ATE225341T1 - In 6-position durch thio substituierte paclitaxele - Google Patents
In 6-position durch thio substituierte paclitaxeleInfo
- Publication number
- ATE225341T1 ATE225341T1 AT97954044T AT97954044T ATE225341T1 AT E225341 T1 ATE225341 T1 AT E225341T1 AT 97954044 T AT97954044 T AT 97954044T AT 97954044 T AT97954044 T AT 97954044T AT E225341 T1 ATE225341 T1 AT E225341T1
- Authority
- AT
- Austria
- Prior art keywords
- paclitaxele
- thio
- substituted
- present
- invention concerns
- Prior art date
Links
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000004579 taxol derivatives Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/6551—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring
- C07F9/65512—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3341996P | 1996-12-24 | 1996-12-24 | |
| US3635197P | 1997-01-23 | 1997-01-23 | |
| PCT/US1997/022152 WO1998028288A1 (en) | 1996-12-24 | 1997-12-05 | 6-thio-substituted paclitaxels |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE225341T1 true ATE225341T1 (de) | 2002-10-15 |
Family
ID=26709670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97954044T ATE225341T1 (de) | 1996-12-24 | 1997-12-05 | In 6-position durch thio substituierte paclitaxele |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5977386A (enExample) |
| EP (1) | EP0960107B1 (enExample) |
| JP (1) | JP2001507029A (enExample) |
| AT (1) | ATE225341T1 (enExample) |
| AU (1) | AU722684B2 (enExample) |
| CA (1) | CA2268774A1 (enExample) |
| DE (1) | DE69716135T2 (enExample) |
| DK (1) | DK0960107T3 (enExample) |
| ES (1) | ES2184149T3 (enExample) |
| PT (1) | PT960107E (enExample) |
| WO (1) | WO1998028288A1 (enExample) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HK1049787B (en) | 1999-10-01 | 2014-07-25 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| US6362217B2 (en) | 2000-03-17 | 2002-03-26 | Bristol-Myers Squibb Company | Taxane anticancer agents |
| DE60131537T2 (de) | 2000-06-22 | 2008-10-23 | Nitromed, Inc., Lexington | Nitrosierte und nitrosylierte taxane, zubereitungen und methoden der verwendung |
| US7351542B2 (en) | 2002-05-20 | 2008-04-01 | The Regents Of The University Of California | Methods of modulating tubulin deacetylase activity |
| DK1530465T4 (en) | 2002-06-26 | 2016-03-21 | Medigene Ag | A method of producing a cationic liposomal preparation comprising a lipophilic compound. |
| JP2007525188A (ja) | 2003-05-16 | 2007-09-06 | インターミューン インコーポレイテッド | 合成ケモカイン受容体リガンドおよびその使用方法 |
| US7597884B2 (en) | 2004-08-09 | 2009-10-06 | Alios Biopharma, Inc. | Hyperglycosylated polypeptide variants and methods of use |
| US8691780B2 (en) | 2005-02-17 | 2014-04-08 | The Board Of Trustees Of The Leland Stanford Junior University | Txr1 and enhanced taxane sensitivity based on the modulation of a pathway mediated thereby |
| US8168216B2 (en) | 2006-03-22 | 2012-05-01 | Medigene Ag | Treatment of triple receptor negative breast cancer |
| PL217731B1 (pl) | 2006-06-01 | 2014-08-29 | Tomasz Byrski | Sposób wykrywania genetycznie uwarunkowanej obniżonej odpowiedzi na chemioterapię cytostatykiem taksanowym, zastosowanie mutacji założycielskiej oraz zestawu do wykrywania takiej odpowiedzi |
| ES2530462T3 (es) | 2008-05-22 | 2015-03-03 | Galera Therapeutics Llc | Combinación terapia antitumoral |
| EP2310507A4 (en) | 2008-07-08 | 2013-03-20 | David Gladstone Inst | METHOD AND COMPOSITIONS FOR ANGIOGENIC MODULATION |
| CN102040570B (zh) * | 2009-10-14 | 2014-07-30 | 江苏先声药物研究有限公司 | 硫代紫杉烷类衍生物及其制备方法和用途 |
| IN2015DN00552A (enExample) | 2012-07-19 | 2015-06-26 | Redwood Bioscience Inc | |
| CA2890190A1 (en) | 2012-11-12 | 2014-05-15 | Redwood Bioscience, Inc. | Compounds and methods for producing a conjugate |
| EP3300745B9 (en) | 2013-02-15 | 2020-04-15 | The Regents of the University of California | Chimeric antigen receptor and methods of use thereof |
| KR20150135332A (ko) | 2013-03-14 | 2015-12-02 | 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 | 미토콘드리아 알데히드 탈수소효소-2 조절인자들 및 이들의 사용 방법 |
| CN115504924A (zh) | 2013-11-27 | 2022-12-23 | 雷德伍德生物科技股份有限公司 | 肼基-吡咯并化合物及用于生成缀合物的方法 |
| KR102319882B1 (ko) | 2014-02-19 | 2021-11-03 | 아비브 테라퓨틱스, 인크. | 암의 치료를 위한 폴리사이클릭 아미드와 결합하는 미토콘드리아 알데히드 탈수소효소 2 (aldh2) 및 그의 용도 |
| AR099812A1 (es) | 2014-03-21 | 2016-08-17 | Abbvie Inc | Anticuerpos y conjugados de anticuerpo y fármaco anti-egfr |
| US10654875B2 (en) | 2015-11-12 | 2020-05-19 | The Board Of Trustees Of The Leland Stanford Junior University | Cell-penetrating, guanidinium-rich oligophosphotriesters for drug and probe delivery |
| WO2017087723A1 (en) | 2015-11-19 | 2017-05-26 | The Regents Of The University Of California | Conditionally repressible immune cell receptors and methods of use thereof |
| TWI760319B (zh) | 2015-12-30 | 2022-04-11 | 杏國新藥股份有限公司 | 乳癌治療 |
| EP3231421A1 (en) | 2016-04-11 | 2017-10-18 | Greenaltech, S.L. | Uses of a carotenoid in the treatment or prevention of stress induced conditions |
| JP2019515677A (ja) | 2016-04-26 | 2019-06-13 | アール．ピー．シェーラー テクノロジーズ エルエルシー | 抗体複合体ならびにそれを作製および使用する方法 |
| AU2017299374B2 (en) | 2016-06-01 | 2021-05-27 | Servier IP UK Limited | Formulations of polyalkylene oxide-asparaginase and methods of making and using the same |
| WO2017214322A1 (en) | 2016-06-08 | 2017-12-14 | Abbvie Inc. | Anti-b7-h3 antibodies and antibody drug conjugates |
| US20200147235A1 (en) | 2016-06-08 | 2020-05-14 | Abbvie Inc. | Anti-cd98 antibodies and antibody drug conjugates |
| MX2018015285A (es) | 2016-06-08 | 2019-09-18 | Abbvie Inc | Anticuerpos anti-b7-h3 y conjugados de anticuerpo y farmaco. |
| PT3458479T (pt) | 2016-06-08 | 2021-03-01 | Abbvie Inc | Anticorpos anti-b7-h3 e conjugados medicamentos-anticorpos |
| AU2017277914A1 (en) | 2016-06-08 | 2019-01-03 | Abbvie Inc. | Anti-CD98 antibodies and antibody drug conjugates |
| TWI852903B (zh) | 2017-01-05 | 2024-08-21 | 杏國新藥股份有限公司 | 胰臟癌治療 |
| SG11201906468TA (en) | 2017-01-18 | 2019-08-27 | F1 Oncology Inc | Chimeric antigen receptors against axl or ror2 and methods of use thereof |
| EP3388082A1 (en) | 2017-04-13 | 2018-10-17 | Galera Labs, LLC | Combination cancer immunotherapy with pentaaza macrocyclic ring complex |
| CN111065623B9 (zh) | 2017-05-24 | 2024-10-25 | 德克萨斯州大学系统董事会 | 用于抗体药物缀合物的接头 |
| CN110003142A (zh) * | 2018-01-04 | 2019-07-12 | 深圳福山生物科技有限公司 | 一种硒氰化合物及其用途 |
| AU2019215032A1 (en) | 2018-01-31 | 2020-09-10 | Board Of Regents Of The University Of Texas System | Combination cancer therapy with pentaaza macrocyclic ring complex and platinum-based anticancer agent |
| WO2019195596A1 (en) | 2018-04-06 | 2019-10-10 | The Regents Of The University Of California | Methods of treating glioblastomas |
| US12144826B2 (en) | 2018-04-06 | 2024-11-19 | The Regents Of The University Of California | Methods of treating EGFRvIII expressing glioblastomas |
| CA3096838A1 (en) | 2018-04-11 | 2019-10-17 | Ohio State Innovation Foundation | Methods and compositions for sustained release microparticles for ocular drug delivery |
| CA3105879A1 (en) | 2018-07-18 | 2020-01-23 | Manzanita Pharmaceuticals, Inc. | Conjugates for delivering an anti-cancer agent to nerve cells, methods of use and methods of making thereof |
| CA3131895A1 (en) | 2019-04-02 | 2020-10-08 | Kenjockety Biotechnology, Inc. | Efflux pump-cancer antigen multi-specific antibodies and compositions, reagents, kits and methods related thereto |
| MX2022009355A (es) | 2020-01-29 | 2022-09-02 | Kenjockety Biotechnology Inc | Anticuerpo anti-mdr1 y uso del mismo. |
| US20230212305A1 (en) | 2020-06-04 | 2023-07-06 | Kenjockety Biotechnology, Inc. | Anti-abcg2 antibodies and uses thereof |
| CA3182969A1 (en) | 2020-06-04 | 2021-12-09 | Kenjockety Biotechnology, Inc. | Abcg2 efflux pump-cancer antigen multi-specific antibodies and compositions, reagents, kits and methods related thereto |
| US20230272117A1 (en) | 2020-09-02 | 2023-08-31 | Kenjockety Biotechnology, Inc. | Anti abcc1 antibodies and uses thereof |
| CA3203652A1 (en) | 2020-11-13 | 2022-05-19 | William Robert ARATHOON | Anti-mrp4 (encoded by abcc4 gene) antibodies and uses thereof |
| JP2023551203A (ja) | 2020-11-20 | 2023-12-07 | アール．ピー．シェーラー テクノロジーズ、エルエルシー | 抗体－薬物コンジュゲートのためのグリコシド二重切断リンカー |
| AR124681A1 (es) | 2021-01-20 | 2023-04-26 | Abbvie Inc | Conjugados anticuerpo-fármaco anti-egfr |
| CA3238353A1 (en) | 2021-12-13 | 2023-06-22 | William Robert ARATHOON | Anti-abcb1 antibodies |
| WO2023159220A1 (en) | 2022-02-18 | 2023-08-24 | Kenjockety Biotechnology, Inc. | Anti-cd47 antibodies |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2601675B1 (fr) * | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent |
| US4876399A (en) * | 1987-11-02 | 1989-10-24 | Research Corporation Technologies, Inc. | Taxols, their preparation and intermediates thereof |
| US4960790A (en) * | 1989-03-09 | 1990-10-02 | University Of Kansas | Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof |
| US5714512A (en) * | 1991-07-08 | 1998-02-03 | Rhone-Poulenc Rorer, S.A. | Compositions containing taxane derivatives |
| KR100239201B1 (ko) * | 1991-09-23 | 2000-02-01 | 로버트 엠 존슨 | 10-데스아세톡시탁솔 유도체 |
| US5272171A (en) * | 1992-02-13 | 1993-12-21 | Bristol-Myers Squibb Company | Phosphonooxy and carbonate derivatives of taxol |
| EP0639186B1 (en) * | 1992-04-17 | 1999-06-23 | Abbott Laboratories | Taxol derivatives |
| US5294637A (en) * | 1992-07-01 | 1994-03-15 | Bristol-Myers Squibb Company | Fluoro taxols |
| US5254580A (en) * | 1993-01-19 | 1993-10-19 | Bristol-Myers Squibb Company | 7,8-cyclopropataxanes |
| FR2697019B1 (fr) * | 1992-10-15 | 1994-11-25 | Rhone Poulenc Rorer Sa | Nouveaux dérivés du taxane, leur préparation et les compositions pharmaceutiques qui les contiennent. |
| CA2109861C (en) * | 1992-12-04 | 1999-03-16 | Shu-Hui Chen | 6,7-modified paclitaxels |
| NZ261070A (en) * | 1992-12-23 | 1997-10-24 | Bristol Myers Squibb Co | Oxazoline-substituted taxane derivatives and their preparation; intermediates |
| NO310238B1 (no) * | 1992-12-24 | 2001-06-11 | Bristol Myers Squibb Co | Kjemiske forbindelser og farmasöytisk preparat samt anvendelse av slike preparater |
| ES2193154T3 (es) * | 1993-03-05 | 2003-11-01 | Univ Florida State | Procedimiento para la preparacion de 9-desoxotaxanos. |
| US5703247A (en) * | 1993-03-11 | 1997-12-30 | Virginia Tech Intellectual Properties, Inc. | 2-Debenzoyl-2-acyl taxol derivatives and methods for making same |
| US5965739A (en) * | 1993-06-11 | 1999-10-12 | Pharmacia & Upjohn Company | Δ6,7 -taxols antineoplastic use and pharmaceutical compositions containing them |
| US5767296A (en) * | 1994-06-09 | 1998-06-16 | Daiichi Pharmaceutical Co., Ltd. | Deacetoxytaxol derivatives |
| AU2814595A (en) * | 1994-06-28 | 1996-01-25 | Pharmacia & Upjohn Company | 7-ether-taxol analogs, antineoplastic use and pharmaceutical compositions containing them |
| CA2195844C (en) * | 1994-07-26 | 2001-10-09 | Ezio Bombardelli | Semi-synthetic taxanes with anti-tumoural activity |
-
1997
- 1997-11-26 US US08/979,139 patent/US5977386A/en not_active Expired - Fee Related
- 1997-12-05 ES ES97954044T patent/ES2184149T3/es not_active Expired - Lifetime
- 1997-12-05 PT PT97954044T patent/PT960107E/pt unknown
- 1997-12-05 AU AU57922/98A patent/AU722684B2/en not_active Ceased
- 1997-12-05 DE DE69716135T patent/DE69716135T2/de not_active Expired - Fee Related
- 1997-12-05 EP EP97954044A patent/EP0960107B1/en not_active Expired - Lifetime
- 1997-12-05 CA CA002268774A patent/CA2268774A1/en not_active Abandoned
- 1997-12-05 JP JP52877098A patent/JP2001507029A/ja not_active Abandoned
- 1997-12-05 AT AT97954044T patent/ATE225341T1/de not_active IP Right Cessation
- 1997-12-05 DK DK97954044T patent/DK0960107T3/da active
- 1997-12-05 WO PCT/US1997/022152 patent/WO1998028288A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU722684B2 (en) | 2000-08-10 |
| EP0960107B1 (en) | 2002-10-02 |
| DK0960107T3 (da) | 2003-02-10 |
| AU5792298A (en) | 1998-07-17 |
| CA2268774A1 (en) | 1998-07-02 |
| JP2001507029A (ja) | 2001-05-29 |
| US5977386A (en) | 1999-11-02 |
| PT960107E (pt) | 2003-02-28 |
| EP0960107A4 (enExample) | 1999-12-01 |
| WO1998028288A1 (en) | 1998-07-02 |
| EP0960107A1 (en) | 1999-12-01 |
| ES2184149T3 (es) | 2003-04-01 |
| DE69716135D1 (en) | 2002-11-07 |
| DE69716135T2 (de) | 2003-06-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0960107 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |