AU6272598A - Highly lipophilic camptothecin derivatives - Google Patents
Highly lipophilic camptothecin derivativesInfo
- Publication number
- AU6272598A AU6272598A AU62725/98A AU6272598A AU6272598A AU 6272598 A AU6272598 A AU 6272598A AU 62725/98 A AU62725/98 A AU 62725/98A AU 6272598 A AU6272598 A AU 6272598A AU 6272598 A AU6272598 A AU 6272598A
- Authority
- AU
- Australia
- Prior art keywords
- derivatives
- camptothecin derivatives
- highly lipophilic
- lipophilic camptothecin
- substitution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000006467 substitution reaction Methods 0.000 abstract 2
- 229940123780 DNA topoisomerase I inhibitor Drugs 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000000365 Topoisomerase I Inhibitor Substances 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000008024 pharmaceutical diluent Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 229940124531 pharmaceutical excipient Drugs 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Silicon Polymers (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3714897P | 1997-02-14 | 1997-02-14 | |
| US60037148 | 1997-02-14 | ||
| PCT/US1998/002375 WO1998035940A1 (en) | 1997-02-14 | 1998-02-11 | Highly lipophilic camptothecin derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU6272598A true AU6272598A (en) | 1998-09-08 |
Family
ID=21892705
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU62725/98A Abandoned AU6272598A (en) | 1997-02-14 | 1998-02-11 | Highly lipophilic camptothecin derivatives |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1017675B1 (enExample) |
| JP (2) | JP4311765B2 (enExample) |
| AT (1) | ATE329903T1 (enExample) |
| AU (1) | AU6272598A (enExample) |
| CA (1) | CA2280905C (enExample) |
| DE (1) | DE69834923T2 (enExample) |
| DK (1) | DK1017675T3 (enExample) |
| ES (1) | ES2262223T3 (enExample) |
| PT (1) | PT1017675E (enExample) |
| WO (1) | WO1998035940A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6743917B2 (en) | 1993-06-30 | 2004-06-01 | University Of Pittsburgh | Camptothecin analogs and methods of preparation thereof |
| US6150343A (en) | 1993-06-30 | 2000-11-21 | University Of Pittsburgh | Camptothecin analogs and methods of preparation thereof |
| US6136978A (en) * | 1993-06-30 | 2000-10-24 | University Of Pittsburgh | Camptothecin analogs and methods of preparation thereof |
| FR2790261B1 (fr) | 1999-02-26 | 2004-09-10 | Sod Conseils Rech Applic | Nouveaux analogues optiquement purs de la camptothecine et leurs procedes de preparation |
| CA2280905C (en) * | 1997-02-14 | 2006-08-29 | Bionumerik Pharmaceuticals, Inc. | Highly lipophilic camptothecin derivatives |
| US6057303A (en) * | 1998-10-20 | 2000-05-02 | Bionumerik Pharmaceuticals, Inc. | Highly lipophilic Camptothecin derivatives |
| US6207832B1 (en) | 1999-04-09 | 2001-03-27 | University Of Pittsburgh | Camptothecin analogs and methods of preparation thereof |
| WO2000066127A1 (en) * | 1999-05-04 | 2000-11-09 | Bionumerik Pharmaceuticals, Inc. | Novel highly lipophilic camptothecin analogs |
| US6350756B1 (en) * | 2001-01-18 | 2002-02-26 | California Pacific Medical Center | Camptothecin derivatives |
| US6855720B2 (en) | 2001-03-01 | 2005-02-15 | California Pacific Medical Center | Nitrogen-based camptothecin derivatives |
| US6372906B1 (en) | 2001-04-12 | 2002-04-16 | University Of Pittsburgh | Synthesis of silyl camptothecins and silyl homocamptothecins |
| US6723853B2 (en) | 2001-08-27 | 2004-04-20 | University Of Pittsburgh | Intermediates and methods of preparation of intermediates in the enantiomeric synthesis of (20R)homocamptothecins and the enantiomeric synthesis of (20R)homocamptothecins |
| MXPA04005185A (es) | 2001-11-30 | 2004-08-11 | Chugai Pharmaceutical Co Ltd | Compuestos hexaciclicos. |
| AU2003243380A1 (en) | 2002-06-03 | 2003-12-19 | California Pacific Medical Center | Nitrogen-based homo-camptothecin derivatives |
| EP1393719A1 (en) * | 2002-08-23 | 2004-03-03 | Munich Biotech AG | Camptothecin-carboxylate formulations |
| US7067666B2 (en) * | 2003-06-27 | 2006-06-27 | Research Triangle Institute | 7-substituted camptothecin and camptothecin analogs and methods for producing the same |
| EP1694242B1 (en) * | 2003-12-17 | 2014-04-16 | Bionumerik Pharmaceuticals, Inc. | Process for making pharmaceutical 7-(2-trimethylsilylethyl) camptothecin formulations |
| EP1757609B1 (en) | 2004-04-09 | 2013-10-16 | Chugai Seiyaku Kabushiki Kaisha | Novel water-soluble prodrug |
| ITRM20040240A1 (it) * | 2004-05-13 | 2004-08-13 | Ist Naz Stud Cura Dei Tumori | Camptotecine coniugate in posizione 7 con antagonisti delle integrine. |
| TW200744603A (en) | 2005-08-22 | 2007-12-16 | Chugai Pharmaceutical Co Ltd | Novel anticancer concomitant drug |
| US7875602B2 (en) | 2005-10-21 | 2011-01-25 | Sutter West Bay Hospitals | Camptothecin derivatives as chemoradiosensitizing agents |
| WO2007075492A1 (en) * | 2005-12-16 | 2007-07-05 | Sonus Pharmaceuticals, Inc. | Lipophilic anticancer drug compounds |
| KR20090036585A (ko) * | 2006-08-11 | 2009-04-14 | 더 크리스터스 스텔린 파운데이션 포 캔서 리서치 | 캄프토테신의 에스테르의 제조 방법 |
| WO2011155501A1 (ja) | 2010-06-11 | 2011-12-15 | 独立行政法人科学技術振興機構 | 薬剤多量体微粒子及びその製造方法 |
| WO2014067960A2 (en) * | 2012-10-30 | 2014-05-08 | Nerviano Medical Sciences S.R.L. | Functionalized 9-bromo-camptothecin derivatives |
| FR3029637B1 (fr) | 2014-12-05 | 2018-01-05 | Universite De Strasbourg | Microdispositif de detection de composes organiques volatils et methode de detection d'au moins un compose organique volatil compris dans un echantillon gazeux |
| WO2025077773A1 (zh) * | 2023-10-10 | 2025-04-17 | 上海翊维康医药有限责任公司 | 新的i型拓扑异构酶抑制剂及其制备方法和用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5004758A (en) * | 1987-12-01 | 1991-04-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells |
| JPH0615547B2 (ja) * | 1988-01-20 | 1994-03-02 | 株式会社ヤクルト本社 | 新規なカンプトテシン誘導体 |
| US5446047A (en) * | 1992-07-23 | 1995-08-29 | Sloan-Kettering Institute For Cancer Research | Camptothecin analogues |
| US5468754A (en) * | 1994-04-19 | 1995-11-21 | Bionumerik Pharmaceuticals, Inc. | 11,7 substituted camptothecin derivatives and formulations of 11,7 substituted camptothecin derivatives and methods for uses thereof |
| GB9510716D0 (en) * | 1995-05-26 | 1995-07-19 | Pharmacia Spa | Substituted camptothecin derivatives and process for their preparation |
| CA2280905C (en) * | 1997-02-14 | 2006-08-29 | Bionumerik Pharmaceuticals, Inc. | Highly lipophilic camptothecin derivatives |
-
1998
- 1998-02-11 CA CA002280905A patent/CA2280905C/en not_active Expired - Lifetime
- 1998-02-11 DK DK98904990T patent/DK1017675T3/da active
- 1998-02-11 DE DE69834923T patent/DE69834923T2/de not_active Expired - Lifetime
- 1998-02-11 EP EP98904990A patent/EP1017675B1/en not_active Expired - Lifetime
- 1998-02-11 JP JP53583598A patent/JP4311765B2/ja not_active Expired - Lifetime
- 1998-02-11 AT AT98904990T patent/ATE329903T1/de active
- 1998-02-11 ES ES98904990T patent/ES2262223T3/es not_active Expired - Lifetime
- 1998-02-11 AU AU62725/98A patent/AU6272598A/en not_active Abandoned
- 1998-02-11 WO PCT/US1998/002375 patent/WO1998035940A1/en not_active Ceased
- 1998-02-11 PT PT98904990T patent/PT1017675E/pt unknown
-
2009
- 2009-03-02 JP JP2009047622A patent/JP5264561B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ATE329903T1 (de) | 2006-07-15 |
| DE69834923D1 (en) | 2006-07-27 |
| DK1017675T3 (da) | 2006-10-16 |
| JP2009149680A (ja) | 2009-07-09 |
| DE69834923T2 (de) | 2006-10-19 |
| CA2280905C (en) | 2006-08-29 |
| ES2262223T3 (es) | 2006-11-16 |
| WO1998035940A1 (en) | 1998-08-20 |
| EP1017675A4 (en) | 2001-08-22 |
| EP1017675B1 (en) | 2006-06-14 |
| JP2001511807A (ja) | 2001-08-14 |
| EP1017675A1 (en) | 2000-07-12 |
| JP5264561B2 (ja) | 2013-08-14 |
| CA2280905A1 (en) | 1998-08-20 |
| JP4311765B2 (ja) | 2009-08-12 |
| PT1017675E (pt) | 2006-09-29 |
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