AU768118B2 - Chemical synthesis and use of soluble membrane protein receptor domains - Google Patents

Chemical synthesis and use of soluble membrane protein receptor domains Download PDF

Info

Publication number
AU768118B2
AU768118B2 AU38748/00A AU3874800A AU768118B2 AU 768118 B2 AU768118 B2 AU 768118B2 AU 38748/00 A AU38748/00 A AU 38748/00A AU 3874800 A AU3874800 A AU 3874800A AU 768118 B2 AU768118 B2 AU 768118B2
Authority
AU
Australia
Prior art keywords
receptor
extramembranous
domain
ligand
ligation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU38748/00A
Other languages
English (en)
Other versions
AU3874800A (en
Inventor
Gerd G. Kochendoerfer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gryphon Therapeutics Inc
Original Assignee
Gryphon Sciences
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gryphon Sciences filed Critical Gryphon Sciences
Publication of AU3874800A publication Critical patent/AU3874800A/en
Application granted granted Critical
Publication of AU768118B2 publication Critical patent/AU768118B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/006—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/13—Labelling of peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
AU38748/00A 1999-03-11 2000-03-09 Chemical synthesis and use of soluble membrane protein receptor domains Ceased AU768118B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12427299P 1999-03-11 1999-03-11
US60/124272 1999-03-11
PCT/US2000/006297 WO2000053624A1 (fr) 1999-03-11 2000-03-09 Synthese chimique et utilisation de domaines de recepteurs de proteines membranaires solubles

Publications (2)

Publication Number Publication Date
AU3874800A AU3874800A (en) 2000-09-28
AU768118B2 true AU768118B2 (en) 2003-12-04

Family

ID=22413849

Family Applications (1)

Application Number Title Priority Date Filing Date
AU38748/00A Ceased AU768118B2 (en) 1999-03-11 2000-03-09 Chemical synthesis and use of soluble membrane protein receptor domains

Country Status (7)

Country Link
EP (1) EP1159289A1 (fr)
JP (1) JP2002539136A (fr)
CN (1) CN1350544A (fr)
AU (1) AU768118B2 (fr)
CA (1) CA2372164A1 (fr)
HK (1) HK1046534A1 (fr)
WO (1) WO2000053624A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7482425B2 (en) 1999-08-26 2009-01-27 Amylin Pharmaceuticals, Inc. Compositions for lipid matrix-assisted chemical ligation
US6784291B2 (en) 2000-05-04 2004-08-31 Avi Biopharma, Inc. Splice-region antisense composition and method
US8618054B2 (en) 2004-05-05 2013-12-31 Valorisation-Rechereche Société en Commandite Interleukin-1 receptor antagonists, compositions, and methods of treatment
EP2366786A3 (fr) * 2005-05-05 2012-08-29 VALORISATION HSJ, Société en Commandite Modulateurs de récepteur de cytokine et utilisations associées
US7785834B2 (en) 2005-11-10 2010-08-31 Ercole Biotech, Inc. Soluble TNF receptors and their use in treatment of disease
AU2007309650A1 (en) * 2006-02-08 2008-05-02 Ercole Biotech, Inc. Soluble TNF receptors and their use in treatment of disease
JP6263773B2 (ja) * 2011-02-23 2018-01-24 マサチューセッツ インスティテュート オブ テクノロジー 水溶性膜タンパク質およびその調製および使用方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995003321A1 (fr) * 1993-07-20 1995-02-02 Bionebraska, Inc. Procede d'endomodification de proteins
DE69828287T2 (de) * 1997-06-13 2005-12-15 Gryphon Therapeutics, Inc., South San Francisco Festphasige native chemische ligation von ungeschützten oder n-cystein-geschützten peptiden in wässrigen lösungen

Also Published As

Publication number Publication date
AU3874800A (en) 2000-09-28
EP1159289A1 (fr) 2001-12-05
JP2002539136A (ja) 2002-11-19
CA2372164A1 (fr) 2000-09-14
WO2000053624A1 (fr) 2000-09-14
CN1350544A (zh) 2002-05-22
HK1046534A1 (zh) 2003-01-17

Similar Documents

Publication Publication Date Title
Sewald et al. Peptides: chemistry and biology
US6451543B1 (en) Lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides
Offer et al. N α-2-Mercaptobenzylamine-assisted chemical ligation
Li et al. Removable backbone modification method for the chemical synthesis of membrane proteins
Liu et al. Chemical synthesis of peptides within the insulin superfamily
Karas et al. The chemical synthesis of insulin: an enduring challenge
JP2002527358A5 (fr)
Wu et al. Synthesis of four-disulfide insulin analogs via sequential disulfide bond formation
Hossain et al. Novel methods for the chemical synthesis of insulin superfamily peptides and of analogues containing disulfide isosteres
AU768118B2 (en) Chemical synthesis and use of soluble membrane protein receptor domains
Nardone et al. Biochemical characterization and crystal structure of a recombinant hen avidin and its acidic mutant expressed in Escherichia coli
JP2003527561A (ja) 蛋白の部位特異的標識化方法およびそのための使用
Thalluri et al. Synthesis of disulfide-rich heterodimeric peptides through an auxiliary N, N-crosslink
US7482425B2 (en) Compositions for lipid matrix-assisted chemical ligation
Umanah et al. Cross-linking of a DOPA-containing peptide ligand into its G protein-coupled receptor
Tang et al. Human gene 2 relaxin chain combination and folding
Zou et al. Biosynthesis and NMR-studies of a double transmembrane domain from the Y4 receptor, a human GPCR
AU2002336501A1 (en) Modular peptide-based reagent
US20130143251A1 (en) Expeditious synthesis of ubiquitinated peptide conjugates
Banerjee et al. Expression of functional scorpion neurotoxin Lqq-V in E. coli
Büllesbach et al. Synthetic cross-links arrest the C-terminal region of the relaxin-like factor in an active conformation
Dong et al. Design and Synthesis of Cross-Link-Dense Peptides by Manipulating Regioselective Bisthioether Cross-Linking and Orthogonal Disulfide Pairing
Grygiel et al. Synthesis by native chemical ligation and crystal structure of human CCL2
Praveen et al. Effects of C-terminal B-chain modifications in a relaxin 3 agonist analogue
Nokihara et al. Chemical synthesis of Maxadilan, a non-mammalian potent vasodilatory peptide consisting of 61 amino acids with two disulfide bridges, and its related peptides

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)