AU636433B2 - Process for dehydrating corticosteroid intermediates - Google Patents

Process for dehydrating corticosteroid intermediates

Info

Publication number
AU636433B2
AU636433B2 AU69625/91A AU6962591A AU636433B2 AU 636433 B2 AU636433 B2 AU 636433B2 AU 69625/91 A AU69625/91 A AU 69625/91A AU 6962591 A AU6962591 A AU 6962591A AU 636433 B2 AU636433 B2 AU 636433B2
Authority
AU
Australia
Prior art keywords
formula
defined hereinbefore
loweralkyl
acid
independently represent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU69625/91A
Other languages
English (en)
Other versions
AU6962591A (en
Inventor
Nicholas Carruthers
Sohaila Garshasb
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of AU6962591A publication Critical patent/AU6962591A/en
Application granted granted Critical
Publication of AU636433B2 publication Critical patent/AU636433B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/006—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Tires In General (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
AU69625/91A 1989-11-27 1990-11-26 Process for dehydrating corticosteroid intermediates Ceased AU636433B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44150089A 1989-11-27 1989-11-27
US441500 1989-11-27

Publications (2)

Publication Number Publication Date
AU6962591A AU6962591A (en) 1991-06-26
AU636433B2 true AU636433B2 (en) 1993-04-29

Family

ID=23753123

Family Applications (1)

Application Number Title Priority Date Filing Date
AU69625/91A Ceased AU636433B2 (en) 1989-11-27 1990-11-26 Process for dehydrating corticosteroid intermediates

Country Status (14)

Country Link
EP (1) EP0502112A1 (oth)
JP (1) JPH05504561A (oth)
KR (1) KR927003619A (oth)
AU (1) AU636433B2 (oth)
CA (1) CA2069645A1 (oth)
HU (1) HUT61030A (oth)
IE (1) IE904252A1 (oth)
IL (1) IL96459A0 (oth)
MY (1) MY105302A (oth)
NZ (1) NZ236206A (oth)
PT (1) PT95988A (oth)
TW (1) TW218022B (oth)
WO (1) WO1991008218A1 (oth)
ZA (1) ZA909444B (oth)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108033990A (zh) * 2017-12-29 2018-05-15 广西万德药业有限公司 地塞米松中间体的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4585590A (en) * 1984-02-03 1986-04-29 The Upjohn Company Cyanohydrin process
EP0294911A1 (en) * 1987-06-12 1988-12-14 Roussel-Uclaf Process for the preparation of 9(11)-dehydro steroids
EP0336521A1 (en) * 1988-04-08 1989-10-11 Roussel-Uclaf 9-Alpha-hydroxy-17-methylene steroids, process for their preparation and their use in the preparation of corticosteroids

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4102907A (en) * 1977-03-07 1978-07-25 The Upjohn Company Desulfinylation process for preparing androsta-4,9(11)-diene-3,17-dione
US4127596A (en) * 1977-04-11 1978-11-28 The Upjohn Company Non-aromatic oxygenated strong acid dehydration of 9α-hydroxyandrostenediones
FR2493324B1 (oth) * 1980-11-05 1983-01-21 Roussel Uclaf
US5352809A (en) * 1986-10-10 1994-10-04 Gist-Brocades N.V. 9-alpha-hydroxy steroids, process for their preparation, process for the preparation of the corresponding 9(11)-dehydro derivatives and pharmaceutical preparations containing such steroids

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4585590A (en) * 1984-02-03 1986-04-29 The Upjohn Company Cyanohydrin process
EP0294911A1 (en) * 1987-06-12 1988-12-14 Roussel-Uclaf Process for the preparation of 9(11)-dehydro steroids
EP0336521A1 (en) * 1988-04-08 1989-10-11 Roussel-Uclaf 9-Alpha-hydroxy-17-methylene steroids, process for their preparation and their use in the preparation of corticosteroids

Also Published As

Publication number Publication date
NZ236206A (en) 1993-03-26
AU6962591A (en) 1991-06-26
MY105302A (en) 1994-09-30
WO1991008218A1 (en) 1991-06-13
ZA909444B (en) 1991-08-28
IL96459A0 (en) 1991-08-16
EP0502112A1 (en) 1992-09-09
HU9201750D0 (en) 1992-08-28
KR927003619A (ko) 1992-12-18
IE904252A1 (en) 1991-06-05
HUT61030A (en) 1992-11-30
CA2069645A1 (en) 1991-05-28
PT95988A (pt) 1991-09-13
JPH05504561A (ja) 1993-07-15
TW218022B (oth) 1993-12-21

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