CA2199252A1 - Methods for the treatment of osteoporosis using bone active phosphonates and parathyroid hormone - Google Patents
Methods for the treatment of osteoporosis using bone active phosphonates and parathyroid hormoneInfo
- Publication number
- CA2199252A1 CA2199252A1 CA002199252A CA2199252A CA2199252A1 CA 2199252 A1 CA2199252 A1 CA 2199252A1 CA 002199252 A CA002199252 A CA 002199252A CA 2199252 A CA2199252 A CA 2199252A CA 2199252 A1 CA2199252 A1 CA 2199252A1
- Authority
- CA
- Canada
- Prior art keywords
- acid
- bisphosphonic acid
- bone
- amino
- osteoporosis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000000034 method Methods 0.000 title claims abstract description 64
- 210000000988 bone and bone Anatomy 0.000 title claims abstract description 49
- 108090000445 Parathyroid hormone Proteins 0.000 title claims abstract description 32
- 239000000199 parathyroid hormone Substances 0.000 title claims abstract description 32
- 102000003982 Parathyroid hormone Human genes 0.000 title claims abstract description 31
- 229960001319 parathyroid hormone Drugs 0.000 title claims abstract description 31
- 208000001132 Osteoporosis Diseases 0.000 title description 38
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical class OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 title description 18
- 238000011282 treatment Methods 0.000 title description 8
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 claims abstract description 20
- 241001465754 Metazoa Species 0.000 claims abstract description 13
- 208000018083 Bone metabolism disease Diseases 0.000 claims abstract description 4
- 239000002253 acid Substances 0.000 claims description 60
- 150000002148 esters Chemical class 0.000 claims description 24
- -1 phosphonate compound Chemical class 0.000 claims description 19
- 150000003839 salts Chemical class 0.000 claims description 19
- 229940122361 Bisphosphonate Drugs 0.000 claims description 16
- 150000004663 bisphosphonates Chemical class 0.000 claims description 16
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 4
- IIDJRNMFWXDHID-UHFFFAOYSA-N Risedronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CC1=CC=CN=C1 IIDJRNMFWXDHID-UHFFFAOYSA-N 0.000 claims description 4
- OGSPWJRAVKPPFI-UHFFFAOYSA-N Alendronic Acid Chemical compound NCCCC(O)(P(O)(O)=O)P(O)(O)=O OGSPWJRAVKPPFI-UHFFFAOYSA-N 0.000 claims description 3
- MBKDYNNUVRNNRF-UHFFFAOYSA-N medronic acid Chemical compound OP(O)(=O)CP(O)(O)=O MBKDYNNUVRNNRF-UHFFFAOYSA-N 0.000 claims description 3
- FEDXBAPTUASPQZ-UHFFFAOYSA-N (1-hydroxy-3-imidazol-1-yl-3-oxo-1-phosphonopropyl)phosphonic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CC(=O)N1C=CN=C1 FEDXBAPTUASPQZ-UHFFFAOYSA-N 0.000 claims description 2
- WCJADIUJTZRJKN-UHFFFAOYSA-N ClCCl.OP(O)=O.OP(O)=O Chemical compound ClCCl.OP(O)=O.OP(O)=O WCJADIUJTZRJKN-UHFFFAOYSA-N 0.000 claims description 2
- MPBVHIBUJCELCL-UHFFFAOYSA-N Ibandronate Chemical compound CCCCCN(C)CCC(O)(P(O)(O)=O)P(O)(O)=O MPBVHIBUJCELCL-UHFFFAOYSA-N 0.000 claims description 2
- PUUSSSIBPPTKTP-UHFFFAOYSA-N neridronic acid Chemical compound NCCCCCC(O)(P(O)(O)=O)P(O)(O)=O PUUSSSIBPPTKTP-UHFFFAOYSA-N 0.000 claims description 2
- WRUUGTRCQOWXEG-UHFFFAOYSA-N pamidronate Chemical compound NCCC(O)(P(O)(O)=O)P(O)(O)=O WRUUGTRCQOWXEG-UHFFFAOYSA-N 0.000 claims description 2
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30392594A | 1994-09-09 | 1994-09-09 | |
| US303,925 | 1994-09-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2199252A1 true CA2199252A1 (en) | 1996-03-14 |
Family
ID=23174289
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002199252A Abandoned CA2199252A1 (en) | 1994-09-09 | 1995-09-06 | Methods for the treatment of osteoporosis using bone active phosphonates and parathyroid hormone |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0779812A4 (ko) |
| JP (1) | JPH10505090A (ko) |
| KR (1) | KR970705400A (ko) |
| CN (1) | CN1157565A (ko) |
| AU (1) | AU686458B2 (ko) |
| CA (1) | CA2199252A1 (ko) |
| IL (1) | IL115224A0 (ko) |
| WO (1) | WO1996007417A1 (ko) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9702401D0 (sv) | 1997-06-19 | 1997-06-19 | Astra Ab | Pharmaceutical use |
| ES2394211T3 (es) | 2000-06-20 | 2013-01-23 | Novartis Ag | Procedimiento de administración de bifosfonatos |
| JP2009515535A (ja) | 2005-11-10 | 2009-04-16 | ボード オブ コントロール オブ ミシガン テクノロジカル ユニヴァーシティー | クロクマの副甲状腺ホルモン及びクロクマの副甲状腺ホルモンを使用する方法 |
| AU2010278860B2 (en) | 2009-07-31 | 2016-05-26 | Thar Pharma, Llc | Crystallization method and bioavailability |
| US9169279B2 (en) | 2009-07-31 | 2015-10-27 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| US20160016982A1 (en) | 2009-07-31 | 2016-01-21 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| EP2509996A1 (en) | 2009-12-07 | 2012-10-17 | Michigan Technological University | Black bear parathyroid hormone and methods of using black bear parathyroid hormone |
| US9340565B2 (en) | 2010-11-24 | 2016-05-17 | Thar Pharmaceuticals, Inc. | Crystalline forms |
| US10195218B2 (en) | 2016-05-31 | 2019-02-05 | Grunenthal Gmbh | Crystallization method and bioavailability |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE114473T1 (de) * | 1984-04-30 | 1994-12-15 | Procter & Gamble | Ausrüstung für die verwendung bei der behandlung von osteoporose. |
| US4812304A (en) * | 1984-12-21 | 1989-03-14 | The Procter & Gamble Company | Treatment of osteoporosis |
| US4833125A (en) * | 1986-12-05 | 1989-05-23 | The General Hospital Corporation | Method of increasing bone mass |
| US4868164A (en) * | 1986-12-19 | 1989-09-19 | Norwich Eaton Pharmaceuticals, Inc. | Octahydro-pyridine diphosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism |
| SK74594A3 (en) * | 1991-12-17 | 1995-01-12 | Procter & Gamble Pharma | Treatment for treating of osteoporosis |
| US5403824A (en) * | 1993-03-19 | 1995-04-04 | The Procter & Gamble Company | Methods for the treatment of osteoporosis |
-
1995
- 1995-09-06 AU AU35475/95A patent/AU686458B2/en not_active Ceased
- 1995-09-06 CN CN95195007A patent/CN1157565A/zh active Pending
- 1995-09-06 KR KR1019970701532A patent/KR970705400A/ko active IP Right Grant
- 1995-09-06 WO PCT/US1995/011335 patent/WO1996007417A1/en not_active Application Discontinuation
- 1995-09-06 CA CA002199252A patent/CA2199252A1/en not_active Abandoned
- 1995-09-06 JP JP8509664A patent/JPH10505090A/ja active Pending
- 1995-09-06 EP EP95932426A patent/EP0779812A4/en not_active Ceased
- 1995-09-08 IL IL11522495A patent/IL115224A0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0779812A4 (en) | 1997-09-10 |
| AU3547595A (en) | 1996-03-27 |
| CN1157565A (zh) | 1997-08-20 |
| JPH10505090A (ja) | 1998-05-19 |
| KR970705400A (ko) | 1997-10-09 |
| EP0779812A1 (en) | 1997-06-25 |
| WO1996007417A1 (en) | 1996-03-14 |
| IL115224A0 (en) | 1995-12-31 |
| AU686458B2 (en) | 1998-02-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |