AU700631B2 - Prothrombin derivatives - Google Patents
Prothrombin derivatives Download PDFInfo
- Publication number
- AU700631B2 AU700631B2 AU58871/96A AU5887196A AU700631B2 AU 700631 B2 AU700631 B2 AU 700631B2 AU 58871/96 A AU58871/96 A AU 58871/96A AU 5887196 A AU5887196 A AU 5887196A AU 700631 B2 AU700631 B2 AU 700631B2
- Authority
- AU
- Australia
- Prior art keywords
- thrombin
- prothrombin
- hirudin
- amino acid
- mutant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6429—Thrombin (3.4.21.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21005—Thrombin (3.4.21.5)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/974—Thrombin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT1006/95 | 1995-06-13 | ||
AT0100695A AT404357B (de) | 1995-06-13 | 1995-06-13 | Prothrombin-derivate |
PCT/AT1996/000105 WO1996041868A2 (fr) | 1995-06-13 | 1996-06-12 | Derives de prothrombine |
Publications (2)
Publication Number | Publication Date |
---|---|
AU5887196A AU5887196A (en) | 1997-01-09 |
AU700631B2 true AU700631B2 (en) | 1999-01-07 |
Family
ID=3504770
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU58871/96A Ceased AU700631B2 (en) | 1995-06-13 | 1996-06-12 | Prothrombin derivatives |
Country Status (9)
Country | Link |
---|---|
US (1) | US6086871A (fr) |
EP (1) | EP0833897A2 (fr) |
JP (1) | JPH11507542A (fr) |
AT (1) | AT404357B (fr) |
AU (1) | AU700631B2 (fr) |
CA (1) | CA2224634A1 (fr) |
CZ (1) | CZ402097A3 (fr) |
HU (1) | HUP9900506A3 (fr) |
WO (1) | WO1996041868A2 (fr) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2452768C (fr) * | 2001-07-06 | 2011-06-07 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Procede relatif a l'elaboration de thrombine humaine par modification genique |
AU2008202376B2 (en) * | 2001-07-06 | 2011-02-10 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Process for producing human thrombin by gene modification technique |
US20030099957A1 (en) * | 2001-09-28 | 2003-05-29 | Vitivity, Inc. | Diagnosis and treatment of vascular disease |
WO2006104398A1 (fr) * | 2005-03-26 | 2006-10-05 | Protemix Corporation Limited | Compositions antagonistes du cuivre |
JPWO2008059917A1 (ja) | 2006-11-15 | 2010-03-04 | チッソ株式会社 | トロンビン変異体 |
PL3078743T3 (pl) | 2007-09-28 | 2020-11-02 | Portola Pharmaceuticals, Inc. | Antidotum dla inhibitorów czynnika XA i sposoby ich stosowania |
EP2344174B1 (fr) * | 2008-10-27 | 2016-04-27 | Trustees Of Tufts College | Acides nucléiques codant des peptides destinés au traitement de blessures, composés antiangiogéniques, et utilisations correspondantes |
JP5709316B2 (ja) | 2008-11-14 | 2015-04-30 | ポートラ ファーマシューティカルズ, インコーポレイテッド | 第Xa因子阻害剤のための解毒剤および血液凝固剤と組み合わせて該解毒剤を使用する方法 |
EP3604510A1 (fr) | 2009-03-30 | 2020-02-05 | Portola Pharmaceuticals, Inc. | Antidotes pour inhibiteurs du facteur xa et procédés d'utilisation associes |
US9056106B2 (en) | 2009-07-15 | 2015-06-16 | Portola Pharmaceuticals, Inc. | Unit dose formulation of antidotes for factor Xa inhibitors and methods of using the same |
AR079944A1 (es) | 2010-01-20 | 2012-02-29 | Boehringer Ingelheim Int | Anticuerpo neutralizante de la actividad de un anticoagulante |
EP2471945A1 (fr) * | 2010-12-30 | 2012-07-04 | Siemens Healthcare Diagnostics Products GmbH | Procédé de détermination d'inhibiteurs de coagulation |
JP2014515740A (ja) | 2011-03-30 | 2014-07-03 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 抗凝固薬の解毒剤 |
CN104470532A (zh) * | 2012-04-17 | 2015-03-25 | 奥胡斯大学 | SorCS1在治疗肥胖症及超重中的应用 |
GB2504499A (en) * | 2012-07-31 | 2014-02-05 | Baxter Healthcare Sa | Selective measurement of active human protease coagulation factors |
WO2015183085A1 (fr) | 2014-05-26 | 2015-12-03 | Academisch Ziekenhuis Leiden | Protéines prohémostatiques pour le traitement d'une hémorragie |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5112615A (en) * | 1988-08-03 | 1992-05-12 | New England Deaconess Hospital Corporation | Soluble hirudin conjugates |
US5167960A (en) * | 1988-08-03 | 1992-12-01 | New England Deaconess Hospital Corporation | Hirudin-coated biocompatible substance |
CA2000887A1 (fr) * | 1988-11-01 | 1990-05-01 | Cecilia S.L. Ku | Materiaux thromboresistants et methode de production |
ATE119195T1 (de) * | 1989-01-25 | 1995-03-15 | Ciba Geigy Ag | Monoklonale antikörper, spezifisch für hirudin. |
WO1991011519A1 (fr) * | 1990-01-26 | 1991-08-08 | Immuno Aktiengesellschaft | Facteurs sanguins produits par recombinaison et procede pour l'expression de ces facteurs sanguins, ainsi que virus de la vaccine utilises dans ce procede |
US5688768A (en) * | 1991-02-19 | 1997-11-18 | Cor Therapeutics, Inc. | Recombinant thrombin receptor and related pharmaceuticals |
DE4203965A1 (de) * | 1992-02-11 | 1993-08-12 | Max Planck Gesellschaft | Antidot fuer hirudin und synthetische thrombininhibitoren |
ATE293168T1 (de) * | 1993-11-12 | 2005-04-15 | Gilead Sciences Inc | Thrombin mutanten |
AT401270B (de) * | 1994-09-26 | 1996-07-25 | Immuno Ag | Verfahren zur quantifizierung von genomischer dna |
-
1995
- 1995-06-13 AT AT0100695A patent/AT404357B/de not_active IP Right Cessation
-
1996
- 1996-06-12 AU AU58871/96A patent/AU700631B2/en not_active Ceased
- 1996-06-12 EP EP96915903A patent/EP0833897A2/fr not_active Withdrawn
- 1996-06-12 CA CA002224634A patent/CA2224634A1/fr not_active Abandoned
- 1996-06-12 CZ CZ974020A patent/CZ402097A3/cs unknown
- 1996-06-12 JP JP9502398A patent/JPH11507542A/ja active Pending
- 1996-06-12 US US08/952,967 patent/US6086871A/en not_active Expired - Lifetime
- 1996-06-12 WO PCT/AT1996/000105 patent/WO1996041868A2/fr not_active Application Discontinuation
- 1996-06-12 HU HU9900506A patent/HUP9900506A3/hu unknown
Also Published As
Publication number | Publication date |
---|---|
US6086871A (en) | 2000-07-11 |
EP0833897A2 (fr) | 1998-04-08 |
JPH11507542A (ja) | 1999-07-06 |
WO1996041868A2 (fr) | 1996-12-27 |
ATA100695A (de) | 1998-03-15 |
HUP9900506A2 (hu) | 1999-06-28 |
CA2224634A1 (fr) | 1996-12-27 |
AU5887196A (en) | 1997-01-09 |
WO1996041868A3 (fr) | 1997-04-10 |
AT404357B (de) | 1998-11-25 |
HUP9900506A3 (en) | 2001-10-29 |
CZ402097A3 (cs) | 1998-04-15 |
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