CA2104943A1 - Technetium-99m labeling of proteins - Google Patents

Technetium-99m labeling of proteins

Info

Publication number
CA2104943A1
CA2104943A1 CA002104943A CA2104943A CA2104943A1 CA 2104943 A1 CA2104943 A1 CA 2104943A1 CA 002104943 A CA002104943 A CA 002104943A CA 2104943 A CA2104943 A CA 2104943A CA 2104943 A1 CA2104943 A1 CA 2104943A1
Authority
CA
Canada
Prior art keywords
technetium
protein
antibody
binding
reducing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002104943A
Other languages
English (en)
French (fr)
Inventor
Ramaswamy Subramanian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo NV
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2104943A1 publication Critical patent/CA2104943A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/008—Peptides; Proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA002104943A 1991-02-27 1992-02-27 Technetium-99m labeling of proteins Abandoned CA2104943A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66179391A 1991-02-27 1991-02-27
US661,793 1991-02-27

Publications (1)

Publication Number Publication Date
CA2104943A1 true CA2104943A1 (en) 1992-08-28

Family

ID=24655142

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002104943A Abandoned CA2104943A1 (en) 1991-02-27 1992-02-27 Technetium-99m labeling of proteins

Country Status (7)

Country Link
EP (1) EP0573577A1 (fi)
JP (1) JPH06505990A (fi)
KR (1) KR100238558B1 (fi)
AU (1) AU658403B2 (fi)
CA (1) CA2104943A1 (fi)
FI (1) FI933760A0 (fi)
WO (1) WO1992015333A1 (fi)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9324807D0 (en) * 1993-12-03 1994-01-19 Cancer Res Campaign Tech Tumour antibody
US7232888B2 (en) 2002-07-01 2007-06-19 Massachusetts Institute Of Technology Antibodies against tumor surface antigens
EP3606664A1 (en) * 2017-04-05 2020-02-12 Archer Daniels Midland Co. Novel esterification catalyst and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4652440A (en) * 1984-05-03 1987-03-24 Paik Chang H Method of stably radiolabeling antibodies with technetium and rhenium
US4732974A (en) * 1986-03-05 1988-03-22 Mallinckrodt, Inc. Metal ion labeling of carrier molecules
US4877868A (en) * 1986-03-12 1989-10-31 Neorx Corporation Radionuclide antibody coupling
DE3728599A1 (de) * 1986-12-10 1988-06-23 Hoechst Ag Verfahren zur herstellung einer mit technetium-99m-markierten organspezifischen substanz
EP0354923B1 (en) * 1987-04-02 1994-06-29 Centocor, Inc. Method for labelling antibodies with a metal ion
US5061641A (en) * 1988-04-01 1991-10-29 Immunomedics, Inc. Method for radiolabeling proteins
US5128119A (en) * 1989-06-12 1992-07-07 Immunomedics, Inc. Methods for technetium/rhenium labeling of f(ab1)2 fragments
ATE172879T1 (de) * 1989-08-09 1998-11-15 Rhomed Inc Direkte radioetikettierung von antikörpern und sonstigen proteinen mittels technetium oder rhenium
CA1340250C (en) * 1989-09-18 1998-12-15 Hans J. Hansen Method for rapidly radiolabeling monovalent antibody fragments with technetium

Also Published As

Publication number Publication date
JPH06505990A (ja) 1994-07-07
FI933760A (fi) 1993-08-26
WO1992015333A1 (en) 1992-09-17
AU1457692A (en) 1992-10-06
EP0573577A4 (fi) 1994-03-02
FI933760A0 (fi) 1993-08-26
KR100238558B1 (ko) 2000-02-01
AU658403B2 (en) 1995-04-13
EP0573577A1 (en) 1993-12-15

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead