AU624595B2 - Method for treating and preventing secondary effects of hyperinsulinemia and for treating type 2 diabetes, obesity and hyperlipidemia by application of insulin-like growth factor (IGF I) - Google Patents
Method for treating and preventing secondary effects of hyperinsulinemia and for treating type 2 diabetes, obesity and hyperlipidemia by application of insulin-like growth factor (IGF I) Download PDFInfo
- Publication number
- AU624595B2 AU624595B2 AU28999/89A AU2899989A AU624595B2 AU 624595 B2 AU624595 B2 AU 624595B2 AU 28999/89 A AU28999/89 A AU 28999/89A AU 2899989 A AU2899989 A AU 2899989A AU 624595 B2 AU624595 B2 AU 624595B2
- Authority
- AU
- Australia
- Prior art keywords
- igf
- insulin
- diabetics
- treating
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title claims description 24
- 230000009291 secondary effect Effects 0.000 title claims description 16
- 206010060378 Hyperinsulinaemia Diseases 0.000 title claims description 15
- 230000003451 hyperinsulinaemic effect Effects 0.000 title claims description 15
- 201000008980 hyperinsulinism Diseases 0.000 title claims description 15
- 208000031226 Hyperlipidaemia Diseases 0.000 title claims description 12
- 208000001072 type 2 diabetes mellitus Diseases 0.000 title description 9
- 208000008589 Obesity Diseases 0.000 title description 7
- 235000020824 obesity Nutrition 0.000 title description 7
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 title description 5
- 102000013275 Somatomedins Human genes 0.000 title description 3
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 118
- 102000004877 Insulin Human genes 0.000 claims description 59
- 108090001061 Insulin Proteins 0.000 claims description 59
- 229940125396 insulin Drugs 0.000 claims description 59
- 210000004369 blood Anatomy 0.000 claims description 20
- 239000008280 blood Substances 0.000 claims description 20
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 19
- 239000008103 glucose Substances 0.000 claims description 19
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 14
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 230000000694 effects Effects 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 238000007796 conventional method Methods 0.000 claims description 4
- 230000002265 prevention Effects 0.000 claims description 4
- 239000011885 synergistic combination Substances 0.000 claims description 2
- 239000003708 ampul Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 101000599951 Homo sapiens Insulin-like growth factor I Proteins 0.000 description 80
- 102100037852 Insulin-like growth factor I Human genes 0.000 description 79
- 238000001802 infusion Methods 0.000 description 34
- 210000002966 serum Anatomy 0.000 description 22
- VOUAQYXWVJDEQY-QENPJCQMSA-N 33017-11-7 Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)CCC1 VOUAQYXWVJDEQY-QENPJCQMSA-N 0.000 description 12
- 230000037396 body weight Effects 0.000 description 12
- 108010075254 C-Peptide Proteins 0.000 description 11
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 9
- 238000007920 subcutaneous administration Methods 0.000 description 8
- 241000282414 Homo sapiens Species 0.000 description 7
- 208000013016 Hypoglycemia Diseases 0.000 description 6
- 238000003556 assay Methods 0.000 description 5
- 230000002218 hypoglycaemic effect Effects 0.000 description 5
- 230000002093 peripheral effect Effects 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- 230000003247 decreasing effect Effects 0.000 description 4
- 230000004190 glucose uptake Effects 0.000 description 4
- 230000003914 insulin secretion Effects 0.000 description 4
- 206010022489 Insulin Resistance Diseases 0.000 description 3
- 241000700159 Rattus Species 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 230000001419 dependent effect Effects 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000003978 infusion fluid Substances 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 230000002503 metabolic effect Effects 0.000 description 3
- 210000003205 muscle Anatomy 0.000 description 3
- 150000003626 triacylglycerols Chemical class 0.000 description 3
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 102000003746 Insulin Receptor Human genes 0.000 description 2
- 108010001127 Insulin Receptor Proteins 0.000 description 2
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 description 2
- 230000036772 blood pressure Effects 0.000 description 2
- 230000036760 body temperature Effects 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 238000001990 intravenous administration Methods 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000003127 radioimmunoassay Methods 0.000 description 2
- 239000008223 sterile water Substances 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 1
- 101100097985 Caenorhabditis elegans mars-1 gene Proteins 0.000 description 1
- 241000518994 Conta Species 0.000 description 1
- 102000018997 Growth Hormone Human genes 0.000 description 1
- 108010051696 Growth Hormone Proteins 0.000 description 1
- 108010023302 HDL Cholesterol Proteins 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 238000008214 LDL Cholesterol Methods 0.000 description 1
- 108010028554 LDL Cholesterol Proteins 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 101000642591 Xenopus laevis Somatotropin-A Proteins 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000003178 anti-diabetic effect Effects 0.000 description 1
- 239000003472 antidiabetic agent Substances 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 235000020934 caloric restriction Nutrition 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 1
- 230000014101 glucose homeostasis Effects 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 239000000122 growth hormone Substances 0.000 description 1
- 230000003284 homeostatic effect Effects 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000002608 insulinlike Effects 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000022001 negative regulation of insulin secretion Effects 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 235000015277 pork Nutrition 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP88810072 | 1988-02-05 | ||
| EP88810072 | 1988-02-05 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2899989A AU2899989A (en) | 1989-08-10 |
| AU624595B2 true AU624595B2 (en) | 1992-06-18 |
Family
ID=8200571
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU28999/89A Expired AU624595B2 (en) | 1988-02-05 | 1989-02-01 | Method for treating and preventing secondary effects of hyperinsulinemia and for treating type 2 diabetes, obesity and hyperlipidemia by application of insulin-like growth factor (IGF I) |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4988675A (de) |
| EP (1) | EP0331630B1 (de) |
| JP (1) | JP2831017B2 (de) |
| KR (1) | KR0131087B1 (de) |
| AU (1) | AU624595B2 (de) |
| CA (1) | CA1336815C (de) |
| DE (1) | DE68905205T2 (de) |
| DK (1) | DK169233B1 (de) |
| IE (1) | IE63163B1 (de) |
| IL (1) | IL89166A0 (de) |
| NZ (1) | NZ227857A (de) |
| PH (1) | PH26085A (de) |
| ZA (1) | ZA89855B (de) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6440928B1 (en) | 1988-12-06 | 2002-08-27 | Colorado State University Research Foundation | Method for treating diabetic neuropathy with NGF |
| GB8920381D0 (en) * | 1989-09-08 | 1989-10-25 | Greater Glasgow Health Board | Treatment of insulin-resistant diabetes |
| US5128320A (en) * | 1990-01-18 | 1992-07-07 | Genentech, Inc. | Method of restoring normal growth, weight gain or lean body mass in patients with glucocorticoid excess by administering igf-i |
| US5126324A (en) * | 1990-06-07 | 1992-06-30 | Genentech, Inc. | Method of enhancing growth in patients using combination therapy |
| US5681814A (en) * | 1990-06-07 | 1997-10-28 | Genentech, Inc. | Formulated IGF-I Composition |
| SE9100099D0 (sv) * | 1991-01-11 | 1991-01-11 | Kabi Pharmacia Ab | Use of growth factor |
| SE9201573D0 (sv) * | 1992-05-19 | 1992-05-19 | Kabi Pharmacia Ab | Use of igf-1 |
| AU670951B2 (en) * | 1992-06-08 | 1996-08-08 | Chiron Corporation | Use of growth factor IGF-I and/or IGF-II |
| US20070078089A1 (en) * | 1992-07-06 | 2007-04-05 | Ishii Douglas N | Method for effecting changes in the central nervous system by administration of IGF-I or IGF-II |
| DE69305091T2 (de) * | 1992-10-29 | 1997-03-13 | Genentech Inc | Methode zur behandlung oder verhütung von fettleibigkeit |
| WO1994016722A1 (en) * | 1993-01-25 | 1994-08-04 | The Beth Israel Hospital Association | Method for modifying, diagnosing, and screening for igf-i sensitive cell barrier properties |
| US5446024A (en) * | 1993-12-17 | 1995-08-29 | Genentech, Inc. | Purification of insulin-like growth factor |
| SE9402331D0 (sv) * | 1994-07-01 | 1994-07-01 | Pharmacia Ab | New use |
| SE9402370D0 (sv) * | 1994-07-04 | 1994-07-04 | Pharmacia Ab | Use of IGF-I |
| US5712249A (en) * | 1994-09-08 | 1998-01-27 | Ciba-Geigy Corporation | Use of insulin-like growth factors I and II for inhibition of inflammatory response |
| US5565428A (en) * | 1995-05-22 | 1996-10-15 | Genentech, Inc. | Method of administration of IGF-I |
| US5741776A (en) * | 1995-05-22 | 1998-04-21 | Genentech, Inc. | Method of administration of IGF-I |
| EP0766966A3 (de) * | 1995-09-08 | 2001-02-28 | Eli Lilly And Company | Methode zur Behandlung der Insulinresistenz |
| US5783556A (en) * | 1996-08-13 | 1998-07-21 | Genentech, Inc. | Formulated insulin-containing composition |
| US6514937B1 (en) | 1997-02-25 | 2003-02-04 | Celtrix Pharmaceuticals, Inc. | Method of treating psychological and metabolic disorders using IGF or IGF/IGFBP-3 |
| US6015786A (en) * | 1997-02-25 | 2000-01-18 | Celtrix Pharmaceuticals, Inc. | Method for increasing sex steroid levels using IGF or IGF/IGFBP-3 |
| US6025368A (en) * | 1997-02-25 | 2000-02-15 | Celtrix Pharmaceuticals, Inc. | Method for treating the symptoms of chronic stress-related disorders using IGF |
| US5916569A (en) * | 1997-03-26 | 1999-06-29 | E. Martin Spencer | Human erectile dysfunction and methods of treatment |
| US6420518B1 (en) | 1997-04-04 | 2002-07-16 | Genetech, Inc. | Insulin-like growth factor agonist molecules |
| US6121416A (en) | 1997-04-04 | 2000-09-19 | Genentech, Inc. | Insulin-like growth factor agonist molecules |
| DE60016560T2 (de) * | 1999-01-06 | 2005-12-15 | Genentech, Inc., South San Francisco | Mutierte variante des insulin-ähnlichen wachstumsfaktor-i (igf-i) |
| DE60005806T2 (de) | 1999-04-08 | 2004-08-05 | Genentech, Inc., South San Francisco | Zusammensetzung auf basis gegensätzlich geladener polypeptide |
| US6040292A (en) * | 1999-06-04 | 2000-03-21 | Celtrix Pharmaceuticals, Inc. | Methods for treating diabetes |
| EP1196189A2 (de) * | 1999-06-25 | 2002-04-17 | Medtronic MiniMed, Inc. | Unterschiedliche wirkstoffe für diabetestherapie |
| DK1282437T3 (da) | 2000-05-16 | 2008-06-30 | Genentech Inc | Behandling af brusklidelser |
| ATE463252T1 (de) * | 2000-08-29 | 2010-04-15 | Aurogen Inc | Methode zur behandlung des zentralnervensystems durch applikation von strukturanaloga von igf |
| NZ526672A (en) * | 2001-02-09 | 2006-10-27 | Genentech Inc | Process for forming crystalline human insulin-like growth factor-1 |
| WO2002067969A2 (en) | 2001-02-21 | 2002-09-06 | Medtronic Minimed, Inc. | Stabilized insulin formulations |
| AU2002248609B2 (en) * | 2001-03-14 | 2007-03-01 | Genentech, Inc. | IGF antagonist peptides |
| US6737401B2 (en) * | 2001-06-28 | 2004-05-18 | Metronic Minimed, Inc. | Methods of evaluating protein formulation stability and surfactant-stabilized insulin formulations derived therefrom |
| DE10316583A1 (de) | 2003-04-10 | 2004-10-28 | B.R.A.H.M.S Aktiengesellschaft | Bestimmung eines midregionalen Proadrenomedullin-Teilpeptids in biologischen Flüssigkeiten zu diagnostischen Zwecken, sowie Immunoassays für die Durchführung einer solchen Bestimmung |
| WO2005020898A2 (en) * | 2003-08-21 | 2005-03-10 | Tercica, Inc. | Methods of reducing visceral fat by increasing levels of insulin-like growth factor-i (igf-i) |
| CN101022820A (zh) * | 2004-08-30 | 2007-08-22 | 特西卡股份有限公司 | 诊断和治疗胰岛素样生长因子缺陷疾病的方法和装置 |
| KR102288366B1 (ko) * | 2018-03-09 | 2021-08-10 | 경북대학교 산학협력단 | 한속단 추출물을 유효성분으로 포함하는 비만 예방 또는 치료용 약학적 조성물 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0123228B1 (de) * | 1983-04-25 | 1993-09-29 | Chiron Corporation | Hybrid-DNS-Synthesis von reifen insulinähnlichen Wachstumsfaktoren |
-
1989
- 1989-01-25 US US07/301,680 patent/US4988675A/en not_active Expired - Lifetime
- 1989-01-26 EP EP89810074A patent/EP0331630B1/de not_active Expired - Lifetime
- 1989-01-26 DE DE8989810074T patent/DE68905205T2/de not_active Expired - Lifetime
- 1989-01-31 PH PH38126A patent/PH26085A/en unknown
- 1989-02-01 AU AU28999/89A patent/AU624595B2/en not_active Expired
- 1989-02-03 ZA ZA89855A patent/ZA89855B/xx unknown
- 1989-02-03 CA CA000590025A patent/CA1336815C/en not_active Expired - Fee Related
- 1989-02-03 DK DK052189A patent/DK169233B1/da not_active IP Right Cessation
- 1989-02-03 NZ NZ227857A patent/NZ227857A/en unknown
- 1989-02-03 IL IL8989166A patent/IL89166A0/xx unknown
- 1989-02-03 IE IE35789A patent/IE63163B1/en not_active IP Right Cessation
- 1989-02-03 JP JP1024105A patent/JP2831017B2/ja not_active Expired - Lifetime
- 1989-02-04 KR KR1019890001312A patent/KR0131087B1/ko not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2831017B2 (ja) | 1998-12-02 |
| IE63163B1 (en) | 1995-03-22 |
| KR890012667A (ko) | 1989-09-18 |
| EP0331630A1 (de) | 1989-09-06 |
| IE890357L (en) | 1989-08-05 |
| EP0331630B1 (de) | 1993-03-10 |
| NZ227857A (en) | 1992-04-28 |
| AU2899989A (en) | 1989-08-10 |
| PH26085A (en) | 1992-02-06 |
| JPH01233227A (ja) | 1989-09-19 |
| DE68905205D1 (de) | 1993-04-15 |
| KR0131087B1 (ko) | 1998-04-17 |
| DK52189D0 (da) | 1989-02-03 |
| DK52189A (da) | 1989-08-06 |
| CA1336815C (en) | 1995-08-29 |
| DK169233B1 (da) | 1994-09-19 |
| US4988675A (en) | 1991-01-29 |
| IL89166A0 (en) | 1989-09-10 |
| DE68905205T2 (de) | 1993-07-22 |
| ZA89855B (en) | 1989-10-25 |
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