | 2013-11-06 | BioMimetic Therapeutics, LLC | Compositions and methods for treating bone |
| US7833270B2 (en) * | 2006-05-05 | 2010-11-16 | Warsaw Orthopedic, Inc | Implant depots to deliver growth factors to treat osteoporotic bone |
| US9161967B2 (en) * | 2006-06-30 | 2015-10-20 | Biomimetic Therapeutics, Llc | Compositions and methods for treating the vertebral column |
| ES2664229T3 (es) | 2006-06-30 | 2018-04-18 | Biomimetic Therapeutics, Llc | Composiciones y métodos de biomatriz-PDGF para el tratamiento de lesiones del manguito rotador |
| US7959683B2 (en) | 2006-07-25 | 2011-06-14 | Musculoskeletal Transplant Foundation | Packed demineralized cancellous tissue forms for disc nucleus augmentation, restoration, or replacement and methods of implantation |
| US8524265B2 (en) * | 2006-08-17 | 2013-09-03 | Warsaw Orthopedic, Inc. | Medical implant sheets useful for tissue regeneration |
| WO2008073628A2 (en) | 2006-11-03 | 2008-06-19 | Biomimetic Therapeutics, Inc. | Compositions and methods for arthrodetic procedures |
| US20080147197A1 (en) * | 2006-12-14 | 2008-06-19 | Mckay William F | Biodegradable osteogenic porous biomedical implant with impermeable membrane |
| US8048857B2 (en) * | 2006-12-19 | 2011-11-01 | Warsaw Orthopedic, Inc. | Flowable carrier compositions and methods of use |
| US7718616B2 (en) | 2006-12-21 | 2010-05-18 | Zimmer Orthobiologics, Inc. | Bone growth particles and osteoinductive composition thereof |
| US20080195476A1 (en) * | 2007-02-09 | 2008-08-14 | Marchese Michael A | Abandonment remarketing system |
| US8435551B2 (en) | 2007-03-06 | 2013-05-07 | Musculoskeletal Transplant Foundation | Cancellous construct with support ring for repair of osteochondral defects |
| EP2148708A4 (en) * | 2007-04-18 | 2012-12-05 | Univ Mcgill | COMPOSITION FOR PROMOTING BONE FORMATION |
| EP2014256A1 (en) | 2007-07-12 | 2009-01-14 | Straumann Holding AG | Composite bone repair material |
| WO2009038783A1 (en) | 2007-09-19 | 2009-03-26 | Surmodics, Inc. | Biocompatible foams, systems, and methods |
| US20090110637A1 (en) * | 2007-10-26 | 2009-04-30 | Warsaw Orthopedic, Inc. | LMP and Regulation of Tissue Growth |
| US9056150B2 (en) | 2007-12-04 | 2015-06-16 | Warsaw Orthopedic, Inc. | Compositions for treating bone defects |
| ES2422259T3 (es) | 2008-02-07 | 2013-09-10 | Biomimetic Therapeutics Inc | Composiciones para la osteogénesis por distracción |
| CA2717725A1 (en) | 2008-03-05 | 2009-09-11 | Musculoskeletal Transplant Foundation | Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles |
| US8840913B2 (en) * | 2008-03-27 | 2014-09-23 | Warsaw Orthopedic, Inc. | Malleable multi-component implants and materials therefor |
| PL2288376T3 (pl) | 2008-04-18 | 2016-07-29 | Collplant Ltd | Sposoby generowania i wykorzystywania prokolagenu |
| US9492375B2 (en) | 2008-07-23 | 2016-11-15 | Warsaw Orthopedic, Inc. | Foam carrier for bone grafting |
| US8039433B2 (en) | 2008-08-19 | 2011-10-18 | Warsaw Orthopedic, Inc. | Osteogenic compositions containing a coloring agent |
| MX2011002555A (es) | 2008-09-09 | 2011-08-03 | Biomimetic Therapeutics Inc | Composiciones de factor de crecimiento derivadas de plaquetas y metodo para el tratamiento de lesiones de tendon y ligamentos. |
| US9192695B2 (en) | 2008-11-20 | 2015-11-24 | Allosource | Allografts combined with tissue derived stem cells for bone healing |
| JP2012519556A (ja) * | 2009-03-05 | 2012-08-30 | バイオミメティック セラピューティクス， インコーポレイテッド | 骨軟骨欠損を治療するための血小板由来増殖因子組成物および方法 |
| US20110060419A1 (en) * | 2009-03-27 | 2011-03-10 | Jennifer Hagyoung Kang Choi | Medical devices with galvanic particulates |
| US20120089232A1 (en) | 2009-03-27 | 2012-04-12 | Jennifer Hagyoung Kang Choi | Medical devices with galvanic particulates |
| US20110117166A1 (en) * | 2009-11-18 | 2011-05-19 | Affinergy, Inc. | Implantable bone graft materials |
| US20140286911A1 (en) | 2013-03-15 | 2014-09-25 | Allosource | Cell repopulated collagen matrix for soft tissue repair and regeneration |
| US8758791B2 (en) | 2010-01-26 | 2014-06-24 | Warsaw Orthopedic, Inc. | Highly compression resistant matrix with porous skeleton |
| US8475824B2 (en) | 2010-01-26 | 2013-07-02 | Warsaw Orthopedic, Inc. | Resorbable matrix having elongated particles |
| CN107080834A (zh) | 2010-02-22 | 2017-08-22 | 生物模拟治疗有限责任公司 | 用于治疗腱病的血小板衍生生长因子组合物和方法 |
| US8501690B2 (en) | 2010-04-30 | 2013-08-06 | John G. Stark | Use of selective estrogen receptor modulator for joint fusion and other repair or healing of connective tissue |
| US9265857B2 (en) | 2010-05-11 | 2016-02-23 | Howmedica Osteonics Corp. | Organophosphorous, multivalent metal compounds, and polymer adhesive interpenetrating network compositions and methods |
| CA2807343C (en) | 2010-08-20 | 2018-05-22 | Wyeth Llc | Designer osteogenic proteins |
| CN103313733A (zh) | 2010-11-15 | 2013-09-18 | 捷迈整形外科生物材料有限公司 | 骨空隙填充剂 |
| US8551525B2 (en) | 2010-12-23 | 2013-10-08 | Biostructures, Llc | Bone graft materials and methods |
| US9358122B2 (en) | 2011-01-07 | 2016-06-07 | K2M, Inc. | Interbody spacer |
| US9717779B2 (en) | 2011-01-31 | 2017-08-01 | Warsaw Orthopedic, Inc. | Implantable matrix having optimum ligand concentrations |
| WO2012161788A1 (en) * | 2011-02-25 | 2012-11-29 | Synthes Usa, Llc | Osteogenic promoting implants and methods of inducing bone growth |
| US8765189B2 (en) | 2011-05-13 | 2014-07-01 | Howmedica Osteonic Corp. | Organophosphorous and multivalent metal compound compositions and methods |
| EP2529764A1 (de) | 2011-05-31 | 2012-12-05 | Curasan AG | Biologisch degradierbares kompositmaterial |
| WO2012177759A1 (en) | 2011-06-20 | 2012-12-27 | Rdc Holdings, Llc | System and method for repairing joints |
| US8998925B2 (en) | 2011-06-20 | 2015-04-07 | Rdc Holdings, Llc | Fixation system for orthopedic devices |
| WO2013075091A1 (en) | 2011-11-17 | 2013-05-23 | Allosource | Multi-piece machine graft systems and methods |
| US9162011B2 (en) | 2011-12-19 | 2015-10-20 | Allosource | Flowable matrix compositions and methods |
| US9642933B2 (en) | 2012-01-30 | 2017-05-09 | Board Of Regents, The University Of Texas System | Compositions comprising bioadhesives and methods of making the same |
| US20150031772A1 (en) * | 2012-02-17 | 2015-01-29 | Bacterin International, Inc. | Adjustable bioactive agent dispersion within a polymeric coating |
| US8697107B2 (en) | 2012-04-27 | 2014-04-15 | Warsaw Orthopedic, Inc. | Flowable implant with crosslinkable surface membrane |
| US10207027B2 (en) | 2012-06-11 | 2019-02-19 | Globus Medical, Inc. | Bioactive bone graft substitutes |
| US9585764B2 (en) * | 2012-07-26 | 2017-03-07 | Warsaw Orthopedic, Inc. | Bone implant device |
| EP2941482B1 (en) | 2013-01-04 | 2020-11-25 | Board Of Regents, The University Of Texas System | Compositions comprising citrate and applications thereof |
| EP2958523B1 (en) | 2013-02-22 | 2020-04-22 | AlloSource | Cartilage mosaic compositions and methods |
| CA2897855A1 (en) | 2013-03-07 | 2014-09-12 | Allosource | Consistent calcium content bone allograft systems and methods |
| HK1220216A1 (zh) * | 2013-03-14 | 2017-04-28 | Genzyme Corporation | 温敏性骨生长组合物 |
| US9168140B2 (en) | 2013-03-15 | 2015-10-27 | Allosource | Perforated osteochondral allograft compositions |
| US9539286B2 (en) | 2013-10-18 | 2017-01-10 | Globus Medical, Inc. | Bone grafts including osteogenic stem cells, and methods relating to the same |
| US9486483B2 (en) | 2013-10-18 | 2016-11-08 | Globus Medical, Inc. | Bone grafts including osteogenic stem cells, and methods relating to the same |
| US9579421B2 (en) | 2014-02-07 | 2017-02-28 | Globus Medical Inc. | Bone grafts and methods of making and using bone grafts |
| US9463264B2 (en) | 2014-02-11 | 2016-10-11 | Globus Medical, Inc. | Bone grafts and methods of making and using bone grafts |
| WO2015175983A1 (en) | 2014-05-16 | 2015-11-19 | Allosource | Composite bone constructs and methods |
| US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
| EP3240563B1 (en) | 2014-12-29 | 2020-12-09 | Bioventus LLC | Systems and methods for improved delivery of osteoinductive molecules in bone repair |
| WO2016187413A1 (en) | 2015-05-21 | 2016-11-24 | Musculoskeletal Transplant Foundation | Modified demineralized cortical bone fibers |
| US11426489B2 (en) | 2015-06-10 | 2022-08-30 | Globus Medical, Inc. | Biomaterial compositions, implants, and methods of making the same |
| US10016529B2 (en) | 2015-06-10 | 2018-07-10 | Globus Medical, Inc. | Biomaterial compositions, implants, and methods of making the same |
| WO2017100339A1 (en) * | 2015-12-07 | 2017-06-15 | Nuvasive, Inc. | Immunomodulation with implantation of cellular allograft bone into a non-bony site |
| US20170319750A1 (en) * | 2016-05-09 | 2017-11-09 | Bioventus, Llc | Composite matrices designed for enhanced bone repair |
| BR112019021533B1 (pt) | 2017-04-13 | 2023-02-14 | Septodont Ou Septodont Sas Ou Specialites Septodont | Material regenerativo de tecidos conjuntivos, tais como osso, dentina ou polpa, compreendendo silicato de cálcio |
| EP3388092A1 (en) | 2017-04-13 | 2018-10-17 | Septodont ou Septodont SAS ou Specialites Septodont | Connective tissues, such as bone, dentin or pulp, regenerative material comprising calcium silicate |
| EP3645066A1 (en) | 2017-06-30 | 2020-05-06 | Allosource | Cellular bone grafts, and methods of manufacture and use |
| US11896736B2 (en) | 2020-07-13 | 2024-02-13 | Globus Medical, Inc | Biomaterial implants and methods of making the same |
| US11883302B2 (en) | 2021-11-22 | 2024-01-30 | Warsaw Orthopedic, Inc. | Spinal implant having a compressible insert |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997040137A1 (en) * | 1996-04-19 | 1997-10-30 | Osiris Therapeutics, Inc. | Regeneration and augmentation of bone using mesenchymal stem cells |
| WO1998017330A1 (en) * | 1996-10-24 | 1998-04-30 | Sdgi Holdings, Inc. | Ceramic fusion implants and compositions containing osteoinductive factors |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2967060D1 (en) | 1979-12-18 | 1984-07-19 | Oscobal Ag | Bone replacement material and process for producing a bone replacement material |
| US4394370A (en) | 1981-09-21 | 1983-07-19 | Jefferies Steven R | Bone graft material for osseous defects and method of making same |
| US4795804A (en) * | 1983-08-16 | 1989-01-03 | The Regents Of The University Of California | Bone morphogenetic agents |
| US5001169A (en) * | 1984-10-24 | 1991-03-19 | Collagen Corporation | Inductive collagen-based bone repair preparations |
| US4888366A (en) * | 1984-10-24 | 1989-12-19 | Collagen Corporation | Inductive collagen-based bone repair preparations |
| US5273964A (en) | 1985-03-20 | 1993-12-28 | Lemons J E | Inorganic and organic composition for treatment of bone lesions |
| US4992226A (en) | 1985-03-28 | 1991-02-12 | Collagen Corporation | Method of making molds with xenogeneic collagen/mineral preparations for bone repair |
| US5246457A (en) | 1985-03-28 | 1993-09-21 | Collagen Corporation | Xenogeneic collagen/mineral preparations in bone repair |
| US4776890A (en) | 1985-12-18 | 1988-10-11 | Collagen Corporation | Preparation of collagen hydroxyapatite matrix for bone repair |
| US4780450A (en) | 1985-12-20 | 1988-10-25 | The University Of Maryland At Baltimore | Physically stable composition and method of use thereof for osseous repair |
| US4743229A (en) | 1986-09-29 | 1988-05-10 | Collagen Corporation | Collagen/mineral mixing device and method |
| US4865602A (en) | 1986-11-06 | 1989-09-12 | Collagen Corporation | Gamma irradiation of collagen/mineral mixtures |
| US4861733A (en) * | 1987-02-13 | 1989-08-29 | Interpore International | Calcium phosphate bone substitute materials |
| CA1339083C (en) * | 1987-11-13 | 1997-07-29 | Steven R. Jefferies | Bone repair material and delayed drug delivery system |
| US5593409A (en) * | 1988-06-13 | 1997-01-14 | Sofamor Danek Group, Inc. | Interbody spinal fusion implants |
| US5573771A (en) * | 1988-08-19 | 1996-11-12 | Osteomedical Limited | Medicinal bone mineral products |
| US5106626A (en) * | 1988-10-11 | 1992-04-21 | International Genetic Engineering, Inc. | Osteogenic factors |
| US5231169A (en) * | 1990-10-17 | 1993-07-27 | Norian Corporation | Mineralized collagen |
| US5270300A (en) * | 1991-09-06 | 1993-12-14 | Robert Francis Shaw | Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone |
| US5626861A (en) * | 1994-04-01 | 1997-05-06 | Massachusetts Institute Of Technology | Polymeric-hydroxyapatite bone composite |
| US5817327A (en) * | 1994-07-27 | 1998-10-06 | The Trustees Of The University Of Pennsylvania | Incorporation of biologically active molecules into bioactive glasses |
| AU6107496A (en) * | 1995-06-06 | 1996-12-24 | Gensci Regeneration Laboratories, Inc. | Modified osteogenic materials |
| CA2172917A1 (en) | 1995-06-07 | 1996-12-08 | Hugh R. Mcmullin | Moldable collagen compositions for hard tissue repair and augmentation |
| US5702449A (en) * | 1995-06-07 | 1997-12-30 | Danek Medical, Inc. | Reinforced porous spinal implants |
| US5776193A (en) | 1995-10-16 | 1998-07-07 | Orquest, Inc. | Bone grafting matrix |
| AU4721696A (en) * | 1996-02-29 | 1997-09-16 | T. Sam Lindholm | An osteogenic device and a method for preparing the device |
| US5741261A (en) * | 1996-06-25 | 1998-04-21 | Sdgi Holdings, Inc. | Minimally invasive spinal surgical methods and instruments |
| US5972368A (en) * | 1997-06-11 | 1999-10-26 | Sdgi Holdings, Inc. | Bone graft composites and spacers |
| DE60006356T2 (de) * | 1999-02-04 | 2004-09-09 | SDGI Holding, Inc., Wilmington | Hochmineralisierte osteogene schwammzusammensetzungen und ihre verwendung |
-
2000
- 2000-02-04 DE DE60006356T patent/DE60006356T2/de not_active Expired - Fee Related
- 2000-02-04 CA CA002362049A patent/CA2362049A1/en not_active Abandoned
- 2000-02-04 AU AU27568/00A patent/AU772682B2/en not_active Ceased
- 2000-02-04 AT AT00905989T patent/ATE253385T1/de not_active IP Right Cessation
- 2000-02-04 ES ES00905989T patent/ES2209820T3/es not_active Expired - Lifetime
- 2000-02-04 EP EP00905989A patent/EP1150726B1/en not_active Expired - Lifetime
- 2000-02-04 JP JP2000596990A patent/JP2002536077A/ja active Pending
- 2000-02-04 WO PCT/US2000/003043 patent/WO2000045871A1/en not_active Ceased
-
2001
- 2001-08-06 US US09/923,116 patent/US7563455B2/en not_active Expired - Fee Related
-
2009
- 2009-01-16 US US12/355,569 patent/US8147862B2/en not_active Expired - Fee Related
-
2012
- 2012-02-09 US US13/369,929 patent/US8399010B2/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997040137A1 (en) * | 1996-04-19 | 1997-10-30 | Osiris Therapeutics, Inc. | Regeneration and augmentation of bone using mesenchymal stem cells |
| WO1998017330A1 (en) * | 1996-10-24 | 1998-04-30 | Sdgi Holdings, Inc. | Ceramic fusion implants and compositions containing osteoinductive factors |
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|---|---|
| US20120141557A1 (en) | 2012-06-07 |
| WO2000045871A1 (en) | 2000-08-10 |
| US8399010B2 (en) | 2013-03-19 |
| CA2362049A1 (en) | 2000-08-10 |
| JP2002536077A (ja) | 2002-10-29 |
| EP1150726B1 (en) | 2003-11-05 |
| EP1150726A1 (en) | 2001-11-07 |
| US20020082694A1 (en) | 2002-06-27 |
| US8147862B2 (en) | 2012-04-03 |
| DE60006356D1 (de) | 2003-12-11 |
| ATE253385T1 (de) | 2003-11-15 |
| US7563455B2 (en) | 2009-07-21 |
| ES2209820T3 (es) | 2004-07-01 |
| DE60006356T2 (de) | 2004-09-09 |
| AU2756800A (en) | 2000-08-25 |
| US20090196904A1 (en) | 2009-08-06 |
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