AU7698496A - Novel fluorinated or hydroxylated phenylimidazolidines having anti-androgenic activity, method for preparing same, resulting intermediates, and pharmaceutical compositions - Google Patents
Novel fluorinated or hydroxylated phenylimidazolidines having anti-androgenic activity, method for preparing same, resulting intermediates, and pharmaceutical compositionsInfo
- Publication number
- AU7698496A AU7698496A AU76984/96A AU7698496A AU7698496A AU 7698496 A AU7698496 A AU 7698496A AU 76984/96 A AU76984/96 A AU 76984/96A AU 7698496 A AU7698496 A AU 7698496A AU 7698496 A AU7698496 A AU 7698496A
- Authority
- AU
- Australia
- Prior art keywords
- phenylimidazolidines
- hydroxylated
- pharmaceutical compositions
- preparing same
- androgenic activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9513836A FR2741342B1 (fr) | 1995-11-22 | 1995-11-22 | Nouvelles phenylimidazolidines fluorees ou hydroxylees, procede, intermediaires de preparation, application comme medicaments, nouvelle utilisation et compositions pharmaceutiques |
FR9513836 | 1995-11-22 | ||
PCT/FR1996/001846 WO1997019064A1 (fr) | 1995-11-22 | 1996-11-21 | Nouvelles phenylimidazolidines fluorees ou hydroxylees ayant une activite anti-androgenique, leur procede de preparation, intermediaires obtenus et compositions pharmaceutiques |
Publications (1)
Publication Number | Publication Date |
---|---|
AU7698496A true AU7698496A (en) | 1997-06-11 |
Family
ID=9484799
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU76984/96A Abandoned AU7698496A (en) | 1995-11-22 | 1996-11-21 | Novel fluorinated or hydroxylated phenylimidazolidines having anti-androgenic activity, method for preparing same, resulting intermediates, and pharmaceutical compositions |
Country Status (7)
Country | Link |
---|---|
US (1) | US6087509A (fr) |
EP (1) | EP0862559A1 (fr) |
JP (1) | JP2000502053A (fr) |
AU (1) | AU7698496A (fr) |
FR (1) | FR2741342B1 (fr) |
WO (1) | WO1997019064A1 (fr) |
ZA (1) | ZA969820B (fr) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE59913181D1 (de) * | 1998-10-23 | 2006-04-27 | Aventis Pharma Sa | Zubereitungen zur topischen applikation von antiandrogen wirksamen substanzen |
CN1596253A (zh) * | 2001-10-01 | 2005-03-16 | 布里斯托尔-迈尔斯斯奎布公司 | 用作抗炎药的螺-乙内酰脲化合物 |
US7592348B2 (en) | 2003-12-15 | 2009-09-22 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
US7700603B2 (en) * | 2003-12-15 | 2010-04-20 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
DE602004031881D1 (de) | 2003-12-19 | 2011-04-28 | Univ California | Verfahren und materialien zur beurteilung von prostatakrebstherapien |
NZ550102A (en) * | 2004-02-24 | 2010-10-29 | Univ California | Methods and materials for assessing prostate cancer therapies and compounds (thiohydantoine derivatives) |
AU2011202578B2 (en) * | 2004-02-24 | 2012-03-22 | The Regents Of The University Of California | Methods and materials for assessing prostate cancer therapies and compounds |
EP1790640A4 (fr) | 2004-09-09 | 2009-07-29 | Chugai Pharmaceutical Co Ltd | Nouveau dérivé d' imidazolidine et utilisation dudit dérivé |
TW200616634A (en) * | 2004-10-01 | 2006-06-01 | Bristol Myers Squibb Co | Crystalline forms and process for preparing spiro-hydantoin compounds |
US20060142319A1 (en) * | 2004-12-14 | 2006-06-29 | Bang-Chi Chen | Pyridyl-substituted spiro-hydantoin crystalline forms and process |
US7186727B2 (en) * | 2004-12-14 | 2007-03-06 | Bristol-Myers Squibb Company | Pyridyl-substituted spiro-hydantoin compounds and use thereof |
AU2015246137B2 (en) * | 2005-05-13 | 2017-06-15 | The Regents Of The University Of California | Diarylhydantoin compounds |
US7709517B2 (en) | 2005-05-13 | 2010-05-04 | The Regents Of The University Of California | Diarylhydantoin compounds |
AU2013200745B2 (en) * | 2005-05-13 | 2015-11-05 | The Regents Of The University Of California | Diarylhydantoin compounds |
ES2535179T3 (es) * | 2005-05-13 | 2015-05-06 | The Regents Of The University Of California | Compuesto de diarilhidantoína como antagonistas de los receptores de andrógenos para el tratamiento de cáncer |
US7709516B2 (en) | 2005-06-17 | 2010-05-04 | Endorecherche, Inc. | Helix 12 directed non-steroidal antiandrogens |
DK2368550T3 (da) | 2006-03-27 | 2013-09-30 | Univ California | Androgenreceptormodulator til behandlingen af prostatakræft og androgenreceptor-associerede sygdomme |
EP2439196A1 (fr) | 2006-03-29 | 2012-04-11 | The Regents of The University of California | Composés de diarylthiohydantoïne destinés à être utilisés dans une méthode de traitement d'une maladie hyperproliférative |
US8168667B2 (en) | 2006-05-31 | 2012-05-01 | Galapagos Nv | Imidazolidine derivatives, uses therefor, preparation thereof and compositions comprising such |
EP2061771A1 (fr) * | 2006-12-12 | 2009-05-27 | Schering Corporation | Inhibiteurs de la protéase aspartyle contenant un système de noyau tricyclique |
US8093254B2 (en) | 2006-12-12 | 2012-01-10 | Schering Corporation | Aspartyl protease inhibitors |
US9284345B2 (en) | 2007-04-12 | 2016-03-15 | Endorecherche, Inc. | 17alpha-substituted steroids as systemic antiandrogens and selective androgen receptor modulators |
UY31432A1 (es) * | 2007-10-26 | 2009-05-29 | Compuestos de diarilhidantoina | |
GB2463514C (en) | 2008-09-11 | 2018-09-26 | Galapagos Nv | Imidazolidine compounds and uses therefor |
JP5659232B2 (ja) * | 2009-09-10 | 2015-01-28 | トン、ヨウヂ | アンドロゲン受容体アンタゴニストおよびその使用 |
AR078793A1 (es) | 2009-10-27 | 2011-12-07 | Orion Corp | Derivados de carboxamidas no esteroidales y acil hidrazona moduladores de receptores androgenicos de tejido selectivo (sarm), composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento del cancer de prostata entre otros |
SG10201501202TA (en) | 2010-02-16 | 2015-04-29 | Aragon Pharmaceuticals Inc | Androgen Receptor Modulators And Uses Thereof |
CN103608333B (zh) | 2011-03-10 | 2016-01-06 | 苏州开拓药业有限公司 | 雄激素受体拮抗剂及其用途 |
EP2699561B1 (fr) | 2011-04-21 | 2015-06-03 | Orion Corporation | Carboxamides modulant les récepteurs d'androgènes |
UY34646A (es) | 2012-03-02 | 2013-10-31 | Novartis Ag | Compuestos de espirohidantoína y su uso como moduladores selectivos del receptor de andrógenos |
ES2836424T3 (es) | 2012-09-26 | 2021-06-25 | Aragon Pharmaceuticals Inc | Antiandrógenos para tratar el cáncer de próstata no metastásico y resistente a la castración |
JOP20200097A1 (ar) | 2013-01-15 | 2017-06-16 | Aragon Pharmaceuticals Inc | معدل مستقبل أندروجين واستخداماته |
US9682960B2 (en) | 2013-12-19 | 2017-06-20 | Endorecherche, Inc. | Non-steroidal antiandrogens and selective androgen receptor modulators with a pyridyl moiety |
TWI726969B (zh) | 2016-01-11 | 2021-05-11 | 比利時商健生藥品公司 | 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物 |
EP3697398A1 (fr) | 2017-10-16 | 2020-08-26 | Aragon Pharmaceuticals, Inc. | Anti-androgènes destinés au traitement du cancer de la prostate résistant à la castration, non métastatique |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS52270A (en) * | 1975-06-18 | 1977-01-05 | Nippon Soda Co Ltd | Hydantoin germicides for agriculture and gardening |
MC1220A1 (fr) * | 1977-10-28 | 1979-07-20 | Hoffmann La Roche | Nouveaux derives d'imidazolidine |
EP0091596B1 (fr) * | 1982-04-08 | 1991-09-11 | Shell Internationale Researchmaatschappij B.V. | Hydantoins, préparation et application |
US4473393A (en) * | 1982-08-06 | 1984-09-25 | Buffalo Color Corporation | Pesticidal thiohydantoin compositions |
US4958028A (en) * | 1988-12-22 | 1990-09-18 | Ici Americas Inc. | Process for the preparation of 5-substituted-3-phenyl imidazolidine-2,4-diones |
FR2656302B1 (fr) * | 1989-12-22 | 1992-05-07 | Roussel Uclaf | Nouveau procede de preparation de l'anandron et derives de l'anandron. |
FR2671348B1 (fr) * | 1991-01-09 | 1993-03-26 | Roussel Uclaf | Nouvelles phenylimidazolidines, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant. |
US5411981A (en) * | 1991-01-09 | 1995-05-02 | Roussel Uclaf | Phenylimidazolidines having antiandrogenic activity |
FR2693461B1 (fr) * | 1992-07-08 | 1994-09-02 | Roussel Uclaf | Nouvelles phénylimidazolidines substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant. |
FR2694290B1 (fr) * | 1992-07-08 | 1994-09-02 | Roussel Uclaf | Nouvelles phénylimidazolidines éventuellement substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant. |
TW521073B (en) * | 1994-01-05 | 2003-02-21 | Hoechst Marion Roussel Inc | New optionally substituted phenylimidazolidines, their preparation process, their use as anti-androgenic agent and the pharmaceutical compositions containing them |
FR2725206B1 (fr) * | 1994-09-29 | 1996-12-06 | Roussel Uclaf | Nouvelles imidazolidines substituees par un heterocycle, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
US5656651A (en) * | 1995-06-16 | 1997-08-12 | Biophysica Inc. | Androgenic directed compositions |
-
1995
- 1995-11-22 FR FR9513836A patent/FR2741342B1/fr not_active Expired - Fee Related
-
1996
- 1996-11-21 US US09/077,223 patent/US6087509A/en not_active Expired - Fee Related
- 1996-11-21 WO PCT/FR1996/001846 patent/WO1997019064A1/fr not_active Application Discontinuation
- 1996-11-21 JP JP9519453A patent/JP2000502053A/ja not_active Ceased
- 1996-11-21 AU AU76984/96A patent/AU7698496A/en not_active Abandoned
- 1996-11-21 EP EP96939961A patent/EP0862559A1/fr not_active Ceased
- 1996-11-22 ZA ZA9609820A patent/ZA969820B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
US6087509A (en) | 2000-07-11 |
EP0862559A1 (fr) | 1998-09-09 |
FR2741342B1 (fr) | 1998-02-06 |
FR2741342A1 (fr) | 1997-05-23 |
ZA969820B (en) | 1997-11-24 |
JP2000502053A (ja) | 2000-02-22 |
WO1997019064A1 (fr) | 1997-05-29 |
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