AU667889B2 - Novel cardioprotective agents - Google Patents

Novel cardioprotective agents Download PDF

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Publication number
AU667889B2
AU667889B2 AU37972/93A AU3797293A AU667889B2 AU 667889 B2 AU667889 B2 AU 667889B2 AU 37972/93 A AU37972/93 A AU 37972/93A AU 3797293 A AU3797293 A AU 3797293A AU 667889 B2 AU667889 B2 AU 667889B2
Authority
AU
Australia
Prior art keywords
compound
tetramethyl
compound according
dihydro
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU37972/93A
Other languages
English (en)
Other versions
AU3797293A (en
Inventor
Frank Bolkenius
J. Martin Grisar
Margaret A. Petty
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Publication of AU3797293A publication Critical patent/AU3797293A/en
Application granted granted Critical
Publication of AU667889B2 publication Critical patent/AU667889B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Paints Or Removers (AREA)
  • Pyrane Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AU37972/93A 1992-04-06 1993-03-08 Novel cardioprotective agents Ceased AU667889B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP92400957 1992-04-06
EP92400957 1992-04-06
PCT/US1993/002102 WO1993020058A1 (en) 1992-04-06 1993-03-08 Novel cardioprotective agents

Publications (2)

Publication Number Publication Date
AU3797293A AU3797293A (en) 1993-11-08
AU667889B2 true AU667889B2 (en) 1996-04-18

Family

ID=8211647

Family Applications (1)

Application Number Title Priority Date Filing Date
AU37972/93A Ceased AU667889B2 (en) 1992-04-06 1993-03-08 Novel cardioprotective agents

Country Status (18)

Country Link
EP (1) EP0635010B1 (en:Method)
JP (1) JP3248183B2 (en:Method)
KR (1) KR100243820B1 (en:Method)
AT (1) ATE146175T1 (en:Method)
AU (1) AU667889B2 (en:Method)
CA (1) CA2132745C (en:Method)
DE (1) DE69306559T2 (en:Method)
DK (1) DK0635010T3 (en:Method)
ES (1) ES2098030T3 (en:Method)
FI (1) FI112658B (en:Method)
GR (1) GR3022471T3 (en:Method)
HU (1) HU217426B (en:Method)
IL (1) IL105320A (en:Method)
NO (1) NO307088B1 (en:Method)
NZ (1) NZ251131A (en:Method)
TW (1) TW232014B (en:Method)
WO (1) WO1993020058A1 (en:Method)
ZA (1) ZA932326B (en:Method)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5721233A (en) * 1992-04-06 1998-02-24 Merrell Pharmaceuticals Inc. Derivatives of 2,3-dihydro benzofuranols
US5545660A (en) * 1992-04-07 1996-08-13 Merrell Pharmaceuticals Inc. Hydrazide derivatives of 3,4-dihydro-2H-1-benzopyrans
US5451603A (en) * 1993-03-11 1995-09-19 Zymogenetics, Inc. 3,4-diarylchromans for treatment of dermatitis
US5416098A (en) * 1993-12-30 1995-05-16 Zymogenetics, Inc. Method for treating dermatitis and related conditions
CN115073413B (zh) * 2022-05-17 2023-06-02 中山大学 一种苯并环醚类倍半萜类化合物及其制备方法与应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6400973A (en) * 1972-12-22 1975-07-03 F. Hoffmann-Laroche & Co. Aktiengesellschaft Chromane derivatives
AU4468289A (en) * 1988-11-14 1990-05-17 Merrell Dow Pharmaceuticals Inc. Cardioprotective tocopherol analogs

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947473A (en) * 1972-12-22 1976-03-30 Hoffman-La Roche Inc. Antioxidant chroman compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6400973A (en) * 1972-12-22 1975-07-03 F. Hoffmann-Laroche & Co. Aktiengesellschaft Chromane derivatives
AU4468289A (en) * 1988-11-14 1990-05-17 Merrell Dow Pharmaceuticals Inc. Cardioprotective tocopherol analogs

Also Published As

Publication number Publication date
EP0635010B1 (en) 1996-12-11
CA2132745A1 (en) 1993-10-14
FI112658B (fi) 2003-12-31
DK0635010T3 (da) 1996-12-30
KR950700896A (ko) 1995-02-20
HUT68982A (en) 1995-08-28
TW232014B (en:Method) 1994-10-11
FI944656A0 (fi) 1994-10-05
DE69306559D1 (de) 1997-01-23
ATE146175T1 (de) 1996-12-15
GR3022471T3 (en) 1997-05-31
NO943727L (no) 1994-12-05
NO307088B1 (no) 2000-02-07
HU9402863D0 (en) 1995-01-30
WO1993020058A1 (en) 1993-10-14
CA2132745C (en) 2000-03-21
NZ251131A (en) 1996-01-26
IL105320A (en) 1998-02-08
FI944656L (fi) 1994-10-05
ES2098030T3 (es) 1997-04-16
AU3797293A (en) 1993-11-08
DE69306559T2 (de) 1997-04-10
KR100243820B1 (ko) 2000-03-02
JPH07505392A (ja) 1995-06-15
JP3248183B2 (ja) 2002-01-21
EP0635010A1 (en) 1995-01-25
IL105320A0 (en) 1993-08-18
ZA932326B (en) 1993-10-18
NO943727D0 (no) 1994-10-05
HU217426B (hu) 2000-01-28

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired