AU746663B2 - Terbenzimidazoles useful for medical therapy (topoisomerase inhibitors) - Google Patents

Terbenzimidazoles useful for medical therapy (topoisomerase inhibitors) Download PDF

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Publication number
AU746663B2
AU746663B2 AU61327/98A AU6132798A AU746663B2 AU 746663 B2 AU746663 B2 AU 746663B2 AU 61327/98 A AU61327/98 A AU 61327/98A AU 6132798 A AU6132798 A AU 6132798A AU 746663 B2 AU746663 B2 AU 746663B2
Authority
AU
Australia
Prior art keywords
alkyl
compound
halo
halogen
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU61327/98A
Other languages
English (en)
Other versions
AU6132798A (en
Inventor
Edmond J. Lavoie
Leroy Fong Liu
Qun Sun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rutgers State University of New Jersey
Original Assignee
Rutgers State University of New Jersey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rutgers State University of New Jersey filed Critical Rutgers State University of New Jersey
Publication of AU6132798A publication Critical patent/AU6132798A/en
Application granted granted Critical
Publication of AU746663B2 publication Critical patent/AU746663B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU61327/98A 1997-01-21 1998-01-21 Terbenzimidazoles useful for medical therapy (topoisomerase inhibitors) Ceased AU746663B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/786629 1997-01-21
US08/786,629 US5770617A (en) 1996-03-20 1997-01-21 Terbenzimidazoles useful as antifungal agents
PCT/US1998/001005 WO1998031673A1 (en) 1997-01-21 1998-01-21 Terbenzimidazoles useful for medical therapy (topoisomerase inhibitors)

Publications (2)

Publication Number Publication Date
AU6132798A AU6132798A (en) 1998-08-07
AU746663B2 true AU746663B2 (en) 2002-05-02

Family

ID=25139154

Family Applications (1)

Application Number Title Priority Date Filing Date
AU61327/98A Ceased AU746663B2 (en) 1997-01-21 1998-01-21 Terbenzimidazoles useful for medical therapy (topoisomerase inhibitors)

Country Status (10)

Country Link
US (1) US5770617A (OSRAM)
EP (1) EP0960103A1 (OSRAM)
JP (1) JP2002513399A (OSRAM)
KR (1) KR20000070359A (OSRAM)
AU (1) AU746663B2 (OSRAM)
CA (1) CA2278452A1 (OSRAM)
IL (1) IL130572A0 (OSRAM)
NZ (1) NZ336606A (OSRAM)
PL (1) PL334662A1 (OSRAM)
WO (1) WO1998031673A1 (OSRAM)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1299358A (zh) * 1997-12-31 2001-06-13 新泽西州州立大学(拉特格斯) 杂环拓扑异构酶毒性剂
IL137351A0 (en) 1998-02-12 2001-07-24 Univ Rutgers Heterocyclic topoisomerase poisons
EP1191948A2 (en) * 1999-06-11 2002-04-03 Neorx Corporation High dose radionuclide complexes for bone marrow suppression
US7094885B2 (en) * 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
US6740650B2 (en) 1999-10-29 2004-05-25 Rutgers, The State University Of New Jersey Heterocyclic cytotoxic agents
AU2002249935A1 (en) * 2001-01-08 2002-08-19 Neorx Corporation Radioactively labelled conjugates of phosphonates
MXPA04004607A (es) * 2001-11-14 2004-09-10 Univ Rutgers Agentes de venenos de topoisomerasa solubilizados.
AU2002352708A1 (en) 2001-11-14 2003-05-26 Edmond J. Lavoie Cytotoxic agents
KR20050044491A (ko) * 2001-11-14 2005-05-12 루트거스, 더 스테이트 유니버시티 가용화된 토포이소머라제 독
WO2003047505A2 (en) * 2001-11-14 2003-06-12 Rutgers, The State University Topoisomerase poison agents
AU2002364552A1 (en) 2001-12-13 2003-06-30 Dow Global Technologies Inc. Treatment of osteomyelitis with radiopharmaceuticals
US6992089B2 (en) * 2002-08-09 2006-01-31 Rutgers, The University Of New Jersey Nitro and amino substituted topoisomerase agents
AU2003265405A1 (en) * 2002-08-09 2004-02-25 Edmond J. Lavoie Nitro and amino substituted heterocycles as topoisomerase i targeting agents
WO2004014918A1 (en) * 2002-08-09 2004-02-19 Rutgers, The State University Nitro and amino substituted topoisomerase agents
WO2004044174A2 (en) * 2002-11-12 2004-05-27 Rutgers, The State University Topoisomerase-targeting agents
GB0619325D0 (en) 2006-09-30 2006-11-08 Univ Strathclyde New compounds
GB0821913D0 (en) 2008-12-02 2009-01-07 Price & Co Antibacterial compounds
EP2403856B1 (en) 2009-03-06 2012-12-19 Rutgers, The State University of New Jersey Methylenedioxybenzo [i]phenanthridine derivatives used to treat cancer
WO2010127363A1 (en) 2009-05-01 2010-11-04 Rutgers, The State University Of New Jersey Toposiomerase inhibitors
HRP20160397T1 (hr) * 2010-06-01 2016-08-12 Summit Therapeutics Plc Spojevi za liječenje clostridium difficile povezanih bolesti
WO2015042438A1 (en) * 2013-09-19 2015-03-26 The Florida International Board Of Trustees Modesto A. Maidique Campus Selective inhibition of bacterial topoisomerase i
GB201506658D0 (en) 2015-04-20 2015-06-03 Cellcentric Ltd Pharmaceutical compounds
GB201506660D0 (en) 2015-04-20 2015-06-03 Cellcentric Ltd Pharmaceutical compounds
WO2017125944A1 (en) * 2016-01-23 2017-07-27 Jawaharlal Nehru University (Jnu) Broad spectrum antibacterial activity of novel bisbenzimidazoles targeting topoisomerase ia and the synergistic composition of bisbenzimidazole with efflux pump inhibitors against pathogenic bacteria
US11091498B2 (en) 2016-04-04 2021-08-17 Rutgers, The State University Of New Jersey Topoisomerase poisons
WO2019004254A1 (ja) 2017-06-27 2019-01-03 株式会社Ｋｙｕｌｕｘ 発光材料、化合物、遅延蛍光体および発光素子
JP7267563B2 (ja) 2017-06-27 2023-05-02 株式会社Kyulux 発光材料、化合物、遅延蛍光体および発光素子

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9608476A (pt) * 1995-05-17 1999-08-17 Univ Rutgers Composto processo para inibir o crescimento de uma célula tumoral de mam¡fero e composicão terapéutica
US5643935A (en) * 1995-06-07 1997-07-01 The University Of North Carolina At Chapel Hill Method of combatting infectious diseases using dicationic bis-benzimidazoles

Also Published As

Publication number Publication date
AU6132798A (en) 1998-08-07
EP0960103A1 (en) 1999-12-01
JP2002513399A (ja) 2002-05-08
KR20000070359A (ko) 2000-11-25
US5770617A (en) 1998-06-23
IL130572A0 (en) 2000-06-01
NZ336606A (en) 2001-04-27
CA2278452A1 (en) 1998-07-23
WO1998031673A1 (en) 1998-07-23
PL334662A1 (en) 2000-03-13

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