AU759838B2 - Use of follistatin to modulate GDF-8 and BMP-11 - Google Patents
Use of follistatin to modulate GDF-8 and BMP-11 Download PDFInfo
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- AU759838B2 AU759838B2 AU27854/99A AU2785499A AU759838B2 AU 759838 B2 AU759838 B2 AU 759838B2 AU 27854/99 A AU27854/99 A AU 27854/99A AU 2785499 A AU2785499 A AU 2785499A AU 759838 B2 AU759838 B2 AU 759838B2
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- follistatin
- bmp
- gdf
- protein
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- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Marine Sciences & Fisheries (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2003231603A AU2003231603B2 (en) | 1998-03-09 | 2003-08-01 | Use of follistatin to modulate GDF-8 and BMP-11 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/037,118 US6004937A (en) | 1998-03-09 | 1998-03-09 | Use of follistatin to modulate growth and differentiation factor 8 [GDF-8] and bone morphogenic protein 11 [BMP-11] |
| US09/037118 | 1998-03-09 | ||
| PCT/US1999/004003 WO1999045949A2 (en) | 1998-03-09 | 1999-02-24 | Use of follistatin to modulate gdf-8 and bmp-11 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003231603A Division AU2003231603B2 (en) | 1998-03-09 | 2003-08-01 | Use of follistatin to modulate GDF-8 and BMP-11 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2785499A AU2785499A (en) | 1999-09-27 |
| AU759838B2 true AU759838B2 (en) | 2003-05-01 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU27854/99A Ceased AU759838B2 (en) | 1998-03-09 | 1999-02-24 | Use of follistatin to modulate GDF-8 and BMP-11 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6004937A (https=) |
| EP (3) | EP1061940B1 (https=) |
| JP (3) | JP2002506044A (https=) |
| AT (1) | ATE256475T1 (https=) |
| AU (1) | AU759838B2 (https=) |
| CA (1) | CA2322716C (https=) |
| DE (1) | DE69913665T2 (https=) |
| DK (1) | DK1061940T3 (https=) |
| ES (1) | ES2212533T3 (https=) |
| PT (1) | PT1061940E (https=) |
| WO (1) | WO1999045949A2 (https=) |
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| US6150328A (en) | 1986-07-01 | 2000-11-21 | Genetics Institute, Inc. | BMP products |
| ATE238417T1 (de) | 1991-11-04 | 2003-05-15 | Inst Genetics Llc | Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung |
| US7566768B1 (en) | 1995-10-26 | 2009-07-28 | The Johns Hopkins University School Of Medicine | Promyostatin peptides and methods of using same |
| US7393682B1 (en) * | 1993-03-19 | 2008-07-01 | The Johns Hopkins University School Of Medicine | Polynucleotides encoding promyostatin polypeptides |
| BR9406715A (pt) * | 1993-05-12 | 1996-02-06 | Genetics Inst | Molécula de DNA isolada célula hospedeira vetor método para produzir uma proteina (BMP-11) polipeptideo de proteina-11 morfogenética de osso purificada (BMP-11) e molécula de DNA quimérica |
| US6291206B1 (en) | 1993-09-17 | 2001-09-18 | Genetics Institute, Inc. | BMP receptor proteins |
| DE69434651T2 (de) | 1993-12-07 | 2007-03-08 | Genetics Institute, Inc., Cambridge | Bmp-12, bmp-13 und diese enthaltende sehne-induzierende zusammensetzungen |
| US6008434A (en) | 1994-07-08 | 1999-12-28 | Johns Hopkins University School Of Medicine | Growth differentiation factor-11 transgenic mice |
| US6696260B1 (en) * | 1997-08-01 | 2004-02-24 | The Johns Hopkins University School Of Medicine | Methods to identify growth differentiation factor (GDF) binding proteins |
| US6656475B1 (en) * | 1997-08-01 | 2003-12-02 | The Johns Hopkins University School Of Medicine | Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same |
| US6891082B2 (en) * | 1997-08-01 | 2005-05-10 | The Johns Hopkins University School Of Medicine | Transgenic non-human animals expressing a truncated activintype II receptor |
| US6004937A (en) * | 1998-03-09 | 1999-12-21 | Genetics Institute, Inc. | Use of follistatin to modulate growth and differentiation factor 8 [GDF-8] and bone morphogenic protein 11 [BMP-11] |
| US6727224B1 (en) | 1999-02-01 | 2004-04-27 | Genetics Institute, Llc. | Methods and compositions for healing and repair of articular cartilage |
| WO2001009368A1 (en) * | 1999-07-30 | 2001-02-08 | The General Hospital Corporation | Follistatin antagonists |
| PT1223990E (pt) | 1999-10-15 | 2004-12-31 | Fidia Advanced Biopolymers Srl | Formulacoes de acido hialuronico para administracao de proteinas osteogenicas |
| TWI329129B (en) * | 2001-02-08 | 2010-08-21 | Wyeth Corp | Modified and stabilized gdf propeptides and uses thereof |
| EP1790726B1 (en) * | 2001-02-08 | 2013-07-03 | Wyeth LLC | Modified and stabilized GDF propeptides and uses thereof |
| KR100420798B1 (ko) * | 2001-02-10 | 2004-03-02 | (주)알에이싸이언스 | 펩타이드 벡터 |
| EP1399023B1 (en) | 2001-06-01 | 2008-04-30 | Wyeth | COMPOSITIONS FOR SYSTEMIC ADMINISTRATION OF SEQUENCES ENCODING BONE MORPHOGENETIC PROTEINS& x9; |
| TWI267378B (en) | 2001-06-08 | 2006-12-01 | Wyeth Corp | Calcium phosphate delivery vehicles for osteoinductive proteins |
| US20030103959A1 (en) * | 2001-06-22 | 2003-06-05 | Hughes Paul E. | Methods of providing neuroprotection and/or neurorestoration via the neural activin type IIB receptor |
| US7320789B2 (en) | 2001-09-26 | 2008-01-22 | Wyeth | Antibody inhibitors of GDF-8 and uses thereof |
| US6798160B2 (en) * | 2001-11-02 | 2004-09-28 | Honda Giken Kogyo Kabushiki Kaisha | Electric working machine |
| US20030144203A1 (en) * | 2001-12-19 | 2003-07-31 | Voyager Pharmaceutical Corporation | Methods for slowing senescence and treating and preventing diseases associated with senescence |
| GB2385052A (en) * | 2002-02-05 | 2003-08-13 | Leuven K U Res & Dev | Treatment of spondyloarthropathies |
| BR0307871A (pt) * | 2002-02-21 | 2005-04-12 | Wyeth Corp | Proteìnas contendo domìnio de folistatina |
| CA2476887A1 (en) | 2002-02-21 | 2003-09-04 | Wyeth | Gasp1:a follistatin domain containing protein |
| EP2192129A1 (en) * | 2002-09-16 | 2010-06-02 | Johns Hopkins University | Metalloprotease activation of myostatin, and methods of modulating myostatin activity |
| AR047392A1 (es) * | 2002-10-22 | 2006-01-18 | Wyeth Corp | Neutralizacion de anticuerpos contra gdf 8 y su uso para tales fines |
| US20040223966A1 (en) * | 2002-10-25 | 2004-11-11 | Wolfman Neil M. | ActRIIB fusion polypeptides and uses therefor |
| US20050192225A1 (en) * | 2002-12-18 | 2005-09-01 | Bowen Richard L. | Methods for treating Parkinson's disease |
| BRPI0410927A (pt) * | 2003-06-02 | 2006-06-27 | Wyeth Corp | métodos terapêuticos e profiláticos para distúrbios neuromusculares |
| AU2004272072B2 (en) | 2003-09-12 | 2010-07-08 | Etex Corporation | Injectable calcium phosphate solid rods and pastes for delivery of osteogenic proteins |
| CA2551877A1 (en) * | 2003-12-31 | 2005-07-21 | Schering-Plough Ltd. | Neutralizing epitope-based growth enhancing vaccine |
| JP4688483B2 (ja) * | 2004-04-15 | 2011-05-25 | 株式会社テクノネットワーク四国 | フォリスタチン変異体ポリペプチド |
| AU2005272646A1 (en) * | 2004-08-12 | 2006-02-23 | Wyeth | Combination therapy for diabetes, obesity, and cardiovascular diseases using GDF-8 inhibitors |
| JP2008526201A (ja) | 2004-12-30 | 2008-07-24 | シェーリング−プラウ・リミテッド | 中和エピトープベースの成長増強ワクチン |
| WO2006081379A1 (en) * | 2005-01-26 | 2006-08-03 | Wyeth | Use of sfrps as markers of bmp activity |
| NZ538097A (en) * | 2005-02-07 | 2006-07-28 | Ovita Ltd | Method and compositions for improving wound healing |
| AU2006232914A1 (en) * | 2005-03-23 | 2006-10-12 | Wyeth | Detection of an immune response to GDF-8 modulating agents |
| US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
| TWI782836B (zh) | 2007-02-02 | 2022-11-01 | 美商艾瑟勒朗法瑪公司 | 衍生自ActRIIB的變體與其用途 |
| WO2008109779A2 (en) * | 2007-03-07 | 2008-09-12 | The Johns Hopkins University | Use of follistatin-like related gene (flrg) to increase muscle mass |
| JP2010535708A (ja) | 2007-08-03 | 2010-11-25 | ビオマリン アイジーエー リミテッド | デュシェンヌ型筋ジストロフィーの治療のための薬物併用 |
| GB0715087D0 (en) | 2007-08-03 | 2007-09-12 | Summit Corp Plc | Drug combinations for the treatment of duchenne muscular dystrophy |
| AU2009262970A1 (en) | 2008-06-26 | 2009-12-30 | Acceleron Pharma Inc. | Methods for dosing an activin-ActRIIa antagonist and monitoring of treated patients |
| US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
| ES3047691T3 (en) | 2012-08-01 | 2025-12-04 | Ikaika Therapeutics Inc | Mitigating tissue damage and fibrosis via latent transforming growth factor beta binding protein (ltbp4) |
| US10010498B2 (en) | 2014-06-04 | 2018-07-03 | Acceleron Pharma Inc. | Methods for treatment of amyotrophic lateral sclerosis with follistatin fusion proteins |
| US10023621B2 (en) | 2014-06-04 | 2018-07-17 | Acceleron Pharma Inc. | Follistatin-related fusion proteins |
| AU2016238254B2 (en) | 2015-03-26 | 2022-05-05 | Acceleron Pharma Inc. | Follistatin-related fusion proteins and uses thereof |
| WO2019046903A1 (en) * | 2017-09-08 | 2019-03-14 | Baker Heart and Diabetes Institute | THERAPEUTIC METHOD FOR INCREASING MUSCLE MASS IN A SUBJECT |
| CA3124415A1 (en) | 2018-12-21 | 2020-06-25 | Northwestern University | Use of annexins in preventing and treating muscle membrane injury |
| US20220062299A1 (en) | 2018-12-26 | 2022-03-03 | Northwestern University | Use of glucocorticoid steroids in preventing and treating conditions of muscle wasting, aging and metabolic disorder |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995010611A1 (en) * | 1993-10-14 | 1995-04-20 | President And Fellows Of Harvard College | Method of inducing and maintaining neuronal cells |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5041538A (en) * | 1987-08-28 | 1991-08-20 | The Salk Institute For Biological Studies | Mammalian follistatin |
| US5171579A (en) * | 1991-10-11 | 1992-12-15 | Genetics Institute, Inc. | Formulations of blood clot-polymer matrix for delivery of osteogenic proteins |
| DK0690873T3 (da) * | 1993-03-19 | 2003-09-29 | Univ Johns Hopkins Med | Vækstdifferentieringsfaktor-8 |
| BR9406715A (pt) * | 1993-05-12 | 1996-02-06 | Genetics Inst | Molécula de DNA isolada célula hospedeira vetor método para produzir uma proteina (BMP-11) polipeptideo de proteina-11 morfogenética de osso purificada (BMP-11) e molécula de DNA quimérica |
| US5545616A (en) * | 1994-09-22 | 1996-08-13 | Genentech, Inc. | Method for predicting and/or preventing preterm labor |
| US6281332B1 (en) * | 1994-12-02 | 2001-08-28 | The Johns Hopkins University School Of Medicine | Hedgehog-derived polypeptides |
| GB2306481A (en) * | 1995-10-21 | 1997-05-07 | Univ Manchester | Pharmaceutical comprising a stimulator of activin and/or inhibin |
| US6004937A (en) * | 1998-03-09 | 1999-12-21 | Genetics Institute, Inc. | Use of follistatin to modulate growth and differentiation factor 8 [GDF-8] and bone morphogenic protein 11 [BMP-11] |
-
1998
- 1998-03-09 US US09/037,118 patent/US6004937A/en not_active Expired - Lifetime
-
1999
- 1999-02-24 CA CA2322716A patent/CA2322716C/en not_active Expired - Fee Related
- 1999-02-24 WO PCT/US1999/004003 patent/WO1999045949A2/en not_active Ceased
- 1999-02-24 AT AT99908416T patent/ATE256475T1/de active
- 1999-02-24 DE DE69913665T patent/DE69913665T2/de not_active Expired - Lifetime
- 1999-02-24 EP EP99908416A patent/EP1061940B1/en not_active Expired - Lifetime
- 1999-02-24 DK DK99908416T patent/DK1061940T3/da active
- 1999-02-24 EP EP10185247A patent/EP2347760A3/en not_active Withdrawn
- 1999-02-24 JP JP2000535362A patent/JP2002506044A/ja not_active Withdrawn
- 1999-02-24 PT PT99908416T patent/PT1061940E/pt unknown
- 1999-02-24 ES ES99908416T patent/ES2212533T3/es not_active Expired - Lifetime
- 1999-02-24 AU AU27854/99A patent/AU759838B2/en not_active Ceased
- 1999-02-24 EP EP03028901A patent/EP1444985A3/en not_active Withdrawn
-
2009
- 2009-09-28 JP JP2009222855A patent/JP2010043099A/ja active Pending
-
2010
- 2010-03-17 JP JP2010061242A patent/JP2010195794A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995010611A1 (en) * | 1993-10-14 | 1995-04-20 | President And Fellows Of Harvard College | Method of inducing and maintaining neuronal cells |
Non-Patent Citations (2)
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| FAINSOD, A ET AL (1997) MECH OF DEV. 63:39-50 * |
| THOMSEN, G-H ET AL (1997),TRENDS IN GENETICS,V 13(6): 209-11 * |
Also Published As
| Publication number | Publication date |
|---|---|
| DE69913665T2 (de) | 2004-09-30 |
| EP1061940B1 (en) | 2003-12-17 |
| JP2002506044A (ja) | 2002-02-26 |
| WO1999045949A3 (en) | 1999-11-18 |
| AU2785499A (en) | 1999-09-27 |
| ES2212533T3 (es) | 2004-07-16 |
| DK1061940T3 (da) | 2004-04-05 |
| PT1061940E (pt) | 2004-03-31 |
| CA2322716C (en) | 2010-08-24 |
| JP2010043099A (ja) | 2010-02-25 |
| EP2347760A2 (en) | 2011-07-27 |
| CA2322716A1 (en) | 1999-09-16 |
| DE69913665D1 (de) | 2004-01-29 |
| EP1444985A3 (en) | 2006-12-27 |
| US6004937A (en) | 1999-12-21 |
| JP2010195794A (ja) | 2010-09-09 |
| EP2347760A3 (en) | 2012-06-06 |
| WO1999045949A2 (en) | 1999-09-16 |
| EP1061940A2 (en) | 2000-12-27 |
| EP1444985A2 (en) | 2004-08-11 |
| ATE256475T1 (de) | 2004-01-15 |
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Legal Events
| Date | Code | Title | Description |
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| TC | Change of applicant's name (sec. 104) |
Owner name: GENETICS INSTITUTE, LLC Free format text: FORMER NAME: GENETICS INSTITUTE, INC. |
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| FGA | Letters patent sealed or granted (standard patent) |