AU611850B2 - Oligopeptidyl nitrile derivatives, agents containing them, a process for their preparation, and their use - Google Patents
Oligopeptidyl nitrile derivatives, agents containing them, a process for their preparation, and their use Download PDFInfo
- Publication number
- AU611850B2 AU611850B2 AU69548/87A AU6954887A AU611850B2 AU 611850 B2 AU611850 B2 AU 611850B2 AU 69548/87 A AU69548/87 A AU 69548/87A AU 6954887 A AU6954887 A AU 6954887A AU 611850 B2 AU611850 B2 AU 611850B2
- Authority
- AU
- Australia
- Prior art keywords
- compound
- formula
- group
- pro
- phe
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19863606480 DE3606480A1 (de) | 1986-02-28 | 1986-02-28 | Oligopeptidylnitrilderivate, diese enthaltende mittel, verfahren zu ihrer herstellung und ihre verwendung |
DE3606480 | 1986-02-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
AU6954887A AU6954887A (en) | 1987-09-03 |
AU611850B2 true AU611850B2 (en) | 1991-06-27 |
Family
ID=6295130
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU69548/87A Ceased AU611850B2 (en) | 1986-02-28 | 1987-02-27 | Oligopeptidyl nitrile derivatives, agents containing them, a process for their preparation, and their use |
Country Status (7)
Country | Link |
---|---|
US (1) | US4927809A (de) |
EP (1) | EP0235692B1 (de) |
JP (1) | JP2540534B2 (de) |
AT (1) | ATE69239T1 (de) |
AU (1) | AU611850B2 (de) |
CA (1) | CA1312702C (de) |
DE (2) | DE3606480A1 (de) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5104869A (en) * | 1989-10-11 | 1992-04-14 | American Cyanamid Company | Renin inhibitors |
GB9024129D0 (en) * | 1990-11-06 | 1990-12-19 | Thrombosis Research Trust | Inhibitors and substrates of thrombin |
SE9103612D0 (sv) * | 1991-12-04 | 1991-12-04 | Astra Ab | New peptide derivatives |
US6387881B1 (en) | 1992-09-19 | 2002-05-14 | Trigen Ltd | Inhibitors and substrates of thrombin |
SE9301916D0 (sv) * | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
US5783563A (en) * | 1993-06-03 | 1998-07-21 | Astra Aktiebolag | Method for treatment or prophylaxis of venous thrombosis |
US6984627B1 (en) | 1993-06-03 | 2006-01-10 | Astrazeneca Ab | Peptide derivatives |
GB9318637D0 (en) * | 1993-09-08 | 1993-10-27 | Ferring Res Ltd | Enzyme inhibitors |
US5436229A (en) * | 1994-03-04 | 1995-07-25 | Eli Lilly And Company | Bisulfite adducts of arginine aldehydes |
SE9404196D0 (sv) * | 1994-12-02 | 1994-12-02 | Astra Ab | New antithrombotic formulation |
TWI238827B (en) | 1995-12-21 | 2005-09-01 | Astrazeneca Ab | Prodrugs of thrombin inhibitors |
US7022677B1 (en) * | 1999-02-18 | 2006-04-04 | Kaken Pharmaceutical Co., Ltd. | Amide derivatives as growth hormone secretagogues |
EP1930021A3 (de) * | 1999-02-18 | 2008-06-18 | Kaken Pharmaceutical Co., Ltd. | Neue Amidderivate als Wachstumshormonssekretagoge |
WO2000055125A2 (en) * | 1999-03-15 | 2000-09-21 | Axys Pharmaceuticals, Inc. | N-cyanomethyl amides as protease inhibitors |
MXPA02006163A (es) * | 1999-12-24 | 2002-12-05 | Hoffmann La Roche | Derivados de nitrilo como inhibidores de la catepsina k. |
US7030116B2 (en) * | 2000-12-22 | 2006-04-18 | Aventis Pharmaceuticals Inc. | Compounds and compositions as cathepsin inhibitors |
US7064123B1 (en) | 2000-12-22 | 2006-06-20 | Aventis Pharmaceuticals Inc. | Compounds and compositions as cathepsin inhibitors |
NZ528944A (en) * | 2001-06-01 | 2007-09-28 | Axys Pharm Inc | Chemical compounds and pharmaceutical compositions as cathepsin S inhibitors |
US20040147503A1 (en) * | 2002-06-04 | 2004-07-29 | Sheila Zipfeil | Novel compounds and compositions as cathepsin inhibitors |
WO2003024924A1 (en) * | 2001-09-14 | 2003-03-27 | Aventis Pharmaceuticals Inc. | Novel compounds and compositions as cathepsin inhibitors |
US20030069187A1 (en) * | 2001-10-05 | 2003-04-10 | Rao Srinivasa K. | Elastase inhibitors |
HUP0401906A3 (en) * | 2001-11-14 | 2008-07-28 | Aventis Pharma Inc | Novel cathepsin s inhibitors, process for their preparation and pharmaceutical compositions containing them |
US7112572B2 (en) | 2002-09-09 | 2006-09-26 | Trigen Limited | Multivalent metal salts of boronic acids |
GB0405272D0 (en) * | 2004-03-09 | 2004-04-21 | Trigen Ltd | Compounds |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU7944682A (en) * | 1981-01-13 | 1982-07-22 | Gyogyszerkutato Intezet Kft | D-phenylalanyl-l-prolyl-l-arginine aldehyde sulfate |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62298568A (ja) * | 1986-06-17 | 1987-12-25 | Sumitomo Chem Co Ltd | 立体異性アミド誘導体およびそれを有効成分とする植物病害防除剤 |
-
1986
- 1986-02-28 DE DE19863606480 patent/DE3606480A1/de not_active Withdrawn
-
1987
- 1987-02-19 DE DE8787102369T patent/DE3774294D1/de not_active Expired - Fee Related
- 1987-02-19 EP EP87102369A patent/EP0235692B1/de not_active Expired - Lifetime
- 1987-02-19 AT AT87102369T patent/ATE69239T1/de not_active IP Right Cessation
- 1987-02-26 US US07/019,122 patent/US4927809A/en not_active Expired - Fee Related
- 1987-02-27 CA CA000530845A patent/CA1312702C/en not_active Expired - Fee Related
- 1987-02-27 JP JP62043243A patent/JP2540534B2/ja not_active Expired - Lifetime
- 1987-02-27 AU AU69548/87A patent/AU611850B2/en not_active Ceased
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU7944682A (en) * | 1981-01-13 | 1982-07-22 | Gyogyszerkutato Intezet Kft | D-phenylalanyl-l-prolyl-l-arginine aldehyde sulfate |
Also Published As
Publication number | Publication date |
---|---|
EP0235692A2 (de) | 1987-09-09 |
DE3774294D1 (de) | 1991-12-12 |
US4927809A (en) | 1990-05-22 |
JPS62207251A (ja) | 1987-09-11 |
EP0235692A3 (en) | 1988-09-07 |
EP0235692B1 (de) | 1991-11-06 |
CA1312702C (en) | 1993-01-12 |
JP2540534B2 (ja) | 1996-10-02 |
DE3606480A1 (de) | 1987-09-03 |
ATE69239T1 (de) | 1991-11-15 |
AU6954887A (en) | 1987-09-03 |
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