AU682669B2 - Allergenic extracts - Google Patents
Allergenic extractsInfo
- Publication number
- AU682669B2 AU682669B2 AU53726/94A AU5372694A AU682669B2 AU 682669 B2 AU682669 B2 AU 682669B2 AU 53726/94 A AU53726/94 A AU 53726/94A AU 5372694 A AU5372694 A AU 5372694A AU 682669 B2 AU682669 B2 AU 682669B2
- Authority
- AU
- Australia
- Prior art keywords
- allergenic
- extract
- extraction
- extraction step
- residue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000284 extract Substances 0.000 title claims description 110
- 230000002009 allergenic effect Effects 0.000 title claims description 76
- 238000000605 extraction Methods 0.000 claims description 50
- 238000000034 method Methods 0.000 claims description 46
- 239000000463 material Substances 0.000 claims description 32
- 238000009169 immunotherapy Methods 0.000 claims description 19
- 230000008569 process Effects 0.000 claims description 12
- 230000002378 acidificating effect Effects 0.000 claims description 10
- 208000026935 allergic disease Diseases 0.000 claims description 9
- 230000002045 lasting effect Effects 0.000 claims description 7
- 238000012544 monitoring process Methods 0.000 claims description 6
- 230000002163 immunogen Effects 0.000 claims description 5
- 239000003929 acidic solution Substances 0.000 claims description 4
- 239000012670 alkaline solution Substances 0.000 claims description 4
- 208000026278 immune system disease Diseases 0.000 claims description 4
- 230000001225 therapeutic effect Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 9
- 239000013566 allergen Substances 0.000 description 35
- 229960004784 allergens Drugs 0.000 description 29
- 239000000706 filtrate Substances 0.000 description 16
- 239000000243 solution Substances 0.000 description 13
- 230000000172 allergic effect Effects 0.000 description 11
- 208000010668 atopic eczema Diseases 0.000 description 11
- 238000012360 testing method Methods 0.000 description 10
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 206010020751 Hypersensitivity Diseases 0.000 description 8
- 230000007815 allergy Effects 0.000 description 6
- 239000000287 crude extract Substances 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 230000000717 retained effect Effects 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 239000002699 waste material Substances 0.000 description 5
- 238000013459 approach Methods 0.000 description 4
- 238000003745 diagnosis Methods 0.000 description 4
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000002953 phosphate buffered saline Substances 0.000 description 4
- 230000009897 systematic effect Effects 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- 239000000427 antigen Substances 0.000 description 3
- 230000000890 antigenic effect Effects 0.000 description 3
- 102000036639 antigens Human genes 0.000 description 3
- 108091007433 antigens Proteins 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 230000001900 immune effect Effects 0.000 description 3
- 230000028993 immune response Effects 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 238000007726 management method Methods 0.000 description 3
- 230000007935 neutral effect Effects 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 241000238876 Acari Species 0.000 description 2
- 241000238631 Hexapoda Species 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 210000001744 T-lymphocyte Anatomy 0.000 description 2
- 208000030961 allergic reaction Diseases 0.000 description 2
- 210000000612 antigen-presenting cell Anatomy 0.000 description 2
- 239000003125 aqueous solvent Substances 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 235000014633 carbohydrates Nutrition 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 238000002405 diagnostic procedure Methods 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000000428 dust Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 210000000987 immune system Anatomy 0.000 description 2
- 238000003018 immunoassay Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 235000018185 Betula X alpestris Nutrition 0.000 description 1
- 235000018212 Betula X uliginosa Nutrition 0.000 description 1
- 235000009109 Betula pendula Nutrition 0.000 description 1
- 241000219430 Betula pendula Species 0.000 description 1
- 240000004585 Dactylis glomerata Species 0.000 description 1
- 241000238740 Dermatophagoides pteronyssinus Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000209082 Lolium Species 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 241000209504 Poaceae Species 0.000 description 1
- 241000221535 Pucciniales Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 241000221561 Ustilaginales Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 229940074608 allergen extract Drugs 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 210000003746 feather Anatomy 0.000 description 1
- 238000002523 gelfiltration Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229940046528 grass pollen Drugs 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 238000010181 skin prick test Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 229940046536 tree pollen allergenic extract Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
- A61K39/36—Allergens from pollen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Botany (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP92203367 | 1992-11-03 | ||
| EP92203367 | 1992-11-03 | ||
| PCT/EP1993/003041 WO1994009824A1 (fr) | 1992-11-03 | 1993-11-03 | Extraits allergeniques |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU5372694A AU5372694A (en) | 1994-05-24 |
| AU682669B2 true AU682669B2 (en) | 1997-10-16 |
Family
ID=8211014
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU53726/94A Expired - Fee Related AU682669B2 (en) | 1992-11-03 | 1993-11-03 | Allergenic extracts |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0667788A1 (fr) |
| JP (1) | JPH08505126A (fr) |
| AU (1) | AU682669B2 (fr) |
| CA (1) | CA2148007A1 (fr) |
| WO (1) | WO1994009824A1 (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1834649A1 (fr) * | 2006-03-14 | 2007-09-19 | Alk-Abello A/S | Méthode pour développer un procédé pour la préparation d'un extrait d'allergène |
| DK1834648T3 (da) * | 2006-03-14 | 2013-11-04 | Alk Abello As | Fremgangsmåde til fremstilling af et allergenekstrakt |
| US7887821B2 (en) | 2007-12-20 | 2011-02-15 | Alk-Abello A/S | Process for producing an allergen extract |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7316346A (fr) * | 1972-12-11 | 1974-06-13 | ||
| US4364938A (en) * | 1981-02-13 | 1982-12-21 | Hoek Gijsberk T | Production of immunogenic products and treatment of allergic reactions therewith |
-
1993
- 1993-11-03 WO PCT/EP1993/003041 patent/WO1994009824A1/fr not_active Application Discontinuation
- 1993-11-03 EP EP93924086A patent/EP0667788A1/fr not_active Withdrawn
- 1993-11-03 AU AU53726/94A patent/AU682669B2/en not_active Expired - Fee Related
- 1993-11-03 CA CA002148007A patent/CA2148007A1/fr not_active Abandoned
- 1993-11-03 JP JP6510713A patent/JPH08505126A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JPH08505126A (ja) | 1996-06-04 |
| CA2148007A1 (fr) | 1994-05-11 |
| EP0667788A1 (fr) | 1995-08-23 |
| WO1994009824A1 (fr) | 1994-05-11 |
| AU5372694A (en) | 1994-05-24 |
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