AU754399B2 - Novel indolocarbazole derivatives useful for the treatment of neurodegenerative diseases and cancer - Google Patents

Novel indolocarbazole derivatives useful for the treatment of neurodegenerative diseases and cancer Download PDF

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Publication number
AU754399B2
AU754399B2 AU47766/99A AU4776699A AU754399B2 AU 754399 B2 AU754399 B2 AU 754399B2 AU 47766/99 A AU47766/99 A AU 47766/99A AU 4776699 A AU4776699 A AU 4776699A AU 754399 B2 AU754399 B2 AU 754399B2
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AU
Australia
Prior art keywords
composition
matter
tau
carbons
halide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU47766/99A
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English (en)
Other versions
AU4776699A (en
Inventor
David R. Brittelli
Timothy B. Lowinger
Hanno Roder
Michael C. Van Zandt
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Nad AG
Original Assignee
NAP AG
Bayer AG
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Filing date
Publication date
Application filed by NAP AG, Bayer AG filed Critical NAP AG
Publication of AU4776699A publication Critical patent/AU4776699A/en
Application granted granted Critical
Publication of AU754399B2 publication Critical patent/AU754399B2/en
Assigned to NAD AKTIENGESELLSCHAFT reassignment NAD AKTIENGESELLSCHAFT Request to Amend Deed and Register Assignors: NAP AG
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/16Peri-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU47766/99A 1998-07-02 1999-06-23 Novel indolocarbazole derivatives useful for the treatment of neurodegenerative diseases and cancer Ceased AU754399B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/109131 1998-07-02
US09/109,131 US6013646A (en) 1998-07-02 1998-07-02 Indolocarbazole derivatives useful for the treatment of neurodegenerative diseases and cancer
PCT/EP1999/004369 WO2000001699A1 (en) 1998-07-02 1999-06-23 Novel indolocarbazole derivatives useful for the treatment of neurodegenerative diseases and cancer

Publications (2)

Publication Number Publication Date
AU4776699A AU4776699A (en) 2000-01-24
AU754399B2 true AU754399B2 (en) 2002-11-14

Family

ID=22325955

Family Applications (1)

Application Number Title Priority Date Filing Date
AU47766/99A Ceased AU754399B2 (en) 1998-07-02 1999-06-23 Novel indolocarbazole derivatives useful for the treatment of neurodegenerative diseases and cancer

Country Status (6)

Country Link
US (2) US6013646A (enExample)
EP (1) EP1091962A1 (enExample)
JP (1) JP2002519425A (enExample)
AU (1) AU754399B2 (enExample)
CA (1) CA2336419A1 (enExample)
WO (1) WO2000001699A1 (enExample)

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* Cited by examiner, † Cited by third party
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US6013646A (en) 1998-07-02 2000-01-11 Bayer Corporation Indolocarbazole derivatives useful for the treatment of neurodegenerative diseases and cancer
US6660750B2 (en) 2000-02-15 2003-12-09 University Of Iowa Research Foundation Flavopiridol methods and compositions for HIV therapy
WO2001064199A2 (en) * 2000-02-29 2001-09-07 Janssen Pharmaceutica N.V. Farnesyl protein transferase inhibitor combinations with taxane compounds
WO2001085151A2 (en) * 2000-05-08 2001-11-15 Psoriasis Research Institute Chimeric animal model and treatment of psoriasis
CA2308994A1 (en) * 2000-05-19 2001-11-19 Aegera Therapeutics Inc. Neuroprotective compounds
US7129250B2 (en) * 2000-05-19 2006-10-31 Aegera Therapeutics Inc. Neuroprotective and anti-proliferative compounds
JP2005511719A (ja) * 2001-12-13 2005-04-28 ファーマサイクリクス,インコーポレイテッド 神経性進行に影響を与えるためのプロセス
DE10161940A1 (de) * 2001-12-17 2003-07-03 Nad Ag N-Carbacyclus-monosubstitutierte Indolocarbazole als Proteinkinase-inhibitoren
CA2477604A1 (en) * 2002-03-13 2003-09-25 Signum Biosciences, Inc. Modulation of protein methylation and phosphoprotein phosphate
DE10255343B4 (de) * 2002-11-27 2006-09-07 Nad Ag N,N-Verbrückte, Stickstoff-Substituierte Carbacyclische Indolocarbazole als Proteinkinase-Inhibitoren
US20100009929A1 (en) 2004-03-29 2010-01-14 Cheng Jin Q Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof
AU2005228410A1 (en) 2004-03-29 2005-10-13 University Of South Florida Effective treatment of tumors and cancer with triciribine and related compounds
US20110008327A1 (en) 2004-03-29 2011-01-13 Cheng Jin Q Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof
US20100028339A1 (en) * 2004-03-29 2010-02-04 Cheng Jin Q Compositions including triciribine and trastuzumab and methods of use thereof
US20100009928A1 (en) 2004-03-29 2010-01-14 Cheng Jin Q Compositions including triciribine and taxanes and methods of use thereof
US20100173864A1 (en) * 2004-03-29 2010-07-08 Cheng Jin Q Compositions including triciribine and one or more platinum compounds and methods of use thereof
DE102004025726B4 (de) 2004-05-26 2006-07-06 Roder, Hanno, Dr. Verwendung eines spezifischen K252a-Derivats zur Verhinderung oder Behandlung der Alzheimerschen Krankheit
US20060058250A1 (en) * 2004-09-10 2006-03-16 Cephalon, Inc. Methods of treating proliferative skin diseases using carbazole derivatives
US7923041B2 (en) 2005-02-03 2011-04-12 Signum Biosciences, Inc. Compositions and methods for enhancing cognitive function
EP1843734A4 (en) * 2005-02-03 2008-09-10 Signum Biosciences Inc COMPOSITIONS AND METHOD FOR INTENSIFYING COGNITIVE FUNCTIONS
KR20080008395A (ko) * 2005-05-02 2008-01-23 더 트러스티스 오브 콜롬비아 유니버시티 인 더 시티 오브 뉴욕 알츠하이머병 치료를 위한 포스포이노시타이드 조절
US20070249590A1 (en) * 2005-10-28 2007-10-25 Wilson Lawrence J Substituted indolo[2,3-a]pyrrolo[3,4-c]carbazole compounds useful in treating kinase disorders
CN1870631B (zh) * 2005-11-11 2010-04-14 华为技术有限公司 媒体网关的门控方法
JP2010513287A (ja) * 2006-12-14 2010-04-30 トータティス, インク. 癌治療のための組成物及び方法
WO2010085799A2 (en) * 2009-01-26 2010-07-29 Tautatis, Inc. Compositions and method for the treatment of parkinson's disease

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US4968690A (en) * 1986-05-27 1990-11-06 United States Government As Represented By The Secretary Of The Dept. Of Health And Human Services 3-deazaneplanocin, intermediates for it, and antiviral composition and method of treatment using it
DE3752123T2 (de) * 1987-03-09 1998-05-14 Kyowa Hakko Kogyo Kk Derivate des physiologisch aktiven mittels k-252
JPH07113027B2 (ja) * 1987-12-24 1995-12-06 協和醗酵工業株式会社 K−252誘導体
US5618809A (en) * 1989-12-14 1997-04-08 Schering Corporation Indolocarbazoles from saccharothrix aerocolonigenes copiosa subsp. nov SCC 1951 ATCC 53856
US5189046A (en) * 1990-08-14 1993-02-23 Nova Pharmaceutical Corporation Protein kinase C modulators
JPH04187686A (ja) * 1990-11-20 1992-07-06 Meiji Seika Kaisha Ltd インドロカルバゾール誘導体
US5955444A (en) 1991-08-09 1999-09-21 Massachusetts Institute Of Technology Method of inhibiting abnormal tau hyper phosphorylation in a cell
WO1993003148A2 (en) * 1991-08-09 1993-02-18 Massachusetts Institute Of Technology Tau/neurofilament protein kinases pk40 and pk36
NZ245203A (en) * 1991-11-29 1997-07-27 Banyu Pharma Co Ltd 5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6h)-dione derivatives substituted in position-13 by a pentose or hexose group; corresponding indolo-furano(anhydride)intermediates
US5607691A (en) * 1992-06-12 1997-03-04 Affymax Technologies N.V. Compositions and methods for enhanced drug delivery
EP0575955B1 (en) * 1992-06-22 1999-09-15 Kyowa Hakko Kogyo Co., Ltd. Process for producing staurosporine derivatives
US5461146A (en) * 1992-07-24 1995-10-24 Cephalon, Inc. Selected protein kinase inhibitors for the treatment of neurological disorders
US5621101A (en) * 1992-07-24 1997-04-15 Cephalon, Inc. Protein kinase inhibitors for treatment of neurological disorders
CA2140653A1 (en) * 1992-08-12 1994-03-03 Irene Abraham Protein kinase inhibitors and related compounds combined with taxol
EP0643966A4 (en) * 1993-03-03 1995-08-09 Kyowa Hakko Kogyo Kk ACTIVE SUBSTANCE FOR IMPROVING SENSITIVITY TO ANTINEOPLASTIC ACTIVE SUBSTANCES.
DK0699204T3 (da) * 1993-05-28 1999-02-22 Cephalon Inc Anvendelse af indolocarbazolderivater til behandling af en patologisk tilstand i prostata
US5468872A (en) * 1993-09-16 1995-11-21 Cephalon, Inc. K-252a functional derivatives potentiate neurotrophin-3 for the treatment of neurological disorders
US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
AU1339895A (en) * 1993-12-23 1995-07-10 Eli Lilly And Company Protein kinase c inhibitors
US5654307A (en) * 1994-01-25 1997-08-05 Warner-Lambert Company Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family
WO1995022331A1 (en) * 1994-02-18 1995-08-24 Cephalon, Inc. Aqueous indolocarbazole solutions
US5491242A (en) * 1994-06-22 1996-02-13 Eli Lilly And Company Protein kinase C inhibitors
US5594009A (en) * 1994-10-14 1997-01-14 Cephalon, Inc. Fused pyrrolocarbazoles
US5648378A (en) * 1995-06-07 1997-07-15 Research Corporation Technologies, Inc. 2-iminochromene derivatives as inhibitors of protein tyrosine kinase
US6013646A (en) 1998-07-02 2000-01-11 Bayer Corporation Indolocarbazole derivatives useful for the treatment of neurodegenerative diseases and cancer

Also Published As

Publication number Publication date
JP2002519425A (ja) 2002-07-02
AU4776699A (en) 2000-01-24
EP1091962A1 (en) 2001-04-18
CA2336419A1 (en) 2000-01-13
US6541468B1 (en) 2003-04-01
US6013646A (en) 2000-01-11
WO2000001699A1 (en) 2000-01-13

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HB Alteration of name in register

Owner name: BAYER AKTIENGESELLSCHAFT, NAD AKTIENGESELLSCHAFT

Free format text: FORMER NAME WAS: BAYER AKTIENGESELLSCHAFT, NAP AG

HB Alteration of name in register

Owner name: NAD AKTIENGESELLSCHAFT

Free format text: FORMER NAME WAS: NAP AG

TH Corrigenda

Free format text: IN VOL 17, NO 13, PAGE(S) 420 UNDER THE HEADING ALTERATION OF NAME IN REGISTER THE NAME OF THE APPLICANT IN REGARD TO PATENT NUMBER 754399 SHOULD HAV DELETED: BAYER AKTIENGESELLSCHAFT

SREP Specification republished
TH Corrigenda

Free format text: IN VOL 16, NO 40, PAGE(S) 7738 UNDER THE HEADING APPLICATIONS ACCEPTED - NAME INDEX IN THE NAME OF BAYER AKTIENGESELLSCHAFT, NAP AG, SERIAL NO. 754399, INID (71), DELETE THE FIRST APPLICANT NAMELY BAYER AKTIENGESELLSCHAFT