AU606925B2 - A method for producing factor viii in high yield - Google Patents

A method for producing factor viii in high yield Download PDF

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Publication number
AU606925B2
AU606925B2 AU13409/88A AU1340988A AU606925B2 AU 606925 B2 AU606925 B2 AU 606925B2 AU 13409/88 A AU13409/88 A AU 13409/88A AU 1340988 A AU1340988 A AU 1340988A AU 606925 B2 AU606925 B2 AU 606925B2
Authority
AU
Australia
Prior art keywords
factor viii
vwf
cells
factor
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU13409/88A
Other languages
English (en)
Other versions
AU1340988A (en
Inventor
Mark P. Pasek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biogen Inc
Original Assignee
Biogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Inc filed Critical Biogen Inc
Publication of AU1340988A publication Critical patent/AU1340988A/en
Application granted granted Critical
Publication of AU606925B2 publication Critical patent/AU606925B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU13409/88A 1987-01-30 1988-01-29 A method for producing factor viii in high yield Expired AU606925B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US923787A 1987-01-30 1987-01-30
US009237 1987-01-30

Publications (2)

Publication Number Publication Date
AU1340988A AU1340988A (en) 1988-08-24
AU606925B2 true AU606925B2 (en) 1991-02-21

Family

ID=21736435

Family Applications (1)

Application Number Title Priority Date Filing Date
AU13409/88A Expired AU606925B2 (en) 1987-01-30 1988-01-29 A method for producing factor viii in high yield

Country Status (6)

Country Link
EP (1) EP0302925A4 (xx)
JP (1) JP2872255B2 (xx)
KR (1) KR890700671A (xx)
AU (1) AU606925B2 (xx)
NZ (1) NZ223369A (xx)
WO (1) WO1988005825A1 (xx)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5198349A (en) * 1986-01-03 1993-03-30 Genetics Institute, Inc. Method for producing factor VIII:C and analogs
CA1331157C (en) * 1987-04-06 1994-08-02 Randal J. Kaufman Method for producing factor viii:c-type proteins
DE3720246A1 (de) * 1987-06-19 1988-12-29 Behringwerke Ag Faktor viii:c-aehnliches molekuel mit koagulationsaktivitaet
JPH0387173A (ja) * 1987-09-10 1991-04-11 Teijin Ltd ヒト活性化天然型ファクター８ｃの製造方法及びそれに用いる形質転換体
CA1340740C (en) * 1987-12-08 1999-09-14 Eileen R. Mulvihill Co-expression in eukaryotic cells
US5648254A (en) * 1988-01-15 1997-07-15 Zymogenetics, Inc. Co-expression in eukaryotic cells
US5914109A (en) * 1990-06-15 1999-06-22 New York University Heterohybridomas producing human monoclonal antibodies to HIV-1
AT403764B (de) 1996-03-15 1998-05-25 Immuno Ag Stabiler faktor viii/vwf-komplex
AT403438B (de) * 1996-05-24 1998-02-25 Immuno Ag Pharmazeutische präparation mit faktor viii prokoagulationsaktivität und vwf-bindungsaktivität
CA2776503C (en) 2009-10-02 2020-07-28 The Children's Hospital Of Philadelphia Compositions and methods for enhancing coagulation factor viii function
US9394353B2 (en) 2011-10-18 2016-07-19 Csl Limited Method for improving the stability of purified factor VIII after reconstitution
WO2014008480A2 (en) 2012-07-06 2014-01-09 Biogen Idec Ma Inc. Cell line expressing single chain factor viii polypeptides and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4134585A (en) * 1984-04-20 1985-10-24 Genentech Inc. Preparation of functional human factor V111
AU5543586A (en) * 1985-03-07 1986-09-24 National Blood Authority Purification of blood coagulation factor viii by precipitation
AU6001586A (en) * 1985-07-11 1987-01-15 Armour Pharmaceutical Company Purification of factor viiic

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07106156B2 (ja) * 1983-10-28 1995-11-15 ジェネティックス、インスティチュ−ト ファクタ−▲ｖｉｉｉ▼および関連生産物の製造
DK165506C (da) * 1984-01-12 1993-04-19 Chiron Corp Proteinpraeparat med koagulationsaktivitet samt fremgangsmaade til fremstilling deraf
NL8500961A (nl) * 1985-04-01 1986-11-03 Stichting Vrienden Van De Stic Cdna-codering voor de humane von willebrand-factor, plasmiden met een dergelijke cdna-codering respektievelijk fragmenten ervan, alsmede micro-organismen, welke dergelijke plasmiden bevatten.
EP0253870B1 (en) * 1986-01-03 1993-03-31 Genetics Institute, Inc. Method for producing factor viii:c-type proteins
EP0251843A1 (fr) * 1986-06-06 1988-01-07 Transgene S.A. Procédé de préparation de facteur VIII à partir de cellules de mammifères

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4134585A (en) * 1984-04-20 1985-10-24 Genentech Inc. Preparation of functional human factor V111
AU5543586A (en) * 1985-03-07 1986-09-24 National Blood Authority Purification of blood coagulation factor viii by precipitation
AU6001586A (en) * 1985-07-11 1987-01-15 Armour Pharmaceutical Company Purification of factor viiic

Also Published As

Publication number Publication date
WO1988005825A1 (en) 1988-08-11
JP2872255B2 (ja) 1999-03-17
KR890700671A (ko) 1989-04-26
NZ223369A (en) 1990-08-28
AU1340988A (en) 1988-08-24
JPH01501683A (ja) 1989-06-15
EP0302925A4 (en) 1989-04-24
EP0302925A1 (en) 1989-02-15

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