AU730546B2 - Pure biologically active colistin, its components and a colistin formulation for treatment of pulmonary infections - Google Patents

Pure biologically active colistin, its components and a colistin formulation for treatment of pulmonary infections Download PDF

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Publication number
AU730546B2
AU730546B2 AU57909/98A AU5790998A AU730546B2 AU 730546 B2 AU730546 B2 AU 730546B2 AU 57909/98 A AU57909/98 A AU 57909/98A AU 5790998 A AU5790998 A AU 5790998A AU 730546 B2 AU730546 B2 AU 730546B2
Authority
AU
Australia
Prior art keywords
colistin
component
colistin component
formulation
dry powder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU57909/98A
Other languages
English (en)
Other versions
AU5790998A (en
Inventor
Alan B. Montgomery
Donald R. Vandevanter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pathogenesis Corp
Original Assignee
Pathogenesis Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/799,200 external-priority patent/US5821623A/en
Application filed by Pathogenesis Corp filed Critical Pathogenesis Corp
Publication of AU5790998A publication Critical patent/AU5790998A/en
Application granted granted Critical
Publication of AU730546B2 publication Critical patent/AU730546B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
    • C07K7/62—Polymyxins; Related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
AU57909/98A 1996-11-15 1997-11-13 Pure biologically active colistin, its components and a colistin formulation for treatment of pulmonary infections Ceased AU730546B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US3093996P 1996-11-15 1996-11-15
US60/030939 1996-11-15
US08/799,200 US5821623A (en) 1996-02-26 1997-02-13 Multi-layer gate structure
US08/799300 1997-02-13
PCT/US1997/021829 WO1998020836A2 (en) 1996-11-15 1997-11-13 Pure biologically active colistin, its components and a colistin formulation for treatment of pulmonary infections

Publications (2)

Publication Number Publication Date
AU5790998A AU5790998A (en) 1998-06-03
AU730546B2 true AU730546B2 (en) 2001-03-08

Family

ID=26706611

Family Applications (1)

Application Number Title Priority Date Filing Date
AU57909/98A Ceased AU730546B2 (en) 1996-11-15 1997-11-13 Pure biologically active colistin, its components and a colistin formulation for treatment of pulmonary infections

Country Status (7)

Country Link
EP (1) EP0920324B1 (enExample)
JP (2) JP2001505557A (enExample)
AT (1) ATE202481T1 (enExample)
AU (1) AU730546B2 (enExample)
CA (1) CA2242335A1 (enExample)
DE (1) DE69705414T2 (enExample)
WO (1) WO1998020836A2 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2316273A1 (en) 1998-01-16 1999-07-22 Takeda Chemical Industries, Ltd. Sustained-release composition, method of its production and use thereof
GB9820746D0 (en) * 1998-09-23 1998-11-18 Pharmax Limited Micronised pharmaceutical compositions
US8820316B2 (en) 2000-02-11 2014-09-02 Respironics Respiratory Drug Delivery (Uk) Ltd Drug delivery apparatus
AU3500901A (en) 2000-02-11 2001-08-20 Medic Aid Ltd Drug delivery apparatus
EP1129705A1 (en) 2000-02-17 2001-09-05 Rijksuniversiteit te Groningen Powder formulation for inhalation
EP1488819A1 (en) 2003-06-16 2004-12-22 Rijksuniversiteit te Groningen Dry powder inhaler and method for pulmonary inhalation of dry powder
WO2008020474A1 (en) * 2006-08-15 2008-02-21 Meiji Seika Kaisha Ltd. Method of producing colistin bulk powder
PL2470555T3 (pl) * 2009-10-30 2015-05-29 Xellia Pharmaceuticals Aps Sposób oczyszczania kolistyny i oczyszczone składniki kolistyny
CN102190712A (zh) * 2010-01-22 2011-09-21 上海医药工业研究院 多黏菌素e1组合物及其制备方法和用途
AU2014204873B2 (en) 2013-01-11 2017-07-06 Xellia Pharmaceuticals Aps Polymyxins, compositions, methods of making and methods of use
JP6508655B2 (ja) * 2014-01-24 2019-05-08 Ｅａファーマ株式会社 メガリン拮抗剤
FR3016888B1 (fr) 2014-01-27 2021-01-22 Centre Nat Rech Scient Synthetases de la colistine et cluster de genes correspondants
CN106661090A (zh) 2014-07-09 2017-05-10 埃克斯利亚制药有限公司 低取代的多粘菌素以及它们的组合物
GB201416788D0 (en) 2014-09-23 2014-11-05 Univ Glasgow Therapeutic applications for pyocins
BR112017006848B1 (pt) * 2014-10-03 2022-10-04 Xellia Pharmaceuticals Aps Composições
RS58792B1 (sr) 2014-10-03 2019-07-31 Xellia Pharmaceuticals Aps Inhalacioni uređaj
EP3366284A1 (en) 2017-02-27 2018-08-29 Zambon S.p.A. Association of n-acetylcysteine and colistin for use in bacterial infections
WO2022146537A1 (en) * 2021-01-01 2022-07-07 Purdue Research Foundation Co-formulation of polymyxins for inhalation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2124060B1 (enExample) * 1971-02-02 1974-04-12 Rhone Poulenc Sa

Also Published As

Publication number Publication date
EP0920324B1 (en) 2001-06-27
CA2242335A1 (en) 1998-05-22
AU5790998A (en) 1998-06-03
DE69705414T2 (de) 2002-05-02
ATE202481T1 (de) 2001-07-15
JP2001505557A (ja) 2001-04-24
WO1998020836A2 (en) 1998-05-22
WO1998020836A3 (en) 1998-07-09
EP0920324A4 (enExample) 1999-06-09
DE69705414D1 (de) 2001-08-02
EP0920324A2 (en) 1999-06-09
JP2007302698A (ja) 2007-11-22

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND PRIORITY DETAILS TO READ: US 19961115 60/030939 US 19972_13 08/799300