CA2387492C - Apparatus for measuring an oxygen concentration gradient and method of use thereof - Google Patents

Apparatus for measuring an oxygen concentration gradient and method of use thereof Download PDF

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Publication number
CA2387492C
CA2387492C CA2387492A CA2387492A CA2387492C CA 2387492 C CA2387492 C CA 2387492C CA 2387492 A CA2387492 A CA 2387492A CA 2387492 A CA2387492 A CA 2387492A CA 2387492 C CA2387492 C CA 2387492C
Authority
CA
Canada
Prior art keywords
phosphorescence
sample
computer
signal
oxygen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2387492A
Other languages
English (en)
French (fr)
Other versions
CA2387492A1 (en
Inventor
David F. Wilson
Sergei A. Vinogradov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxygen Enterprises Ltd
Original Assignee
Oxygen Enterprises Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxygen Enterprises Ltd filed Critical Oxygen Enterprises Ltd
Publication of CA2387492A1 publication Critical patent/CA2387492A1/en
Application granted granted Critical
Publication of CA2387492C publication Critical patent/CA2387492C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14556—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases by fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6432—Quenching

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
CA2387492A 1999-10-14 2000-10-13 Apparatus for measuring an oxygen concentration gradient and method of use thereof Expired - Fee Related CA2387492C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15961699P 1999-10-14 1999-10-14
US60/159,616 1999-10-14
PCT/US2000/041171 WO2001027585A2 (en) 1999-10-14 2000-10-13 Oxygen concentration gradient measurement apparatus and method

Publications (2)

Publication Number Publication Date
CA2387492A1 CA2387492A1 (en) 2001-04-19
CA2387492C true CA2387492C (en) 2012-07-10

Family

ID=22573286

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2387492A Expired - Fee Related CA2387492C (en) 1999-10-14 2000-10-13 Apparatus for measuring an oxygen concentration gradient and method of use thereof

Country Status (4)

Country Link
EP (1) EP1220639A4 (de)
AU (1) AU766128B2 (de)
CA (1) CA2387492C (de)
WO (1) WO2001027585A2 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1742038A1 (de) * 2005-07-06 2007-01-10 Academisch Medisch Centrum bij de Universiteit van Amsterdam Vorrichtung und Verfahren zur Bestimmung der Konzentration einer Substanz
EP2318823B1 (de) 2008-08-15 2015-12-02 Erasmus University Medical Center Rotterdam Verfahren und vorrichtungen zur beurteilung der mitochondrienfunktion

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5186173A (en) * 1990-08-14 1993-02-16 Drexel University Method for in vivo measurement of oxygen concentration levels
US5281825A (en) * 1991-09-05 1994-01-25 The University Of Maryland School Of Medicine Phase fluorometry using a modulated electroluminescent lamp as a light source
US5462879A (en) * 1993-10-14 1995-10-31 Minnesota Mining And Manufacturing Company Method of sensing with emission quenching sensors
US5515864A (en) * 1994-04-21 1996-05-14 Zuckerman; Ralph Method and apparatus for the in vivo measurement of oxygen concentration levels by the indirect determination of fluoescence lifetime
US5515694A (en) * 1995-01-30 1996-05-14 Carrier Corporation Subcooler level control for a turbine expansion refrigeration cycle
US5863460A (en) * 1996-04-01 1999-01-26 Chiron Diagnostics Corporation Oxygen sensing membranes and methods of making same
US5830138A (en) * 1996-12-16 1998-11-03 Trustees Of The University Of Pennsylvania Intravascular catheter probe for clinical oxygen, pH and CO2 measurement
US6165741A (en) * 1997-05-30 2000-12-26 The Trustees Of The University Of Pennsylvania Method for rapid detection of bacterial growth in cultures

Also Published As

Publication number Publication date
EP1220639A2 (de) 2002-07-10
CA2387492A1 (en) 2001-04-19
WO2001027585A3 (en) 2002-01-03
AU766128B2 (en) 2003-10-09
WO2001027585A2 (en) 2001-04-19
AU1964901A (en) 2001-04-23
EP1220639A4 (de) 2006-06-07

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Effective date: 20141014