AU766128B2 - Apparatus for measuring an oxygen concentration gradient and method of use thereof - Google Patents

Apparatus for measuring an oxygen concentration gradient and method of use thereof Download PDF

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Publication number
AU766128B2
AU766128B2 AU19649/01A AU1964901A AU766128B2 AU 766128 B2 AU766128 B2 AU 766128B2 AU 19649/01 A AU19649/01 A AU 19649/01A AU 1964901 A AU1964901 A AU 1964901A AU 766128 B2 AU766128 B2 AU 766128B2
Authority
AU
Australia
Prior art keywords
phosphorescence
sample
oxygen
lifetime
signal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU19649/01A
Other languages
English (en)
Other versions
AU1964901A (en
Inventor
Sergei A. Vinogradov
David F. Wilson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxygen Enterprises Ltd
Original Assignee
University of Pennsylvania Penn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Pennsylvania Penn filed Critical University of Pennsylvania Penn
Publication of AU1964901A publication Critical patent/AU1964901A/en
Application granted granted Critical
Publication of AU766128B2 publication Critical patent/AU766128B2/en
Assigned to OXYGEN ENTERPRISES, LTD reassignment OXYGEN ENTERPRISES, LTD Alteration of Name(s) in Register under S187 Assignors: TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14556—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases by fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6432—Quenching

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
AU19649/01A 1999-10-14 2000-10-13 Apparatus for measuring an oxygen concentration gradient and method of use thereof Ceased AU766128B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15961699P 1999-10-14 1999-10-14
US60/159616 1999-10-14
PCT/US2000/041171 WO2001027585A2 (en) 1999-10-14 2000-10-13 Oxygen concentration gradient measurement apparatus and method

Publications (2)

Publication Number Publication Date
AU1964901A AU1964901A (en) 2001-04-23
AU766128B2 true AU766128B2 (en) 2003-10-09

Family

ID=22573286

Family Applications (1)

Application Number Title Priority Date Filing Date
AU19649/01A Ceased AU766128B2 (en) 1999-10-14 2000-10-13 Apparatus for measuring an oxygen concentration gradient and method of use thereof

Country Status (4)

Country Link
EP (1) EP1220639A4 (de)
AU (1) AU766128B2 (de)
CA (1) CA2387492C (de)
WO (1) WO2001027585A2 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1742038A1 (de) 2005-07-06 2007-01-10 Academisch Medisch Centrum bij de Universiteit van Amsterdam Vorrichtung und Verfahren zur Bestimmung der Konzentration einer Substanz
WO2010019041A1 (en) 2008-08-15 2010-02-18 Erasmus University Medical Center Rotterdam Methods and devices for assessment of mitochondrial function

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5515694A (en) * 1995-01-30 1996-05-14 Carrier Corporation Subcooler level control for a turbine expansion refrigeration cycle
US5515864A (en) * 1994-04-21 1996-05-14 Zuckerman; Ralph Method and apparatus for the in vivo measurement of oxygen concentration levels by the indirect determination of fluoescence lifetime

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5186173A (en) * 1990-08-14 1993-02-16 Drexel University Method for in vivo measurement of oxygen concentration levels
US5281825A (en) * 1991-09-05 1994-01-25 The University Of Maryland School Of Medicine Phase fluorometry using a modulated electroluminescent lamp as a light source
US5462879A (en) * 1993-10-14 1995-10-31 Minnesota Mining And Manufacturing Company Method of sensing with emission quenching sensors
US5863460A (en) * 1996-04-01 1999-01-26 Chiron Diagnostics Corporation Oxygen sensing membranes and methods of making same
US5830138A (en) * 1996-12-16 1998-11-03 Trustees Of The University Of Pennsylvania Intravascular catheter probe for clinical oxygen, pH and CO2 measurement
US6165741A (en) * 1997-05-30 2000-12-26 The Trustees Of The University Of Pennsylvania Method for rapid detection of bacterial growth in cultures

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5515864A (en) * 1994-04-21 1996-05-14 Zuckerman; Ralph Method and apparatus for the in vivo measurement of oxygen concentration levels by the indirect determination of fluoescence lifetime
US5515694A (en) * 1995-01-30 1996-05-14 Carrier Corporation Subcooler level control for a turbine expansion refrigeration cycle

Also Published As

Publication number Publication date
WO2001027585A2 (en) 2001-04-19
CA2387492A1 (en) 2001-04-19
AU1964901A (en) 2001-04-23
EP1220639A2 (de) 2002-07-10
EP1220639A4 (de) 2006-06-07
WO2001027585A3 (en) 2002-01-03
CA2387492C (en) 2012-07-10

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