AU747543B2 - Process for converting propargylic amine-N-oxides to enaminones - Google Patents

Process for converting propargylic amine-N-oxides to enaminones Download PDF

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Publication number
AU747543B2
AU747543B2 AU85121/98A AU8512198A AU747543B2 AU 747543 B2 AU747543 B2 AU 747543B2 AU 85121/98 A AU85121/98 A AU 85121/98A AU 8512198 A AU8512198 A AU 8512198A AU 747543 B2 AU747543 B2 AU 747543B2
Authority
AU
Australia
Prior art keywords
phenyl
chain alkyl
group
cycloalkyl
branched chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU85121/98A
Other languages
English (en)
Other versions
AU8512198A (en
Inventor
Russell George Dushin
Eugene John Trybulski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/106,471 external-priority patent/US5932745A/en
Application filed by American Home Products Corp filed Critical American Home Products Corp
Publication of AU8512198A publication Critical patent/AU8512198A/en
Application granted granted Critical
Publication of AU747543B2 publication Critical patent/AU747543B2/en
Assigned to WYETH reassignment WYETH Amend patent request/document other than specification (104) Assignors: AMERICAN HOME PRODUCTS CORPORATION
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • C07C291/04—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds containing amino-oxide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrane Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU85121/98A 1997-07-30 1998-07-24 Process for converting propargylic amine-N-oxides to enaminones Ceased AU747543B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US90329997A 1997-07-30 1997-07-30
US08/903299 1997-07-30
US09/106471 1998-06-30
US09/106,471 US5932745A (en) 1997-07-30 1998-06-30 Process for converting propargylic amine-N-oxides to enaminones
PCT/US1998/015391 WO1999006351A1 (fr) 1997-07-30 1998-07-24 Procede permettant de convertir des amino-n-oxydes propargyliques en enaminones

Publications (2)

Publication Number Publication Date
AU8512198A AU8512198A (en) 1999-02-22
AU747543B2 true AU747543B2 (en) 2002-05-16

Family

ID=26803694

Family Applications (1)

Application Number Title Priority Date Filing Date
AU85121/98A Ceased AU747543B2 (en) 1997-07-30 1998-07-24 Process for converting propargylic amine-N-oxides to enaminones

Country Status (7)

Country Link
EP (1) EP1000012A1 (fr)
JP (1) JP2001512095A (fr)
AR (1) AR013375A1 (fr)
AU (1) AU747543B2 (fr)
CA (1) CA2298595A1 (fr)
TW (1) TW513394B (fr)
WO (1) WO1999006351A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6235900B1 (en) * 1999-02-04 2001-05-22 American Home Products Corporation Tricyclic pyridine N-oxides vasopressin agonists
JP4706320B2 (ja) * 2005-04-25 2011-06-22 宇部興産株式会社 Ｎ，ｎ−ジメチルアミノアルケノン化合物の製法
JP4706325B2 (ja) * 2005-05-10 2011-06-22 宇部興産株式会社 ４−置換−１−ｎ，ｎ−ジアルキルアミノ−１−ブテン−３−オンの取得方法
WO2013006143A1 (fr) * 2011-07-06 2013-01-10 Agency For Science, Technology And Research Procédé de production d'un aminopropyne ou d'une énaminone

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5059709A (en) * 1990-11-13 1991-10-22 American Cyanamid Company Process for the synthesis of α-[(dialkylamino)substituted-methylene]-β-oxo-(substituted)propanentriles

Also Published As

Publication number Publication date
TW513394B (en) 2002-12-11
AU8512198A (en) 1999-02-22
AR013375A1 (es) 2000-12-27
JP2001512095A (ja) 2001-08-21
EP1000012A1 (fr) 2000-05-17
WO1999006351A1 (fr) 1999-02-11
CA2298595A1 (fr) 1999-02-11

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
TC Change of applicant's name (sec. 104)

Owner name: WYETH

Free format text: FORMER NAME: AMERICAN HOME PRODUCTS CORPORATION

MK14 Patent ceased section 143(a) (annual fees not paid) or expired