AU747012B2 - Preparation of thioarabinofuranosyl compounds and use thereof - Google Patents
Preparation of thioarabinofuranosyl compounds and use thereof Download PDFInfo
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- AU747012B2 AU747012B2 AU51239/99A AU5123999A AU747012B2 AU 747012 B2 AU747012 B2 AU 747012B2 AU 51239/99 A AU51239/99 A AU 51239/99A AU 5123999 A AU5123999 A AU 5123999A AU 747012 B2 AU747012 B2 AU 747012B2
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- thio
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
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Priority Applications (1)
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| AU2002300586A AU2002300586B2 (en) | 1998-07-23 | 2002-08-09 | A method for treating solid tumors |
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| PCT/US1999/016630 WO2000004866A2 (en) | 1998-07-23 | 1999-07-23 | Preparation of thioarabinofuranosyl compounds and use thereof |
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| AU2002300586A Division AU2002300586B2 (en) | 1998-07-23 | 2002-08-09 | A method for treating solid tumors |
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| NZ (1) | NZ509405A (OSRAM) |
| WO (1) | WO2000004866A2 (OSRAM) |
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| US7524831B2 (en) | 2005-03-02 | 2009-04-28 | Schering Corporation | Treatments for Flaviviridae virus infection |
| WO2008118852A1 (en) * | 2007-03-23 | 2008-10-02 | Southern Research Institute | Method for treating and preventing arthritis |
| AR064165A1 (es) | 2007-12-06 | 2009-03-18 | Richmond Sa Com Ind Y Financie | Un procedimiento para la preparacion de capecitabina e intermediarios utilizables en dicho procedimiento |
| JP5622725B2 (ja) * | 2008-06-25 | 2014-11-12 | エンド ファーマスーティカルズ ソリューションズ インコーポレイテッド．Ｅｎｄｏ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｓｏｌｕｔｉｏｎｓｉｎｃ． | エキセナチド及び他のポリペプチド類の持続的送達 |
| US20110218170A1 (en) * | 2010-03-02 | 2011-09-08 | Southern Research Institute | Use of 2'-deoxy-4'-thiocytidine and its analogues as dna hypomethylating anticancer agents |
| PL2832740T3 (pl) | 2012-03-28 | 2019-09-30 | Fujifilm Corporation | Sól 1-(2-deoksy-2-fluoro-4-tio-beta-d-arabinofuranozylo)cytozyny |
| EP3109245B1 (en) | 2014-02-18 | 2018-01-03 | FUJIFILM Corporation | Method for producting thiolane skeleton-type glycoconjugate, and thiolane skeleton-type glycoconjugate |
| JP6351107B2 (ja) * | 2014-02-18 | 2018-07-04 | 富士フイルム株式会社 | チオラン骨格型糖化合物の製造方法およびチオラン骨格型糖化合物 |
| JP6245527B2 (ja) * | 2014-03-24 | 2017-12-13 | 富士フイルム株式会社 | チオラン環もしくはチアン環骨格を有する化合物の製造方法 |
| TWI678373B (zh) | 2014-10-31 | 2019-12-01 | 日商富士軟片股份有限公司 | 硫代核苷衍生物或其鹽及醫藥組合物 |
| EP3303361A1 (en) * | 2015-05-27 | 2018-04-11 | Idenix Pharmaceuticals LLC | Nucleotides for the treatment of cancer |
| WO2017091836A1 (en) * | 2015-11-25 | 2017-06-01 | University Of South Carolina | Enhancement of cytarabine activity by inhibiting cdk8/19 |
| TWI787201B (zh) | 2016-08-31 | 2022-12-21 | 日商富士軟片股份有限公司 | 抗腫瘤劑、抗腫瘤效果增強劑及抗腫瘤用套組 |
| CA3089728C (en) | 2018-01-29 | 2023-01-10 | Fujifilm Corporation | Antitumor agent for biliary tract cancer and method for treating biliary tract cancer |
| AU2019256465B2 (en) * | 2018-04-19 | 2024-10-03 | Southern Research Institute | 4'-thio-nucleotide and -nucleoside prodrugs for the treatment of cancer |
| EP3993806A4 (en) * | 2019-06-05 | 2023-09-13 | Southern Research Institute | THIARABINE AND THIARABINE PRODRUG BASED TREATMENTS |
| CA3176543A1 (en) | 2020-04-23 | 2021-10-28 | Mark J. Suto | Composition for treating blood cancer using 4'-thio-5-aza-2'-deoxycytidine and uses thereof |
Family Cites Families (10)
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| WO1991004033A1 (en) * | 1989-09-15 | 1991-04-04 | Southern Research Institute | 2'-deoxy-4'-thioribonucleosides as antiviral and anticancer agents |
| IE74701B1 (en) * | 1989-10-04 | 1997-07-30 | Univ Birmingham | Further antiviral pyrimidine nucleosides |
| JPH04505929A (ja) * | 1989-12-08 | 1992-10-15 | シティ・オブ・ホープ | ヒトの抗癌剤の耐性の回避 |
| JPH09249690A (ja) | 1995-07-14 | 1997-09-22 | Yamasa Shoyu Co Ltd | ４’−チオアラビノプリンヌクレオシド |
| JPH0925289A (ja) | 1995-07-14 | 1997-01-28 | Yamasa Shoyu Co Ltd | ４’−チオアラビノピリミジンヌクレオシドの製造方法 |
| JP2943690B2 (ja) | 1996-04-17 | 1999-08-30 | 日本電気株式会社 | セル衝突検出装置 |
| AU749561B2 (en) | 1997-05-09 | 2002-06-27 | Ribozyme Pharmaceuticals, Inc. | Nucleic acid molecules having endonuclease and/or catalytic activity |
| US6548657B1 (en) * | 1997-06-09 | 2003-04-15 | Ribozyme Pharmaceuticals, Inc. | Method for screening nucleic acid catalysts |
| WO1999043690A1 (en) | 1998-02-25 | 1999-09-02 | Rational Drug Design Laboratories | L-4'-arabinofuranonucleoside compound and medicine composition comprising the same |
| ES2402799T3 (es) * | 1998-07-23 | 2013-05-09 | Southern Research Institute | Prepreparación de compuestos de tioarabinofuranosilo y utilización de los mismos |
-
1999
- 1999-07-23 ES ES10179999T patent/ES2402799T3/es not_active Expired - Lifetime
- 1999-07-23 CA CA002338415A patent/CA2338415C/en not_active Expired - Lifetime
- 1999-07-23 ES ES10170453.4T patent/ES2438144T3/es not_active Expired - Lifetime
- 1999-07-23 ES ES99935854T patent/ES2376862T3/es not_active Expired - Lifetime
- 1999-07-23 JP JP2000560859A patent/JP4719356B2/ja not_active Expired - Fee Related
- 1999-07-23 EP EP10179999A patent/EP2332551B1/en not_active Expired - Lifetime
- 1999-07-23 WO PCT/US1999/016630 patent/WO2000004866A2/en not_active Ceased
- 1999-07-23 NZ NZ509405A patent/NZ509405A/en not_active IP Right Cessation
- 1999-07-23 AU AU51239/99A patent/AU747012B2/en not_active Expired
- 1999-07-23 AT AT99935854T patent/ATE531376T1/de active
- 1999-07-23 EP EP99935854A patent/EP1100512B1/en not_active Expired - Lifetime
- 1999-07-23 EP EP10170453.4A patent/EP2335706B1/en not_active Expired - Lifetime
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2000
- 2000-01-28 US US09/493,247 patent/US6576621B1/en not_active Expired - Lifetime
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2003
- 2003-04-07 US US10/407,135 patent/US6870052B2/en not_active Expired - Lifetime
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2004
- 2004-09-13 US US10/938,542 patent/US7138385B2/en not_active Expired - Lifetime
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2006
- 2006-08-24 US US11/509,030 patent/US7691820B2/en not_active Expired - Fee Related
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2010
- 2010-02-23 US US12/710,537 patent/US8178510B2/en not_active Expired - Fee Related
- 2010-04-27 JP JP2010102499A patent/JP2010202655A/ja active Pending
- 2010-10-29 JP JP2010243705A patent/JP5357857B2/ja not_active Expired - Lifetime
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| EP1100512A2 (en) | 2001-05-23 |
| EP1100512A4 (en) | 2001-10-10 |
| NZ509405A (en) | 2004-10-29 |
| US20100216797A1 (en) | 2010-08-26 |
| US20060287320A1 (en) | 2006-12-21 |
| US7138385B2 (en) | 2006-11-21 |
| JP2011032281A (ja) | 2011-02-17 |
| JP4719356B2 (ja) | 2011-07-06 |
| CA2338415C (en) | 2006-10-10 |
| CA2338415A1 (en) | 2000-02-03 |
| US6576621B1 (en) | 2003-06-10 |
| EP2332551B1 (en) | 2013-01-09 |
| EP2335706A1 (en) | 2011-06-22 |
| US20050038025A1 (en) | 2005-02-17 |
| US6870052B2 (en) | 2005-03-22 |
| ES2376862T3 (es) | 2012-03-20 |
| ES2438144T3 (es) | 2014-01-16 |
| ES2402799T3 (es) | 2013-05-09 |
| AU5123999A (en) | 2000-02-14 |
| JP2010202655A (ja) | 2010-09-16 |
| EP1100512B1 (en) | 2011-11-02 |
| ATE531376T1 (de) | 2011-11-15 |
| WO2000004866A2 (en) | 2000-02-03 |
| WO2000004866A3 (en) | 2000-04-20 |
| EP2335706B1 (en) | 2013-10-23 |
| EP2332551A1 (en) | 2011-06-15 |
| US7691820B2 (en) | 2010-04-06 |
| WO2000004866A9 (en) | 2000-08-10 |
| US20030203872A1 (en) | 2003-10-30 |
| JP2002521318A (ja) | 2002-07-16 |
| US8178510B2 (en) | 2012-05-15 |
| JP5357857B2 (ja) | 2013-12-04 |
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