AU674137B2 - Chiral synthesis with modified enzymes - Google Patents

Chiral synthesis with modified enzymes

Info

Publication number
AU674137B2
AU674137B2 AU33659/93A AU3365993A AU674137B2 AU 674137 B2 AU674137 B2 AU 674137B2 AU 33659/93 A AU33659/93 A AU 33659/93A AU 3365993 A AU3365993 A AU 3365993A AU 674137 B2 AU674137 B2 AU 674137B2
Authority
AU
Australia
Prior art keywords
enzyme
dna
region
loop
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU33659/93A
Other languages
English (en)
Other versions
AU3365993A (en
Inventor
Ayman Elhawrani
Keith William Hart
Joseph John Holbrook
Helen Margaret Wilks
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euroapi UK Ltd
Original Assignee
Genzyme Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929202033A external-priority patent/GB9202033D0/en
Priority claimed from GB929204702A external-priority patent/GB9204702D0/en
Application filed by Genzyme Ltd filed Critical Genzyme Ltd
Publication of AU3365993A publication Critical patent/AU3365993A/en
Application granted granted Critical
Publication of AU674137B2 publication Critical patent/AU674137B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU33659/93A 1992-01-30 1993-01-29 Chiral synthesis with modified enzymes Ceased AU674137B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9202033 1992-01-30
GB929202033A GB9202033D0 (en) 1992-01-30 1992-01-30 Chiral synthesis
GB929204702A GB9204702D0 (en) 1992-03-04 1992-03-04 Chiral synthesis
GB9204702 1992-03-04
PCT/GB1993/000204 WO1993015208A1 (fr) 1992-01-30 1993-01-29 Synthese chirale effectuee au moyen d'enzymes modifiees

Publications (2)

Publication Number Publication Date
AU3365993A AU3365993A (en) 1993-09-01
AU674137B2 true AU674137B2 (en) 1996-12-12

Family

ID=26300234

Family Applications (1)

Application Number Title Priority Date Filing Date
AU33659/93A Ceased AU674137B2 (en) 1992-01-30 1993-01-29 Chiral synthesis with modified enzymes

Country Status (5)

Country Link
EP (1) EP0625205A1 (fr)
JP (1) JP3431146B2 (fr)
AU (1) AU674137B2 (fr)
CA (1) CA2127126A1 (fr)
WO (1) WO1993015208A1 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5332699A (en) * 1986-02-20 1994-07-26 Manville Corp Inorganic fiber composition
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US20060257890A1 (en) * 1996-05-20 2006-11-16 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6165793A (en) * 1996-03-25 2000-12-26 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6335160B1 (en) 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
US6309883B1 (en) 1994-02-17 2001-10-30 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
EP0806964B1 (fr) * 1994-12-23 2002-08-14 AstraZeneca AB Composes chimiques
KR19990036383A (ko) 1995-08-16 1999-05-25 크로우 캐씨 엘 화학적 화합물
US6153410A (en) * 1997-03-25 2000-11-28 California Institute Of Technology Recombination of polynucleotide sequences using random or defined primers
GB9712512D0 (en) 1997-06-16 1997-08-20 Bioinvent Int Ab A method for in vitro molecular evolution of protein function
US6958213B2 (en) 2000-12-12 2005-10-25 Alligator Bioscience Ab Method for in vitro molecular evolution of protein function
US20020086292A1 (en) 2000-12-22 2002-07-04 Shigeaki Harayama Synthesis of hybrid polynucleotide molecules using single-stranded polynucleotide molecules
WO2003031368A2 (fr) 2001-10-09 2003-04-17 3M Innovative Properties Company Compositions contenant des fibres inorganiques biosolubles et des liants micaces
GB2383793B (en) * 2002-01-04 2003-11-19 Morgan Crucible Co Saline soluble inorganic fibres
US9919957B2 (en) 2016-01-19 2018-03-20 Unifrax I Llc Inorganic fiber

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0285123A2 (fr) * 1987-04-03 1988-10-05 Stabra AG Méthode de mutagénèse complète d'acides nucléiques
EP0319759A2 (fr) * 1987-12-11 1989-06-14 Abbott Laboratories Méthode de mutagénèse par réparation de rupture de chaîne dirigée par une oligonucléotide
EP0383620A2 (fr) * 1989-02-17 1990-08-22 Repligen Corporation Procédé de préparation de gènes codant des polymères statistiques d'aminoacides

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ208612A (en) * 1983-06-24 1991-09-25 Genentech Inc Method of producing "procaryotic carbonyl hydrolases" containing predetermined, site specific mutations
DE3750916T2 (de) * 1986-04-30 1995-06-01 Genencor Int Mutante einer nicht menschlichen Carbonyl-Hydrolase, für diese kodierende DNS-Sequenzen und Vektoren und durch diese Vektoren transformierte Wirte.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0285123A2 (fr) * 1987-04-03 1988-10-05 Stabra AG Méthode de mutagénèse complète d'acides nucléiques
EP0319759A2 (fr) * 1987-12-11 1989-06-14 Abbott Laboratories Méthode de mutagénèse par réparation de rupture de chaîne dirigée par une oligonucléotide
EP0383620A2 (fr) * 1989-02-17 1990-08-22 Repligen Corporation Procédé de préparation de gènes codant des polymères statistiques d'aminoacides

Also Published As

Publication number Publication date
JP3431146B2 (ja) 2003-07-28
JPH07503371A (ja) 1995-04-13
EP0625205A1 (fr) 1994-11-23
CA2127126A1 (fr) 1993-08-05
AU3365993A (en) 1993-09-01
WO1993015208A1 (fr) 1993-08-05

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired