AU759838B2 - Use of follistatin to modulate GDF-8 and BMP-11 - Google Patents
Use of follistatin to modulate GDF-8 and BMP-11 Download PDFInfo
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- AU759838B2 AU759838B2 AU27854/99A AU2785499A AU759838B2 AU 759838 B2 AU759838 B2 AU 759838B2 AU 27854/99 A AU27854/99 A AU 27854/99A AU 2785499 A AU2785499 A AU 2785499A AU 759838 B2 AU759838 B2 AU 759838B2
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- follistatin
- bmp
- gdf
- protein
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- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Psychology (AREA)
- Zoology (AREA)
- Marine Sciences & Fisheries (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2003231603A AU2003231603B2 (en) | 1998-03-09 | 2003-08-01 | Use of follistatin to modulate GDF-8 and BMP-11 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/037,118 US6004937A (en) | 1998-03-09 | 1998-03-09 | Use of follistatin to modulate growth and differentiation factor 8 [GDF-8] and bone morphogenic protein 11 [BMP-11] |
| US09/037118 | 1998-03-09 | ||
| PCT/US1999/004003 WO1999045949A2 (en) | 1998-03-09 | 1999-02-24 | Use of follistatin to modulate gdf-8 and bmp-11 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003231603A Division AU2003231603B2 (en) | 1998-03-09 | 2003-08-01 | Use of follistatin to modulate GDF-8 and BMP-11 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2785499A AU2785499A (en) | 1999-09-27 |
| AU759838B2 true AU759838B2 (en) | 2003-05-01 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU27854/99A Ceased AU759838B2 (en) | 1998-03-09 | 1999-02-24 | Use of follistatin to modulate GDF-8 and BMP-11 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6004937A (https=) |
| EP (3) | EP1444985A3 (https=) |
| JP (3) | JP2002506044A (https=) |
| AT (1) | ATE256475T1 (https=) |
| AU (1) | AU759838B2 (https=) |
| CA (1) | CA2322716C (https=) |
| DE (1) | DE69913665T2 (https=) |
| DK (1) | DK1061940T3 (https=) |
| ES (1) | ES2212533T3 (https=) |
| PT (1) | PT1061940E (https=) |
| WO (1) | WO1999045949A2 (https=) |
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|---|---|---|---|---|
| US6150328A (en) | 1986-07-01 | 2000-11-21 | Genetics Institute, Inc. | BMP products |
| WO1993009229A1 (en) | 1991-11-04 | 1993-05-13 | Genetics Institute, Inc. | Recombinant bone morphogenetic protein heterodimers, compositions and methods of use |
| US7393682B1 (en) | 1993-03-19 | 2008-07-01 | The Johns Hopkins University School Of Medicine | Polynucleotides encoding promyostatin polypeptides |
| US7566768B1 (en) | 1995-10-26 | 2009-07-28 | The Johns Hopkins University School Of Medicine | Promyostatin peptides and methods of using same |
| WO1994026892A1 (en) * | 1993-05-12 | 1994-11-24 | Genetics Institute, Inc. | Bmp-11 compositions |
| US6291206B1 (en) | 1993-09-17 | 2001-09-18 | Genetics Institute, Inc. | BMP receptor proteins |
| AU689184B2 (en) | 1993-12-07 | 1998-03-26 | Genetics Institute, Llc | BMP-12, BMP-13 and tendon-inducing compositions thereof |
| US6008434A (en) | 1994-07-08 | 1999-12-28 | Johns Hopkins University School Of Medicine | Growth differentiation factor-11 transgenic mice |
| US6656475B1 (en) | 1997-08-01 | 2003-12-02 | The Johns Hopkins University School Of Medicine | Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same |
| US6891082B2 (en) * | 1997-08-01 | 2005-05-10 | The Johns Hopkins University School Of Medicine | Transgenic non-human animals expressing a truncated activintype II receptor |
| US6696260B1 (en) * | 1997-08-01 | 2004-02-24 | The Johns Hopkins University School Of Medicine | Methods to identify growth differentiation factor (GDF) binding proteins |
| US6004937A (en) * | 1998-03-09 | 1999-12-21 | Genetics Institute, Inc. | Use of follistatin to modulate growth and differentiation factor 8 [GDF-8] and bone morphogenic protein 11 [BMP-11] |
| US6727224B1 (en) | 1999-02-01 | 2004-04-27 | Genetics Institute, Llc. | Methods and compositions for healing and repair of articular cartilage |
| WO2001009368A1 (en) * | 1999-07-30 | 2001-02-08 | The General Hospital Corporation | Follistatin antagonists |
| DK1223990T3 (da) | 1999-10-15 | 2004-11-29 | Inst Genetics Llc | Formuleringer af hyaluronsyre til tilförsel af osteogene proteiner |
| TW200526779A (en) * | 2001-02-08 | 2005-08-16 | Wyeth Corp | Modified and stabilized GDF propeptides and uses thereof |
| EP1790726B1 (en) * | 2001-02-08 | 2013-07-03 | Wyeth LLC | Modified and stabilized GDF propeptides and uses thereof |
| KR100420798B1 (ko) * | 2001-02-10 | 2004-03-02 | (주)알에이싸이언스 | 펩타이드 벡터 |
| US7226587B2 (en) | 2001-06-01 | 2007-06-05 | Wyeth | Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins |
| TWI267378B (en) | 2001-06-08 | 2006-12-01 | Wyeth Corp | Calcium phosphate delivery vehicles for osteoinductive proteins |
| US20030103959A1 (en) * | 2001-06-22 | 2003-06-05 | Hughes Paul E. | Methods of providing neuroprotection and/or neurorestoration via the neural activin type IIB receptor |
| US7320789B2 (en) * | 2001-09-26 | 2008-01-22 | Wyeth | Antibody inhibitors of GDF-8 and uses thereof |
| US6798160B2 (en) * | 2001-11-02 | 2004-09-28 | Honda Giken Kogyo Kabushiki Kaisha | Electric working machine |
| US20030144203A1 (en) * | 2001-12-19 | 2003-07-31 | Voyager Pharmaceutical Corporation | Methods for slowing senescence and treating and preventing diseases associated with senescence |
| GB2385052A (en) * | 2002-02-05 | 2003-08-13 | Leuven K U Res & Dev | Treatment of spondyloarthropathies |
| EP1572909A4 (en) * | 2002-02-21 | 2007-06-06 | Wyeth Corp | PROTEIN CONTAINING A DOMAINE OF FOLLISTATIN |
| BR0307871A (pt) | 2002-02-21 | 2005-04-12 | Wyeth Corp | Proteìnas contendo domìnio de folistatina |
| MXPA05002968A (es) * | 2002-09-16 | 2005-09-08 | Univ Johns Hopkins | Activacion de miostatina por metaloproteasa, y metodos de modular la actividad de miostatina. |
| AR047392A1 (es) | 2002-10-22 | 2006-01-18 | Wyeth Corp | Neutralizacion de anticuerpos contra gdf 8 y su uso para tales fines |
| US20040223966A1 (en) * | 2002-10-25 | 2004-11-11 | Wolfman Neil M. | ActRIIB fusion polypeptides and uses therefor |
| US20050192225A1 (en) * | 2002-12-18 | 2005-09-01 | Bowen Richard L. | Methods for treating Parkinson's disease |
| RU2322261C2 (ru) * | 2003-06-02 | 2008-04-20 | Уайт | Применение ингибиторов миостатика (gdf8) в сочетании с кортикостероидами для лечения нервно-мышечных заболеваний |
| JP5392981B2 (ja) | 2003-09-12 | 2014-01-22 | ワイス・エルエルシー | 骨形成蛋白の送達のための注入可能なリン酸カルシウム固体ロッドおよびペースト |
| EP1699820A2 (en) * | 2003-12-31 | 2006-09-13 | Schering-Plough Ltd. | Neutralizing epitope-based growth enhancing vaccine |
| JP4688483B2 (ja) * | 2004-04-15 | 2011-05-25 | 株式会社テクノネットワーク四国 | フォリスタチン変異体ポリペプチド |
| AU2005272646A1 (en) * | 2004-08-12 | 2006-02-23 | Wyeth | Combination therapy for diabetes, obesity, and cardiovascular diseases using GDF-8 inhibitors |
| CA2594276A1 (en) | 2004-12-30 | 2006-07-13 | Schering-Plough Ltd. | Neutralizing epitope-based growth enhancing vaccine |
| WO2006081379A1 (en) * | 2005-01-26 | 2006-08-03 | Wyeth | Use of sfrps as markers of bmp activity |
| NZ538097A (en) * | 2005-02-07 | 2006-07-28 | Ovita Ltd | Method and compositions for improving wound healing |
| JP2008537777A (ja) * | 2005-03-23 | 2008-09-25 | ワイス | Ｇｄｆ−８調節剤に対する免疫応答の検出 |
| US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
| TW201803890A (zh) | 2007-02-02 | 2018-02-01 | 艾瑟勒朗法瑪公司 | 衍生自ＡｃｔＲＩＩＢ的變體與其用途 |
| US8236751B2 (en) * | 2007-03-07 | 2012-08-07 | The Johns Hopkins University | Methods of increasing muscle mass using follistatin-like related gene (FLRG) |
| CA2685540C (en) | 2007-08-03 | 2018-10-16 | Graham Michael Wynne | Drug combinations for the treatment of duchenne muscular dystrophy |
| GB0715087D0 (en) | 2007-08-03 | 2007-09-12 | Summit Corp Plc | Drug combinations for the treatment of duchenne muscular dystrophy |
| CN102131822A (zh) | 2008-06-26 | 2011-07-20 | 阿塞勒隆制药公司 | 进行激活素-ActRIIa拮抗剂给药和监测受治疗患者的方法 |
| US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
| US9873739B2 (en) | 2012-08-01 | 2018-01-23 | Ikaika Therapeutics, Llc | Mitigating tissue damage and fibrosis via latent transforming growth factor beta binding protein (LTBP4) |
| EA202090632A1 (ru) | 2014-06-04 | 2020-07-31 | Акселерон Фарма Инк. | Способы и композиции для лечения расстройств с использованием фоллистатиновых полипептидов |
| US10010498B2 (en) | 2014-06-04 | 2018-07-03 | Acceleron Pharma Inc. | Methods for treatment of amyotrophic lateral sclerosis with follistatin fusion proteins |
| EP3274457A4 (en) | 2015-03-26 | 2018-08-08 | Acceleron Pharma Inc. | Follistatin-related fusion proteins and uses thereof |
| WO2019046903A1 (en) * | 2017-09-08 | 2019-03-14 | Baker Heart and Diabetes Institute | THERAPEUTIC METHOD FOR INCREASING MUSCLE MASS IN A SUBJECT |
| WO2020132647A1 (en) | 2018-12-21 | 2020-06-25 | Northwestern University | Use of annexins in preventing and treating muscle membrane injury |
| WO2020139977A1 (en) | 2018-12-26 | 2020-07-02 | Northwestern University | Use of glucocorticoid steroids in preventing and treating conditions of muscle wasting, aging and metabolic disorder |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995010611A1 (en) * | 1993-10-14 | 1995-04-20 | President And Fellows Of Harvard College | Method of inducing and maintaining neuronal cells |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5041538A (en) * | 1987-08-28 | 1991-08-20 | The Salk Institute For Biological Studies | Mammalian follistatin |
| US5171579A (en) * | 1991-10-11 | 1992-12-15 | Genetics Institute, Inc. | Formulations of blood clot-polymer matrix for delivery of osteogenic proteins |
| DK0690873T3 (da) * | 1993-03-19 | 2003-09-29 | Univ Johns Hopkins Med | Vækstdifferentieringsfaktor-8 |
| WO1994026892A1 (en) * | 1993-05-12 | 1994-11-24 | Genetics Institute, Inc. | Bmp-11 compositions |
| US5545616A (en) * | 1994-09-22 | 1996-08-13 | Genentech, Inc. | Method for predicting and/or preventing preterm labor |
| US6281332B1 (en) * | 1994-12-02 | 2001-08-28 | The Johns Hopkins University School Of Medicine | Hedgehog-derived polypeptides |
| GB2306481A (en) * | 1995-10-21 | 1997-05-07 | Univ Manchester | Pharmaceutical comprising a stimulator of activin and/or inhibin |
| US6004937A (en) * | 1998-03-09 | 1999-12-21 | Genetics Institute, Inc. | Use of follistatin to modulate growth and differentiation factor 8 [GDF-8] and bone morphogenic protein 11 [BMP-11] |
-
1998
- 1998-03-09 US US09/037,118 patent/US6004937A/en not_active Expired - Lifetime
-
1999
- 1999-02-24 DK DK99908416T patent/DK1061940T3/da active
- 1999-02-24 PT PT99908416T patent/PT1061940E/pt unknown
- 1999-02-24 AU AU27854/99A patent/AU759838B2/en not_active Ceased
- 1999-02-24 EP EP03028901A patent/EP1444985A3/en not_active Withdrawn
- 1999-02-24 WO PCT/US1999/004003 patent/WO1999045949A2/en not_active Ceased
- 1999-02-24 ES ES99908416T patent/ES2212533T3/es not_active Expired - Lifetime
- 1999-02-24 EP EP99908416A patent/EP1061940B1/en not_active Expired - Lifetime
- 1999-02-24 EP EP10185247A patent/EP2347760A3/en not_active Withdrawn
- 1999-02-24 AT AT99908416T patent/ATE256475T1/de active
- 1999-02-24 DE DE69913665T patent/DE69913665T2/de not_active Expired - Lifetime
- 1999-02-24 CA CA2322716A patent/CA2322716C/en not_active Expired - Fee Related
- 1999-02-24 JP JP2000535362A patent/JP2002506044A/ja not_active Withdrawn
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2009
- 2009-09-28 JP JP2009222855A patent/JP2010043099A/ja active Pending
-
2010
- 2010-03-17 JP JP2010061242A patent/JP2010195794A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO1995010611A1 (en) * | 1993-10-14 | 1995-04-20 | President And Fellows Of Harvard College | Method of inducing and maintaining neuronal cells |
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| FAINSOD, A ET AL (1997) MECH OF DEV. 63:39-50 * |
| THOMSEN, G-H ET AL (1997),TRENDS IN GENETICS,V 13(6): 209-11 * |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2785499A (en) | 1999-09-27 |
| DE69913665D1 (de) | 2004-01-29 |
| EP1444985A3 (en) | 2006-12-27 |
| CA2322716A1 (en) | 1999-09-16 |
| ATE256475T1 (de) | 2004-01-15 |
| EP1061940B1 (en) | 2003-12-17 |
| CA2322716C (en) | 2010-08-24 |
| EP1444985A2 (en) | 2004-08-11 |
| JP2010195794A (ja) | 2010-09-09 |
| DE69913665T2 (de) | 2004-09-30 |
| DK1061940T3 (da) | 2004-04-05 |
| JP2002506044A (ja) | 2002-02-26 |
| ES2212533T3 (es) | 2004-07-16 |
| WO1999045949A2 (en) | 1999-09-16 |
| PT1061940E (pt) | 2004-03-31 |
| US6004937A (en) | 1999-12-21 |
| JP2010043099A (ja) | 2010-02-25 |
| WO1999045949A3 (en) | 1999-11-18 |
| EP2347760A2 (en) | 2011-07-27 |
| EP1061940A2 (en) | 2000-12-27 |
| EP2347760A3 (en) | 2012-06-06 |
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Owner name: GENETICS INSTITUTE, LLC Free format text: FORMER NAME: GENETICS INSTITUTE, INC. |
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| FGA | Letters patent sealed or granted (standard patent) |