AU658403B2 - Technetium-99m labeling of proteins - Google Patents

Technetium-99m labeling of proteins Download PDF

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Publication number
AU658403B2
AU658403B2 AU14576/92A AU1457692A AU658403B2 AU 658403 B2 AU658403 B2 AU 658403B2 AU 14576/92 A AU14576/92 A AU 14576/92A AU 1457692 A AU1457692 A AU 1457692A AU 658403 B2 AU658403 B2 AU 658403B2
Authority
AU
Australia
Prior art keywords
technetium
protein
antibody
dtpa
bound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU14576/92A
Other languages
English (en)
Other versions
AU1457692A (en
Inventor
Ramaswamy Subramanian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo NV
Original Assignee
Akzo NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo NV filed Critical Akzo NV
Publication of AU1457692A publication Critical patent/AU1457692A/en
Application granted granted Critical
Publication of AU658403B2 publication Critical patent/AU658403B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/008—Peptides; Proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AU14576/92A 1991-02-27 1992-02-27 Technetium-99m labeling of proteins Ceased AU658403B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US66179391A 1991-02-27 1991-02-27
US661793 1991-02-27
PCT/US1992/001577 WO1992015333A1 (en) 1991-02-27 1992-02-27 TECHNETIUM-99m LABELING OF PROTEINS

Publications (2)

Publication Number Publication Date
AU1457692A AU1457692A (en) 1992-10-06
AU658403B2 true AU658403B2 (en) 1995-04-13

Family

ID=24655142

Family Applications (1)

Application Number Title Priority Date Filing Date
AU14576/92A Ceased AU658403B2 (en) 1991-02-27 1992-02-27 Technetium-99m labeling of proteins

Country Status (7)

Country Link
EP (1) EP0573577A1 (fi)
JP (1) JPH06505990A (fi)
KR (1) KR100238558B1 (fi)
AU (1) AU658403B2 (fi)
CA (1) CA2104943A1 (fi)
FI (1) FI933760A0 (fi)
WO (1) WO1992015333A1 (fi)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9324807D0 (en) * 1993-12-03 1994-01-19 Cancer Res Campaign Tech Tumour antibody
US7232888B2 (en) 2002-07-01 2007-06-19 Massachusetts Institute Of Technology Antibodies against tumor surface antigens
EP3606664A1 (en) * 2017-04-05 2020-02-12 Archer Daniels Midland Co. Novel esterification catalyst and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988007382A2 (en) * 1987-04-02 1988-10-06 Centocor Cardiovascular Imaging Partners, L.P. Method for labelling antibodies with a metal ion
WO1989009405A1 (en) * 1988-04-01 1989-10-05 Immunomedics, Inc. Method for radiolabeling proteins

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4652440A (en) * 1984-05-03 1987-03-24 Paik Chang H Method of stably radiolabeling antibodies with technetium and rhenium
US4732974A (en) * 1986-03-05 1988-03-22 Mallinckrodt, Inc. Metal ion labeling of carrier molecules
US4877868A (en) * 1986-03-12 1989-10-31 Neorx Corporation Radionuclide antibody coupling
DE3728599A1 (de) * 1986-12-10 1988-06-23 Hoechst Ag Verfahren zur herstellung einer mit technetium-99m-markierten organspezifischen substanz
US5128119A (en) * 1989-06-12 1992-07-07 Immunomedics, Inc. Methods for technetium/rhenium labeling of f(ab1)2 fragments
DK0486622T3 (da) * 1989-08-09 1999-07-19 Rhomed Inc Direkte radiomærkning af antistoffer og andre proteiner med technetium eller rhenium
CA1340250C (en) * 1989-09-18 1998-12-15 Hans J. Hansen Method for rapidly radiolabeling monovalent antibody fragments with technetium

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988007382A2 (en) * 1987-04-02 1988-10-06 Centocor Cardiovascular Imaging Partners, L.P. Method for labelling antibodies with a metal ion
WO1989009405A1 (en) * 1988-04-01 1989-10-05 Immunomedics, Inc. Method for radiolabeling proteins

Also Published As

Publication number Publication date
FI933760A (fi) 1993-08-26
EP0573577A4 (fi) 1994-03-02
FI933760A0 (fi) 1993-08-26
JPH06505990A (ja) 1994-07-07
CA2104943A1 (en) 1992-08-28
EP0573577A1 (en) 1993-12-15
WO1992015333A1 (en) 1992-09-17
AU1457692A (en) 1992-10-06
KR100238558B1 (ko) 2000-02-01

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired