AU657554B2 - Dialkyl (dialkoxyphosphinyl)methyl phosphates as anti-inflammatory agents - Google Patents

Dialkyl (dialkoxyphosphinyl)methyl phosphates as anti-inflammatory agents Download PDF

Info

Publication number
AU657554B2
AU657554B2 AU20292/92A AU2029292A AU657554B2 AU 657554 B2 AU657554 B2 AU 657554B2 AU 20292/92 A AU20292/92 A AU 20292/92A AU 2029292 A AU2029292 A AU 2029292A AU 657554 B2 AU657554 B2 AU 657554B2
Authority
AU
Australia
Prior art keywords
group
alkyl
diethoxyphosphinyl
phosphoric acid
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU20292/92A
Other languages
English (en)
Other versions
AU2029292A (en
Inventor
Roy Allen Johnson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of AU2029292A publication Critical patent/AU2029292A/en
Application granted granted Critical
Publication of AU657554B2 publication Critical patent/AU657554B2/en
Assigned to PHARMACIA & UPJOHN COMPANY reassignment PHARMACIA & UPJOHN COMPANY Request to Amend Deed and Register Assignors: UPJOHN COMPANY, THE
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
    • C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analyzing Materials By The Use Of Fluid Adsorption Or Reactions (AREA)
  • Liquid Carbonaceous Fuels (AREA)
AU20292/92A 1991-06-19 1992-05-21 Dialkyl (dialkoxyphosphinyl)methyl phosphates as anti-inflammatory agents Ceased AU657554B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71742891A 1991-06-19 1991-06-19
US717428 1991-06-19
PCT/US1992/004013 WO1992022559A1 (en) 1991-06-19 1992-05-21 Dialkyl (dialkoxyphosphinyl)methyl phosphates as anti-inflammatory agents

Publications (2)

Publication Number Publication Date
AU2029292A AU2029292A (en) 1993-01-12
AU657554B2 true AU657554B2 (en) 1995-03-16

Family

ID=24881993

Family Applications (1)

Application Number Title Priority Date Filing Date
AU20292/92A Ceased AU657554B2 (en) 1991-06-19 1992-05-21 Dialkyl (dialkoxyphosphinyl)methyl phosphates as anti-inflammatory agents

Country Status (10)

Country Link
US (1) US5347029A (OSRAM)
EP (1) EP0590009B1 (OSRAM)
JP (1) JPH06508365A (OSRAM)
AT (1) ATE164163T1 (OSRAM)
AU (1) AU657554B2 (OSRAM)
CA (1) CA2102303A1 (OSRAM)
DE (1) DE69224830D1 (OSRAM)
MX (1) MX9202997A (OSRAM)
TW (1) TW201751B (OSRAM)
WO (1) WO1992022559A1 (OSRAM)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5681798A (en) * 1996-08-01 1997-10-28 Farng; Liehpao O. Load-carrying additives based on organo-phosphites and amine phosphates
AU2002322720B2 (en) 2001-07-25 2008-11-13 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
EP2206718B1 (en) * 2003-06-09 2012-11-07 Daihachi Chemical Industry Co., Ltd. Organophosphorus compound having phosphate-phosphonate bond, and flame-retardant polyester fiber and flame-retardant polyurethane resin composition each containing the same
CN102379684B (zh) 2005-04-28 2014-11-19 普罗透斯数字保健公司 药物信息系统
KR20090071598A (ko) 2006-09-18 2009-07-01 랩터 파마슈티컬 인코포레이티드 수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
CN102014897B (zh) 2008-04-21 2015-08-05 西格纳姆生物科学公司 化合物、组合物和其制备方法
EP2398500B1 (en) 2009-02-20 2019-03-13 2-BBB Medicines B.V. Glutathione-based drug delivery system
ES2942923T3 (es) 2009-05-06 2023-06-07 Laboratory Skin Care Inc Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
CN102630227B (zh) * 2009-10-26 2016-03-23 沃纳奇尔科特有限责任公司 用于治疗骨代谢紊乱的双膦酸盐化合物
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
ES2686880T3 (es) * 2016-03-31 2018-10-22 Ivoclar Vivadent Ag Monómeros híbridos ácidos y materiales dentales basados en los mismos
EP4146198A4 (en) 2020-05-08 2024-05-15 Psilera Inc. Novel compositions of matter and pharmaceutical compositions
CA3218110A1 (en) 2021-05-25 2022-12-01 Majed Fawaz New n,n-dimethyltryptamine salts and crystalline salt forms
EP4457214A4 (en) 2021-12-30 2025-12-03 Atai Therapeutics Inc DIMETHYLTRYPTAMINE ANALOGUES USED AS NITRIC OXIDE ADMINISTRATION MEDICINES
AU2023395940A1 (en) * 2022-12-15 2025-06-19 Atai Therapeutics, Inc. Prodrugs of dimethyltryptamine and derivatives thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0015370A1 (en) * 1979-02-13 1980-09-17 Symphar S.A. Diphosphonate or phosphate-phosphonate derivatives and pharmaceutical compositions containing them
EP0186405B1 (en) * 1984-12-21 1991-03-06 The Procter & Gamble Company Pharmaceutical compositions containing geminal diphosphonates

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB207285A (en) * 1922-09-06 1923-11-29 Herbert Cowburn Improvements in artificial flowers
US3808237A (en) * 1970-04-13 1974-04-30 Monsanto Co Substituted epoxy ethane polyphosphonic acids and salts
FR2531088B1 (fr) * 1982-07-29 1987-08-28 Sanofi Sa Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation
DE3623397A1 (de) * 1986-07-11 1988-01-14 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE3643684A1 (de) * 1986-12-20 1988-06-30 Hoechst Ag Verfahren zur herstellung von halogenierten phosphono-phosphorsaeureestern und ihre verwendung
US5190930A (en) * 1987-12-11 1993-03-02 Ciba-Geigy Corporation Araliphatylaminoalkanediphosphonic acids
CA1339805C (en) * 1988-01-20 1998-04-07 Yasuo Isomura (cycloalkylamino)methylenebis(phosphonic acid) and medicines containing the same as an active
JPH0377894A (ja) * 1989-08-18 1991-04-03 Toray Ind Inc メチレンジホスホン酸化合物
ATE133677T1 (de) * 1990-12-19 1996-02-15 Takeda Chemical Industries Ltd Bisphosphonsäurederivate, ihre produktion und ihre verwendung
US5254544A (en) * 1992-09-25 1993-10-19 E. R. Squibb & Sons, Inc. Hydroxyphosphinyl phosphonate squalene synthetase inhibitors and method

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0015370A1 (en) * 1979-02-13 1980-09-17 Symphar S.A. Diphosphonate or phosphate-phosphonate derivatives and pharmaceutical compositions containing them
EP0186405B1 (en) * 1984-12-21 1991-03-06 The Procter & Gamble Company Pharmaceutical compositions containing geminal diphosphonates

Also Published As

Publication number Publication date
CA2102303A1 (en) 1992-12-20
ATE164163T1 (de) 1998-04-15
MX9202997A (es) 1993-02-01
WO1992022559A1 (en) 1992-12-23
DE69224830D1 (en) 1998-04-23
EP0590009A1 (en) 1994-04-06
US5347029A (en) 1994-09-13
TW201751B (OSRAM) 1993-03-11
JPH06508365A (ja) 1994-09-22
EP0590009B1 (en) 1998-03-18
AU2029292A (en) 1993-01-12

Similar Documents

Publication Publication Date Title
Froestl et al. Phosphinic acid analogs of GABA. 1. New potent and selective GABAB agonists
Blazis et al. Reactions of Chiral Phosphorous Acid Diamides: The Asymmetric Synthesis of Chiral. alpha.-Hydroxy Phosphonamides, Phosphonates, and Phosphonic Acids
US4316896A (en) Aminoacid derivatives as antihypertensives
EP0590009B1 (en) Dialkyl (dialkoxyphosphinyl)methyl phosphates as anti-inflammatory agents
US5538957A (en) Phosphonosuccinic acid derivatives, processes for their preparation and medicaments containing these compounds
SU988194A3 (ru) Способ получени фосфинилалканоилпролинов
JPH0822865B2 (ja) フェノール置換ジェム―ジホスホネート誘導体、その調製法およびそれを含む医薬組成物
KR100233986B1 (ko) 신규한 메틸렌비 스포스폰산 유도체
EP0559079B1 (en) Substituted aminophosphonate derivatives, process for their preparation and pharmaceutical compositions containing them
IE59310B1 (en) Substituted alpha-amino acids, their preparation and pharmaceutical compositions containing them
US5273989A (en) 3,5-disubstituted 2-isoxazolines and isoxazoles, agents containing them and their use
RU2100364C1 (ru) Производные амидов метиленбисфосфоновых кислот и способы их получения
CZ121793A3 (en) Novel derivatives of methylbisphosphonic acid, process of their preparation and a pharmaceutical mixture therefrom
US5130304A (en) N-heterocyclic propylidene-1,1-bisphosphonic acids, their production and a pharmaceutical composition
US5424441A (en) N-aralkyl-and N-heteroaralkyl-aminoalkanephosphinic acids
US5294608A (en) Guanidinoalkyl-1,1-bisphosphonic acid derivatives, process for their preparation and their use
AU670457B2 (en) Alpha-phosphonosulfonate squalene synthetase inhibitors and method
DE69022593T2 (de) Neue methylenbisphosphonsäurederivate.
CA2511753C (en) Phospholipid derivatives
AU652399B2 (en) New heterocyclic compounds as antagonists of excitatory amino acid receptors, processes for their preparation and their use
EP0364996A2 (en) Phosphono-hydroisoquinoline compounds useful in reducing neurotoxic injury
US5683994A (en) Phosphosuccinic acid derivatives, processes for the production thereof and pharmaceutical agents containing these compounds
US5177240A (en) O-phosphono(alkyl)-n-sulfonyl-phenyl-alanine derivatives useful as intermediates for preparation of phosphono-hydroisoquinolines
Broeders et al. A phosphorus-31 NMR stereochemical and kinetic study of the alkaline hydrolysis of cis-nucleoside 3', 5'-cyclic aryl [18O] monophosphates and unlabeled analogs
JPH0390091A (ja) 置換アミノ酸またはイミノ酸誘導体およびそれを含有する抗高血圧症剤