AU611850B2 - Oligopeptidyl nitrile derivatives, agents containing them, a process for their preparation, and their use - Google Patents

Oligopeptidyl nitrile derivatives, agents containing them, a process for their preparation, and their use Download PDF

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Publication number
AU611850B2
AU611850B2 AU69548/87A AU6954887A AU611850B2 AU 611850 B2 AU611850 B2 AU 611850B2 AU 69548/87 A AU69548/87 A AU 69548/87A AU 6954887 A AU6954887 A AU 6954887A AU 611850 B2 AU611850 B2 AU 611850B2
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AU
Australia
Prior art keywords
compound
formula
group
pro
phe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU69548/87A
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English (en)
Other versions
AU6954887A (en
Inventor
Werner Stuber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Behringwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke AG filed Critical Behringwerke AG
Publication of AU6954887A publication Critical patent/AU6954887A/en
Application granted granted Critical
Publication of AU611850B2 publication Critical patent/AU611850B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU69548/87A 1986-02-28 1987-02-27 Oligopeptidyl nitrile derivatives, agents containing them, a process for their preparation, and their use Ceased AU611850B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19863606480 DE3606480A1 (de) 1986-02-28 1986-02-28 Oligopeptidylnitrilderivate, diese enthaltende mittel, verfahren zu ihrer herstellung und ihre verwendung
DE3606480 1986-02-28

Publications (2)

Publication Number Publication Date
AU6954887A AU6954887A (en) 1987-09-03
AU611850B2 true AU611850B2 (en) 1991-06-27

Family

ID=6295130

Family Applications (1)

Application Number Title Priority Date Filing Date
AU69548/87A Ceased AU611850B2 (en) 1986-02-28 1987-02-27 Oligopeptidyl nitrile derivatives, agents containing them, a process for their preparation, and their use

Country Status (7)

Country Link
US (1) US4927809A (de)
EP (1) EP0235692B1 (de)
JP (1) JP2540534B2 (de)
AT (1) ATE69239T1 (de)
AU (1) AU611850B2 (de)
CA (1) CA1312702C (de)
DE (2) DE3606480A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5104869A (en) * 1989-10-11 1992-04-14 American Cyanamid Company Renin inhibitors
GB9024129D0 (en) * 1990-11-06 1990-12-19 Thrombosis Research Trust Inhibitors and substrates of thrombin
SE9103612D0 (sv) * 1991-12-04 1991-12-04 Astra Ab New peptide derivatives
US6387881B1 (en) 1992-09-19 2002-05-14 Trigen Ltd Inhibitors and substrates of thrombin
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
US5783563A (en) * 1993-06-03 1998-07-21 Astra Aktiebolag Method for treatment or prophylaxis of venous thrombosis
US6984627B1 (en) 1993-06-03 2006-01-10 Astrazeneca Ab Peptide derivatives
GB9318637D0 (en) * 1993-09-08 1993-10-27 Ferring Res Ltd Enzyme inhibitors
US5436229A (en) * 1994-03-04 1995-07-25 Eli Lilly And Company Bisulfite adducts of arginine aldehydes
SE9404196D0 (sv) * 1994-12-02 1994-12-02 Astra Ab New antithrombotic formulation
TWI238827B (en) 1995-12-21 2005-09-01 Astrazeneca Ab Prodrugs of thrombin inhibitors
US7022677B1 (en) * 1999-02-18 2006-04-04 Kaken Pharmaceutical Co., Ltd. Amide derivatives as growth hormone secretagogues
EP1930021A3 (de) * 1999-02-18 2008-06-18 Kaken Pharmaceutical Co., Ltd. Neue Amidderivate als Wachstumshormonssekretagoge
WO2000055125A2 (en) * 1999-03-15 2000-09-21 Axys Pharmaceuticals, Inc. N-cyanomethyl amides as protease inhibitors
MXPA02006163A (es) * 1999-12-24 2002-12-05 Hoffmann La Roche Derivados de nitrilo como inhibidores de la catepsina k.
US7030116B2 (en) * 2000-12-22 2006-04-18 Aventis Pharmaceuticals Inc. Compounds and compositions as cathepsin inhibitors
US7064123B1 (en) 2000-12-22 2006-06-20 Aventis Pharmaceuticals Inc. Compounds and compositions as cathepsin inhibitors
NZ528944A (en) * 2001-06-01 2007-09-28 Axys Pharm Inc Chemical compounds and pharmaceutical compositions as cathepsin S inhibitors
US20040147503A1 (en) * 2002-06-04 2004-07-29 Sheila Zipfeil Novel compounds and compositions as cathepsin inhibitors
WO2003024924A1 (en) * 2001-09-14 2003-03-27 Aventis Pharmaceuticals Inc. Novel compounds and compositions as cathepsin inhibitors
US20030069187A1 (en) * 2001-10-05 2003-04-10 Rao Srinivasa K. Elastase inhibitors
HUP0401906A3 (en) * 2001-11-14 2008-07-28 Aventis Pharma Inc Novel cathepsin s inhibitors, process for their preparation and pharmaceutical compositions containing them
US7112572B2 (en) 2002-09-09 2006-09-26 Trigen Limited Multivalent metal salts of boronic acids
GB0405272D0 (en) * 2004-03-09 2004-04-21 Trigen Ltd Compounds

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7944682A (en) * 1981-01-13 1982-07-22 Gyogyszerkutato Intezet Kft D-phenylalanyl-l-prolyl-l-arginine aldehyde sulfate

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62298568A (ja) * 1986-06-17 1987-12-25 Sumitomo Chem Co Ltd 立体異性アミド誘導体およびそれを有効成分とする植物病害防除剤

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7944682A (en) * 1981-01-13 1982-07-22 Gyogyszerkutato Intezet Kft D-phenylalanyl-l-prolyl-l-arginine aldehyde sulfate

Also Published As

Publication number Publication date
EP0235692A2 (de) 1987-09-09
DE3774294D1 (de) 1991-12-12
US4927809A (en) 1990-05-22
JPS62207251A (ja) 1987-09-11
EP0235692A3 (en) 1988-09-07
EP0235692B1 (de) 1991-11-06
CA1312702C (en) 1993-01-12
JP2540534B2 (ja) 1996-10-02
DE3606480A1 (de) 1987-09-03
ATE69239T1 (de) 1991-11-15
AU6954887A (en) 1987-09-03

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