AU629048B2 - N-(-4-(phenyl)-1,2-dihydro-3-quinolyl)-N'-(phenyl) urea derivatives and their use - Google Patents
N-(-4-(phenyl)-1,2-dihydro-3-quinolyl)-N'-(phenyl) urea derivatives and their useInfo
- Publication number
- AU629048B2 AU629048B2 AU63707/90A AU6370790A AU629048B2 AU 629048 B2 AU629048 B2 AU 629048B2 AU 63707/90 A AU63707/90 A AU 63707/90A AU 6370790 A AU6370790 A AU 6370790A AU 629048 B2 AU629048 B2 AU 629048B2
- Authority
- AU
- Australia
- Prior art keywords
- phenyl
- quinolyl
- dihydro
- chem
- urea derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- OUJIBGNLZGAJAG-UHFFFAOYSA-N 1-phenyl-3-(4-phenyl-1,2-dihydroquinolin-3-yl)urea Chemical class C1(=CC=CC=C1)C1=C(CNC2=CC=CC=C12)NC(=O)NC1=CC=CC=C1 OUJIBGNLZGAJAG-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 102000001494 Sterol O-Acyltransferase Human genes 0.000 abstract 1
- 108010054082 Sterol O-acyltransferase Proteins 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Holo Graphy (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Measurement Of Radiation (AREA)
- Quinoline Compounds (AREA)
- Detergent Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26278289 | 1989-10-06 | ||
| JP1-262782 | 1989-10-06 | ||
| JP32229089 | 1989-12-11 | ||
| JP1-322290 | 1989-12-11 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU6370790A AU6370790A (en) | 1991-04-11 |
| AU629048B2 true AU629048B2 (en) | 1992-09-24 |
Family
ID=26545706
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU63707/90A Ceased AU629048B2 (en) | 1989-10-06 | 1990-09-28 | N-(-4-(phenyl)-1,2-dihydro-3-quinolyl)-N'-(phenyl) urea derivatives and their use |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5223513A (OSRAM) |
| EP (1) | EP0421456B1 (OSRAM) |
| KR (1) | KR910007883A (OSRAM) |
| CN (1) | CN1050715A (OSRAM) |
| AT (1) | ATE116301T1 (OSRAM) |
| AU (1) | AU629048B2 (OSRAM) |
| CA (1) | CA2026890C (OSRAM) |
| DE (1) | DE69015541T2 (OSRAM) |
| FI (1) | FI904915A7 (OSRAM) |
| HU (1) | HUT55364A (OSRAM) |
| IE (1) | IE903454A1 (OSRAM) |
| IL (1) | IL95839A (OSRAM) |
| NO (1) | NO904300L (OSRAM) |
| NZ (1) | NZ235582A (OSRAM) |
| PT (1) | PT95515A (OSRAM) |
| RU (1) | RU2001910C1 (OSRAM) |
| TW (1) | TW205037B (OSRAM) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03181465A (ja) * | 1989-12-11 | 1991-08-07 | Takeda Chem Ind Ltd | キノリン誘導体 |
| WO1992019614A1 (en) * | 1991-04-26 | 1992-11-12 | Pfizer Inc. | 4-aryl-3-(heteroarylureido)quinoline derivatives |
| AU3323393A (en) * | 1992-01-23 | 1993-09-01 | Pfizer Inc. | 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents |
| TW241258B (OSRAM) * | 1992-04-15 | 1995-02-21 | Takeda Pharm Industry Co Ltd | |
| JPH07503737A (ja) * | 1992-05-28 | 1995-04-20 | フアイザー・インコーポレイテツド | アシル補酵素ａ：コレステロールアシルトランスフェラーゼ（ａｃａｔ）の阻害剤としての新規なｎ−アリールおよびｎ−ヘテロアリール尿素誘導体 |
| DE69315920T2 (de) * | 1992-09-04 | 1998-06-10 | Takeda Chemical Industries Ltd | Kondensierte heterozyklische Verbindungen, deren Herstellung und Verwendung |
| US5565472A (en) * | 1992-12-21 | 1996-10-15 | Pfizer Inc. | 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents |
| NZ264063A (en) * | 1993-08-13 | 1995-11-27 | Nihon Nohyaku Co Ltd | N-(2-phenylpyrid-3-yl)- and n-(4-phenylpyrimidin-5-yl)-n'-phenylurea derivatives and pharmaceutical compositions |
| TW263498B (OSRAM) * | 1993-11-10 | 1995-11-21 | Takeda Pharm Industry Co Ltd | |
| US6133326A (en) | 1994-08-31 | 2000-10-17 | Pfizer Inc | Compositions and methods for decreasing sebum production |
| US5843957A (en) * | 1995-05-19 | 1998-12-01 | Sumitomo Pharmaceuticals Company, Ltd. | Naphthyridine derivatives |
| JP2001513560A (ja) * | 1997-08-28 | 2001-09-04 | ブリストル−マイヤーズ スクイブ カンパニー | ４−アリール−３−アミノキノリン−２−オン誘導体カリウムチャンネル調節剤 |
| US6452008B2 (en) | 1998-02-25 | 2002-09-17 | Sumitomo Pharmaceuticals Company, Limited | Pyridone derivatives and process for preparing the same |
| CA2321237A1 (en) | 1998-02-25 | 1999-09-02 | Masami Muraoka | Pyridone derivatives and process for producing the same |
| CN1129582C (zh) * | 1998-12-04 | 2003-12-03 | 布里斯托尔-迈尔斯斯奎布公司 | 作为钾通道调节剂的3－取代－4－芳基喹啉－2－酮衍生物 |
| WO2001056556A2 (en) * | 2000-02-02 | 2001-08-09 | Warner-Lambert Company | Dual inhibitors of cholesteryl ester and wax ester synthesis for sebaceous gland disorders |
| CN1234691C (zh) * | 2001-03-02 | 2006-01-04 | 住友化学工业株式会社 | 喹啉－3－羧酸化合物的制备方法 |
| PL366700A1 (en) * | 2001-04-30 | 2005-02-07 | Pfizer Products Inc. | Methods for preparing cetp inhibitors |
| CA2539760C (en) * | 2003-09-23 | 2011-01-25 | Merck & Co., Inc. | Quinoline potassium channel inhibitors |
| WO2013064465A1 (en) * | 2011-11-04 | 2013-05-10 | F. Hoffmann-La Roche Ag | New aryl-quinoline derivatives |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1216878B (de) * | 1963-04-02 | 1966-05-18 | Cassella Farbwerke Mainkur Ag | Verfahren zur Herstellung von coronargefaesserweiternden Derivaten des 7-Hydroxy-2-oxo-1, 2-dihydrochinolins |
| NO133758C (OSRAM) * | 1970-04-04 | 1976-06-23 | Takeda Chemical Industries Ltd | |
| JPS555502B1 (OSRAM) * | 1971-07-31 | 1980-02-07 | ||
| US4530931A (en) * | 1983-01-03 | 1985-07-23 | Usv Pharmaceutical Corp. | 8-Quinoline carbanilates for the inhibition of lipolysis |
| DE3586445T2 (de) * | 1984-06-26 | 1993-01-14 | Merck & Co Inc | Kondensierte benzo-laktam-verbindungen und deren pharmazeutische zusammensetzungen. |
| IE892088L (en) * | 1988-07-12 | 1990-01-12 | William Henry Deryk Morris | Quinoline derivatives, their production and use |
-
1990
- 1990-09-20 TW TW079107912A patent/TW205037B/zh active
- 1990-09-25 US US07/587,795 patent/US5223513A/en not_active Expired - Fee Related
- 1990-09-25 IE IE345490A patent/IE903454A1/en unknown
- 1990-09-28 IL IL9583990A patent/IL95839A/en not_active IP Right Cessation
- 1990-09-28 AU AU63707/90A patent/AU629048B2/en not_active Ceased
- 1990-10-03 NO NO90904300A patent/NO904300L/no unknown
- 1990-10-04 PT PT95515A patent/PT95515A/pt not_active Application Discontinuation
- 1990-10-04 CA CA002026890A patent/CA2026890C/en not_active Expired - Fee Related
- 1990-10-05 NZ NZ235582A patent/NZ235582A/en unknown
- 1990-10-05 RU SU904831426A patent/RU2001910C1/ru active
- 1990-10-05 EP EP90119128A patent/EP0421456B1/en not_active Expired - Lifetime
- 1990-10-05 FI FI904915A patent/FI904915A7/fi not_active Application Discontinuation
- 1990-10-05 HU HU906360A patent/HUT55364A/hu unknown
- 1990-10-05 CN CN90108222A patent/CN1050715A/zh active Pending
- 1990-10-05 DE DE69015541T patent/DE69015541T2/de not_active Expired - Fee Related
- 1990-10-05 AT AT90119128T patent/ATE116301T1/de not_active IP Right Cessation
- 1990-10-06 KR KR1019900015908A patent/KR910007883A/ko not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JPH03223254A (ja) | 1991-10-02 |
| NZ235582A (en) | 1992-03-26 |
| PT95515A (pt) | 1991-08-14 |
| EP0421456A2 (en) | 1991-04-10 |
| DE69015541T2 (de) | 1995-06-01 |
| IL95839A0 (en) | 1991-06-30 |
| IE903454A1 (en) | 1991-04-10 |
| EP0421456A3 (en) | 1991-05-29 |
| HUT55364A (en) | 1991-05-28 |
| KR910007883A (ko) | 1991-05-30 |
| HU906360D0 (en) | 1991-04-29 |
| NO904300D0 (no) | 1990-10-03 |
| FI904915A7 (fi) | 1991-04-07 |
| AU6370790A (en) | 1991-04-11 |
| DE69015541D1 (de) | 1995-02-09 |
| CA2026890C (en) | 2001-09-18 |
| IL95839A (en) | 1995-03-15 |
| FI904915A0 (fi) | 1990-10-05 |
| RU2001910C1 (ru) | 1993-10-30 |
| NO904300L (no) | 1991-04-08 |
| EP0421456B1 (en) | 1994-12-28 |
| ATE116301T1 (de) | 1995-01-15 |
| CN1050715A (zh) | 1991-04-17 |
| US5223513A (en) | 1993-06-29 |
| CA2026890A1 (en) | 1991-04-07 |
| TW205037B (OSRAM) | 1993-05-01 |
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