AU684946B2 - SYNTHESIS OF 17B CYANO-3-ETHOXY-17a-HYDROXY-6-METHYLANDROSTA-3,5,9-(11)-TRIEN 9(11)-triene - Google Patents

SYNTHESIS OF 17B CYANO-3-ETHOXY-17a-HYDROXY-6-METHYLANDROSTA-3,5,9-(11)-TRIEN 9(11)-triene Download PDF

Info

Publication number
AU684946B2
AU684946B2 AU23628/95A AU2362895A AU684946B2 AU 684946 B2 AU684946 B2 AU 684946B2 AU 23628/95 A AU23628/95 A AU 23628/95A AU 2362895 A AU2362895 A AU 2362895A AU 684946 B2 AU684946 B2 AU 684946B2
Authority
AU
Australia
Prior art keywords
cyano
document
ethyl ether
methylandrosta
triene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
AU23628/95A
Other languages
English (en)
Other versions
AU2362895A (en
Inventor
Therese Debiak-Krook
John Gregory Reid
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Pharmacia and Upjohn Co
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co, Upjohn Co filed Critical Pharmacia and Upjohn Co
Publication of AU2362895A publication Critical patent/AU2362895A/en
Application granted granted Critical
Publication of AU684946B2 publication Critical patent/AU684946B2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU23628/95A 1994-05-09 1995-05-02 SYNTHESIS OF 17B CYANO-3-ETHOXY-17a-HYDROXY-6-METHYLANDROSTA-3,5,9-(11)-TRIEN 9(11)-triene Expired - Fee Related AU684946B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24003694A 1994-05-09 1994-05-09
US240036 1994-05-09
PCT/US1995/005026 WO1995030684A1 (fr) 1994-05-09 1995-05-02 SYNTHESE DU 17β-CYANO-3-ETHOXY-17α-HYDROXY-6-METHYLANDROSTA-3,5,9(11)-TRIENE

Publications (2)

Publication Number Publication Date
AU2362895A AU2362895A (en) 1995-11-29
AU684946B2 true AU684946B2 (en) 1998-01-08

Family

ID=22904843

Family Applications (1)

Application Number Title Priority Date Filing Date
AU23628/95A Expired - Fee Related AU684946B2 (en) 1994-05-09 1995-05-02 SYNTHESIS OF 17B CYANO-3-ETHOXY-17a-HYDROXY-6-METHYLANDROSTA-3,5,9-(11)-TRIEN 9(11)-triene

Country Status (9)

Country Link
EP (1) EP0759928A1 (fr)
JP (1) JPH10500946A (fr)
KR (1) KR970702873A (fr)
CN (1) CN1147816A (fr)
AU (1) AU684946B2 (fr)
CA (1) CA2187522A1 (fr)
HU (1) HUT75517A (fr)
MX (1) MX9605428A (fr)
WO (1) WO1995030684A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112898365B (zh) * 2021-03-08 2023-02-28 营口德瑞化工有限公司 一种17β-氰基-17α-羟基雄甾-4-烯-3-酮的合成方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0153001A2 (fr) * 1984-02-03 1985-08-28 The Upjohn Company Stéroides porteurs d'un groupe énamide ou énimide et leur préparation
WO1986000907A1 (fr) * 1984-07-23 1986-02-13 Schering Aktiengesellschaft Berlin Und Bergkamen Procede pour la production de steroides de 6alpha-methyle
EP0268400A1 (fr) * 1986-11-05 1988-05-25 The Upjohn Company 17 alpha silyléthers de stéroides et procédé de préparation de corticoides et de progestérones

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2468617A1 (fr) * 1979-10-26 1981-05-08 Roussel Uclaf Nouveaux derives acetyleniques chlores de l'androst-4-ene leur procede de preparation, et leur application a titre de medicament et les compositions pharmaceutiques les renfermant
DE3434448A1 (de) * 1984-09-17 1986-03-27 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur herstellung von pregnan-derivaten
DD281394A5 (de) * 1984-12-10 1990-08-08 Jenapharm Veb Verfahren zur herstellung von steroid-c-17 alpha-carbonitrilen
KR960010793B1 (ko) * 1986-10-10 1996-08-08 루쎌 위클라프 소시에떼 아노님 9-알파-히드록시 스테로이드 및 그의 제조방법

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0153001A2 (fr) * 1984-02-03 1985-08-28 The Upjohn Company Stéroides porteurs d'un groupe énamide ou énimide et leur préparation
WO1986000907A1 (fr) * 1984-07-23 1986-02-13 Schering Aktiengesellschaft Berlin Und Bergkamen Procede pour la production de steroides de 6alpha-methyle
EP0268400A1 (fr) * 1986-11-05 1988-05-25 The Upjohn Company 17 alpha silyléthers de stéroides et procédé de préparation de corticoides et de progestérones

Also Published As

Publication number Publication date
JPH10500946A (ja) 1998-01-27
CN1147816A (zh) 1997-04-16
HU9603110D0 (en) 1997-01-28
AU2362895A (en) 1995-11-29
HUT75517A (en) 1997-05-28
WO1995030684A1 (fr) 1995-11-16
EP0759928A1 (fr) 1997-03-05
MX9605428A (es) 1997-12-31
CA2187522A1 (fr) 1995-11-16
KR970702873A (ko) 1997-06-10

Similar Documents

Publication Publication Date Title
JP2677626B2 (ja) １７−置換アンドロスタ−１，４−ジエン−３−オン誘導体
JPH04117394A (ja) １０位置に置換エチル基を含有する新規のステロイド化合物、それらの製造方法、それらの薬剤としての使用及びそれらを含有する製薬組成物
AU684946B2 (en) SYNTHESIS OF 17B CYANO-3-ETHOXY-17a-HYDROXY-6-METHYLANDROSTA-3,5,9-(11)-TRIEN 9(11)-triene
US5998639A (en) Sulfatation of estrogen mixtures
IE62526B1 (en) "Process for the preparation of 9(11)-dehydro Steroids"
US2781342A (en) Steroid enamines
US4416821A (en) Process for preparing 16-methylene steroids
US3060205A (en) Process for preparation of 3-amino-1, 3, 5(10)-estratriene derivatives
US2950291A (en) 17-oxygenated estra-1, 3, 5(10)-triene-1, 4-diols, their esters, and a corresponding quinone
US3214447A (en) 2alpha-methyl-11-oxygenated androstanes and intermediates therefor
Tweit et al. 15-Oxygenated Progesterones. A New Series of Synthetic Mineralocorticoid Antagonists
US3160644A (en) 1-dehydro-11-keto-9alpha-fluoro-17alpha-methyl testosterones
US3083199A (en) delta3-5alpha-steroids and 3alpha-hydroxy-5alpha-steroids and the preparation thereof
US3629298A (en) Steroidal 3-keto-delta 1 4-diene-3-enamines
IE60754B1 (en) Steroidic aromatase inhibitors
EP0875515B1 (fr) Sulphation des mélanges d'estrogènes
US3130212A (en) delta1, 3, 5(10), 9(11) pregnatetraene-3, 20-diones and process for the production thereof
US3845040A (en) Protection of steroid carbonyl group by enolisation
US3465011A (en) 11-oxygenated-8-iso steroids
US2889344A (en) Dehydro-16-acetoxy-17-hydroxypregna-3, 20-diones
US5866559A (en) 17α-cyanomethylestra-4,9-dien derivatives and pharmaceutical compositions containing same
US3700670A (en) Process for making delta**5 (10)-estrenes or pregnenes and products obtained there
HU184804B (en) Process for preparing 9/11/- and/or 16-insaturated steroids
US3017419A (en) 11alpha-methyl-androstane derivatives
US3210392A (en) Lower alkanoyl esters of 11-oxygenated androst-4-ene-3beta, 17beta-diols and intermediates thereto