AU746258B2 - Genetic immunization with nonstructural proteins of hepatitis C virus - Google Patents
Genetic immunization with nonstructural proteins of hepatitis C virus Download PDFInfo
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- AU746258B2 AU746258B2 AU24786/99A AU2478699A AU746258B2 AU 746258 B2 AU746258 B2 AU 746258B2 AU 24786/99 A AU24786/99 A AU 24786/99A AU 2478699 A AU2478699 A AU 2478699A AU 746258 B2 AU746258 B2 AU 746258B2
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- 239000012466 permeate Substances 0.000 description 1
- CWCMIVBLVUHDHK-ZSNHEYEWSA-N phleomycin D1 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC[C@@H](N=1)C=1SC=C(N=1)C(=O)NCCCCNC(N)=N)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C CWCMIVBLVUHDHK-ZSNHEYEWSA-N 0.000 description 1
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- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
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- 239000000829 suppository Substances 0.000 description 1
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Wood Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7315698P | 1998-01-30 | 1998-01-30 | |
| US60/073156 | 1998-01-30 | ||
| PCT/US1999/001823 WO1999038880A1 (en) | 1998-01-30 | 1999-01-28 | Genetic immunization with nonstructural proteins of hepatitis c virus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2478699A AU2478699A (en) | 1999-08-16 |
| AU746258B2 true AU746258B2 (en) | 2002-04-18 |
Family
ID=22112053
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU24786/99A Ceased AU746258B2 (en) | 1998-01-30 | 1999-01-28 | Genetic immunization with nonstructural proteins of hepatitis C virus |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1056762A4 (zh) |
| JP (1) | JP2002501737A (zh) |
| KR (2) | KR20060057653A (zh) |
| CN (3) | CN101126095A (zh) |
| AU (1) | AU746258B2 (zh) |
| BR (1) | BR9908540A (zh) |
| CA (1) | CA2318744A1 (zh) |
| IL (1) | IL137458A0 (zh) |
| WO (1) | WO1999038880A1 (zh) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6562346B1 (en) * | 1999-10-27 | 2003-05-13 | Chiron Corporation | Activation of HCV-specific T cells |
| US6986892B1 (en) | 1999-11-24 | 2006-01-17 | Chiron Corporation | Immunogenic Hepatitis C virus non-structural polypeptides |
| KR100788812B1 (ko) * | 1999-11-24 | 2007-12-27 | 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 | 신규한 ｈｃｖ 비구조 폴리펩티드 |
| CN1582337B (zh) | 2001-10-11 | 2011-12-14 | 默沙东公司 | 丙型肝炎病毒疫苗 |
| FR2855758B1 (fr) | 2003-06-05 | 2005-07-22 | Biomerieux Sa | Composition comprenant la polyproteine ns3/ns4 et le polypeptide ns5b du vhc, vecteurs d'expression incluant les sequences nucleiques correspondantes et leur utilisation en therapeutique |
| CA2851336C (en) * | 2011-10-24 | 2021-01-12 | The Trustees Of The University Of Pennsylvania | Improved hcv vaccines and methods for using the same |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69133402T2 (de) * | 1990-04-04 | 2004-11-11 | Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville | Protease von hepatitis-c-virus |
| US5593972A (en) * | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
| AU675702B2 (en) * | 1993-01-26 | 1997-02-13 | Leslie R. Coney | Compositions and methods for delivery of genetic material |
| IL118364A0 (en) * | 1995-05-22 | 1996-09-12 | Bionova Corp | A hepatitis C virus-derived composition methods for the preparation thereof and assays for the detection of hepatitis C virus |
| AU719929B2 (en) * | 1996-05-24 | 2000-05-18 | Grifols Worldwide Operations Limited | Multiple epitope fusion protein |
| JP2002500502A (ja) * | 1996-06-11 | 2002-01-08 | メルク エンド カンパニー インコーポレーテッド | 合成ｃ型肝炎遺伝子 |
| EP1037974B1 (en) * | 1997-12-11 | 2007-10-03 | SmithKline Beecham Corporation | Hepatitis c virus ns5b truncated protein and methods thereof to identify antiviral compounds |
-
1999
- 1999-01-28 JP JP2000529347A patent/JP2002501737A/ja not_active Withdrawn
- 1999-01-28 AU AU24786/99A patent/AU746258B2/en not_active Ceased
- 1999-01-28 CN CNA2007101398938A patent/CN101126095A/zh active Pending
- 1999-01-28 BR BR9908540-2A patent/BR9908540A/pt not_active Application Discontinuation
- 1999-01-28 CN CNB998024813A patent/CN100335637C/zh not_active Expired - Fee Related
- 1999-01-28 KR KR1020067008960A patent/KR20060057653A/ko not_active IP Right Cessation
- 1999-01-28 CA CA002318744A patent/CA2318744A1/en not_active Abandoned
- 1999-01-28 IL IL13745899A patent/IL137458A0/xx unknown
- 1999-01-28 WO PCT/US1999/001823 patent/WO1999038880A1/en not_active Application Discontinuation
- 1999-01-28 KR KR1020007008307A patent/KR100628411B1/ko not_active IP Right Cessation
- 1999-01-28 EP EP99904381A patent/EP1056762A4/en not_active Withdrawn
- 1999-01-28 CN CNA2007101384653A patent/CN101126094A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR100628411B1 (ko) | 2006-09-28 |
| CN100335637C (zh) | 2007-09-05 |
| EP1056762A1 (en) | 2000-12-06 |
| CA2318744A1 (en) | 1999-08-05 |
| WO1999038880A1 (en) | 1999-08-05 |
| CN101126094A (zh) | 2008-02-20 |
| IL137458A0 (en) | 2001-07-24 |
| BR9908540A (pt) | 2000-11-28 |
| AU2478699A (en) | 1999-08-16 |
| KR20060057653A (ko) | 2006-05-26 |
| CN1289339A (zh) | 2001-03-28 |
| CN101126095A (zh) | 2008-02-20 |
| EP1056762A4 (en) | 2003-07-23 |
| KR20010086226A (ko) | 2001-09-10 |
| JP2002501737A (ja) | 2002-01-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) |