AU661659B2 - Anti-thrombotic peptide and pseudopeptide derivatives - Google Patents

Anti-thrombotic peptide and pseudopeptide derivatives Download PDF

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Publication number
AU661659B2
AU661659B2 AU80896/91A AU8089691A AU661659B2 AU 661659 B2 AU661659 B2 AU 661659B2 AU 80896/91 A AU80896/91 A AU 80896/91A AU 8089691 A AU8089691 A AU 8089691A AU 661659 B2 AU661659 B2 AU 661659B2
Authority
AU
Australia
Prior art keywords
aspartyl
valine
trifluoroacetate
compound
guanidi
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU80896/91A
Other languages
English (en)
Other versions
AU8089691A (en
Inventor
Michael R. Becker
Mark Czekaj
Jeffrey M Dener
Scott I Klein
Bruce F. Molino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Rorer International Holdings Inc
Original Assignee
Rhone Poulenc Rorer International Holdings Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer International Holdings Inc filed Critical Rhone Poulenc Rorer International Holdings Inc
Publication of AU8089691A publication Critical patent/AU8089691A/en
Application granted granted Critical
Publication of AU661659B2 publication Critical patent/AU661659B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU80896/91A 1991-04-11 1991-04-11 Anti-thrombotic peptide and pseudopeptide derivatives Ceased AU661659B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1991/002471 WO1992018117A1 (fr) 1991-04-11 1991-04-11 Derives peptidiques et pseudopeptidiques antithrombotiques

Publications (2)

Publication Number Publication Date
AU8089691A AU8089691A (en) 1992-11-17
AU661659B2 true AU661659B2 (en) 1995-08-03

Family

ID=22225448

Family Applications (1)

Application Number Title Priority Date Filing Date
AU80896/91A Ceased AU661659B2 (en) 1991-04-11 1991-04-11 Anti-thrombotic peptide and pseudopeptide derivatives

Country Status (4)

Country Link
EP (1) EP0584066A4 (fr)
JP (1) JPH08503920A (fr)
AU (1) AU661659B2 (fr)
WO (1) WO1992018117A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08505846A (ja) * 1992-12-29 1996-06-25 スミスクライン・ビーチャム・コーポレイション 血小板凝集阻害用化合物
US5652242A (en) * 1993-03-29 1997-07-29 Zeneca Limited Heterocyclic derivatives
US5750754A (en) * 1993-03-29 1998-05-12 Zeneca Limited Heterocyclic compounds
US5753659A (en) * 1993-03-29 1998-05-19 Zeneca Limited Heterocyclic compouds
DK0825184T3 (da) * 1993-03-29 2001-09-10 Astrazeneca Ab Heterocykliske derivater som blodpladeaggregeringsinhibitorer
WO1994022835A2 (fr) * 1993-03-29 1994-10-13 Zeneca Limited Composes heterocycliques en tant qu'inhibiteurs de l'agregation plaquettaire
US5463011A (en) * 1993-06-28 1995-10-31 Zeneca Limited Acid derivatives
GB9313268D0 (en) * 1993-06-28 1993-08-11 Zeneca Ltd Chemical compounds
GB9313285D0 (en) * 1993-06-28 1993-08-11 Zeneca Ltd Acid derivatives
CZ291378B6 (cs) * 1993-10-15 2003-02-12 Aventis Pharmaceuticals Inc. Pseudopeptidové sloučeniny jako antitrombotické látky, farmaceutické prostředky obsahující tyto sloučeniny a meziprodukty
US5780590A (en) * 1993-10-15 1998-07-14 Rhone-Poulenc Rorer Pharmaceuticals Inc. Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4634715A (en) * 1981-02-17 1987-01-06 Merck & Co., Inc. Aza analogs of carboxyalkyl dipeptide derivatives as antihypertensives
US4870207A (en) * 1983-06-17 1989-09-26 Zaiden Hojin Biseibutsu Kagaku Kenkyu Kai Synthesis of arphamenine A
US4956504A (en) * 1986-04-04 1990-09-11 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Novel spergualin-related compounds and process for producing the same

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4105789A (en) * 1976-05-10 1978-08-08 E. R. Squibb & Sons, Inc. Carboxyalkylacylamino acids
JPS5753446A (en) * 1980-09-16 1982-03-30 Torii Yakuhin Kk Peptide derivative
US4857508A (en) * 1987-12-03 1989-08-15 Monsanto Company Novel platelet-aggregation inhibitor peptide derivatives
US4879313A (en) * 1988-07-20 1989-11-07 Mosanto Company Novel platelet-aggregation inhibitors
US4952562A (en) * 1989-09-29 1990-08-28 Rorer Pharmaceutical Corporation Anti-thrombotic peptides and pseudopeptides
US5086069A (en) * 1990-02-05 1992-02-04 Rorer Pharmaceutical Corporation Anti-thrombotic peptide and pseudopeptide derivatives
CA2037153A1 (fr) * 1990-03-09 1991-09-10 Leo Alig Derives de l'acide acetique
GB9007751D0 (en) * 1990-04-05 1990-06-06 Ciba Geigy Ag Novel platelet-aggregation inhibitors
JPH06505978A (ja) * 1991-02-05 1994-07-07 スミスクライン・ビーチャム・コーポレイション 芳香族エステルまたはアミドを含有する抗凝集性ペプチド
IE920710A1 (en) * 1991-03-06 1992-09-09 Searle & Co Phenyl amidines derivatives useful as platelet aggregation¹inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4634715A (en) * 1981-02-17 1987-01-06 Merck & Co., Inc. Aza analogs of carboxyalkyl dipeptide derivatives as antihypertensives
US4870207A (en) * 1983-06-17 1989-09-26 Zaiden Hojin Biseibutsu Kagaku Kenkyu Kai Synthesis of arphamenine A
US4956504A (en) * 1986-04-04 1990-09-11 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Novel spergualin-related compounds and process for producing the same

Also Published As

Publication number Publication date
JPH08503920A (ja) 1996-04-30
EP0584066A4 (fr) 1994-10-12
AU8089691A (en) 1992-11-17
WO1992018117A1 (fr) 1992-10-29
EP0584066A1 (fr) 1994-03-02

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