WO2001027585A3 - Oxygen concentration gradient measurement apparatus and method - Google Patents

Oxygen concentration gradient measurement apparatus and method Download PDF

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Publication number
WO2001027585A3
WO2001027585A3 PCT/US2000/041171 US0041171W WO0127585A3 WO 2001027585 A3 WO2001027585 A3 WO 2001027585A3 US 0041171 W US0041171 W US 0041171W WO 0127585 A3 WO0127585 A3 WO 0127585A3
Authority
WO
WIPO (PCT)
Prior art keywords
concentration gradient
oxygen concentration
sample
measurement apparatus
oxygen
Prior art date
Application number
PCT/US2000/041171
Other languages
French (fr)
Other versions
WO2001027585A2 (en
Inventor
David F Wilson
Sergei A Vinogradov
Original Assignee
Univ Pennsylvania
David F Wilson
Sergei A Vinogradov
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania, David F Wilson, Sergei A Vinogradov filed Critical Univ Pennsylvania
Priority to EP00982645A priority Critical patent/EP1220639A4/en
Priority to CA2387492A priority patent/CA2387492C/en
Priority to US10/111,831 priority patent/US6701168B1/en
Priority to AU19649/01A priority patent/AU766128B2/en
Publication of WO2001027585A2 publication Critical patent/WO2001027585A2/en
Publication of WO2001027585A3 publication Critical patent/WO2001027585A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14556—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases by fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6432—Quenching

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

The invention provides an improved, reliable and efficient way of measuring the oxygen concentration gradient in a sample by calculating linear oxygen concentrations within the sample, permitting diagnostic testing, for example, of the effects of a developmental or metabolic change in a cell or tissue, in vitro or in vivo, in response to disease, injury, radiation, or mechanical or chemical intervention, or simply to changed circumstances, or to measure the oxygen permeability of a membrane or plastic. The apparatus in a preferred embodiment comprises a core digital signal processor (45) having sufficient memory to perform the necessary calculations, to control output of excitation light from a light source, and to collect phosphorescent lifetime data (41) and signal processors (A/D and D/A) (44, 46).
PCT/US2000/041171 1999-10-14 2000-10-13 Oxygen concentration gradient measurement apparatus and method WO2001027585A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP00982645A EP1220639A4 (en) 1999-10-14 2000-10-13 Apparatus for measuring an oxygen concentration gradient and method of use thereof
CA2387492A CA2387492C (en) 1999-10-14 2000-10-13 Apparatus for measuring an oxygen concentration gradient and method of use thereof
US10/111,831 US6701168B1 (en) 1999-10-14 2000-10-13 Apparatus for measuring an oxygen concentration gradient and method of use thereof
AU19649/01A AU766128B2 (en) 1999-10-14 2000-10-13 Apparatus for measuring an oxygen concentration gradient and method of use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15961699P 1999-10-14 1999-10-14
US60/159,616 1999-10-14

Publications (2)

Publication Number Publication Date
WO2001027585A2 WO2001027585A2 (en) 2001-04-19
WO2001027585A3 true WO2001027585A3 (en) 2002-01-03

Family

ID=22573286

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/041171 WO2001027585A2 (en) 1999-10-14 2000-10-13 Oxygen concentration gradient measurement apparatus and method

Country Status (4)

Country Link
EP (1) EP1220639A4 (en)
AU (1) AU766128B2 (en)
CA (1) CA2387492C (en)
WO (1) WO2001027585A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1742038A1 (en) 2005-07-06 2007-01-10 Academisch Medisch Centrum bij de Universiteit van Amsterdam Device and method for determining the concentration of a substance
WO2010019041A1 (en) 2008-08-15 2010-02-18 Erasmus University Medical Center Rotterdam Methods and devices for assessment of mitochondrial function

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5515864A (en) * 1994-04-21 1996-05-14 Zuckerman; Ralph Method and apparatus for the in vivo measurement of oxygen concentration levels by the indirect determination of fluoescence lifetime
US5518694A (en) * 1993-10-14 1996-05-21 Minnesota Mining And Manufacturing Company Emission quenching sensors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5186173A (en) * 1990-08-14 1993-02-16 Drexel University Method for in vivo measurement of oxygen concentration levels
US5281825A (en) * 1991-09-05 1994-01-25 The University Of Maryland School Of Medicine Phase fluorometry using a modulated electroluminescent lamp as a light source
US5515694A (en) * 1995-01-30 1996-05-14 Carrier Corporation Subcooler level control for a turbine expansion refrigeration cycle
US5863460A (en) * 1996-04-01 1999-01-26 Chiron Diagnostics Corporation Oxygen sensing membranes and methods of making same
US5830138A (en) * 1996-12-16 1998-11-03 Trustees Of The University Of Pennsylvania Intravascular catheter probe for clinical oxygen, pH and CO2 measurement
US6165741A (en) * 1997-05-30 2000-12-26 The Trustees Of The University Of Pennsylvania Method for rapid detection of bacterial growth in cultures

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5518694A (en) * 1993-10-14 1996-05-21 Minnesota Mining And Manufacturing Company Emission quenching sensors
US5515864A (en) * 1994-04-21 1996-05-14 Zuckerman; Ralph Method and apparatus for the in vivo measurement of oxygen concentration levels by the indirect determination of fluoescence lifetime

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1220639A4 *

Also Published As

Publication number Publication date
EP1220639A4 (en) 2006-06-07
WO2001027585A2 (en) 2001-04-19
AU1964901A (en) 2001-04-23
AU766128B2 (en) 2003-10-09
CA2387492A1 (en) 2001-04-19
EP1220639A2 (en) 2002-07-10
CA2387492C (en) 2012-07-10

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