AU722684B2 - 6-thio-substituted paclitaxels - Google Patents

6-thio-substituted paclitaxels Download PDF

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Publication number
AU722684B2
AU722684B2 AU57922/98A AU5792298A AU722684B2 AU 722684 B2 AU722684 B2 AU 722684B2 AU 57922/98 A AU57922/98 A AU 57922/98A AU 5792298 A AU5792298 A AU 5792298A AU 722684 B2 AU722684 B2 AU 722684B2
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AU
Australia
Prior art keywords
alkyl
sch
hydrogen
och
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU57922/98A
Other languages
English (en)
Other versions
AU5792298A (en
Inventor
John F. Kadow
Harold A. Mastalerz
Andrew J. Staab
Dolatrai M. Vyas
Mark D. Wittman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AU5792298A publication Critical patent/AU5792298A/en
Application granted granted Critical
Publication of AU722684B2 publication Critical patent/AU722684B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6551—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring
    • C07F9/65512—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring condensed with carbocyclic rings or carbocyclic ring systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
AU57922/98A 1996-12-24 1997-12-05 6-thio-substituted paclitaxels Ceased AU722684B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US3341996P 1996-12-24 1996-12-24
US60/033419 1996-12-24
US3635197P 1997-01-23 1997-01-23
US60/036351 1997-01-23
PCT/US1997/022152 WO1998028288A1 (en) 1996-12-24 1997-12-05 6-thio-substituted paclitaxels

Publications (2)

Publication Number Publication Date
AU5792298A AU5792298A (en) 1998-07-17
AU722684B2 true AU722684B2 (en) 2000-08-10

Family

ID=26709670

Family Applications (1)

Application Number Title Priority Date Filing Date
AU57922/98A Ceased AU722684B2 (en) 1996-12-24 1997-12-05 6-thio-substituted paclitaxels

Country Status (11)

Country Link
US (1) US5977386A (enExample)
EP (1) EP0960107B1 (enExample)
JP (1) JP2001507029A (enExample)
AT (1) ATE225341T1 (enExample)
AU (1) AU722684B2 (enExample)
CA (1) CA2268774A1 (enExample)
DE (1) DE69716135T2 (enExample)
DK (1) DK0960107T3 (enExample)
ES (1) ES2184149T3 (enExample)
PT (1) PT960107E (enExample)
WO (1) WO1998028288A1 (enExample)

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US20210206826A1 (en) 2015-11-19 2021-07-08 The Regents Of The University Of California Conditionally repressible immune cell receptors and methods of use thereof
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CN109071634A (zh) 2016-04-26 2018-12-21 R.P.谢勒技术有限责任公司 抗体偶联物及其制备和使用方法
EP3463308B2 (en) 2016-06-01 2026-01-07 Servier IP UK Limited Formulations of polyalkylene oxide-asparaginase and methods of making and using the same
EP3468598A1 (en) 2016-06-08 2019-04-17 AbbVie Inc. Anti-cd98 antibodies and antibody drug conjugates
BR112018075649A2 (pt) 2016-06-08 2019-04-09 Abbvie Inc. anticorpos anti-b7-h3 e conjugados de fármaco de anticorpo
TWI762487B (zh) 2016-06-08 2022-05-01 美商艾伯維有限公司 抗-b7-h3抗體及抗體藥物結合物
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CN110003142A (zh) * 2018-01-04 2019-07-12 深圳福山生物科技有限公司 一种硒氰化合物及其用途
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Also Published As

Publication number Publication date
WO1998028288A1 (en) 1998-07-02
ES2184149T3 (es) 2003-04-01
CA2268774A1 (en) 1998-07-02
PT960107E (pt) 2003-02-28
JP2001507029A (ja) 2001-05-29
US5977386A (en) 1999-11-02
EP0960107B1 (en) 2002-10-02
DK0960107T3 (da) 2003-02-10
DE69716135T2 (de) 2003-06-05
EP0960107A1 (en) 1999-12-01
EP0960107A4 (enExample) 1999-12-01
AU5792298A (en) 1998-07-17
ATE225341T1 (de) 2002-10-15
DE69716135D1 (en) 2002-11-07

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