AU747345B2 - Detection of analytes using reorganization energy - Google Patents
Detection of analytes using reorganization energy Download PDFInfo
- Publication number
- AU747345B2 AU747345B2 AU78355/98A AU7835598A AU747345B2 AU 747345 B2 AU747345 B2 AU 747345B2 AU 78355/98 A AU78355/98 A AU 78355/98A AU 7835598 A AU7835598 A AU 7835598A AU 747345 B2 AU747345 B2 AU 747345B2
- Authority
- AU
- Australia
- Prior art keywords
- transition metal
- solvent
- metal complex
- electrode
- binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
- G01N33/5438—Electrodes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Nanotechnology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Composite Materials (AREA)
- Materials Engineering (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/873977 | 1997-06-12 | ||
US08/873,977 US6013459A (en) | 1997-06-12 | 1997-06-12 | Detection of analytes using reorganization energy |
PCT/US1998/012082 WO1998057158A1 (en) | 1997-06-12 | 1998-06-12 | Detection of analytes using reorganization energy |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2002300599 Division | 1998-06-12 | ||
AU2002300547A Division AU2002300547A1 (en) | 1997-06-12 | 2002-08-14 | Detection of analytes using reorganization energy |
Publications (2)
Publication Number | Publication Date |
---|---|
AU7835598A AU7835598A (en) | 1998-12-30 |
AU747345B2 true AU747345B2 (en) | 2002-05-16 |
Family
ID=25362727
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU78355/98A Ceased AU747345B2 (en) | 1997-06-12 | 1998-06-12 | Detection of analytes using reorganization energy |
Country Status (6)
Families Citing this family (180)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5620850A (en) * | 1994-09-26 | 1997-04-15 | President And Fellows Of Harvard College | Molecular recognition at surfaces derivatized with self-assembled monolayers |
US7195871B2 (en) * | 1996-01-24 | 2007-03-27 | Third Wave Technologies, Inc | Methods and compositions for detecting target sequences |
US7393645B2 (en) * | 1996-11-05 | 2008-07-01 | Clinical Micro Sensors, Inc. | Compositions for the electronic detection of analytes utilizing monolayers |
US7381525B1 (en) * | 1997-03-07 | 2008-06-03 | Clinical Micro Sensors, Inc. | AC/DC voltage apparatus for detection of nucleic acids |
US7014992B1 (en) * | 1996-11-05 | 2006-03-21 | Clinical Micro Sensors, Inc. | Conductive oligomers attached to electrodes and nucleoside analogs |
US6060327A (en) | 1997-05-14 | 2000-05-09 | Keensense, Inc. | Molecular wire injection sensors |
US7220550B2 (en) * | 1997-05-14 | 2007-05-22 | Keensense, Inc. | Molecular wire injection sensors |
US6699667B2 (en) | 1997-05-14 | 2004-03-02 | Keensense, Inc. | Molecular wire injection sensors |
EP0878711A1 (en) * | 1997-05-15 | 1998-11-18 | Interuniversitair Micro-Elektronica Centrum Vzw | Chemically sensitive sensor comprising arylene alkenylene oligomers |
US6013459A (en) * | 1997-06-12 | 2000-01-11 | Clinical Micro Sensors, Inc. | Detection of analytes using reorganization energy |
EP0988534B1 (en) | 1997-06-12 | 2011-02-16 | Clinical Micro Sensors, Inc. | Electronic methods and apparatus for the detection of analytes |
IL121312A (en) * | 1997-07-14 | 2001-09-13 | Technion Res & Dev Foundation | Microelectronic components, their manufacture and electronic networks containing them |
US7407811B2 (en) * | 1997-12-22 | 2008-08-05 | Roche Diagnostics Operations, Inc. | System and method for analyte measurement using AC excitation |
US8071384B2 (en) | 1997-12-22 | 2011-12-06 | Roche Diagnostics Operations, Inc. | Control and calibration solutions and methods for their use |
EP2085778B1 (en) * | 1997-12-22 | 2017-11-29 | Roche Diagnostics Operations, Inc. | Meter |
US7390667B2 (en) * | 1997-12-22 | 2008-06-24 | Roche Diagnostics Operations, Inc. | System and method for analyte measurement using AC phase angle measurements |
US20050244954A1 (en) * | 1998-06-23 | 2005-11-03 | Blackburn Gary F | Binding acceleration techniques for the detection of analytes |
US6761816B1 (en) * | 1998-06-23 | 2004-07-13 | Clinical Micro Systems, Inc. | Printed circuit boards with monolayers and capture ligands |
US6740518B1 (en) * | 1998-09-17 | 2004-05-25 | Clinical Micro Sensors, Inc. | Signal detection techniques for the detection of analytes |
US6541617B1 (en) * | 1998-10-27 | 2003-04-01 | Clinical Micro Sensors, Inc. | Detection of target analytes using particles and electrodes |
US6432723B1 (en) | 1999-01-22 | 2002-08-13 | Clinical Micro Sensors, Inc. | Biosensors utilizing ligand induced conformation changes |
US6942771B1 (en) | 1999-04-21 | 2005-09-13 | Clinical Micro Sensors, Inc. | Microfluidic systems in the electrochemical detection of target analytes |
US7312087B2 (en) * | 2000-01-11 | 2007-12-25 | Clinical Micro Sensors, Inc. | Devices and methods for biochip multiplexing |
EP1925678B1 (en) | 1999-05-03 | 2009-07-22 | Gen-Probe Incorporated | Polynucleotide matrix-based method of identifying microorganisms |
US6821770B1 (en) | 1999-05-03 | 2004-11-23 | Gen-Probe Incorporated | Polynucleotide matrix-based method of identifying microorganisms |
US6326486B1 (en) | 1999-05-03 | 2001-12-04 | Gen-Probe Incorporated | Polynucleotide probes for detection and quantitation of bacteria in the family enterobacteriaceae |
US6235484B1 (en) | 1999-05-03 | 2001-05-22 | Gen-Probe Incorporated | Polynucleotide probes for detection and quantitation of actinomycetes |
ATE335847T1 (de) | 1999-05-03 | 2006-09-15 | Gen Probe Inc | Poynukleotidsonden zur exklusiven detektion und quantifizierung von staphylococcus |
IL147119A0 (en) * | 1999-07-01 | 2002-08-14 | Univ | High density non-volatile memory device |
US6381169B1 (en) * | 1999-07-01 | 2002-04-30 | The Regents Of The University Of California | High density non-volatile memory device |
US6324091B1 (en) * | 2000-01-14 | 2001-11-27 | The Regents Of The University Of California | Tightly coupled porphyrin macrocycles for molecular memory storage |
KR100348786B1 (ko) * | 1999-10-01 | 2002-08-17 | 엘지전자주식회사 | 핵산검출방법, 및 핵산검출기와 이의 제조방법 |
US6361958B1 (en) * | 1999-11-12 | 2002-03-26 | Motorola, Inc. | Biochannel assay for hybridization with biomaterial |
US6824669B1 (en) * | 2000-02-17 | 2004-11-30 | Motorola, Inc. | Protein and peptide sensors using electrical detection methods |
JP4382265B2 (ja) * | 2000-07-12 | 2009-12-09 | 日本電気株式会社 | 酸化シリコン膜の形成方法及びその形成装置 |
US6488828B1 (en) * | 2000-07-20 | 2002-12-03 | Roche Diagnostics Corporation | Recloseable biosensor |
WO2002054052A1 (en) * | 2001-01-08 | 2002-07-11 | Leonard Fish | Diagnostic instruments and methods for detecting analytes |
WO2002077633A1 (en) | 2001-03-23 | 2002-10-03 | The Regents Of The University Of California | Open circuit potential amperometry and voltammetry |
CA2457964C (en) * | 2001-08-28 | 2013-05-28 | Duke University | Biosensor |
US7348206B2 (en) * | 2001-10-26 | 2008-03-25 | The Regents Of The University Of California | Formation of self-assembled monolayers of redox SAMs on silicon for molecular memory applications |
US7074519B2 (en) * | 2001-10-26 | 2006-07-11 | The Regents Of The University Of California | Molehole embedded 3-D crossbar architecture used in electrochemical molecular memory device |
US20030082560A1 (en) * | 2001-10-29 | 2003-05-01 | Yingjian Wang | Method of making interactive protein arrays |
US6756223B2 (en) * | 2001-12-18 | 2004-06-29 | Motorola, Inc. | Electro-chemical analysis device with integrated thermal sensor and method for monitoring a sample using the device |
US6728129B2 (en) | 2002-02-19 | 2004-04-27 | The Regents Of The University Of California | Multistate triple-decker dyads in three distinct architectures for information storage applications |
GB0205455D0 (en) | 2002-03-07 | 2002-04-24 | Molecular Sensing Plc | Nucleic acid probes, their synthesis and use |
US20030198960A1 (en) * | 2002-04-01 | 2003-10-23 | Wenhong Fan | Signal amplifying targeted reporters for biological and chemical sensor applications |
WO2003095494A1 (en) | 2002-05-10 | 2003-11-20 | Bio-Layer Pty Limited | Generation of surface coating diversity |
EP1513958B1 (en) | 2002-06-14 | 2011-08-10 | Gen-Probe Incorporated | Compositions for detecting hepatitis b virus |
US7462448B2 (en) * | 2002-08-02 | 2008-12-09 | Stratatech Corporation | Species specific DNA detection |
ES2321931T3 (es) | 2002-10-16 | 2009-06-15 | Duke University | Biosensores para detectar glucosa. |
CA3081071A1 (en) | 2002-10-16 | 2004-04-29 | Gen-Probe Incorporated | Compositions and methods for detecting west nile virus |
KR100475312B1 (ko) * | 2002-12-10 | 2005-03-10 | 한국전자통신연구원 | Dna 감지체 및 이를 이용한 dna 감지방법 |
AU2003297541A1 (en) | 2002-12-18 | 2004-07-14 | Third Wave Technologies, Inc. | Detection of small nucleic acids |
US8206904B2 (en) * | 2002-12-18 | 2012-06-26 | Third Wave Technologies, Inc. | Detection of nucleic acids |
US7297780B2 (en) | 2003-01-06 | 2007-11-20 | Third Wave Technologies, Inc. | Reactive functional groups for preparation of modified nucleic acid |
WO2005007806A2 (en) * | 2003-05-07 | 2005-01-27 | Duke University | Protein design for receptor-ligand recognition and binding |
CA2526946A1 (en) * | 2003-05-14 | 2005-04-07 | Nantero, Inc. | Sensor platform using a non-horizontally oriented nanotube element |
US7645421B2 (en) * | 2003-06-20 | 2010-01-12 | Roche Diagnostics Operations, Inc. | System and method for coding information on a biosensor test strip |
US7452457B2 (en) * | 2003-06-20 | 2008-11-18 | Roche Diagnostics Operations, Inc. | System and method for analyte measurement using dose sufficiency electrodes |
US7604721B2 (en) * | 2003-06-20 | 2009-10-20 | Roche Diagnostics Operations, Inc. | System and method for coding information on a biosensor test strip |
US7597793B2 (en) * | 2003-06-20 | 2009-10-06 | Roche Operations Ltd. | System and method for analyte measurement employing maximum dosing time delay |
US8058077B2 (en) | 2003-06-20 | 2011-11-15 | Roche Diagnostics Operations, Inc. | Method for coding information on a biosensor test strip |
US7718439B2 (en) | 2003-06-20 | 2010-05-18 | Roche Diagnostics Operations, Inc. | System and method for coding information on a biosensor test strip |
US8206565B2 (en) | 2003-06-20 | 2012-06-26 | Roche Diagnostics Operation, Inc. | System and method for coding information on a biosensor test strip |
US7488601B2 (en) | 2003-06-20 | 2009-02-10 | Roche Diagnostic Operations, Inc. | System and method for determining an abused sensor during analyte measurement |
US8148164B2 (en) | 2003-06-20 | 2012-04-03 | Roche Diagnostics Operations, Inc. | System and method for determining the concentration of an analyte in a sample fluid |
US7645373B2 (en) * | 2003-06-20 | 2010-01-12 | Roche Diagnostic Operations, Inc. | System and method for coding information on a biosensor test strip |
AU2004296412B2 (en) * | 2003-12-12 | 2011-03-10 | Anteo Technologies Pty Ltd | A method for designing surfaces |
CA2547750C (en) | 2003-12-19 | 2014-04-08 | Gen-Probe Incorporated | Compositions, methods and kits for detecting the nucleic acids of hiv-1 and hiv-2 |
WO2005078118A1 (en) | 2004-02-06 | 2005-08-25 | Bayer Healthcare Llc | Oxidizable species as an internal reference for biosensors and method of use |
US7807043B2 (en) * | 2004-02-23 | 2010-10-05 | Oakville Hong Kong Company Limited | Microfluidic test device |
US7462451B2 (en) * | 2004-04-26 | 2008-12-09 | Third Wave Technologies, Inc. | Compositions for modifying nucleic acids |
WO2006093505A2 (en) * | 2004-05-10 | 2006-09-08 | Northwestern University | Compositions and methods for analyte detection |
US7556723B2 (en) * | 2004-06-18 | 2009-07-07 | Roche Diagnostics Operations, Inc. | Electrode design for biosensor |
US7569126B2 (en) | 2004-06-18 | 2009-08-04 | Roche Diagnostics Operations, Inc. | System and method for quality assurance of a biosensor test strip |
AU2005259833B2 (en) * | 2004-07-02 | 2011-09-22 | Anteo Technologies Pty Ltd | Use of metal complexes |
WO2007013872A2 (en) * | 2004-07-22 | 2007-02-01 | The Board Of Trustees Of The University Of Illinois | Sensors employing single-walled carbon nanotubes |
WO2006121461A2 (en) * | 2004-09-16 | 2006-11-16 | Nantero, Inc. | Light emitters using nanotubes and methods of making same |
AU2005291899A1 (en) | 2004-09-30 | 2006-04-13 | Gen-Probe Incorporated | Assay for detecting and quantifying HIV-1 |
JP2006098342A (ja) * | 2004-09-30 | 2006-04-13 | Kyushu Univ | 異常プリオンの電気化学的検出方法 |
CA2582661C (en) | 2004-11-09 | 2015-08-11 | Gen-Probe Incorporated | Compositions and methods for detecting group a streptococci |
EP1861414B9 (en) | 2005-02-07 | 2011-04-06 | Gen-Probe Incorporated | Compositions and methods for detecting group b streptococci |
US20060238696A1 (en) * | 2005-04-20 | 2006-10-26 | Chien-Hui Wen | Method of aligning negative dielectric anisotropic liquid crystals |
CA2609379C (en) * | 2005-06-03 | 2016-11-29 | Allen J. Bard | Electrochemistry and electrogenerated chemiluminescence with a single faradaic electrode |
KR101503072B1 (ko) | 2005-07-20 | 2015-03-16 | 바이엘 헬스케어 엘엘씨 | 게이트형 전류 측정법 |
KR101577176B1 (ko) | 2005-09-30 | 2015-12-14 | 바이엘 헬스케어 엘엘씨 | 게이트형 전압 전류 측정 분석물 결정 방법 |
US20070207455A1 (en) * | 2005-11-17 | 2007-09-06 | Third Wave Technologies, Inc. | Compositions and methods for detecting an HCV-1 subtype |
AU2006332457A1 (en) * | 2005-12-30 | 2007-07-12 | Bio-Layer Pty Limited | Binding of molecules |
US20090036315A1 (en) * | 2006-02-07 | 2009-02-05 | Antara Biosciences Inc. | Device and methods for detecting and quantifying one or more target agents |
US20080067056A1 (en) * | 2006-05-19 | 2008-03-20 | The Johns Hopkins University | Method and device for controlled release of biomolecules and nanoparticles |
CN101541975B (zh) | 2006-06-01 | 2013-04-03 | 第三次浪潮技术公司 | 核酸的检测 |
US7892816B2 (en) * | 2006-09-28 | 2011-02-22 | Colorado State University Research Foundation | Electrochemical detection of substrates |
JP4321599B2 (ja) * | 2007-02-06 | 2009-08-26 | セイコーエプソン株式会社 | 検出素子 |
WO2008124706A2 (en) | 2007-04-06 | 2008-10-16 | Arizona Board Of Regents Acting For And On Behalf Of Arizona State University | Devices and methods for target molecule characterization |
CN101970111B (zh) | 2007-06-21 | 2013-09-11 | 简·探针公司 | 用于执行处理的仪器和容器 |
GB0713183D0 (en) * | 2007-07-06 | 2007-08-15 | King S College London | Method |
EP2183394B1 (en) * | 2007-09-07 | 2012-12-12 | Third Wave Technologies, Inc. | Methods and applications for target quantification |
WO2009052436A1 (en) * | 2007-10-17 | 2009-04-23 | Ohmx Corporation | Novel chemistry used in biosensors |
US8951400B2 (en) | 2007-10-17 | 2015-02-10 | Ohmx Corporation | Chemistry used in biosensors |
WO2009076302A1 (en) | 2007-12-10 | 2009-06-18 | Bayer Healthcare Llc | Control markers for auto-detection of control solution and methods of use |
KR101419980B1 (ko) * | 2008-03-15 | 2014-07-15 | 홀로직, 인크. | 증폭 반응 도중에 핵산 분자를 분석하기 위한 조성물 및 방법 |
WO2009117522A2 (en) * | 2008-03-18 | 2009-09-24 | Reinhart, Kevin | Nanopore and carbon nanotube based dna sequencer and a serial recognition sequencer |
US8961757B2 (en) * | 2008-03-18 | 2015-02-24 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University | Nanopore and carbon nanotube based DNA sequencer |
EP2808405B1 (en) | 2008-04-21 | 2018-06-06 | Gen-Probe Incorporated | Method for Detecting Chikungunya Virus |
WO2010042514A1 (en) | 2008-10-06 | 2010-04-15 | Arizona Board Of Regents | Nanopore and carbon nanotube based dna sequencer and a serial recognition elements |
EP2391452B1 (en) | 2009-01-30 | 2015-06-17 | Gen-Probe Incorporated | Systems and methods for detecting a signal and applying thermal energy to a signal transmission element |
US20110091931A1 (en) * | 2009-04-24 | 2011-04-21 | Colby Pharmaceutical Company | Methods and Kits for Determining Oxygen Free Radical (OFR) Levels in Animal and Human Tissues as a Prognostic Marker for Cancer and Other Pathophysiologies |
CA2770071C (en) | 2009-08-07 | 2014-07-15 | Ohmx Corporation | Enzyme triggered redox altering chemical elimination (e-trace) immunoassay |
US9250234B2 (en) | 2011-01-19 | 2016-02-02 | Ohmx Corporation | Enzyme triggered redox altering chemical elimination (E-TRACE) immunoassay |
US8394589B2 (en) | 2009-12-21 | 2013-03-12 | Northwestern University | Methods for diagnosing scapuloperoneal spinal muscular atrophy or Charcot-Marie-Tooth disease type 2C by detecting mutations in TRPV4 |
CN102687027B (zh) | 2010-02-02 | 2016-05-25 | 阿利桑那卅评议会 | 用于测序聚合物的受控的隧道间隙设备 |
US20120034638A1 (en) | 2010-05-21 | 2012-02-09 | Michael Ahrens | Electrochemical assay for the detection of enzymatically active PSA |
WO2012003289A1 (en) | 2010-06-30 | 2012-01-05 | Gen-Probe Incorporated | Method and apparatus for identifying analyte-containing samples using single-read determination of analyte and process control signals |
GB2497495B (en) | 2010-10-04 | 2018-06-06 | Gen Probe Prodesse Inc | Compositions, methods and kits to detect adenovirus nucleic acids |
US20150225792A1 (en) | 2014-01-17 | 2015-08-13 | Northwestern University | Compositions and methods for identifying depressive disorders |
US10093981B2 (en) | 2010-10-19 | 2018-10-09 | Northwestern University | Compositions and methods for identifying depressive disorders |
US20150218639A1 (en) | 2014-01-17 | 2015-08-06 | Northwestern University | Biomarkers predictive of predisposition to depression and response to treatment |
US10233501B2 (en) | 2010-10-19 | 2019-03-19 | Northwestern University | Biomarkers predictive of predisposition to depression and response to treatment |
CA2826696C (en) | 2011-02-02 | 2019-12-03 | Exact Sciences Corporation | Digital sequence analysis of dna methylation |
WO2012145449A1 (en) * | 2011-04-22 | 2012-10-26 | International Park Of Creativity | Methods and devices for amplifying nucleic acids |
WO2012155072A2 (en) | 2011-05-12 | 2012-11-15 | Exact Sciences Corporation | Isolation of nucleic acids |
US8993341B2 (en) | 2011-05-12 | 2015-03-31 | Exact Sciences Corporation | Removal of PCR inhibitors |
US8808990B2 (en) | 2011-05-12 | 2014-08-19 | Exact Sciences Corporation | Serial isolation of multiple DNA targets from stool |
JP6203183B2 (ja) | 2011-10-17 | 2017-09-27 | オームクス コーポレイション | 酵素誘発レドックス変化化学的脱離(e−trace)イムノアッセイを使用する、ヘモグロビンa1cのパーセンテージの単回直接検出 |
CA2854459A1 (en) | 2011-11-04 | 2013-05-10 | Ohmx Corporation | Novel chemistry used in biosensors |
DE102011120550B4 (de) | 2011-12-05 | 2013-11-07 | Gen-Probe Prodesse, Inc. | Zusammensetzungen, Verfahren und Kits zur Detektion von Adenovirusnukleinsäuren |
US20140349858A1 (en) | 2011-12-22 | 2014-11-27 | Ibis Bioscience, Inc. | Amplification of a sequence from a ribonucleic acid |
EP2802669A1 (en) | 2012-01-09 | 2014-11-19 | Ohmx Corporation | Enzyme cascade methods for e-trace assay signal amplification |
WO2013148344A1 (en) * | 2012-03-28 | 2013-10-03 | Arizona Board Of Regents | Method for improving the accuracy of chemical identification in a recognition-tunneling junction |
AU2013205064B2 (en) | 2012-06-04 | 2015-07-30 | Gen-Probe Incorporated | Compositions and Methods for Amplifying and Characterizing HCV Nucleic Acid |
US9404883B2 (en) | 2012-07-27 | 2016-08-02 | Ohmx Corporation | Electronic measurements of monolayers following homogeneous reactions of their components |
US9044729B2 (en) | 2012-07-27 | 2015-06-02 | International Park Of Creativity | Methods and devices for electromagnetic amplification of nucleic acids |
EP2877851A1 (en) | 2012-07-27 | 2015-06-03 | Ohmx Corporation | Electric measurement of monolayers following pro-cleave detection of presence and activity of enzymes and other target analytes |
US9212392B2 (en) | 2012-09-25 | 2015-12-15 | Exact Sciences Corporation | Normalization of polymerase activity |
EP2906720A4 (en) | 2012-10-10 | 2016-06-01 | Univ Arizona | SYSTEMS AND DEVICES FOR DETECTING MOLECULES AND METHOD FOR THE PRODUCTION THEREOF |
EP3427830B1 (en) | 2012-10-24 | 2021-06-23 | Genmark Diagnostics Inc. | Integrated multiplex target analysis |
US20140322706A1 (en) | 2012-10-24 | 2014-10-30 | Jon Faiz Kayyem | Integrated multipelx target analysis |
ES2859645T3 (es) | 2013-03-14 | 2021-10-04 | Mayo Found Medical Education & Res | Detección de neoplasia |
US9222623B2 (en) | 2013-03-15 | 2015-12-29 | Genmark Diagnostics, Inc. | Devices and methods for manipulating deformable fluid vessels |
US20150232931A1 (en) | 2013-09-20 | 2015-08-20 | The Regents Of The University Of Michigan | Compositions and methods for the analysis of radiosensitivity |
WO2015042493A2 (en) | 2013-09-20 | 2015-03-26 | Ohmx Corporation | Psa enzymatic activity: a new biomarker for assessing prostate cancer aggressiveness |
US9498778B2 (en) | 2014-11-11 | 2016-11-22 | Genmark Diagnostics, Inc. | Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system |
USD881409S1 (en) | 2013-10-24 | 2020-04-14 | Genmark Diagnostics, Inc. | Biochip cartridge |
WO2015066695A1 (en) | 2013-11-04 | 2015-05-07 | Exact Sciences Corporation | Multiple-control calibrators for dna quantitation |
US9909181B2 (en) | 2013-12-13 | 2018-03-06 | Northwestern University | Biomarkers for post-traumatic stress states |
WO2015095689A1 (en) | 2013-12-19 | 2015-06-25 | Exact Sciences Corporation | Synthetic nucleic acid control molecules |
US10336713B2 (en) | 2014-02-27 | 2019-07-02 | Arizona Board Of Regents, Acting For And On Behalf Of, Arizona State University | Triazole-based reader molecules and methods for synthesizing and use thereof |
CN106662583A (zh) | 2014-04-29 | 2017-05-10 | Ohmx公司 | 使用峰曲线的生物电子结合测定 |
WO2016025539A1 (en) | 2014-08-11 | 2016-02-18 | Ohmx Corporation | Enzyme triggered redox altering chemical elimination (-trace) assay with multiplexing capabilities |
AU2015346527A1 (en) | 2014-11-11 | 2017-06-29 | Genmark Diagnostics, Inc. | Instrument and cartridge for performing assays in a closed sample preparation and reaction system |
US9598722B2 (en) | 2014-11-11 | 2017-03-21 | Genmark Diagnostics, Inc. | Cartridge for performing assays in a closed sample preparation and reaction system |
US10005080B2 (en) | 2014-11-11 | 2018-06-26 | Genmark Diagnostics, Inc. | Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation |
WO2016094839A2 (en) | 2014-12-12 | 2016-06-16 | Exact Sciences Corporation | Compositions and methods for performing methylation detection assays |
CN113981057A (zh) | 2014-12-12 | 2022-01-28 | 精密科学公司 | 用于进行甲基化检测测定的组合物和方法 |
US9506890B2 (en) | 2014-12-16 | 2016-11-29 | Eastman Chemical Company | Physical vapor deposited biosensor components |
US20160178562A1 (en) | 2014-12-19 | 2016-06-23 | Ohmx Corporation | Competitive enzymatic assay |
EP3054017A1 (en) | 2015-02-03 | 2016-08-10 | Johann Wolfgang Goethe-Universität, Frankfurt am Main | Circular RNA for the diagnosis and treatment of cardiovascular diseases |
EP3274440A4 (en) | 2015-03-27 | 2019-03-06 | Exact Sciences Corporation | PROOF OF DISEASES OF THE DISHES |
AU2016343937B2 (en) | 2015-10-30 | 2023-01-19 | Exact Sciences Corporation | Multiplex amplification detection assay and isolation and detection of DNA from plasma |
US20170321286A1 (en) | 2016-05-05 | 2017-11-09 | Exact Sciences Corporation | Detection of lung neoplasia by amplification of rna sequences |
CA3022911A1 (en) | 2016-05-05 | 2017-11-09 | Exact Sciences Development Company, Llc | Detection of lung neoplasia by analysis of methylated dna |
CN109312384B (zh) | 2016-06-15 | 2022-12-30 | 伊士曼化工公司 | 物理气相沉积的生物传感器组件 |
EP3978624A1 (en) | 2016-07-19 | 2022-04-06 | Exact Sciences Corporation | Methylated control dna |
US11208680B2 (en) | 2016-07-19 | 2021-12-28 | Exact Sciences Development Company, Llc | Nucleic acid control molecules from non-human organisms |
CN116064795A (zh) | 2016-09-02 | 2023-05-05 | 梅约医学教育与研究基金会 | 确定差异甲基化区域的甲基化状态的方法和试剂盒 |
CN109689880B (zh) | 2016-09-16 | 2022-12-13 | 伊士曼化工公司 | 通过物理气相沉积制备的生物传感器电极 |
WO2018052711A1 (en) | 2016-09-16 | 2018-03-22 | Eastman Chemical Company | Biosensor electrodes prepared by physical vapor deposition |
US11300578B2 (en) | 2016-09-19 | 2022-04-12 | Roche Molecular Systems, Inc. | Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system |
EP3574110A4 (en) | 2017-01-27 | 2021-01-13 | Exact Sciences Development Company, LLC | DETECTION OF COLUMN NEOPLASIA BY ANALYSIS OF METHYLATED DNA |
WO2018236572A1 (en) | 2017-06-22 | 2018-12-27 | Eastman Chemical Company | PHYSICAL DEPOSITION ELECTRODE IN VAPOR PHASE FOR ELECTROCHEMICAL SENSORS |
US20190062809A1 (en) | 2017-08-24 | 2019-02-28 | Clinical Micro Sensors, Inc. (dba GenMark Diagnostics, Inc.) | Electrochemical detection of bacterial and/or fungal infections |
WO2019040769A1 (en) | 2017-08-24 | 2019-02-28 | Clinical Micro Sensors, Inc. (dba GenMark Diagnostics, Inc.) | ELECTROCHEMICAL DETECTION OF BACTERIAL AND / OR FUNGAL INFECTIONS |
US10648025B2 (en) | 2017-12-13 | 2020-05-12 | Exact Sciences Development Company, Llc | Multiplex amplification detection assay II |
CA3095292A1 (en) | 2018-04-02 | 2019-10-10 | Progenity, Inc. | Methods, systems, and compositions for counting nucleic acid molecules |
US11408030B2 (en) | 2018-09-10 | 2022-08-09 | Andy Madrid | Test for detecting Alzheimer's disease |
WO2020206170A1 (en) | 2019-04-02 | 2020-10-08 | Progenity, Inc. | Methods, systems, and compositions for counting nucleic acid molecules |
JP2022553575A (ja) | 2019-10-31 | 2022-12-23 | マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ | 卵巣癌の検出 |
JP2023539128A (ja) | 2020-08-19 | 2023-09-13 | マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ | 非ホジキンリンパ腫の検出 |
AU2021345359A1 (en) | 2020-09-21 | 2023-05-11 | Progenity, Inc. | Compositions and methods for isolation of cell-free dna |
WO2023011660A1 (en) | 2021-08-06 | 2023-02-09 | Sansure Biotech Inc. | Compositions for liquefying a viscous biological sample, combination products, liquefying agents, and kits thereof, and methods and application thereof |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0142301A2 (en) * | 1983-10-25 | 1985-05-22 | Serono Diagnostics Limited | Methods of assay |
EP0339821A1 (en) * | 1988-04-21 | 1989-11-02 | United Kingdom Atomic Energy Authority | Bonding to metal surfaces |
WO1997027473A1 (en) * | 1996-01-23 | 1997-07-31 | Canadian Bioconcepts, Inc. | Electrodes and metallo isoindole ringed compounds |
Family Cites Families (110)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1219824A (en) * | 1981-04-17 | 1987-03-31 | David C. Ward | Modified nucleotides and methods of preparing and using same |
US4711955A (en) * | 1981-04-17 | 1987-12-08 | Yale University | Modified nucleotides and methods of preparing and using same |
JPS5866048A (ja) * | 1981-10-15 | 1983-04-20 | Meidensha Electric Mfg Co Ltd | 硝酸イオン濃度自動測定装置 |
US5241060A (en) * | 1982-06-23 | 1993-08-31 | Enzo Diagnostics, Inc. | Base moiety-labeled detectable nucleatide |
US4994373A (en) * | 1983-01-27 | 1991-02-19 | Enzo Biochem, Inc. | Method and structures employing chemically-labelled polynucleotide probes |
DE3479522D1 (en) * | 1983-12-16 | 1989-09-28 | Medisense Inc | Assay for nucleic acids |
US4849513A (en) * | 1983-12-20 | 1989-07-18 | California Institute Of Technology | Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups |
US4943523A (en) * | 1984-01-30 | 1990-07-24 | Enzo Biochem, Inc. | Detectable molecules, method of preparation and use |
US4707440A (en) * | 1984-01-30 | 1987-11-17 | Enzo Biochem, Inc. | Nucleic acid hybridization assay and detectable molecules useful in such assay |
US5175269A (en) * | 1984-01-30 | 1992-12-29 | Enzo Diagnostics, Inc. | Compound and detectable molecules having an oligo- or polynucleotide with modifiable reactive group |
US5002885A (en) * | 1984-01-30 | 1991-03-26 | Enzo Biochem, Inc. | Detectable molecules, method preparation and use |
US5013831A (en) * | 1984-01-30 | 1991-05-07 | Enzo Biochem, Inc. | Detectable molecules, method of preparation and use |
US4952685A (en) * | 1984-01-30 | 1990-08-28 | Enzo Biochem, Inc. | Detectable molecules, method of preparation and use |
US4707352A (en) * | 1984-01-30 | 1987-11-17 | Enzo Biochem, Inc. | Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group |
CA1260372A (en) * | 1984-04-27 | 1989-09-26 | Elazar Rabbani | Hybridization method for the detection of genetic materials |
GB8417301D0 (en) | 1984-07-06 | 1984-08-08 | Serono Diagnostics Ltd | Assay |
US4755458A (en) * | 1984-08-30 | 1988-07-05 | Enzo Biochem, Inc. | Composition and method for the detection of the presence of a polynucleotide sequence of interest |
US5238808A (en) | 1984-10-31 | 1993-08-24 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
US5112974A (en) * | 1985-01-18 | 1992-05-12 | The Trustees Of Columbia University In The City Of New York | Mixed ligand complexes and uses thereof as binding agents to DNA |
GB8507706D0 (en) | 1985-03-25 | 1985-05-01 | Genetics Int Inc | Magnetic nucleic acid sequences |
US5595908A (en) * | 1985-09-26 | 1997-01-21 | University Of Southern Mississipi | Piezoelectric device for detection of polynucleotide hybridization |
CA1273552A (en) * | 1985-12-23 | 1990-09-04 | Michael J. Heller | Fluorescent stokes shift probes for polynucleotide hybridization assays |
US4868103A (en) * | 1986-02-19 | 1989-09-19 | Enzo Biochem, Inc. | Analyte detection by means of energy transfer |
CA1254945A (en) * | 1986-02-27 | 1989-05-30 | Marco F. Cardosi | Application of tetrathiafulvalenes in bioelectrochemical processes |
US4704193A (en) * | 1986-05-14 | 1987-11-03 | Gte Laboratories Incorporated | Covalently coupled cofactor modified electrodes and methods of synthesis and use |
JPS63238166A (ja) * | 1987-03-26 | 1988-10-04 | Mitsubishi Electric Corp | 有機電子素子材料 |
GB8712582D0 (en) * | 1987-05-28 | 1987-07-01 | Neotronics Ltd | Acidic gas sensors |
US5192507A (en) * | 1987-06-05 | 1993-03-09 | Arthur D. Little, Inc. | Receptor-based biosensors |
US5082830A (en) * | 1988-02-26 | 1992-01-21 | Enzo Biochem, Inc. | End labeled nucleotide probe |
US5308754A (en) | 1988-03-21 | 1994-05-03 | Kankare Jouko J | Electrogenerated luminescence in solution |
US4920047A (en) * | 1988-05-20 | 1990-04-24 | General Electric Company | Electrical detection of the immune reaction |
SE462454B (sv) | 1988-11-10 | 1990-06-25 | Pharmacia Ab | Maetyta foer anvaendning i biosensorer |
US4952585A (en) * | 1988-12-15 | 1990-08-28 | Merrell Dow Pharmaceuticals Inc. | Castanospermine esters in the inhibition of tumor metastasis |
US5089112A (en) | 1989-03-20 | 1992-02-18 | Associated Universities, Inc. | Electrochemical biosensor based on immobilized enzymes and redox polymers |
CA2033692A1 (en) * | 1990-01-25 | 1991-07-26 | Wilhelm Bannwarth | Energy transfer systems |
US5776672A (en) | 1990-09-28 | 1998-07-07 | Kabushiki Kaisha Toshiba | Gene detection method |
JPH04136751A (ja) * | 1990-09-28 | 1992-05-11 | Terumo Corp | 二酸化炭素濃度測定用電極 |
DE4039677A1 (de) * | 1990-12-12 | 1992-06-17 | Boehringer Mannheim Gmbh | Universalbindefilm |
US5180968A (en) | 1991-03-01 | 1993-01-19 | Research Foundation Of State University Of New York | Method and apparatus for compensation of double layer charging current in electrochemical cells |
JPH04278450A (ja) | 1991-03-04 | 1992-10-05 | Adam Heller | バイオセンサー及び分析物を分析する方法 |
RU1794088C (ru) | 1991-03-18 | 1993-02-07 | Институт Молекулярной Биологии Ан@ Ссср | Способ определени нуклеотидной последовательности ДНК и устройство дл его осуществлени |
US6017696A (en) | 1993-11-01 | 2000-01-25 | Nanogen, Inc. | Methods for electronic stringency control for molecular biological analysis and diagnostics |
US6051380A (en) | 1993-11-01 | 2000-04-18 | Nanogen, Inc. | Methods and procedures for molecular biological analysis and diagnostics |
CA2123133C (en) | 1991-11-07 | 2005-01-04 | Michael J. Heller | Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to-donor energy transfer system |
US6048690A (en) | 1991-11-07 | 2000-04-11 | Nanogen, Inc. | Methods for electronic fluorescent perturbation for analysis and electronic perturbation catalysis for synthesis |
US5605662A (en) | 1993-11-01 | 1997-02-25 | Nanogen, Inc. | Active programmable electronic devices for molecular biological analysis and diagnostics |
EP0569578A1 (en) | 1991-11-15 | 1993-11-18 | Amoco Corporation | Method of enhancing hybridization signals in growth media |
DK0567635T3 (da) * | 1991-11-15 | 2000-09-25 | Igen Int Inc | Hurtige assays for amplifikationsprodukter |
IL103674A0 (en) | 1991-11-19 | 1993-04-04 | Houston Advanced Res Center | Method and apparatus for molecule detection |
US5846708A (en) | 1991-11-19 | 1998-12-08 | Massachusetts Institiute Of Technology | Optical and electrical methods and apparatus for molecule detection |
US5565552A (en) * | 1992-01-21 | 1996-10-15 | Pharmacyclics, Inc. | Method of expanded porphyrin-oligonucleotide conjugate synthesis |
US5391272A (en) | 1992-03-06 | 1995-02-21 | Andcare, Inc. | Electrochemical immunoassay methods |
EP0566751B1 (en) * | 1992-03-23 | 1996-01-10 | F. Hoffmann-La Roche Ag | DNA detection method |
CA2094785A1 (en) * | 1992-05-08 | 1993-11-09 | Jean Gariepy | Metal chelating peptide |
GB9212010D0 (en) * | 1992-06-05 | 1992-07-15 | Medisense Inc | Mediators to oxidoreductase enzymes |
JPH0641183A (ja) * | 1992-07-23 | 1994-02-15 | Mitsubishi Kasei Corp | オリゴヌクレオチド単分子膜 |
IL102930A (en) * | 1992-08-25 | 1997-03-18 | Yissum Res Dev Co | Electrobiochemical analytical method and electrodes |
US5312527A (en) * | 1992-10-06 | 1994-05-17 | Concordia University | Voltammetric sequence-selective sensor for target polynucleotide sequences |
US5472881A (en) * | 1992-11-12 | 1995-12-05 | University Of Utah Research Foundation | Thiol labeling of DNA for attachment to gold surfaces |
DE69333991T2 (de) * | 1992-11-27 | 2006-12-14 | Canon K.K. | Verfahren und Sonde zum Nachweis von Nukleinsäuren |
EP0690983A4 (en) * | 1993-03-05 | 1998-01-28 | Univ Wollongong | PULSE ELECTROCHEMICAL DETECTION BY ELECTRODES WITH ELECTROACTIVE POLYMER |
FR2703359B1 (fr) | 1993-03-31 | 1995-06-23 | Cis Bio Int | Copolymère nucléotide(s)/polymère conducteur électronique ; son procédé de préparation et son utilisation . |
RU2041263C1 (ru) | 1993-08-11 | 1995-08-09 | Геннадий Моисеевич Ершов | Способ микродозирования водных растворов веществ на носитель и устройство для его осуществления |
RU2041261C1 (ru) | 1993-08-11 | 1995-08-09 | Институт молекулярной биологии им.В.А.Энгельгардта РАН | Способ изготовления матрицы для детектирования мисматчей |
RU2041262C1 (ru) | 1993-08-11 | 1995-08-09 | Институт молекулярной биологии им.В.А.Энгельгардта РАН | Способ иммобилизации водорастворимых биоорганических соединений на капиллярно-пористый носитель |
US6331274B1 (en) | 1993-11-01 | 2001-12-18 | Nanogen, Inc. | Advanced active circuits and devices for molecular biological analysis and diagnostics |
US6207373B1 (en) | 1998-02-25 | 2001-03-27 | Nanogen, Inc. | Methods for determining nature of repeat units in DNA |
US5824473A (en) * | 1993-12-10 | 1998-10-20 | California Institute Of Technology | Nucleic acid mediated electron transfer |
US6071699A (en) | 1996-06-07 | 2000-06-06 | California Institute Of Technology | Nucleic acid mediated electron transfer |
US5591578A (en) * | 1993-12-10 | 1997-01-07 | California Institute Of Technology | Nucleic acid mediated electron transfer |
US5952172A (en) | 1993-12-10 | 1999-09-14 | California Institute Of Technology | Nucleic acid mediated electron transfer |
IL108726A (en) | 1994-02-22 | 1999-12-31 | Yissum Res Dev Co | Electrobiochemical method and system for the determination of an analyte which is a member of a recognition pair in a liquid medium and electrodes therefor |
US5871918A (en) | 1996-06-20 | 1999-02-16 | The University Of North Carolina At Chapel Hill | Electrochemical detection of nucleic acid hybridization |
US6379897B1 (en) | 2000-11-09 | 2002-04-30 | Nanogen, Inc. | Methods for gene expression monitoring on electronic microarrays |
US5620850A (en) | 1994-09-26 | 1997-04-15 | President And Fellows Of Harvard College | Molecular recognition at surfaces derivatized with self-assembled monolayers |
US5601982A (en) * | 1995-02-07 | 1997-02-11 | Sargent; Jeannine P. | Method and apparatus for determining the sequence of polynucleotides |
CN1192097C (zh) | 1995-03-10 | 2005-03-09 | 梅索磅秤技术有限公司 | 多阵列、多特异性的电化学发光检验 |
US6140045A (en) | 1995-03-10 | 2000-10-31 | Meso Scale Technologies | Multi-array, multi-specific electrochemiluminescence testing |
US6207369B1 (en) | 1995-03-10 | 2001-03-27 | Meso Scale Technologies, Llc | Multi-array, multi-specific electrochemiluminescence testing |
US5679519A (en) | 1995-05-09 | 1997-10-21 | Oprandy; John J. | Multi-label complex for enhanced sensitivity in electrochemiluminescence assay |
CA2225935A1 (en) * | 1995-06-27 | 1997-01-16 | The University Of North Carolina At Chapel Hill | Electrochemical detection of nucleic acid hybridization |
US6127127A (en) | 1995-06-27 | 2000-10-03 | The University Of North Carolina At Chapel Hill | Monolayer and electrode for detecting a label-bearing target and method of use thereof |
US5795453A (en) * | 1996-01-23 | 1998-08-18 | Gilmartin; Markas A. T. | Electrodes and metallo isoindole ringed compounds |
US5861247A (en) | 1996-01-26 | 1999-01-19 | University Of Chicago | Rapid method to detect duplex formation in sequencing by hybridization methods |
US5851772A (en) | 1996-01-29 | 1998-12-22 | University Of Chicago | Microchip method for the enrichment of specific DNA sequences |
US6107080A (en) | 1996-04-25 | 2000-08-22 | Mcgill University | Biosensor device and method |
WO1997044651A1 (en) | 1996-05-22 | 1997-11-27 | Australian Membrane And Biotechnology Research Institute | Nucleic acid sensor |
US5874046A (en) | 1996-10-30 | 1999-02-23 | Raytheon Company | Biological warfare agent sensor system employing ruthenium-terminated oligonucleotides complementary to target live agent DNA sequences |
US7045285B1 (en) | 1996-11-05 | 2006-05-16 | Clinical Micro Sensors, Inc. | Electronic transfer moieties attached to peptide nucleic acids |
CA2270633A1 (en) * | 1996-11-05 | 1998-05-14 | Clinical Micro Sensors | Electrodes linked via conductive oligomers to nucleic acids |
US7381525B1 (en) | 1997-03-07 | 2008-06-03 | Clinical Micro Sensors, Inc. | AC/DC voltage apparatus for detection of nucleic acids |
US7160678B1 (en) * | 1996-11-05 | 2007-01-09 | Clinical Micro Sensors, Inc. | Compositions for the electronic detection of analytes utilizing monolayers |
US6096273A (en) | 1996-11-05 | 2000-08-01 | Clinical Micro Sensors | Electrodes linked via conductive oligomers to nucleic acids |
US7014992B1 (en) | 1996-11-05 | 2006-03-21 | Clinical Micro Sensors, Inc. | Conductive oligomers attached to electrodes and nucleoside analogs |
US5942397A (en) | 1996-12-11 | 1999-08-24 | Tarlov; Michael J. | Surface immobilization of biopolymers |
US5905024A (en) | 1996-12-17 | 1999-05-18 | University Of Chicago | Method for performing site-specific affinity fractionation for use in DNA sequencing |
EP0951569A2 (en) | 1996-12-23 | 1999-10-27 | University Of Chicago | Customized oligonucleotide microchips as multiple biosensors |
US6306584B1 (en) | 1997-01-21 | 2001-10-23 | President And Fellows Of Harvard College | Electronic-property probing of biological molecules at surfaces |
WO1998035232A2 (en) | 1997-02-06 | 1998-08-13 | The University Of North Carolina At Chapel Hill | Electrochemical detection of specific binding |
US6060327A (en) | 1997-05-14 | 2000-05-09 | Keensense, Inc. | Molecular wire injection sensors |
US6013459A (en) * | 1997-06-12 | 2000-01-11 | Clinical Micro Sensors, Inc. | Detection of analytes using reorganization energy |
EP0988534B1 (en) | 1997-06-12 | 2011-02-16 | Clinical Micro Sensors, Inc. | Electronic methods and apparatus for the detection of analytes |
US6060023A (en) | 1998-03-31 | 2000-05-09 | Motorola, Inc. | Molecular sensing apparatus |
CA2331189A1 (en) * | 1998-05-06 | 1999-11-11 | Clinical Micro Sensors, Inc. | Electronic methods for the detection of analytes utilizing monolayers |
US20050244954A1 (en) | 1998-06-23 | 2005-11-03 | Blackburn Gary F | Binding acceleration techniques for the detection of analytes |
US6761816B1 (en) | 1998-06-23 | 2004-07-13 | Clinical Micro Systems, Inc. | Printed circuit boards with monolayers and capture ligands |
US6290839B1 (en) | 1998-06-23 | 2001-09-18 | Clinical Micro Sensors, Inc. | Systems for electrophoretic transport and detection of analytes |
US6740518B1 (en) * | 1998-09-17 | 2004-05-25 | Clinical Micro Sensors, Inc. | Signal detection techniques for the detection of analytes |
US6541617B1 (en) * | 1998-10-27 | 2003-04-01 | Clinical Micro Sensors, Inc. | Detection of target analytes using particles and electrodes |
US7018532B2 (en) * | 2004-01-27 | 2006-03-28 | Kaufman Michael J | Aeration and mixing trough |
-
1997
- 1997-06-12 US US08/873,977 patent/US6013459A/en not_active Expired - Lifetime
-
1998
- 1998-06-12 CA CA002292696A patent/CA2292696A1/en not_active Abandoned
- 1998-06-12 WO PCT/US1998/012082 patent/WO1998057158A1/en active IP Right Grant
- 1998-06-12 JP JP50318499A patent/JP2002504230A/ja active Pending
- 1998-06-12 US US09/096,504 patent/US6013170A/en not_active Expired - Lifetime
- 1998-06-12 AU AU78355/98A patent/AU747345B2/en not_active Ceased
- 1998-06-12 EP EP10180837A patent/EP2312304A1/en not_active Withdrawn
- 1998-06-12 EP EP98926542.6A patent/EP0988532B1/en not_active Expired - Lifetime
-
1999
- 1999-10-13 US US09/417,988 patent/US6248229B1/en not_active Expired - Lifetime
-
2001
- 2001-04-24 US US09/841,809 patent/US7018523B2/en not_active Expired - Lifetime
-
2005
- 2005-11-18 US US11/283,233 patent/US7267939B2/en not_active Expired - Fee Related
-
2007
- 2007-08-02 US US11/832,792 patent/US7514228B2/en not_active Expired - Fee Related
- 2007-10-30 US US11/978,931 patent/US7566534B2/en not_active Expired - Fee Related
- 2007-10-30 US US11/978,930 patent/US7582419B2/en not_active Expired - Fee Related
- 2007-10-30 US US11/978,971 patent/US7579145B2/en not_active Expired - Fee Related
- 2007-10-30 US US11/980,203 patent/US7595153B2/en not_active Expired - Fee Related
-
2009
- 2009-08-20 US US12/544,682 patent/US20100038262A1/en not_active Abandoned
- 2009-11-09 JP JP2009256449A patent/JP4929337B2/ja not_active Expired - Lifetime
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0142301A2 (en) * | 1983-10-25 | 1985-05-22 | Serono Diagnostics Limited | Methods of assay |
EP0339821A1 (en) * | 1988-04-21 | 1989-11-02 | United Kingdom Atomic Energy Authority | Bonding to metal surfaces |
WO1997027473A1 (en) * | 1996-01-23 | 1997-07-31 | Canadian Bioconcepts, Inc. | Electrodes and metallo isoindole ringed compounds |
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US7579145B2 (en) | 2009-08-25 |
US6013170A (en) | 2000-01-11 |
US20100038262A1 (en) | 2010-02-18 |
US7514228B2 (en) | 2009-04-07 |
US6013459A (en) | 2000-01-11 |
US20080173553A1 (en) | 2008-07-24 |
US7582419B2 (en) | 2009-09-01 |
JP2010091573A (ja) | 2010-04-22 |
AU7835598A (en) | 1998-12-30 |
US20080171340A1 (en) | 2008-07-17 |
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US20060073532A1 (en) | 2006-04-06 |
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US7595153B2 (en) | 2009-09-29 |
WO1998057158A1 (en) | 1998-12-17 |
US20080135420A1 (en) | 2008-06-12 |
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