AU719450B2 - Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease - Google Patents

Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease Download PDF

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Publication number
AU719450B2
AU719450B2 AU63328/96A AU6332896A AU719450B2 AU 719450 B2 AU719450 B2 AU 719450B2 AU 63328/96 A AU63328/96 A AU 63328/96A AU 6332896 A AU6332896 A AU 6332896A AU 719450 B2 AU719450 B2 AU 719450B2
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AU
Australia
Prior art keywords
salen
group
antioxidant
activity
metal compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU63328/96A
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English (en)
Other versions
AU6332896A (en
Inventor
Susan Robin Doctrow
Bernard Malfroy-Camine
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eukarion Inc
Original Assignee
Eukarion Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eukarion Inc filed Critical Eukarion Inc
Publication of AU6332896A publication Critical patent/AU6332896A/en
Application granted granted Critical
Publication of AU719450B2 publication Critical patent/AU719450B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
    • C07C251/24—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A61K2800/522—Antioxidants; Radical scavengers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/58—Metal complex; Coordination compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU63328/96A 1995-06-07 1996-06-06 Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease Ceased AU719450B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/485,489 US5696109A (en) 1992-12-07 1995-06-07 Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease
US08/485489 1995-06-07
PCT/US1996/010267 WO1996040149A1 (en) 1995-06-07 1996-06-06 Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease

Publications (2)

Publication Number Publication Date
AU6332896A AU6332896A (en) 1996-12-30
AU719450B2 true AU719450B2 (en) 2000-05-11

Family

ID=23928377

Family Applications (2)

Application Number Title Priority Date Filing Date
AU63328/96A Ceased AU719450B2 (en) 1995-06-07 1996-06-06 Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease
AU62725/96A Abandoned AU6272596A (en) 1995-06-07 1996-06-06 Synthetic catalytic free radical scavengers useful as antiox idants for prevention and therapy of disease

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU62725/96A Abandoned AU6272596A (en) 1995-06-07 1996-06-06 Synthetic catalytic free radical scavengers useful as antiox idants for prevention and therapy of disease

Country Status (6)

Country Link
US (6) US5696109A (enExample)
EP (1) EP0831836A4 (enExample)
JP (1) JP4160115B2 (enExample)
AU (2) AU719450B2 (enExample)
CA (1) CA2223510C (enExample)
WO (2) WO1996040148A1 (enExample)

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US6127356A (en) 1993-10-15 2000-10-03 Duke University Oxidant scavengers
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Also Published As

Publication number Publication date
WO1996040149A1 (en) 1996-12-19
US20030216371A1 (en) 2003-11-20
CA2223510C (en) 2008-05-20
AU6272596A (en) 1996-12-30
JPH11507646A (ja) 1999-07-06
US6573257B2 (en) 2003-06-03
JP4160115B2 (ja) 2008-10-01
CA2223510A1 (en) 1996-12-19
US6046188A (en) 2000-04-04
US6900198B2 (en) 2005-05-31
EP0831836A1 (en) 1998-04-01
US5696109A (en) 1997-12-09
US20020002157A1 (en) 2002-01-03
EP0831836A4 (en) 2000-09-27
AU6332896A (en) 1996-12-30
WO1996040148A1 (en) 1996-12-19
US20090311230A1 (en) 2009-12-17
US20050249796A1 (en) 2005-11-10

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