AU605172B2 - Polyesters containing alkylene oxide blocks as drug delivery systems - Google Patents

Polyesters containing alkylene oxide blocks as drug delivery systems Download PDF

Info

Publication number
AU605172B2
AU605172B2 AU77970/87A AU7797087A AU605172B2 AU 605172 B2 AU605172 B2 AU 605172B2 AU 77970/87 A AU77970/87 A AU 77970/87A AU 7797087 A AU7797087 A AU 7797087A AU 605172 B2 AU605172 B2 AU 605172B2
Authority
AU
Australia
Prior art keywords
block
polymer
peo
copolymer
gly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU77970/87A
Other languages
English (en)
Other versions
AU7797087A (en
Inventor
Donald James Casey
Peter Kendrick Jarrett
Louis Rosati
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/903,801 external-priority patent/US4882168A/en
Priority claimed from US06/903,797 external-priority patent/US4716203A/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of AU7797087A publication Critical patent/AU7797087A/en
Application granted granted Critical
Publication of AU605172B2 publication Critical patent/AU605172B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/64—Polyesters containing both carboxylic ester groups and carbonate groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Materials For Medical Uses (AREA)
AU77970/87A 1986-09-05 1987-09-04 Polyesters containing alkylene oxide blocks as drug delivery systems Ceased AU605172B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US903801 1986-09-05
US06/903,801 US4882168A (en) 1986-09-05 1986-09-05 Polyesters containing alkylene oxide blocks as drug delivery systems
US903797 1986-09-05
US06/903,797 US4716203A (en) 1986-09-05 1986-09-05 Diblock and triblock copolymers

Publications (2)

Publication Number Publication Date
AU7797087A AU7797087A (en) 1988-03-10
AU605172B2 true AU605172B2 (en) 1991-01-10

Family

ID=27129378

Family Applications (1)

Application Number Title Priority Date Filing Date
AU77970/87A Ceased AU605172B2 (en) 1986-09-05 1987-09-04 Polyesters containing alkylene oxide blocks as drug delivery systems

Country Status (13)

Country Link
EP (1) EP0258780B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR880003985A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU605172B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BR (1) BR8704648A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1283988C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3786309T2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK462287A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2058081T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI873840L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR3008526T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HU205711B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL83764A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ221647A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL9401703A (nl) * 1994-10-14 1996-05-01 Rijksuniversiteit Kauwgom.
US5702717A (en) * 1995-10-25 1997-12-30 Macromed, Inc. Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers
US5665428A (en) * 1995-10-25 1997-09-09 Macromed, Inc. Preparation of peptide containing biodegradable microspheres by melt process
DE19726412A1 (de) * 1997-06-21 1998-12-24 Merck Patent Gmbh Implantatmaterial mit einer Träger-Wirkstoff-Kombination
US6201072B1 (en) 1997-10-03 2001-03-13 Macromed, Inc. Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US6004573A (en) * 1997-10-03 1999-12-21 Macromed, Inc. Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US6117949A (en) * 1998-10-01 2000-09-12 Macromed, Inc. Biodegradable low molecular weight triblock poly (lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
WO1999018142A1 (en) * 1997-10-03 1999-04-15 Macromed, Inc. BIODEGRADABLE LOW MOLECULAR WEIGHT TRIBLOCK POLY(LACTIDE-co-GLYCOLIDE) POLYETHYLENE GLYCOL COPOLYMERS HAVING REVERSE THERMAL GELATION PROPERTIES
US7662409B2 (en) 1998-09-25 2010-02-16 Gel-Del Technologies, Inc. Protein matrix materials, devices and methods of making and using thereof
US7018645B1 (en) 2000-04-27 2006-03-28 Macromed, Inc. Mixtures of various triblock polyester polyethylene glycol copolymers having improved gel properties
JP2004524410A (ja) * 2001-03-23 2004-08-12 ガムリンク エー／エス チューインガム用の分解可能な樹脂置換体
DK1370153T4 (en) 2001-03-23 2015-05-18 Gumlink As COATED degradable CHEWING GUM WITH IMPROVED STABILITY AND PROCESS FOR THE PREPARATION OF THIS
AU2002324447B2 (en) 2001-06-22 2006-06-29 Durect Corporation Zero-order prolonged release coaxial implants
ES2304501T3 (es) * 2002-02-15 2008-10-16 Nektar Therapeutics Al, Corporation Polimeros a base de oxido de alquileno degradables hidroliticamente.
WO2003092468A2 (en) 2002-04-29 2003-11-13 Gel-Del Technologies, Inc. Biomatrix structural containment and fixation systems and methods of use thereof
US20060034797A1 (en) * 2002-05-03 2006-02-16 Arien Albertina M E Polymeric micromulsions
US7649023B2 (en) 2002-06-11 2010-01-19 Novartis Ag Biodegradable block copolymeric compositions for drug delivery
ES2417324T3 (es) 2002-09-06 2013-08-07 Cerulean Pharma Inc. Polímeros a base de ciclodextrina para el suministro de los agentes terapéuticos enlazados covalentemente a ellos
CN1668209A (zh) 2002-09-24 2005-09-14 古木林科有限公司 含至少一种高分子量生物可降解聚合物的生物可降解口香糖
MXPA05002961A (es) 2002-09-24 2005-06-03 Gumlink As Goma de mascar que comprende al menos dos diferentes polimeros biodegradables.
DK1474995T3 (da) 2003-05-06 2013-02-18 Gumlink As Fremgangsmåde til fremstilling af tyggegummigranulater, et gummisammensætningsekstruder- og granuleringssystem og et tyggegummiprodukt
ATE405170T1 (de) 2003-05-06 2008-09-15 Gumlink As Methode zur herstellung von kaugummigranulat und komprimierten kaugummiprodukten, sowie ein kaugummigranuliersystem
US8465537B2 (en) 2003-06-17 2013-06-18 Gel-Del Technologies, Inc. Encapsulated or coated stent systems
EP1660013A4 (en) 2003-08-26 2011-07-20 Gel Del Technologies Inc BIOMATERIAL AND PROTEIN BIOCOACERVATES, METHODS OF MAKING AND USING THEM
WO2005055945A2 (en) 2003-12-08 2005-06-23 Gel-Del Technologies, Inc. Mucoadhesive drug delivery devices and methods of making and using thereof
US20080176958A1 (en) 2007-01-24 2008-07-24 Insert Therapeutics, Inc. Cyclodextrin-based polymers for therapeutics delivery
US11890371B2 (en) 2007-12-26 2024-02-06 Petvivo Holdings, Inc. Biocompatible protein-based particles and methods thereof
WO2010057177A2 (en) 2008-11-17 2010-05-20 Gel-Del Technologies, Inc. Protein biomaterial and biocoacervate vessel graft systems and methods of making and using thereof
JP5855568B2 (ja) 2009-09-15 2016-02-09 セルリアン・ファーマ・インコーポレイテッド 癌の治療法
CN103037903A (zh) 2010-05-18 2013-04-10 天蓝制药公司 用于治疗自身免疫性疾病或其它疾病的组合物和方法
US20140094432A1 (en) 2012-10-02 2014-04-03 Cerulean Pharma Inc. Methods and systems for polymer precipitation and generation of particles
US20230285576A1 (en) 2020-08-05 2023-09-14 Ellipses Pharma Ltd Treatment of cancer using a cyclodextrin-containing polymer-topoisomerase inhibitor conjugate and a parp inhibitor

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4047533A (en) * 1976-09-20 1977-09-13 American Cyanamid Company Absorbable surgical sutures coated with polyoxyethylene-polyoxypropylene copolymer lubricant
US4438253A (en) * 1982-11-12 1984-03-20 American Cyanamid Company Poly(glycolic acid)/poly(alkylene glycol) block copolymers and method of manufacturing the same
US4452973A (en) * 1982-11-12 1984-06-05 American Cyanamid Company Poly(glycolic acid)/poly(oxyethylene) triblock copolymers and method of manufacturing the same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3736646A (en) * 1971-10-18 1973-06-05 American Cyanamid Co Method of attaching surgical needles to multifilament polyglycolic acid absorbable sutures
US4429080A (en) * 1982-07-01 1984-01-31 American Cyanamid Company Synthetic copolymer surgical articles and method of manufacturing the same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4047533A (en) * 1976-09-20 1977-09-13 American Cyanamid Company Absorbable surgical sutures coated with polyoxyethylene-polyoxypropylene copolymer lubricant
US4438253A (en) * 1982-11-12 1984-03-20 American Cyanamid Company Poly(glycolic acid)/poly(alkylene glycol) block copolymers and method of manufacturing the same
US4452973A (en) * 1982-11-12 1984-06-05 American Cyanamid Company Poly(glycolic acid)/poly(oxyethylene) triblock copolymers and method of manufacturing the same

Also Published As

Publication number Publication date
HU205711B (en) 1992-06-29
FI873840A7 (fi) 1988-03-06
FI873840L (fi) 1988-03-06
DE3786309T2 (de) 1994-02-10
HUT52945A (en) 1990-09-28
GR3008526T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1993-10-29
DK462287A (da) 1988-03-06
IL83764A (en) 1991-05-12
NZ221647A (en) 1990-09-26
AU7797087A (en) 1988-03-10
EP0258780A2 (en) 1988-03-09
IL83764A0 (en) 1988-02-29
CA1283988C (en) 1991-05-07
BR8704648A (pt) 1988-04-26
EP0258780B1 (en) 1993-06-23
KR880003985A (ko) 1988-05-31
DE3786309D1 (de) 1993-07-29
ES2058081T3 (es) 1994-11-01
DK462287D0 (da) 1987-09-04
FI873840A0 (fi) 1987-09-04
EP0258780A3 (en) 1988-05-18

Similar Documents

Publication Publication Date Title
AU605172B2 (en) Polyesters containing alkylene oxide blocks as drug delivery systems
US4882168A (en) Polyesters containing alkylene oxide blocks as drug delivery systems
US5514380A (en) Biodegradable hydrogel copolymer as drug delivery matrix
US5548035A (en) Biodegradable copolymer as drug delivery matrix comprising polyethyleneoxide and aliphatic polyester blocks
Leong et al. Bioerodible polyanhydrides as drug‐carrier matrices. I: Characterization, degradation, and release characteristics
Park et al. Poly (L-lactic acid)/Pluronic blends: characterization of phase separation behavior, degradation, and morphology and use as protein-releasing matrixes
CA1246265A (en) Continuous release formulations
US4716203A (en) Diblock and triblock copolymers
CA1100041A (en) Absorbable pharmaceutical compositions based on isomorphic copolyoxalates
US6984393B2 (en) Biodegradable elastomer and method of preparing same
CA2553619C (en) Biodegradable multi-block co-polymers
Penco et al. Degradation behaviour of block copolymers containing poly (lactic-glycolic acid) and poly (ethylene glycol) segments
EP0260415A2 (en) Synthesis and application of high molecular weight polyanhydrides
US7074883B2 (en) Acid end group poly(D,L-lactide-co-glycolide) copolymers with high glycolide content
WO1989000855A1 (en) Polyanhydrides with improved hydrolytic degradation properties
EP1024790A4 (en) INJECTABLE BIODEGRADABLE BLOCK COPOLYMER GELS FOR USE IN DRUG ADMINISTRATION
KR20050058291A (ko) 약물 전달을 위한 생분해가능 블록 공중합성 조성물
JP2002500640A (ja) ポリ脂環式ホスホエステル化合物よりなる生分解性組成物、物品、及びその使用方法
US7193007B2 (en) Environment responsive gelling copolymer
Maa et al. Controlled release of 5-fluorouracil from linear poly (ortho esters)
JP2000512322A (ja) 制御された物理的状態と生物侵食性を持つポリマー
CA2402546C (en) Environment responsive gelling copolymer
JP2014221731A (ja) 温度応答性生分解性高分子組成物及びその製造方法
KR100527408B1 (ko) 카프로락톤과 락티드의 랜덤공중합체와 폴리에테르를이용한 생분해성 블록공중합체의 제조방법 및 이의 응용
JP5264103B2 (ja) 温度応答性を有する生分解性グラフト共重合体