ATE329903T1 - Hochgradig lipophile camptothecin-derivate - Google Patents

Hochgradig lipophile camptothecin-derivate

Info

Publication number
ATE329903T1
ATE329903T1 AT98904990T AT98904990T ATE329903T1 AT E329903 T1 ATE329903 T1 AT E329903T1 AT 98904990 T AT98904990 T AT 98904990T AT 98904990 T AT98904990 T AT 98904990T AT E329903 T1 ATE329903 T1 AT E329903T1
Authority
AT
Austria
Prior art keywords
derivatives
camptothecin derivatives
highly lipophilic
lipophilic camptothecin
substitution
Prior art date
Application number
AT98904990T
Other languages
German (de)
English (en)
Inventor
Frederick H Hausheer
Kochat Haridas
P Seetharamulu
Dasharatha G Reddy
Shijie Yao
Pavankumar N V Petluru
Dhanabalan Murali
Original Assignee
Bionumerik Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bionumerik Pharmaceuticals Inc filed Critical Bionumerik Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE329903T1 publication Critical patent/ATE329903T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Silicon Polymers (AREA)
  • Saccharide Compounds (AREA)
AT98904990T 1997-02-14 1998-02-11 Hochgradig lipophile camptothecin-derivate ATE329903T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3714897P 1997-02-14 1997-02-14

Publications (1)

Publication Number Publication Date
ATE329903T1 true ATE329903T1 (de) 2006-07-15

Family

ID=21892705

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98904990T ATE329903T1 (de) 1997-02-14 1998-02-11 Hochgradig lipophile camptothecin-derivate

Country Status (10)

Country Link
EP (1) EP1017675B1 (enExample)
JP (2) JP4311765B2 (enExample)
AT (1) ATE329903T1 (enExample)
AU (1) AU6272598A (enExample)
CA (1) CA2280905C (enExample)
DE (1) DE69834923T2 (enExample)
DK (1) DK1017675T3 (enExample)
ES (1) ES2262223T3 (enExample)
PT (1) PT1017675E (enExample)
WO (1) WO1998035940A1 (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6743917B2 (en) 1993-06-30 2004-06-01 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
US6150343A (en) 1993-06-30 2000-11-21 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
US6136978A (en) * 1993-06-30 2000-10-24 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
FR2790261B1 (fr) 1999-02-26 2004-09-10 Sod Conseils Rech Applic Nouveaux analogues optiquement purs de la camptothecine et leurs procedes de preparation
CA2280905C (en) * 1997-02-14 2006-08-29 Bionumerik Pharmaceuticals, Inc. Highly lipophilic camptothecin derivatives
US6057303A (en) * 1998-10-20 2000-05-02 Bionumerik Pharmaceuticals, Inc. Highly lipophilic Camptothecin derivatives
US6207832B1 (en) 1999-04-09 2001-03-27 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
WO2000066127A1 (en) * 1999-05-04 2000-11-09 Bionumerik Pharmaceuticals, Inc. Novel highly lipophilic camptothecin analogs
US6350756B1 (en) * 2001-01-18 2002-02-26 California Pacific Medical Center Camptothecin derivatives
US6855720B2 (en) 2001-03-01 2005-02-15 California Pacific Medical Center Nitrogen-based camptothecin derivatives
US6372906B1 (en) 2001-04-12 2002-04-16 University Of Pittsburgh Synthesis of silyl camptothecins and silyl homocamptothecins
US6723853B2 (en) 2001-08-27 2004-04-20 University Of Pittsburgh Intermediates and methods of preparation of intermediates in the enantiomeric synthesis of (20R)homocamptothecins and the enantiomeric synthesis of (20R)homocamptothecins
MXPA04005185A (es) 2001-11-30 2004-08-11 Chugai Pharmaceutical Co Ltd Compuestos hexaciclicos.
AU2003243380A1 (en) 2002-06-03 2003-12-19 California Pacific Medical Center Nitrogen-based homo-camptothecin derivatives
EP1393719A1 (en) * 2002-08-23 2004-03-03 Munich Biotech AG Camptothecin-carboxylate formulations
US7067666B2 (en) * 2003-06-27 2006-06-27 Research Triangle Institute 7-substituted camptothecin and camptothecin analogs and methods for producing the same
EP1694242B1 (en) * 2003-12-17 2014-04-16 Bionumerik Pharmaceuticals, Inc. Process for making pharmaceutical 7-(2-trimethylsilylethyl) camptothecin formulations
EP1757609B1 (en) 2004-04-09 2013-10-16 Chugai Seiyaku Kabushiki Kaisha Novel water-soluble prodrug
ITRM20040240A1 (it) * 2004-05-13 2004-08-13 Ist Naz Stud Cura Dei Tumori Camptotecine coniugate in posizione 7 con antagonisti delle integrine.
TW200744603A (en) 2005-08-22 2007-12-16 Chugai Pharmaceutical Co Ltd Novel anticancer concomitant drug
US7875602B2 (en) 2005-10-21 2011-01-25 Sutter West Bay Hospitals Camptothecin derivatives as chemoradiosensitizing agents
WO2007075492A1 (en) * 2005-12-16 2007-07-05 Sonus Pharmaceuticals, Inc. Lipophilic anticancer drug compounds
KR20090036585A (ko) * 2006-08-11 2009-04-14 더 크리스터스 스텔린 파운데이션 포 캔서 리서치 캄프토테신의 에스테르의 제조 방법
WO2011155501A1 (ja) 2010-06-11 2011-12-15 独立行政法人科学技術振興機構 薬剤多量体微粒子及びその製造方法
WO2014067960A2 (en) * 2012-10-30 2014-05-08 Nerviano Medical Sciences S.R.L. Functionalized 9-bromo-camptothecin derivatives
FR3029637B1 (fr) 2014-12-05 2018-01-05 Universite De Strasbourg Microdispositif de detection de composes organiques volatils et methode de detection d'au moins un compose organique volatil compris dans un echantillon gazeux
WO2025077773A1 (zh) * 2023-10-10 2025-04-17 上海翊维康医药有限责任公司 新的i型拓扑异构酶抑制剂及其制备方法和用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5004758A (en) * 1987-12-01 1991-04-02 Smithkline Beecham Corporation Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
JPH0615547B2 (ja) * 1988-01-20 1994-03-02 株式会社ヤクルト本社 新規なカンプトテシン誘導体
US5446047A (en) * 1992-07-23 1995-08-29 Sloan-Kettering Institute For Cancer Research Camptothecin analogues
US5468754A (en) * 1994-04-19 1995-11-21 Bionumerik Pharmaceuticals, Inc. 11,7 substituted camptothecin derivatives and formulations of 11,7 substituted camptothecin derivatives and methods for uses thereof
GB9510716D0 (en) * 1995-05-26 1995-07-19 Pharmacia Spa Substituted camptothecin derivatives and process for their preparation
CA2280905C (en) * 1997-02-14 2006-08-29 Bionumerik Pharmaceuticals, Inc. Highly lipophilic camptothecin derivatives

Also Published As

Publication number Publication date
DE69834923D1 (en) 2006-07-27
AU6272598A (en) 1998-09-08
DK1017675T3 (da) 2006-10-16
JP2009149680A (ja) 2009-07-09
DE69834923T2 (de) 2006-10-19
CA2280905C (en) 2006-08-29
ES2262223T3 (es) 2006-11-16
WO1998035940A1 (en) 1998-08-20
EP1017675A4 (en) 2001-08-22
EP1017675B1 (en) 2006-06-14
JP2001511807A (ja) 2001-08-14
EP1017675A1 (en) 2000-07-12
JP5264561B2 (ja) 2013-08-14
CA2280905A1 (en) 1998-08-20
JP4311765B2 (ja) 2009-08-12
PT1017675E (pt) 2006-09-29

Similar Documents

Publication Publication Date Title
ATE329903T1 (de) Hochgradig lipophile camptothecin-derivate
ATE261974T1 (de) Hoch-lipophile campothecin-derivate
AR022860A1 (es) Derivados de camptotecina que poseen actividad antitumoral
EA200100111A1 (ru) Ингибиторы фарнезилпротеинтрансферазы, обладающие in vivo радиосенсибилизирующими свойствами
PT1212312E (pt) Novos derivados de flavonas xantonas e cumarinas
DE60021381D1 (de) Chinonverbindungen zur behandlung von krankheiten
ATE344670T1 (de) Synergistische kombination zur behandlung von kolorektalkarzinom
NO20015338D0 (no) Androgenderivater og anvendelse derav
NO20031410D0 (no) Antitumorterapi innbefattende distamycinderivater
PT1107793E (pt) Conjugados de dextrano-leptina, composicoes farmaceuticas e processos relacionados
ATE217531T1 (de) Verwendung von natriumchlorid zur verminderung der gastrointestinalen toxizität von camptotecinderivaten.
TR200302134T4 (tr) 2-metil-tiazolidin-2,4-dikarboksilik asit ve/veya bunun fizyolojik olarak uygun tuzlarının anti-kanser ajanları olarak kullanımı.
WO2002078690A3 (en) Taxoid anti-tumor agents and pharmaceutical compositions thereof
BR0014687A (pt) Compostos de taxano pentacìclico
DK1373260T3 (da) Dibenzo C chromen-6-onderivater som anticancermidler
SE9803107D0 (sv) Novel Compunds
CY1106306T1 (el) Παραγωγα 5-ιμινο-13-δεοξυ ανθρακυκλινης, οι χρησεις τους και διepγασιες παρασκευης αυτων
SE9602262D0 (sv) New use of derivatives of cystine
SE9803277D0 (sv) Novel compounds
ATE480522T1 (de) 9-alkylamino-1-nitroacridin-derivate

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1017675

Country of ref document: EP