AU686458B2 - Methods for the treatment of osteoporosis using bone active phosphonates and parathyroid hormone - Google Patents
Methods for the treatment of osteoporosis using bone active phosphonates and parathyroid hormoneInfo
- Publication number
- AU686458B2 AU686458B2 AU35475/95A AU3547595A AU686458B2 AU 686458 B2 AU686458 B2 AU 686458B2 AU 35475/95 A AU35475/95 A AU 35475/95A AU 3547595 A AU3547595 A AU 3547595A AU 686458 B2 AU686458 B2 AU 686458B2
- Authority
- AU
- Australia
- Prior art keywords
- bisphosphonic acid
- acid
- bone
- amino
- osteoporosis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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- 210000000988 bone and bone Anatomy 0.000 title claims description 50
- 108090000445 Parathyroid hormone Proteins 0.000 title claims description 37
- 239000000199 parathyroid hormone Substances 0.000 title claims description 36
- 102000003982 Parathyroid hormone Human genes 0.000 title claims description 35
- 229960001319 parathyroid hormone Drugs 0.000 title claims description 35
- 208000001132 Osteoporosis Diseases 0.000 title description 41
- 238000011282 treatment Methods 0.000 title description 29
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical class OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 title description 19
- 239000002253 acid Substances 0.000 claims description 30
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- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 claims description 21
- 150000003839 salts Chemical class 0.000 claims description 20
- 229940122361 Bisphosphonate Drugs 0.000 claims description 19
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- -1 phosphonate compound Chemical class 0.000 claims description 19
- 241001465754 Metazoa Species 0.000 claims description 13
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- LWRDQHOZTAOILO-UHFFFAOYSA-N incadronic acid Chemical compound OP(O)(=O)C(P(O)(O)=O)NC1CCCCCC1 LWRDQHOZTAOILO-UHFFFAOYSA-N 0.000 claims description 4
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- PUUSSSIBPPTKTP-UHFFFAOYSA-N neridronic acid Chemical compound NCCCCCC(O)(P(O)(O)=O)P(O)(O)=O PUUSSSIBPPTKTP-UHFFFAOYSA-N 0.000 claims description 4
- FEDXBAPTUASPQZ-UHFFFAOYSA-N (1-hydroxy-3-imidazol-1-yl-3-oxo-1-phosphonopropyl)phosphonic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CC(=O)N1C=CN=C1 FEDXBAPTUASPQZ-UHFFFAOYSA-N 0.000 claims description 3
- 208000018083 Bone metabolism disease Diseases 0.000 claims description 3
- WCJADIUJTZRJKN-UHFFFAOYSA-N ClCCl.OP(O)=O.OP(O)=O Chemical compound ClCCl.OP(O)=O.OP(O)=O WCJADIUJTZRJKN-UHFFFAOYSA-N 0.000 claims description 3
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30392594A | 1994-09-09 | 1994-09-09 | |
| US303925 | 1994-09-09 | ||
| PCT/US1995/011335 WO1996007417A1 (en) | 1994-09-09 | 1995-09-06 | Methods for the treatment of osteoporosis using bone active phosphonates and parathyroid hormone |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU3547595A AU3547595A (en) | 1996-03-27 |
| AU686458B2 true AU686458B2 (en) | 1998-02-05 |
Family
ID=23174289
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU35475/95A Ceased AU686458B2 (en) | 1994-09-09 | 1995-09-06 | Methods for the treatment of osteoporosis using bone active phosphonates and parathyroid hormone |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0779812A4 (ko) |
| JP (1) | JPH10505090A (ko) |
| KR (1) | KR970705400A (ko) |
| CN (1) | CN1157565A (ko) |
| AU (1) | AU686458B2 (ko) |
| CA (1) | CA2199252A1 (ko) |
| IL (1) | IL115224A0 (ko) |
| WO (1) | WO1996007417A1 (ko) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9702401D0 (sv) * | 1997-06-19 | 1997-06-19 | Astra Ab | Pharmaceutical use |
| US8052987B2 (en) | 2000-06-20 | 2011-11-08 | Novartis Pharmaceuticals Corporation | Method of administering bisphosphonates |
| WO2007059470A2 (en) | 2005-11-10 | 2007-05-24 | Board Of Control Of Michigan Technological University | Black bear parathyroid hormone and methods of using black bear parathyroid hormone |
| US20160016982A1 (en) | 2009-07-31 | 2016-01-21 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| US9169279B2 (en) | 2009-07-31 | 2015-10-27 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| HUE034784T2 (en) | 2009-07-31 | 2018-02-28 | Gruenenthal Gmbh | Crystallization process and bioavailability |
| JP2013512688A (ja) | 2009-12-07 | 2013-04-18 | ミシガン テクノロジカル ユニバーシティ | クロクマの副甲状腺ホルモン及びクロクマの副甲状腺ホルモンを使用する方法 |
| WO2012071517A2 (en) | 2010-11-24 | 2012-05-31 | Thar Pharmaceuticals, Inc. | Novel crystalline forms |
| WO2017208070A1 (en) | 2016-05-31 | 2017-12-07 | Grünenthal GmbH | Bisphosphonic acid and coformers with lysin, glycin, nicotinamide for treating psoriatic arthritis |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE114473T1 (de) * | 1984-04-30 | 1994-12-15 | Procter & Gamble | Ausrüstung für die verwendung bei der behandlung von osteoporose. |
| US4812304A (en) * | 1984-12-21 | 1989-03-14 | The Procter & Gamble Company | Treatment of osteoporosis |
| US4833125A (en) * | 1986-12-05 | 1989-05-23 | The General Hospital Corporation | Method of increasing bone mass |
| US4868164A (en) * | 1986-12-19 | 1989-09-19 | Norwich Eaton Pharmaceuticals, Inc. | Octahydro-pyridine diphosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism |
| SK74594A3 (en) * | 1991-12-17 | 1995-01-12 | Procter & Gamble Pharma | Treatment for treating of osteoporosis |
| US5403824A (en) * | 1993-03-19 | 1995-04-04 | The Procter & Gamble Company | Methods for the treatment of osteoporosis |
-
1995
- 1995-09-06 WO PCT/US1995/011335 patent/WO1996007417A1/en not_active Application Discontinuation
- 1995-09-06 KR KR1019970701532A patent/KR970705400A/ko active IP Right Grant
- 1995-09-06 CN CN95195007A patent/CN1157565A/zh active Pending
- 1995-09-06 JP JP8509664A patent/JPH10505090A/ja active Pending
- 1995-09-06 EP EP95932426A patent/EP0779812A4/en not_active Ceased
- 1995-09-06 CA CA002199252A patent/CA2199252A1/en not_active Abandoned
- 1995-09-06 AU AU35475/95A patent/AU686458B2/en not_active Ceased
- 1995-09-08 IL IL11522495A patent/IL115224A0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH10505090A (ja) | 1998-05-19 |
| WO1996007417A1 (en) | 1996-03-14 |
| CN1157565A (zh) | 1997-08-20 |
| EP0779812A1 (en) | 1997-06-25 |
| EP0779812A4 (en) | 1997-09-10 |
| AU3547595A (en) | 1996-03-27 |
| CA2199252A1 (en) | 1996-03-14 |
| IL115224A0 (en) | 1995-12-31 |
| KR970705400A (ko) | 1997-10-09 |
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